LOCUS       NM_001352129             783 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens small transmembrane regulator of ion transport 1
            (STRIT1), mRNA.
ACCESSION   NM_001352129 NR_037902
VERSION     NM_001352129.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 783)
  AUTHORS   Cleary,S.R., Fang,X., Cho,E.E., Pribadi,M.P., Seflova,J.,
            Beach,J.R., Kekenes-Huskey,P.M. and Robia,S.L.
  TITLE     Inhibitory and stimulatory micropeptides preferentially bind to
            different conformations of the cardiac calcium pump
  JOURNAL   J Biol Chem 298 (7), 102060 (2022)
   PUBMED   35605666
  REMARK    GeneRIF: Inhibitory and stimulatory micropeptides preferentially
            bind to different conformations of the cardiac calcium pump.
REFERENCE   2  (bases 1 to 783)
  AUTHORS   Fisher,M.E., Bovo,E., Aguayo-Ortiz,R., Cho,E.E., Pribadi,M.P.,
            Dalton,M.P., Rathod,N., Lemieux,M.J., Espinoza-Fonseca,L.M.,
            Robia,S.L., Zima,A.V. and Young,H.S.
  TITLE     Dwarf open reading frame (DWORF) is a direct activator of the
            sarcoplasmic reticulum calcium pump SERCA
  JOURNAL   Elife 10, e65545 (2021)
   PUBMED   34075877
  REMARK    GeneRIF: Dwarf open reading frame (DWORF) is a direct activator of
            the sarcoplasmic reticulum calcium pump SERCA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 783)
  AUTHORS   Li,A., Yuen,S.L., Stroik,D.R., Kleinboehl,E., Cornea,R.L. and
            Thomas,D.D.
  TITLE     The transmembrane peptide DWORF activates SERCA2a via dual
            mechanisms
  JOURNAL   J Biol Chem 296, 100412 (2021)
   PUBMED   33581112
  REMARK    GeneRIF: The transmembrane peptide DWORF activates SERCA2a via dual
            mechanisms.
REFERENCE   4  (bases 1 to 783)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 783)
  AUTHORS   Pirkmajer,S., Kirchner,H., Lundell,L.S., Zelenin,P.V.,
            Zierath,J.R., Makarova,K.S., Wolf,Y.I. and Chibalin,A.V.
  TITLE     Early vertebrate origin and diversification of small transmembrane
            regulators of cellular ion transport
  JOURNAL   J Physiol 595 (14), 4611-4630 (2017)
   PUBMED   28436536
REFERENCE   6  (bases 1 to 783)
  AUTHORS   Rion,N. and Ruegg,M.A.
  TITLE     LncRNA-encoded peptides: More than translational noise?
  JOURNAL   Cell Res 27 (5), 604-605 (2017)
   PUBMED   28290465
REFERENCE   7  (bases 1 to 783)
  AUTHORS   Oehler,D. and Haas,J.
  TITLE     Hide and Seek: Protein-coding Sequences Inside 'Non-coding' RNAs
  JOURNAL   Genomics Proteomics Bioinformatics 14 (4), 179-180 (2016)
   PUBMED   27071812
REFERENCE   8  (bases 1 to 783)
  AUTHORS   Nelson,B.R., Makarewich,C.A., Anderson,D.M., Winders,B.R.,
            Troupes,C.D., Wu,F., Reese,A.L., McAnally,J.R., Chen,X.,
            Kavalali,E.T., Cannon,S.C., Houser,S.R., Bassel-Duby,R. and
            Olson,E.N.
  TITLE     A peptide encoded by a transcript annotated as long noncoding RNA
            enhances SERCA activity in muscle
  JOURNAL   Science 351 (6270), 271-275 (2016)
   PUBMED   26816378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104831.3 and BC015836.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001352129.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.57659.1,
                                           SRR5189655.110266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162946 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000489090.2/ ENSP00000489859.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC104831.3         20231-20231
            2-615               BC015836.1         7-620
            616-783             AC104831.3         23520-23687
FEATURES             Location/Qualifiers
     source          1..783
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.2"
     gene            1..783
                     /gene="STRIT1"
                     /gene_synonym="DWORF"
                     /note="small transmembrane regulator of ion transport 1"
                     /db_xref="GeneID:100507537"
                     /db_xref="HGNC:HGNC:52297"
                     /db_xref="MIM:616891"
     exon            1..64
                     /gene="STRIT1"
                     /gene_synonym="DWORF"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..159
                     /gene="STRIT1"
                     /gene_synonym="DWORF"
                     /note="SERCA regulator DWORF"
                     /codon_start=1
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase regulator DWORF"
                     /protein_id="NP_001339058.1"
                     /db_xref="CCDS:CCDS87158.1"
                     /db_xref="GeneID:100507537"
                     /db_xref="HGNC:HGNC:52297"
                     /db_xref="MIM:616891"
                     /translation="MAEKAGSTFSHLLVPILLLIGWIVGCIIMIYVVFS"
     exon            65..163
                     /gene="STRIT1"
                     /gene_synonym="DWORF"
                     /inference="alignment:Splign:2.1.0"
     exon            164..783
                     /gene="STRIT1"
                     /gene_synonym="DWORF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      226..231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRIT1"
                     /gene_synonym="DWORF"
                     /note="hexamer: ATTAAA"
     polyA_site      248
                     /gene="STRIT1"
                     /gene_synonym="DWORF"
                     /note="major polyA site"
     regulatory      762..767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRIT1"
                     /gene_synonym="DWORF"
                     /note="hexamer: AATAAA"
     polyA_site      763
                     /gene="STRIT1"
                     /gene_synonym="DWORF"
     polyA_site      783
                     /gene="STRIT1"
                     /gene_synonym="DWORF"
ORIGIN      
        1 caaaagaaag aggtaagcgt ggcctgacct agccacccac caacaggaat aatggctgaa
       61 aaagcggggt ctacattttc acaccttctg gttcctattc ttctcctgat tggctggatt
      121 gtgggctgca tcataatgat ttatgttgtc ttctcttaga aaggcaagaa gatatcagat
      181 tgacatcatt tagaagaatt aagaaaacta tgaacatgac tgattattaa atgtctcatg
      241 ttaaacaatg caatgtttga catcacttta caaacttgga tcataaactg gcactttggt
      301 atgcataaga atttcttcag gacaataaga aattatgagt gaatttctct atattctgag
      361 tgagaaaaat gtttagctgt gatgaaaaat gcatgtcatt aaaaaaagtt tgataaattt
      421 aatcacatta caaaaaatta tccccccttc cctctggaaa aaactataga gaaagtgggc
      481 tgaggctgtg caaggtggct catgcctgta atcccagcac tttgtgagga tcctttgagc
      541 ccagaaattg gagaccttcc taggcgacag agagagaccc catctctaca aaaaaaaaaa
      601 aaaaaaaaaa aaaaaagaaa gaaaatgggc tagagataaa aacagacaat tcagagaaca
      661 tataatgtaa aagtacactt acttaatctc ttgttcacaa aaagagaaat gtaattaaaa
      721 ctacactgag gaattgttgc tcacttatca gatgggaaaa aaataaagat gtttgacaac
      781 ata
//
