LOCUS       NM_001083893            4195 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens striatin 3 (STRN3), transcript variant 1, mRNA.
ACCESSION   NM_001083893
VERSION     NM_001083893.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4195)
  AUTHORS   Zhu,J., Tang,W., Fang,P., Wang,C., Gu,M., Yang,W., Pan,B., Wang,B.
            and Guo,W.
  TITLE     STRN3 promotes tumour growth in hepatocellular carcinoma by
            inhibiting the hippo pathway
  JOURNAL   J Cell Mol Med 28 (6), e18147 (2024)
   PUBMED   38429901
  REMARK    GeneRIF: STRN3 promotes tumour growth in hepatocellular carcinoma
            by inhibiting the hippo pathway.
REFERENCE   2  (bases 1 to 4195)
  AUTHORS   Liu,L., Weber,A., Linne,U., Shehata,M., Pleschka,S., Kracht,M. and
            Schmitz,M.L.
  TITLE     Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine
            108 Controls Its Multimerization State and Functional Association
            with the STRIPAK Complex
  JOURNAL   mBio 14 (1), e0323122 (2023)
   PUBMED   36602306
  REMARK    GeneRIF: Phosphorylation of Influenza A Virus Matrix Protein 1 at
            Threonine 108 Controls Its Multimerization State and Functional
            Association with the STRIPAK Complex.
REFERENCE   3  (bases 1 to 4195)
  AUTHORS   Bisoyi,P., Devi,P., Besra,K., Prasad,A., Jain,B.P. and Goswami,S.K.
  TITLE     The profile of expression of the scaffold protein SG2NA(s) differs
            between cancer types and its interactome in normal vis-a-vis breast
            tumor tissues suggests its wide roles in regulating multiple
            cellular pathways
  JOURNAL   Mol Cell Biochem 477 (6), 1653-1668 (2022)
   PUBMED   35230605
  REMARK    GeneRIF: The profile of expression of the scaffold protein SG2NA(s)
            differs between cancer types and its interactome in normal
            vis-a-vis breast tumor tissues suggests its wide roles in
            regulating multiple cellular pathways.
REFERENCE   4  (bases 1 to 4195)
  AUTHORS   Tu,Y.X.I., Sydor,A.M., Coyaud,E., Laurent,E.M.N., Dyer,D.,
            Mellouk,N., St-Germain,J., Vernon,R.M., Forman-Kay,J.D., Li,T.,
            Hua,R., Zhao,K., Ridgway,N.D., Kim,P.K., Raught,B. and Brumell,J.H.
  TITLE     Global Proximity Interactome of the Human Macroautophagy Pathway
  JOURNAL   Autophagy 18 (5), 1174-1186 (2022)
   PUBMED   34524948
REFERENCE   5  (bases 1 to 4195)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 4195)
  AUTHORS   Baillat,G., Moqrich,A., Castets,F., Baude,A., Bailly,Y.,
            Benmerah,A. and Monneron,A.
  TITLE     Molecular cloning and characterization of phocein, a protein found
            from the Golgi complex to dendritic spines
  JOURNAL   Mol Biol Cell 12 (3), 663-673 (2001)
   PUBMED   11251078
REFERENCE   7  (bases 1 to 4195)
  AUTHORS   Castets,F., Rakitina,T., Gaillard,S., Moqrich,A., Mattei,M.G. and
            Monneron,A.
  TITLE     Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat
            proteins principally expressed in the brain
  JOURNAL   J Biol Chem 275 (26), 19970-19977 (2000)
   PUBMED   10748158
REFERENCE   8  (bases 1 to 4195)
  AUTHORS   Moreno,C.S., Park,S., Nelson,K., Ashby,D., Hubalek,F., Lane,W.S.
            and Pallas,D.C.
  TITLE     WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are
            members of a novel family of calmodulin-binding proteins that
            associate with protein phosphatase 2A
  JOURNAL   J Biol Chem 275 (8), 5257-5263 (2000)
   PUBMED   10681496
REFERENCE   9  (bases 1 to 4195)
  AUTHORS   Muro,Y., Chan,E.K., Landberg,G. and Tan,E.M.
  TITLE     A cell-cycle nuclear autoantigen containing WD-40 motifs expressed
            mainly in S and G2 phase cells
  JOURNAL   Biochem Biophys Res Commun 207 (3), 1029-1037 (1995)
   PUBMED   7864889
REFERENCE   10 (bases 1 to 4195)
  AUTHORS   Landberg,G. and Tan,E.M.
  TITLE     Characterization of a DNA-binding nuclear autoantigen mainly
            associated with S phase and G2 cells
  JOURNAL   Exp Cell Res 212 (2), 255-261 (1994)
   PUBMED   7910562
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA854600.1, BC132673.1, AF243424.1, AL049830.3 and AA572712.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001083893.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1), also known as the
            beta isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2689399.1,
                                           SRR11853567.8877.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357479.10/ ENSP00000350071.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                DA854600.1         25-84
            61-549              BC132673.1         1-489
            550-1605            AF243424.1         1-1056
            1606-2654           BC132673.1         1294-2342
            2655-4021           AL049830.3         81363-82729         c
            4022-4195           AA572712.1         17-190              c
FEATURES             Location/Qualifiers
     source          1..4195
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..4195
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /note="striatin 3"
                     /db_xref="GeneID:29966"
                     /db_xref="HGNC:HGNC:15720"
                     /db_xref="MIM:614766"
     exon            1..476
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2588
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear autoantigen; cell cycle S/G2 nuclear autoantigen;
                     s/G2 antigen; cell cycle autoantigen SG2NA; striatin,
                     calmodulin binding protein 3; protein phosphatase 2
                     regulatory subunit B'''beta"
                     /codon_start=1
                     /product="striatin-3 isoform 1"
                     /protein_id="NP_001077362.1"
                     /db_xref="CCDS:CCDS41938.1"
                     /db_xref="GeneID:29966"
                     /db_xref="HGNC:HGNC:15720"
                     /db_xref="MIM:614766"
                     /translation="MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPP
                     ASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQG
                     ERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTE
                     APTAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETK
                     NLEQILNGGESPKQKGQEIKRSSGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKH
                     RMNKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDL
                     SPTAEVWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGDDELPHIPSGI
                     INQSRSASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVT
                     NDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN
                     LQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPS
                     VDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICT
                     YNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNN
                     HINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMS
                     GSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV"
     exon            477..580
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            581..654
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            655..736
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            737..910
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1040
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1182
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1293
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1434
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1568
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1744
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1792
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1914
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2082
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2223
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2331
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2418
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..4195
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4091..4096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /note="hexamer: AATAAA"
     polyA_site      4116
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /note="major polyA site"
     regulatory      4150..4155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /note="hexamer: AATAAA"
     polyA_site      4195
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
ORIGIN      
        1 agatggagga gggattgtaa tggcggcagc cggcagctcc ctgctctgac ccacggcagg
       61 cacacagcaa cgaccccttc cccgcccctc tcccggccgg cctccgcccc gcagccagcg
      121 cggggccacc ctctccggcc cttcccccag ctgtcggcgt ctcgccctgc gccccggccg
      181 gggccccaca cacaatggac gagcttgccg gaggcggtgg tggcggcccg gggatggcgg
      241 cccctccccg gcagcagcag ggacctgggg ggaacctggg cctttcgccc ggggggaacg
      301 gagcggcggg cggcgggggt cctccggcct ccgagggagc gggtcccgcg gcaggccccg
      361 agctgtcccg gccgcagcag tacactatcc cggggatact gcactacatc cagcacgagt
      421 gggctcggtt cgagatggag cgggcgcact gggaggtgga acgggccgaa ctgcaggccc
      481 ggattgcatt tctacaaggc gaaagaaaag gtcaagagaa cctgaagaag gacttagtaa
      541 gaagaataaa gatgttagag tatgcattaa aacaagaaag ggcaaaatat cacaaattaa
      601 aatatggcac ggaactgaac caaggtgact tgaaaatgcc aacctttgag tcagaagaaa
      661 ccaaagacac agaggctccc acagcacctc agaatagcca gttaacgtgg aagcaaggca
      721 gacagctttt aagacagtat cttcaggaag taggttatac agatacaata ttagatgtac
      781 ggtctcagcg ggtaaggtca ttacttggac tatctaattc agaaccaaat ggatcagtag
      841 aaacaaagaa tttagaacag atcctgaatg gaggtgaatc tcctaagcaa aagggacaag
      901 aaataaaaag gtcctctggt gatgttcttg agacgttcaa tttcttagaa aatgccgatg
      961 acagtgatga agatgaggaa aatgacatga tcgaaggcat cccagaagga aaagacaaac
     1021 atcggatgaa taaacataaa ataggtaatg aaggtttagc tgctgaccta actgacgatc
     1081 ctgatactga ggaagcactg aaagaatttg attttttagt gactgctgaa gatggtgaag
     1141 gagctggaga agcacggagt tcgggggatg gcacagaatg ggataaagat gacctctccc
     1201 caactgctga ggtttgggat gtagaccagg gactaataag taaactgaag gaacagtaca
     1261 agaaggaacg aaaggggaag aaaggggtga agagggccaa caggacaaaa ctctacgaca
     1321 tgatagctga tctgggagat gatgagctgc cccacatccc ttcaggaatc attaatcagt
     1381 ctaggtcagc ctctactaga atgactgatc atgaaggtgc aagagcagag gaagctgaac
     1441 caataacgtt tccatctgga ggaggcaagt catttattat gggttctgat gatgttttgt
     1501 taagtgtact gggccttgga gaccttgcag acttgacggt aacaaatgat gcagactata
     1561 gttatgattt gcctgctaat aaagatgcct ttcgaaagac atggaatccc aagtatacac
     1621 tacgtagcca ttttgatgga gtacgggcat tagcttttca tcctgtagaa cctgtgctgg
     1681 ttactgcttc tgaggaccat accctgaaac tttggaacct gcaaaaaaca gttcctgcca
     1741 aaaagagtgc ctctttagat gtagagccta tctacacatt tagggcccac atcggccctg
     1801 ttctgtcatt agctattagt tctaatggag aacagtgttt tagtggtggt attgatgcaa
     1861 ccatccagtg gtggaatatg ccgagtccca gtgtagatcc atatgataca tatgagccaa
     1921 atgttctagc tggcacttta gttggtcata cagatgcagt ttggggtctt gcttatagtg
     1981 gcataaaaaa tcaattactg tcttgttcag cagatggcac tgttaggtta tggaatccac
     2041 aagaaaaatt gccatgtatt tgcacttaca atggagataa aaagcatgga atacctacat
     2101 cagttgactt tataggctgt gatccagctc atatggtaac ctctttcaac actggtagtg
     2161 cagtaattta tgatttagaa acatcacagt cattggtgat actttcatca caggtagatt
     2221 ctggtttaca atctaataat catatcaaca gagtagtaag tcatcccaca cttcctgtta
     2281 caataactgc tcatgaagat agacacatca aattttttga caataaaacg ggtaaaatga
     2341 tccattctat ggtagctcac ttggatgctg ttacaagtct agcagtagat cctaatggaa
     2401 tctatttgat gtctggaagc catgactgtt ccatcagatt atggaattta gacagcaaga
     2461 catgtgtgca agaaataaca gctcacagaa agaaattgga tgaatcaatt tatgatgttg
     2521 ctttccactc gtcaaaagca tatatagcta gtgcaggagc tgatgctctt gccaaagtat
     2581 ttgtatgaat caacaaaaac ttgcatcgta acaagatttg cttggacaga aagagggtct
     2641 gcatcactgc catcagaaag gttactgata tgacactaca tgtgatctgc ctggtgaagg
     2701 ctatctgggg caggcacaaa ttggtggaaa tcacatctta atgtcaagct cattaagtta
     2761 actgtaatta ctgtattttg tgggacaaag aaaaaaggac tccagtattt gtggcctgta
     2821 ctggatgtga actgagcgta tatctgtttt taggtgtctt taagccaatg tggagtctga
     2881 tctttcaaaa aagttttttt ttttctcttc ttcttcttct tttttttttt tttttttttt
     2941 tttttggact ctgtgtgctg ccttaggggt taggaatgtg gtgctcttgt tgggggaagt
     3001 gagctccaag agtagctttt tttcatctct tagtgatctt ctgtttatcg gttgaatgcc
     3061 acagattccc ttttaaactt attttgcttt aaaaaaaaaa aaaaagaaaa agaaaattta
     3121 acttaaaata ttttagcatt agttgcacaa aatgtttgga taaaattcta gtttttataa
     3181 gtctttttat atatttagcc tgtcacaaca gtgctcaaga ttgtattgaa gtttttctgc
     3241 attatacaac cctaaaacac agagatctca ctgacccgtt gccctgtaac cactttcttt
     3301 ccttcttttg cctaatacag ctcagctaag tccttccata aagatgctaa ataactttca
     3361 tcatcacata aatgtcttca taaaccaagg actattaagt gtattaaaat gaaacagtgg
     3421 ggtttagtac tccaaatgaa ctcttaaaga aaaaaactaa tcttggcatc ctatcactat
     3481 gtgatatttt gtacatctta ctgtatttac aagtttattt atcaaggatt atccatcttg
     3541 ctaatggcct attatttatt tcactttttg ttggtcttta tatcctttta ttaatgtgct
     3601 aaaggaacct gtatatctat tttggaactc tttgaatagt ctaaaataga ctaaaaatgg
     3661 agtattttat agtttaaatt acaaaccaag gtggttcccc ctaagatata tatcttggtt
     3721 taccatgatt ccaaacaaaa ctaacttgtt taaaaatatt tggagtaaag ttttatttgc
     3781 attacaaata ggatacaaaa atagttgaat caggatacag aaatctgctg tgttttgact
     3841 agttatccct gttttatttt tttagatgtg cttaatttta tggtgtaact aaagattttg
     3901 tttgtgtaat gcatgattaa gacaataaag tattttttct agtcttccga gaaacttttc
     3961 tgatcagttt gcgagttttg atgagttttg taaggttttt gttttacaaa ctatgaatca
     4021 gcaaattttt aagattgtac cacatagcaa acatacagct gttgaaaaat aatgtatata
     4081 aaatgcatat aataaatatt aaattgtgta cctgtatgtt actgttggct acatcatttt
     4141 gtgttgaata ataaagtgca atactttatt ctccataatt aaactaggaa atgga
//
