LOCUS       NM_003162              14174 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens striatin (STRN), mRNA.
ACCESSION   NM_003162
VERSION     NM_003162.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14174)
  AUTHORS   Gholami,S.K., Heydarpour,M., Williams,J.S., Pojoga,L.H.,
            Adler,G.K., Williams,G.H. and Romero,J.R.
  TITLE     Striatin Gene Variants Are Associated With Salt Sensitivity of
            Blood Pressure by Mechanisms That Differ in Women and Men
  JOURNAL   Hypertension 81 (2), 330-339 (2024)
   PUBMED   38018471
  REMARK    GeneRIF: Striatin Gene Variants Are Associated With Salt
            Sensitivity of Blood Pressure by Mechanisms That Differ in Women
            and Men.
REFERENCE   2  (bases 1 to 14174)
  AUTHORS   Viveka,M., Chaturvedula,L., Ram,A.K. and Vairappan,B.
  TITLE     Placental expression of striatin & endothelial nitric oxide
            synthase in women with & without pre-eclampsia
  JOURNAL   Indian J Med Res 157 (4), 345-352 (2023)
   PUBMED   37147942
  REMARK    GeneRIF: Placental expression of striatin & endothelial nitric
            oxide synthase in women with & without pre-eclampsia.
REFERENCE   3  (bases 1 to 14174)
  AUTHORS   Liu,L., Weber,A., Linne,U., Shehata,M., Pleschka,S., Kracht,M. and
            Schmitz,M.L.
  TITLE     Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine
            108 Controls Its Multimerization State and Functional Association
            with the STRIPAK Complex
  JOURNAL   mBio 14 (1), e0323122 (2023)
   PUBMED   36602306
  REMARK    GeneRIF: Phosphorylation of Influenza A Virus Matrix Protein 1 at
            Threonine 108 Controls Its Multimerization State and Functional
            Association with the STRIPAK Complex.
REFERENCE   4  (bases 1 to 14174)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 14174)
  AUTHORS   Hu,Z., Sankar,D.S., Vu,B., Leytens,A., Vionnet,C., Wu,W.,
            Stumpe,M., Martinez-Martinez,E., Stork,B. and Dengjel,J.
  TITLE     ULK1 phosphorylation of striatin activates protein phosphatase 2A
            and autophagy
  JOURNAL   Cell Rep 36 (13), 109762 (2021)
   PUBMED   34592149
  REMARK    GeneRIF: ULK1 phosphorylation of striatin activates protein
            phosphatase 2A and autophagy.
REFERENCE   6  (bases 1 to 14174)
  AUTHORS   Gaillard,S., Bartoli,M., Castets,F. and Monneron,A.
  TITLE     Striatin, a calmodulin-dependent scaffolding protein, directly
            binds caveolin-1
  JOURNAL   FEBS Lett 508 (1), 49-52 (2001)
   PUBMED   11707266
REFERENCE   7  (bases 1 to 14174)
  AUTHORS   Castets,F., Rakitina,T., Gaillard,S., Moqrich,A., Mattei,M.G. and
            Monneron,A.
  TITLE     Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat
            proteins principally expressed in the brain
  JOURNAL   J Biol Chem 275 (26), 19970-19977 (2000)
   PUBMED   10748158
REFERENCE   8  (bases 1 to 14174)
  AUTHORS   Moreno,C.S., Park,S., Nelson,K., Ashby,D., Hubalek,F., Lane,W.S.
            and Pallas,D.C.
  TITLE     WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are
            members of a novel family of calmodulin-binding proteins that
            associate with protein phosphatase 2A
  JOURNAL   J Biol Chem 275 (8), 5257-5263 (2000)
   PUBMED   10681496
REFERENCE   9  (bases 1 to 14174)
  AUTHORS   Moqrich,A., Mattei,M.G., Bartoli,M., Rakitina,T., Baillat,G.,
            Monneron,A. and Castets,F.
  TITLE     Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21,
            and preferential expression in brain
  JOURNAL   Genomics 51 (1), 136-139 (1998)
   PUBMED   9693043
REFERENCE   10 (bases 1 to 14174)
  AUTHORS   Castets,F., Bartoli,M., Barnier,J.V., Baillat,G., Salin,P.,
            Moqrich,A., Bourgeois,J.P., Denizot,F., Rougon,G., Calothy,G. and
            Monneron,A.
  TITLE     A novel calmodulin-binding protein, belonging to the WD-repeat
            family, is localized in dendrites of a subset of CNS neurons
  JOURNAL   J Cell Biol 134 (4), 1051-1062 (1996)
   PUBMED   8769426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007404.4, AJ223814.1, AK026934.1 and AC007382.3.
            
            On Nov 23, 2018 this sequence version replaced NM_003162.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.9708.1,
                                           SRR1803617.227778.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263918.9/ ENSP00000263918.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC007404.4         106674-106737
            65-644              AJ223814.1         1-580
            645-1163            AK026934.1         152-670
            1164-1340           AJ223814.1         1100-1276
            1341-2357           AK026934.1         848-1864
            2358-2667           AJ223814.1         2294-2603
            2668-14174          AC007382.3         55700-67206
FEATURES             Location/Qualifiers
     source          1..14174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2"
     gene            1..14174
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /note="striatin"
                     /db_xref="GeneID:6801"
                     /db_xref="HGNC:HGNC:11424"
                     /db_xref="MIM:614765"
     exon            1..307
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2416
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /note="striatin, calmodulin binding protein; protein
                     phosphatase 2 regulatory subunit B'''alpha"
                     /codon_start=1
                     /product="striatin"
                     /protein_id="NP_003153.2"
                     /db_xref="CCDS:CCDS1784.1"
                     /db_xref="GeneID:6801"
                     /db_xref="HGNC:HGNC:11424"
                     /db_xref="MIM:614765"
                     /translation="MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAAR
                     AQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRI
                     KMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQ
                     LLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAM
                     IAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSG
                     EDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKE
                     QYKKERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINR
                     ADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALR
                     KTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEP
                     IYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLL
                     GHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVS
                     SDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITA
                     HEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTC
                     IQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV"
     exon            308..411
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..485
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..564
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..732
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..868
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1004
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1115
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1259
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1396
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1572
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1620
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1742
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1910
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2051
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2159
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2246
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..14174
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5678..5683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /note="hexamer: ATTAAA"
     polyA_site      5700
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /note="major polyA site"
     regulatory      8053..8058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /note="hexamer: AATAAA"
     polyA_site      8076
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
     regulatory      13201..13206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /note="hexamer: AATAAA"
     polyA_site      13224
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
     regulatory      14149..14154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
                     /note="hexamer: AATAAA"
     polyA_site      14174
                     /gene="STRN"
                     /gene_synonym="PPP2R6A; SG2NA; STRN1"
ORIGIN      
        1 gaggcgctgc ttgccgccgc tgttgcctcc gctgctgggc gccggggcag ctccccgggt
       61 atctgcggcc gccatggacg agcaggcggg tcccggcgtc ttcttcagca acaaccaccc
      121 gggcgccggc ggtgccaagg ggctcgggcc tctggcggag gctgccgcgg ccggcgacgg
      181 ggcggctgcg gcgggggcgg cccgagccca gtacagtctc ccggggatcc tgcacttcct
      241 gcagcacgag tgggcccgct tcgaggtgga gagagcccag tgggaggtgg agcgggcgga
      301 gctgcaggcc cagattgcct tcctgcaggg agaaaggaag ggccaagaaa atttgaagaa
      361 ggatcttgtg aggaggatca aaatgttgga gtatgctctt aaacaggaaa gagccaaata
      421 ccacaagttg aaatacggga cagaattgaa tcagggagat atgaagcctc caagctatga
      481 ttctgatgaa ggtaatgaaa cagaagtgca gccacaacaa aacagccagt taatgtggaa
      541 acaaggtcga caactactca gacagtatct acaggaggtg ggttatacag atactattct
      601 agatgtgaaa tctaaacgag tgcgagcttt gttgggcttt tcaagtgatg tcacggacag
      661 ggaagatgac aaaaatcagg actcagttgt aaatggcaca gaggctgaag ttaaagagac
      721 agcaatgatt gcaaaatctg agttaacaga ttctgcctcc gtgctggata atttcaaatt
      781 ccttgaaagt gcagctgcag atttcagtga tgaagatgaa gatgatgatg ttgatggaag
      841 agagaaaagc gtcattgata cttcaacaat tgttaggaaa aaagcattgc ctgacagcgg
      901 tgaagatcga gatacaaaag aagctctaaa ggagtttgac ttcttggtta catcagagga
      961 aggagacaat gaatctagaa gtgcaggcga tggaacagac tgggaaaagg aagaccagtg
     1021 tctcatgcct gaagcctgga atgtggacca gggagtaatt accaaactca aggaacaata
     1081 caaaaaggag agaaagggga aaaagggggt gaagaggccc aataggtcaa aactacaaga
     1141 tatgcttgct aatttgagag atgttgatga acttccttca ttgcagccat ctgtgggttc
     1201 accttccaga cccagcagct ccaggcttcc tgaacatgaa attaataggg cagatgaagt
     1261 ggaagcattg acatttcctc cttcttctgg aaagtcattc atcatgggag cagatgaagc
     1321 ccttgaaagt gaactgggac ttggagaact agcaggcctt acggtggcca atgaagcaga
     1381 ctcactaact tatgatatag caaacaataa agatgcattg aggaagacat ggaaccctaa
     1441 gtttacattg agaagtcact ttgatggcat ccgagccctt gctttccatc ccattgagcc
     1501 tgttttgata acagcatcag aggatcacac attaaaaatg tggaatttac agaaaacagc
     1561 cccagccaaa aagagcactt ctcttgatgt agaacctatc tatacattca gagcccataa
     1621 aggtccagtg ctttgtgtgg taatgagcag caatggtgag cagtgttaca gtggtggtac
     1681 tgatggactg atccagggct ggaataccac taatcccaac atcgacccct atgattctta
     1741 tgatccttct gttttacgag gccctctgct aggccacacg gatgcagtct ggggtttggc
     1801 ttatagtgca gcacatcagc gtttgttgtc ctgttcagca gatggcactc tgcgtttatg
     1861 gaatacaact gaggttgctc cagcactaag tgtatttaat gatactaaag aactgggaat
     1921 ccctgcctct gtggatctag tgagcagtga cccgagccat atggtagcat cattcagcaa
     1981 gggatataca agcattttta acatggaaac acaacaacgc attctcactt tagaatccaa
     2041 tgtagataca acagccaact cttcctgcca aataaataga gtcatcagtc atcctactct
     2101 tccgatcagc atcactgctc atgaagacag gcacatcaaa ttctatgata acaatacagg
     2161 caaactgatc cactcgatgg tagcccacct agaagctgtt acaagtttag cagttgatcc
     2221 caatggcctt tacttgatgt ctggcagtca tgactgttca atacgtttat ggaatctaga
     2281 aagtaagacg tgtatccaag aattcacagc tcatcgaaaa aagtttgaag aatcgattca
     2341 tgatgtagct ttccacccat ccaaatgcta tatagccagt gctggagctg acgcactggc
     2401 taaagtcttt gtatgacgca atgcatcatc ttcaccttct agctgtttat aagtaatcaa
     2461 ctgcacacaa gagatacaga agacgagggc aagaatcatc tcgtcctgcc cttttgttct
     2521 gctgaaggag cacagagaac atttgttgaa gtatagtttt gcaattcata tactgttttc
     2581 taaaactaag gtttgttcag gttgctgcaa gctcagctga atctgtgagc ctgaggtctg
     2641 tttcaaattt ctccccaata ggcgccttta tttctgaggt ggttctaatt cgctaggcag
     2701 gcctgagcga atacaagttt agcttgtccc tgttgagtaa gtagggcatg ctacaatgga
     2761 taatttaaaa gcttgatagc tgggactgaa tagaagaaaa cgggaaactt agaccaagtt
     2821 ctcccctgag aaatcttgtt aaaacacatt aagtagtcaa aatagtaatc tttatcatat
     2881 ctgccatatt aacccctttg tgtataatga ccaggcagtg ttaaactgag tttttaattt
     2941 gactctcctt tcagctgttc acataaagca cctggcaaag cattttacct gttaggggga
     3001 gaaaaatgca ataatatgtt aaatatatta ttattcagaa atgctagaca aatagtttgc
     3061 aagcagattt ctatattgta ttacagtttt gaaaacagat ttggtatcat tctaaagttt
     3121 agctatcaag cactcaccat tgtgaagaat agttgatcga ctctgctttt actaacagat
     3181 ttaacttatt caggtttgaa attctgttta tttttaaggg taaacagggc atatctcttt
     3241 aataatttct attttaaaat tcactttatt catgtgacat ttatagtacc agagtgatta
     3301 tttcatacca atgaaatctt acttttcagt gactgaaaag atagaattta tttgctaata
     3361 atcatttatc aacacccacc taatcatgct tcagatgatc tgtgctcttt cttctttgtc
     3421 acgttcaagt tatctgacat ctaccaagaa cagttcataa ttattaatag cccaaagagt
     3481 atggttaact tcacgcagct gcttttgcag aagcactaat aaaaacaaat attttgtacc
     3541 ctagaagtcc tctattaatc cctgtaagaa tctcctggaa acctggatga aagagtttaa
     3601 tgccaaatat tggctaaaaa gttctgtctt tctctctccc tattcctccc ccattgttta
     3661 attgagatat acatgtttta atgggcagtg gatcagtatt gtttctgggg aaatccacac
     3721 cttaaaaggc caggcttccc cagcccaact tacctgtgac ccacctacat gtgttcacct
     3781 tttgggattc tgaagaccct gctatctaga cctagtctcc tgtcataaag acattatttc
     3841 tatagtggtt tatgtctctc ttactctttg tcccaaatga cagagaccaa tctagaaatt
     3901 ggaaataaat tattaacgtc caactttcca ccaaaaaaca tataaatagg ctcttagatt
     3961 ttaaaaatat taaatctata gatattttaa ccaattaaaa caatttctac atattccatt
     4021 ccccacattt tccatcgtca taacaatgat gcttctcatg atacgtacat ctactccttg
     4081 aaaaagtatt ctggtggtgg tgtggctaat gattgacaaa tatttctgta aaatttctgc
     4141 ctgtttgcct ctagaattct gcattataca ggcaaatttt ctttaaagct agagacttgt
     4201 gctaaatttg cctgattttc atacagatat gctgtagtaa tacagctacc ttttcatttc
     4261 atctttgtgc tttggttaac aagcaggctc aagagactgc tttgtgtaat taaatgaatt
     4321 gacctaaaca tgagctgtca ggtgaatact taatatttcc atgcagatac agaattccat
     4381 attgtgttca gtaaatttct tttggttctt cacagtgaag aaagaatgtt tctaacctaa
     4441 catttgtaga aggatactgg aaaattcctt ccaggaagga aggaaggaag atgccattac
     4501 ttggtgtatt tatgatggat gaccacaaag ctattgttct accagttatt aattaccttc
     4561 taagatcttc agttactgct ttattaatgt cactgaaatt ctaaaaacca ggacattctt
     4621 cccccgttca ttttatgctt catggttgaa atttttctgt cagtgagtgg aaaataacca
     4681 tgagatacat agactgtagc gcaaatggaa ctgttgaaag ttccttagaa agccagtgct
     4741 gtggcattgg agactacgga gagagtcttc tctaccagca ctgcatgatc tcagcctaga
     4801 aatgagccaa agctgtcttc caaccagagt agcatataca tgtgtctgac ttttccccta
     4861 gcctgttgaa cattcaatga aaattcacag aatgaacaaa ttcaatgttt aaacagccat
     4921 tgaaatgctt tcatagtgct tcatttgtaa atattttgtt tgaaatgtat tggaatagta
     4981 tgaaaattag cgggaggttt ggatccctgc cttattttca tatgctgtgg atacatctct
     5041 gggagcttgc agcacccttc tcaaaactca actgtcatat ggagctcatt tgctactcaa
     5101 accatagaca gattatttaa caaaagtgat ataatgacct tcagtatttt tctattgaac
     5161 aagtttaaca acttttgcca ttaaacaaat acttagttat gcaaaatatt tcgcttttat
     5221 aatcatttta gttatgacta aaacggggga aattgagctg catcactgat gatgaacttt
     5281 gtgagaaatt ttttttttaa tctgactttc attccttcag tattcttgct ataaatttct
     5341 tttggagata atgatgaaga tttatttgaa aatgtctaaa atgtatgtat attttataaa
     5401 tatatattat atatattgta agaatatata taatatataa actatatata tatatatata
     5461 tatatatata tatatatata tataaaccat aggtgcattt tactgttttg tattttcatt
     5521 tttggaggta gtatacacag cagataatga tgagtatgat gagtgttgtg ctgtttgctt
     5581 ttgcagtata atatatagtt ctaagtgttt aaattactgt atatacaata ttcattatag
     5641 gctagcatgc ttgttttaaa gactgtcatt ctagtgtatt aaaatctgaa tgtaagaaaa
     5701 cctggctatt caaatgtgaa ttgaaaaata ttttattctc agtactgaac tatttccatt
     5761 gaacattcag actttttaac aaaaacaaat atcatcaaga aggcaatagc tagaaaatga
     5821 gaggtgcctt taaaaaaaaa aatgcagcct tacagtgagg atgaagattg agtttgggga
     5881 gggggtggga gggggggcac agagagagag agagagttag tgtgtgtgtg tgtgtgtgtg
     5941 tgtgtgtgtg tgtgtgcatg catgcgtgtg tgtgtgtgtg tgtgtgttta ccaatctgtg
     6001 aaggtcctga tttgtgacca tcaatgtctt tttaatgtat ctgctcaact tctaggactt
     6061 caggggacat ttcatgcgct ttgtgctctt ctgagcacca tatatacttt ccaagaattt
     6121 tgaatgtgaa ttcctagaaa tttcagtaga gaaaacaata gctattcttt aattatagta
     6181 aagttcaggt agaaggagaa attatttgtt caccaaaatt atgggatctc attaatgttg
     6241 gctaagtaaa tgtaattttt taaaggctca ctttttaata cttcatatat ttccctctta
     6301 caaaacagca tgtcatgaag ttcttatgtg gtaaagattc aactagtaaa tatttttagg
     6361 ttaaatacct gaactagtta aaattccacc taagaatagt cttaaaatat ttaaaaagca
     6421 tctctcatat ctacctcttt gtcattgctg ccattttaac tgaagcaaat ctttatgaca
     6481 tctgaaatga tggttggatg caattaaaaa aaaatctatg ttggtgcttt tctcaggctt
     6541 tgtcatttaa gttatattgt attaagatgt cacaaatcag actgaaaggc ttagaattaa
     6601 ttttgttttt ctttgaaaga attgcttaaa attaaccatc aatgttttta gcgagtggag
     6661 ataatgaatc tttggttggt gtctgtctgt gtgatgtttt caaccaatag ccaaataatt
     6721 attgaactta catgaaaaag agtgctaagt ataattttat ttagattact ttattctttg
     6781 aaagtgacta caaggctatt aagtacataa tcattcattt tatttactca gaagttgcct
     6841 ctccattact gttaacttgt ttagtaattt atataattgc agtactttta agtgttggac
     6901 actgggattc aggttgtata caaagtagta gctgacgaaa aatatgtata tttttgtgaa
     6961 atgtatcaag ccctaaagtt cattttagag aaaggcccag aaaaacgtat ctgtgtttaa
     7021 aaacaaagga caggtcattc gtcaatttga atcattttta cttttgccac tacaaacttt
     7081 ttaattggca atatccatca tccaactgga tcttcatgtc agtgtcaggg atgccaggtt
     7141 gacaaagtat ttaacagatc ctttcagttt ttgttttgtt tttttaattc taaaaaaaac
     7201 aaatgttagg ccaaacagat ccctagatcc cactcattga ttctggcggt attcctaaag
     7261 tggtgcttag ggggtcagaa ttttctggat ctttgctaat ccaagcttta gatttaattt
     7321 aaccaggacc acatgcttgt catctctctg atgcaaattt tcaaaatcat tttaatttag
     7381 attctaatgt ctgcctgggt ttttaacagg ctgtgaacca gtgagtgcct tgttaatgta
     7441 gaatgatttt tcccccctgg gtgggtgtta gttagctcct ctctgaaaat gtctcagaga
     7501 atggtatttt aattgacttg tagagagctg ctaaatttgt tattatcagc aatcagaaag
     7561 tctttggtct accacacatc tccctcccta ctatctcttc attgtttggc tgaagtttgc
     7621 ctcttgtgag aaaacaatac aactcccctt ctccacacac tttttttcca gcccagatta
     7681 ataggtatcc cctaccctaa tcccaactct atgatctaat acctttttta ggaggaacca
     7741 cttcttttta atattgaaat ctgctggtta ctttatgttt tctcaagttc agttgactag
     7801 agctgaccac agggtgtcat caattcagat tcctaaataa ccctttctct ccacacccag
     7861 tcctccagct ggtgagccct gggccagatt gtttgatctt caggtatttt aaattttagt
     7921 tacatcaatt aatgtaaatt aatccaaatg ctaatttttg tggtgcaaga agtttcttat
     7981 gtaaattcag ggtatggata agctaattaa gatatccatc tttggtggct ctaagtgtat
     8041 tatttgtttt taaataaagt gtacaaatat agataacatg ctataggtgt ctcatgaatt
     8101 ggaatatttg tcagatttgg gatctagctg tggctttaca gtaatcagtt aaattaacat
     8161 agtctgattt ggggcttttg ggggaggagt tgtagagggg tgcagagaaa taaaaggata
     8221 ttagacaaag tatacatgag tccaaaatta atgaaccagt cttaattact gattgtgagg
     8281 aaggagaagt ttatagagaa tttgggcctc tgaaaagcca aattaaaata gcttctagga
     8341 ttgggtcagt ggtactttca gagacacata tgtttaatga ataggtttta tgtttttcaa
     8401 atgttcagtt taaatggctt ttaaaattta tacacatata taaatacaat gtttttattt
     8461 tttgtttcgc tacttaacag acatacacaa gccttccaca ctccctgccc cttcaaatca
     8521 acattatttt tcaaggcctt tggcctgccc agaactcaca gtctttttgt tccaatcagg
     8581 atccacaata caatatgaaa tttaaaaggc atctcttctg atatccttga aactatccac
     8641 cattgtttgg tgttctgtat gctggtatac taatgagtat tatatccttt ggtatgtaca
     8701 cacattttca gtagtgttgg aaacacctct tttatctttt taatgagaac tgagacatga
     8761 ttagcttgag taattttgga gatctatctc aggaggtcat taaaactcca aaaattattc
     8821 acggattgat gaacctcctg gggtcagcct aagattgcca ggtagtattc tgacctcctc
     8881 tgggtttccc aagatcactg atgttttgca gggccccagc attgtcctgg cacataaaat
     8941 attcccagaa caccttggga gtcaagcata ccttttaacc taaacattat aatcatggag
     9001 catccctccg cctgttactt ctcaggatga ccagaacact ccagttctct aaggaagcac
     9061 tgacatacgg ctctgaaaat tggaatccgt tttctgaaac acaaatttta actcagtaag
     9121 ttttgtatat caaatgattc aaaacccacc aaacataaaa tgactcgctt ctaagtatca
     9181 ctcaaaccct acaaaaccta accctttcct tattcctaat tgatatttca ctaaaggtaa
     9241 tggtagtttc agttagattg gaagtcatta tttgggtgag caaagtctgc aataacctac
     9301 tgataggaag gacctatttc atagaaaagt atcttgtcct tggtgattta gccattcacc
     9361 ttacgtgaag agtggtccag atgccagctc cacattgact ttttctgtgt ccctctttag
     9421 gtaattaacc cagtgatgta aaggagagcc cacagtaaaa catctgttaa acagcacttg
     9481 gagtactata gtgttattaa tttatgtgct ataatttctt atgccatcat aaaatctagt
     9541 gtatgtacca ggttcccaat tcattgcctc aaacaaaaga tttttaaaaa ttctaatagc
     9601 atcaaattaa gggtaatggt agggaaaccc atcatccaca attaaatatg cccaaactga
     9661 aaactttaag aaaaaaaagc acatggaaag caacgtttta cattaatcgt gagttgtaga
     9721 aataaacagc ttgtggtttg tatatgtgcc gaaatgttaa agtatgctgg catccaacta
     9781 cttccctttg gaaatgggac caagacaata atttttcatg cataaacaaa attaacttag
     9841 agcaaaagta attttatcag aaacagttta ttttgggggc tggataactt gggtgagagt
     9901 gtggggaaag aagtacctta ccaaaaagga gaagcaactg accctgtggc ctgagccaca
     9961 ttgtcttcca tttcaacttc aatgggctgg cagtatacca cttctgacct caaagaatga
    10021 atggttccaa ttctggcttg tcattggtcc ttgttatcta aattaaatat ttttaggaaa
    10081 tatatcaaaa gtatcctaga gccccatggc aaagtgtcag aggaaatagt tttcattata
    10141 ttttaggaag ctgtaaaaat ataagcccaa gtattttgtg tcatctgcat atgtcaggat
    10201 gaagaccagg catgtaagaa atatcctaaa gtagccaagt gataatctca tgaaaaaata
    10261 tgagaatcgt ttttacagag tgagttctct tttgaatggt tttgactatg cttttaaaaa
    10321 catttttaaa atgtacttac atctttttcg atagcccacg tatttcagaa tatcctcttg
    10381 atagaataat atcactcagt gtgattttta gaaaaagaaa aactcggtgg tctcatatct
    10441 tttgacagtt gtttgtgaat aataccctcc ccaacaacct tcccagtact caactgctat
    10501 gtaagaatgc tttcttatgt ggtaaatgtc tcagtatttt gctgcctggt atttgttcag
    10561 tttccttgta tatctcaggg tcagaaggaa tcaggctttc tcccaactct gaaacattca
    10621 gacttacttt ctttttggtc agccttttaa caagcaagac aataaactcc ttttgtcaga
    10681 atcgatttga ttaaaaaaaa aaaaaaagaa tgtgctcctt atttctcatt gctgtagaat
    10741 acgtaggaat acacatctac taatcacaat taaaaaataa gagaatcttt agaaacatca
    10801 ttgctttctg gaggtagaaa ttttgaactt gaaggttgta gttccaggca attttgtgcc
    10861 cttgaggtgt ccaattgata gtatagcttg cctctgctaa taaatacaca aaagttttct
    10921 ttcctgtgat tttcagaaat tatttttgga atacaaagat taataaggaa tatgtgatgt
    10981 ttatctcctg catttcaaaa tcttctggat tttttttgag gcatgaggag caggtaatga
    11041 gatttttttt ctgaatatct tgattctctc ccttaaccca gattttgcat attatgcatt
    11101 gctcatttgt cacctacaaa aataaaggtt aatgattatt tgtttgcttt tgtctatata
    11161 agctccctaa ggcacagacc atgttcgttt ttcttatgtt cctcttagca ctgtgcctgg
    11221 tgccttgcca tataaaaggt accctataaa tatttgttgg ctgagtaatc agagagccca
    11281 tttcaaaatc taaattatac aaatcatcaa agaccaaaaa aaaaaaaaaa aaatctcttg
    11341 acagttgatg ctcaaatgca tttggttctg tggagcttat cctgagattg aggtctgcac
    11401 cttgactgga gaggaatttg gactttacct cacaggtagc aacaaaatgc ctgagtagca
    11461 acgtctttat actgcacagt tccagtcctg cctgcgtgaa aactgagcag agcatggtgg
    11521 ggacaggaag gtgtccctaa accctgttga tgacctccca tctatccccg gacccccata
    11581 tctcctctgc tcatcccctg ttccccactg gcctctgatc agttgaaagg gagcttttct
    11641 agcctggaac ctgagcctgc cttgattatc ctgggctcag aacaggtcca cttccacact
    11701 ctttccttgc aacctacaga tggccctact gactgctgtt gtccaggaga aagacgaacc
    11761 tcccagtgga atcttgtcag gaaaggcatc cctctgggga gctttctttg gagaggaaaa
    11821 ttctgggaca aagttcctca ggatgctctc aggctggttt ttgtcttgaa gattttatag
    11881 taattgtacc aatgtttatt aactctccta ggaacatctc tgtctttggt tttctgacag
    11941 cactccagca gggcccaggg ctttagctga acagtgcaat tgttttagga ataaaacagt
    12001 caacaagtta gagaccaact atttatattt aatattcaaa tgactttaaa tcattaaaag
    12061 aatcagcaaa ttacatatga aatattcaac gaataatctc aacattaaac atataccatg
    12121 taagaactgt cattaaaatt actaaaaata tgattccttt aagatcagtt caacacagaa
    12181 gaaagcagga atttggcctg gacaatagga catttattgt ctgttagatt ttagacaagt
    12241 caactcttct aaattggctt ctcatctatg aaatggggat aatagatctg cctaattagg
    12301 ttgatttgag ataacggatg taaaacacct aataaaataa gcatccagca aatgacttgt
    12361 tcactctctg aatacagact tctggtcatg tagttcggtc acactcctga tagcttctag
    12421 aacatcaggg ttttaggaga aataggttaa aatgaacatc aagagtagca gaagactact
    12481 ttccttaata tttgagtgcc agctatatgc cacacagttc tagttgctgg cagtcagcag
    12541 taaacaaaaa cttcacctga tgcagcacat tccaggtggg ggaacaagtg aaaatatagg
    12601 gaatattagt gataagtgca gagggaaaaa aaatagagca gggaaggggg atgatttgat
    12661 gtttttcagg ttaagaaagt gacagaaatg aatttaaatg caaaaaacaa tgcataaaga
    12721 ttcataatgg caaaacgaag catgtcccat catacccctt cattcctacc tccctgatat
    12781 gtatctttct aattattcat acaaatgtgt atacccagtt attacatatg gggttttatt
    12841 ctacatatta tgctgcactt gctttttcta atataatgtg tatcatgagc accttacaaa
    12901 tttttaaagg tctctcaaat ttatcagtaa acatatacag tctaacgtta atgagaagat
    12961 attttggtgg gcagtttgct ttaaataaat gggatcatgt acgttctctg catctcacat
    13021 ttctcattta acaatgtagg atgagaattt ctctaagtct atcatagctc ttatttcctt
    13081 tttattatta caataaacat tcctgtgtat atgtttgtca ccatgatggt tttacgtctg
    13141 cggaatagat tccctggagt aggattgctg cattgaggag tatgtatatt taaattttta
    13201 aataaatatt gacagattgt ttcccaaagt ggccggaaca gtttttattt ccatcagtaa
    13261 atgtataaaa acacttttcc cttaatactc atggcaataa ctattgtaac attaaaaaat
    13321 acgtagaaaa aagaaaaaaa tcctggtgga tgtagtgatt tttcagtgtt attttaattt
    13381 ccattttcct gactactata aatgtagaca tcttttcaaa tgttttggtc atctggattg
    13441 cactcagaac tgaattatct attcaaagtt ctgtaggtta gaactccagg gaaactcaac
    13501 tgggctgtct gttcaaggcc caacaaggct gaaatgaaag tgtcttccag ggtgggtact
    13561 caactaaagc tctgaggagg aattcgcttc cagcctcatt aaagtcagag gatggaggtc
    13621 cctgtctcct agctgactgt caaatctgat cctttagagg ttgctccgtg gtccttgcac
    13681 gtggtccctt ccaccttcaa agcttgccag ggtgcatcaa attattttta tactttgact
    13741 ctacttctac cagccagaga aaactgcttt taaagggctc ttgtgactag tttaagcaca
    13801 cccagattgt taaggtcaac tgattagtag ctttaattac atctgccaag tccctctgcc
    13861 ctgcaatgta acatcaacca tggaagtaac atgaggggca gagttcatgg gggccatctt
    13921 agaattctgc ctaccacaaa tattcgtagt tatactttta tatacatttt taaatttttc
    13981 ttatttttgg tccatatgtt tgtaccgttt gtctttttag ttaactagtt tgtgaaagca
    14041 ttttgtatgt tgtacaatat atgttcagat tttcttatct tggatgcaaa catttttttc
    14101 caactcttgt aagttgtctg ttgaccacat tcaaaagtac tttttccaaa taaaactttg
    14161 ccttttgaat ttca
//
