LOCUS       NM_013403               3176 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens striatin 4 (STRN4), transcript variant 1, mRNA.
ACCESSION   NM_013403
VERSION     NM_013403.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3176)
  AUTHORS   Czauderna,C., Poplawski,A., O'Rourke,C.J., Castven,D.,
            Perez-Aguilar,B., Becker,D., Heilmann-Heimbach,S., Odenthal,M.,
            Amer,W., Schmiel,M., Drebber,U., Binder,H., Ridder,D.A.,
            Schindeldecker,M., Straub,B.K., Galle,P.R., Andersen,J.B.,
            Thorgeirsson,S.S., Park,Y.N. and Marquardt,J.U.
  TITLE     Epigenetic modifications precede molecular alterations and drive
            human hepatocarcinogenesis
  JOURNAL   JCI Insight 6 (17), e146196 (2021)
   PUBMED   34375307
  REMARK    GeneRIF: Epigenetic modifications precede molecular alterations and
            drive human hepatocarcinogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3176)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3176)
  AUTHORS   Seo,G., Han,H., Vargas,R.E., Yang,B., Li,X. and Wang,W.
  TITLE     MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component
            in Hippo Pathway Regulation
  JOURNAL   Cell Rep 32 (1), 107860 (2020)
   PUBMED   32640226
  REMARK    GeneRIF: MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex
            Component in Hippo Pathway Regulation.
REFERENCE   4  (bases 1 to 3176)
  AUTHORS   Wong,M., Hyodo,T., Asano,E., Funasaka,K., Miyahara,R., Hirooka,Y.,
            Goto,H., Hamaguchi,M. and Senga,T.
  TITLE     Silencing of STRN4 suppresses the malignant characteristics of
            cancer cells
  JOURNAL   Cancer Sci 105 (12), 1526-1532 (2014)
   PUBMED   25250919
  REMARK    GeneRIF: Results showed that depletion of STRN4 suppresses
            proliferation, migration, invasion and the anchorage-independent
            growth of cancer cells.
REFERENCE   5  (bases 1 to 3176)
  AUTHORS   Varjosalo,M., Sacco,R., Stukalov,A., van Drogen,A., Planyavsky,M.,
            Hauri,S., Aebersold,R., Bennett,K.L., Colinge,J., Gstaiger,M. and
            Superti-Furga,G.
  TITLE     Interlaboratory reproducibility of large-scale human
            protein-complex analysis by standardized AP-MS
  JOURNAL   Nat Methods 10 (4), 307-314 (2013)
   PUBMED   23455922
REFERENCE   6  (bases 1 to 3176)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3176)
  AUTHORS   Goudreault,M., D'Ambrosio,L.M., Kean,M.J., Mullin,M.J.,
            Larsen,B.G., Sanchez,A., Chaudhry,S., Chen,G.I., Sicheri,F.,
            Nesvizhskii,A.I., Aebersold,R., Raught,B. and Gingras,A.C.
  TITLE     A PP2A phosphatase high density interaction network identifies a
            novel striatin-interacting phosphatase and kinase complex linked to
            the cerebral cavernous malformation 3 (CCM3) protein
  JOURNAL   Mol Cell Proteomics 8 (1), 157-171 (2009)
   PUBMED   18782753
REFERENCE   8  (bases 1 to 3176)
  AUTHORS   Di Bernardo,M.C., Crowther-Swanepoel,D., Broderick,P., Webb,E.,
            Sellick,G., Wild,R., Sullivan,K., Vijayakrishnan,J., Wang,Y.,
            Pittman,A.M., Sunter,N.J., Hall,A.G., Dyer,M.J., Matutes,E.,
            Dearden,C., Mainou-Fowler,T., Jackson,G.H., Summerfield,G.,
            Harris,R.J., Pettitt,A.R., Hillmen,P., Allsup,D.J., Bailey,J.R.,
            Pratt,G., Pepper,C., Fegan,C., Allan,J.M., Catovsky,D. and
            Houlston,R.S.
  TITLE     A genome-wide association study identifies six susceptibility loci
            for chronic lymphocytic leukemia
  JOURNAL   Nat Genet 40 (10), 1204-1210 (2008)
   PUBMED   18758461
REFERENCE   9  (bases 1 to 3176)
  AUTHORS   Breitman,M., Zilberberg,A., Caspi,M. and Rosin-Arbesfeld,R.
  TITLE     The armadillo repeat domain of the APC tumor suppressor protein
            interacts with Striatin family members
  JOURNAL   Biochim Biophys Acta 1783 (10), 1792-1802 (2008)
   PUBMED   18502210
REFERENCE   10 (bases 1 to 3176)
  AUTHORS   Castets,F., Rakitina,T., Gaillard,S., Moqrich,A., Mattei,M.G. and
            Monneron,A.
  TITLE     Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat
            proteins principally expressed in the brain
  JOURNAL   J Biol Chem 275 (26), 19970-19977 (2000)
   PUBMED   10748158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA510367.1, AF212940.1 and BC034604.1.
            
            On Nov 23, 2018 this sequence version replaced NM_013403.2.
            
            Transcript Variant: This variant (1) uses an alternate splice site
            in the central coding region, compared to variant 2. The resulting
            isoform (1) lacks an internal 7-aa segment, compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF212940.1, BC034604.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263280.11/ ENSP00000263280.4
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA510367.1         14-33
            21-1085             AF212940.1         1-1065
            1086-2295           BC034604.1         1076-2285
            2296-3176           AF212940.1         2276-3156
FEATURES             Location/Qualifiers
     source          1..3176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..3176
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /note="striatin 4"
                     /db_xref="GeneID:29888"
                     /db_xref="HGNC:HGNC:15721"
                     /db_xref="MIM:614767"
     exon            1..302
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..2282
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /note="isoform 1 is encoded by transcript variant 1;
                     striatin, calmodulin binding protein 4; protein
                     phosphatase 2 regulatory subunit B'''gamma"
                     /codon_start=1
                     /product="striatin-4 isoform 1"
                     /protein_id="NP_037535.2"
                     /db_xref="CCDS:CCDS12690.1"
                     /db_xref="GeneID:29888"
                     /db_xref="HGNC:HGNC:15721"
                     /db_xref="MIM:614767"
                     /translation="MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPA
                     GKGGGGGGSPGPTAGPEPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQG
                     ERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVE
                     SVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEG
                     APRAPPGPAGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDS
                     DEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDP
                     RRCTVDGSPHELESRRVKLQGILADLRDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTI
                     GGGEVSLGDLADLTVTNDNDLSCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQ
                     SALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYS
                     GGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADG
                     TVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGS
                     ALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAV
                     TCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALI
                     ASAGADALAKVFV"
     exon            303..406
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            407..480
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            481..559
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            560..757
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            758..899
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1059
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1173
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1268
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1444
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1492
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1614
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1785
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1926
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2025
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2112
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2348
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..3176
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3158..3163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /note="hexamer: AATAAA"
     polyA_site      3176
                     /gene="STRN4"
                     /gene_synonym="PPP2R6C; ZIN; zinedin"
                     /note="major polyA site"
ORIGIN      
        1 aggccggccc cggggcctcc atgatggagg agcgagcggc cgccgcggtc gccgccgccg
       61 cctcctcctg ccgtccgctc ggctcaggcg cgggccctgg ccccactggg gcggccccgg
      121 tctccgcccc tgcccccggg ccgggcccgg caggtaaggg aggcggcggc ggaggcagcc
      181 ccgggcccac ggcgggcccg gagcccctga gcctgccggg gatcctgcac tttatccagc
      241 acgagtgggc gcgcttcgaa gccgagaaag cccgctggga ggccgagcgc gccgagttac
      301 aggctcaggt ggccttcctt cagggagaga ggaaagggca ggagaatcta aagacggacc
      361 tggtgcggcg gatcaagatg ctagagtatg cgctgaagca ggaaagggcc aaatatcata
      421 aactgaagtt tgggacagac ctgaaccagg gggagaagaa agcagatgtg tcagaacaag
      481 tctccaatgg ccccgtggaa tcggtcaccc tggagaacag cccgttggtg tggaaggagg
      541 ggcggcagct tctccgacag tacctggaag aggtgggcta cacagacacc atcctcgaca
      601 tgcggtccaa gcgcgtccgt tccctgctgg gccgctcgct ggagctcaac ggggcagtgg
      661 agccgagtga aggggccccc agggctccac caggccctgc agggctcagt ggtggggagt
      721 cgctgctggt gaaacagatc gaggagcaga taaagaggaa cgcggcaggc aaagatggca
      781 aagagcgctt gggcggctca gtgctggggc agatcccctt cctgcagaac tgcgaggacg
      841 aagacagcga cgaggacgat gagctggaca gcgtgcagca caagaagcag cgtgtgaagc
      901 tcccatccaa ggctctggtg cccgaaatgg aagacgagga tgaggaagac gactctgagg
      961 atgctatcaa tgagtttgat ttcctgggct caggagagga tggggaaggg gctccagacc
     1021 ctcggcggtg cactgtggat gggagccccc atgagctgga aagccgtcgg gtcaaactcc
     1081 aaggcattct ggctgacctg cgggatgtgg atgggctgcc cccaaaagtg actggcccgc
     1141 ctcctggcac accccagccc cggccacatg aagacgtctt catcatggac actatcgggg
     1201 gcggggaggt gagcctgggg gacttggcag atctcaccgt caccaacgac aacgacctca
     1261 gctgcgatct gtctgacagc aaagatgctt ttaagaagac gtggaacccc aagttcaccc
     1321 tgcgctcgca ctacgacggc attcgttccc tggccttcca ccacagccag tcggctctgc
     1381 tcaccgcctc cgaggacggc acgctcaagc tctggaacct gcagaaggcg gtcacggcca
     1441 agaagaatgc ggcgctagat gtggaaccta tacatgcttt ccgggctcac aggggcccag
     1501 tgttggctgt ggctatgggc agcaacagtg aatactgcta cagtggcggg gcagatgcct
     1561 gcatccatag ttggaagatt ccagacctca gcatggatcc ctatgatggc tacgacccaa
     1621 gcgtgctgag ccacgtcctg gagggccacg gggacgccgt gtggggcctg gccttcagtc
     1681 ccacctccca gcgcctggcc tcctgttctg ctgatggcac cgtccgcatc tgggacccca
     1741 gcagcagcag cccggcctgc ctctgcacct tccccacagc cagcgagcac ggggtcccca
     1801 cctcagtggc cttcaccagc accgagcctg cccacatcgt ggcctccttc cgctctggcg
     1861 acaccgtctt gtatgacatg gaggttggca gtgccctcct cacgctggag tcccggggca
     1921 gcagcggtcc aacccagatc aaccaagtgg tgagtcatcc aaaccagcct ctcaccatca
     1981 ccgcccacga cgacaggggc atccgcttcc tggacaatcg gacaggtaag ccggtgcact
     2041 ccatggttgc acacctggac gcagtcacct gcctagccgt ggaccccaac ggcgcattcc
     2101 tgatgtcagg aagccatgac tgctccctgc gtctctggag cctggacaac aaaacgtgcg
     2161 tgcaggagat cacggcccac cgcaagaagc acgaggaggc catccacgct gttgcctgcc
     2221 accccagcaa ggccctcatt gccagtgctg gcgctgatgc cctggccaag gtcttcgtat
     2281 gatgcccacc tggccctgcc ctggccgcca cgctggctgg ggtgtagggc cgggcaggtg
     2341 gggctgaggg gactcccagc ctcgctggag gtgcagaggc ctggcctctg tctgtttgcc
     2401 atggagcctg gtggtgctaa cggccctttc cccaggaatc cctccccaac ggctgccttc
     2461 cccaagcatc cagcctgggg atgggcccct ttcaggaatc acccccgagg atggcctcgg
     2521 ggtttccccc tgtgccctga cagccgctcc tggtatcaga gctgctttcc agagggcagc
     2581 acagccaggg ccgggtgtct ttagggatca gtttttccaa gactccagaa ggtgccaggt
     2641 tctccccttg agctcctgct cccccatccc ccatcctccc agacctgggc aggagctgtg
     2701 ctgggagaaa gggtggcagc cgggagcctc agagctgagc cccggcctgg ctgcccctcc
     2761 cctccggccc tctccactgc tttccagaca ctaaccaagg cttccaggcc agggattgcc
     2821 caacactcct agggcagccc tcccagcgcc ccatggggtc gcccatgggt agagacggct
     2881 ttcttgtgcc cctccctggg gcatggaggg tggagtgggc ctcgggtccc cctgaactcc
     2941 ctgtatatct gtataaataa cgggattttc atggcgccgc cccacccgca ttatcactgt
     3001 gtgatggtct cagtcagtct cctccctgtc tccactcttt ccctctattt atttcactct
     3061 cttgtttggt tctaccctgc accctcggtc cccttccagg ttcctgttta taagccccaa
     3121 cccctctgtc cccatcttgt atgtgaaaac ttgtctcaat aaaccctttg gagtaa
//
