LOCUS       NM_020704               5116 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens striatin interacting protein 2 (STRIP2), transcript
            variant 1, mRNA.
ACCESSION   NM_020704 XM_045907 XM_379923
VERSION     NM_020704.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5116)
  AUTHORS   Pan,J., Zhang,Y., He,L., Wu,Y., Xiao,W., Zhang,J. and Xu,Y.
  TITLE     STRIP2 is regulated by the transcription factor Sp1 and promotes
            lung adenocarcinoma progression via activating the
            PI3K/AKT/mTOR/MYC signaling pathway
  JOURNAL   Genomics 116 (5), 110923 (2024)
   PUBMED   39191354
  REMARK    GeneRIF: STRIP2 is regulated by the transcription factor Sp1 and
            promotes lung adenocarcinoma progression via activating the
            PI3K/AKT/mTOR/MYC signaling pathway.
REFERENCE   2  (bases 1 to 5116)
  AUTHORS   Zhang,X., Chen,Q., He,Y., Shi,Q., Yin,C., Xie,Y., Yu,H., Bao,Y.,
            Wang,X., Tang,C. and Dong,Z.
  TITLE     STRIP2 motivates non-small cell lung cancer progression by
            modulating the TMBIM6 stability through IGF2BP3 dependent
  JOURNAL   J Exp Clin Cancer Res 42 (1), 19 (2023)
   PUBMED   36639675
  REMARK    GeneRIF: STRIP2 motivates non-small cell lung cancer progression by
            modulating the TMBIM6 stability through IGF2BP3 dependent.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5116)
  AUTHORS   Qiu,L.M., Sun,Y.H., Chen,T.T., Chen,J.J. and Ma,H.T.
  TITLE     STRIP2, a member of the striatin-interacting phosphatase and kinase
            complex, is implicated in lung adenocarcinoma cell growth and
            migration
  JOURNAL   FEBS Open Bio 10 (3), 351-361 (2020)
   PUBMED   31901223
  REMARK    GeneRIF: STRIP2, a member of the striatin-interacting phosphatase
            and kinase complex, is implicated in lung adenocarcinoma cell
            growth and migration.
REFERENCE   4  (bases 1 to 5116)
  AUTHORS   Suryavanshi,N., Furmston,J. and Ridley,A.J.
  TITLE     The STRIPAK complex components FAM40A and FAM40B regulate
            endothelial cell contractility via ROCKs
  JOURNAL   BMC Cell Biol 19 (1), 26 (2018)
   PUBMED   30509168
  REMARK    GeneRIF: These results demonstrate the importance of the FAM40
            proteins for endothelial cell physiology, and suggest that they act
            as part of the CCM3-containing STRIPAK complex.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5116)
  AUTHORS   Eden,M., Meder,B., Volkers,M., Poomvanicha,M., Domes,K.,
            Branchereau,M., Marck,P., Will,R., Bernt,A., Rangrez,A., Busch,M.,
            Hrabe de Angelis,M., Heymes,C., Rottbauer,W., Most,P., Hofmann,F.
            and Frey,N.
  CONSRTM   German Mouse Clinic Consortium
  TITLE     Myoscape controls cardiac calcium cycling and contractility via
            regulation of L-type calcium channel surface expression
  JOURNAL   Nat Commun 7, 11317 (2016)
   PUBMED   27122098
  REMARK    GeneRIF: Data indicate that a cardiac protein named
            Myoscape/FAM40B/STRIP2, which directly interacts with the L-type
            calcium channel CaV1.2.
            Erratum:[Nat Commun. 2016 May 26;7:11835. doi:
            10.1038/ncomms11835.. PMID: 27225593]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5116)
  AUTHORS   Lisa-Santamaria,P., Jimenez,A. and Revuelta,J.L.
  TITLE     The protein factor-arrest 11 (Far11) is essential for the toxicity
            of human caspase-10 in yeast and participates in the regulation of
            autophagy and the DNA damage signaling
  JOURNAL   J Biol Chem 287 (35), 29636-29647 (2012)
   PUBMED   22782902
REFERENCE   7  (bases 1 to 5116)
  AUTHORS   Pracheil,T., Thornton,J. and Liu,Z.
  TITLE     TORC2 signaling is antagonized by protein phosphatase 2A and the
            Far complex in Saccharomyces cerevisiae
  JOURNAL   Genetics 190 (4), 1325-1339 (2012)
   PUBMED   22298706
REFERENCE   8  (bases 1 to 5116)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5116)
  AUTHORS   Goudreault,M., D'Ambrosio,L.M., Kean,M.J., Mullin,M.J.,
            Larsen,B.G., Sanchez,A., Chaudhry,S., Chen,G.I., Sicheri,F.,
            Nesvizhskii,A.I., Aebersold,R., Raught,B. and Gingras,A.C.
  TITLE     A PP2A phosphatase high density interaction network identifies a
            novel striatin-interacting phosphatase and kinase complex linked to
            the cerebral cavernous malformation 3 (CCM3) protein
  JOURNAL   Mol Cell Proteomics 8 (1), 157-171 (2009)
   PUBMED   18782753
REFERENCE   10 (bases 1 to 5116)
  AUTHORS   Kemp,H.A. and Sprague,G.F. Jr.
  TITLE     Far3 and five interacting proteins prevent premature recovery from
            pheromone arrest in the budding yeast Saccharomyces cerevisiae
  JOURNAL   Mol Cell Biol 23 (5), 1750-1763 (2003)
   PUBMED   12588993
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009244.25, DA409007.1 and AB032996.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020704.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032996.1, SRR1803612.238534.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249344.7/ ENSP00000249344.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC009244.25        68112-68112
            2-27                DA409007.1         1-26
            28-2625             AB032996.1         1-2598
            2626-5116           AC009244.25        119589-122079
FEATURES             Location/Qualifiers
     source          1..5116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..5116
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /note="striatin interacting protein 2"
                     /db_xref="GeneID:57464"
                     /db_xref="HGNC:HGNC:22209"
                     /db_xref="MIM:617919"
     exon            1..170
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2546
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /note="isoform a is encoded by transcript variant 1;
                     homolog of yeast FAR11 protein 2; protein FAM40B; family
                     with sequence similarity 40, member B; FAR11 factor arrest
                     11 homolog B"
                     /codon_start=1
                     /product="striatin-interacting protein 2 isoform a"
                     /protein_id="NP_065755.1"
                     /db_xref="CCDS:CCDS34752.1"
                     /db_xref="GeneID:57464"
                     /db_xref="HGNC:HGNC:22209"
                     /db_xref="MIM:617919"
                     /translation="MEDPAAPGTGGPPANGNGNGGGKGKQAAPKGREAFRSQRRESEG
                     SVDCPTLEFEYGDADGHAAELSELYSYTENLEFTNNRRCFEEDFKTQVQGKEWLELEE
                     DAQKAYIMGLLDRLEVVSRERRLKVARAVLYLAQGTFGECDSEVDVLHWSRYNCFLLY
                     QMGTFSTFLELLHMEIDNSQACSSALRKPAVSIADSTELRVLLSVMYLMVENIRLERE
                     TDPCGWRTARETFRTELSFSMHNEEPFALLLFSMVTKFCSGLAPHFPIKKVLLLLWKV
                     VMFTLGGFEHLQTLKVQKRAELGLPPLAEDSIQVVKSMRAASPPSYTLDLGESQLAPP
                     PSKLRGRRGSRRQLLTKQDSLDIYNERDLFKTEEPATEEEEESAGDGERTLDGELDLL
                     EQDPLVPPPPSQAPLSAERVAFPKGLPWAPKVRQKDIEHFLEMSRNKFIGFTLGQDTD
                     TLVGLPRPIHESVKTLKQHKYISIADVQIKNEEELEKCPMSLGEEVVPETPCEILYQG
                     MLYSLPQYMIALLKILLAAAPTSKAKTDSINILADVLPEEMPITVLQSMKLGIDVNRH
                     KEIIVKSISTLLLLLLKHFKLNHIYQFEYVSQHLVFANCIPLILKFFNQNILSYITAK
                     NSISVLDYPCCTIQDLPELTTESLEAGDNSQFCWRNLFSCINLLRLLNKLTKWKHSRT
                     MMLVVFKSAPILKRALKVKQAMLQLYVLKLLKLQTKYLGRQWRKSNMKTMSAIYQKVR
                     HRMNDDWAYGNDIDARPWDFQAEECTLRANIEAFNSRRYDRPQDSEFSPVDNCLQSVL
                     GQRLDLPEDFHYSYELWLEREVFSQPICWEELLQNH"
     exon            171..240
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            241..315
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            316..450
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            451..571
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            572..640
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            641..747
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            748..875
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1079
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1315
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1381
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1445
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1517
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1592
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1690
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1817
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1918
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..1985
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2090
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2295
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..5116
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5093..5098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /note="hexamer: AATAAA"
     polyA_site      5116
                     /gene="STRIP2"
                     /gene_synonym="FAM40B; FAR11B"
                     /note="major polyA site"
ORIGIN      
        1 caaagcgagc tgaaccctga ggggagccgc tgaccagcag catggaggac cccgccgcgc
       61 ctgggaccgg gggcccgccc gcaaatggca atggcaacgg cggcggcaaa gggaagcagg
      121 cggcgcccaa gggccgcgaa gcgttccgaa gccagcggcg ggagtcagag ggctctgtgg
      181 actgtcccac tctggagttt gagtatggag atgcagatgg gcatgcagcc gagttgtcag
      241 aattgtatag ttacactgag aacctggaat tcaccaataa caggaggtgc tttgaagaag
      301 atttcaagac tcaagtgcag ggcaaggaat ggctggagtt ggaagaagat gcccaaaagg
      361 cctatataat gggactcttg gaccggctag aggtggtcag tagggaacgg cggctgaagg
      421 tggcccgggc tgttctctac ctggcccaag gtacttttgg ggaatgtgat tcagaggtcg
      481 atgtgctaca ctggtccagg tacaactgct tcctgctgta tcagatgggg accttctcca
      541 ccttcctgga gctactccac atggaaattg acaacagcca ggcctgtagc agtgcccttc
      601 ggaaaccagc tgtctccata gctgatagca cagagctcag ggtgctgctg agtgttatgt
      661 acctaatggt ggaaaatatt cgcctggagc gagagacaga cccctgtggg tggagaacag
      721 cccgggagac cttccgcact gaattaagct tctccatgca taatgaggag ccttttgccc
      781 ttttactctt ctccatggtt accaagttct gcagtggcct ggctcctcac ttccccataa
      841 agaaggtcct gctcctgctc tggaaggtgg tcatgtttac cctcggtgga tttgagcatc
      901 tgcagactct caaagtacag aagcgggcag aattgggcct gcctccactg gctgaagaca
      961 gtatccaggt ggtgaagagc atgcgtgctg cctccccgcc ctcttacact cttgacctgg
     1021 gagagtctca gctggcaccc ccaccctcca agctgcgagg ccgccgtggc tctcgaaggc
     1081 aactcctcac taagcaggac agcctggaca tctacaatga aagggatctc ttcaagactg
     1141 aggagcccgc cacagaggag gaagaggagt ctgctggtga tggagaacga accttggatg
     1201 gagagctaga cctgctagag caggaccctc tggtgccacc tccaccctca caggcacccc
     1261 tctctgctga gcgggtggct tttcccaagg gcctgccctg ggccccaaag gtcagacaga
     1321 aggacattga gcacttcttg gagatgagca ggaacaagtt catcggattc accctggggc
     1381 aggacacaga tacattggtt ggattaccca ggcccatcca tgagagtgtg aagaccctaa
     1441 agcagcacaa gtatatctcc atcgcagatg tgcagatcaa gaatgaagag gagctggaga
     1501 agtgccctat gtctttgggg gaagaggtgg taccagagac gccatgtgaa atcctctacc
     1561 agggaatgct gtacagcctt ccgcagtata tgatcgctct gcttaagatt ctgctggctg
     1621 cagctcccac ctctaaggct aagacagact ctatcaatat cctggcagat gtcctacctg
     1681 aggagatgcc catcactgtt ctccagagca tgaagctggg catcgatgtg aacaggcaca
     1741 aggagattat tgtaaagagt atctctaccc tgcttctgct actcctcaaa cacttcaaac
     1801 tcaaccatat ctaccagttt gaatatgtat cgcaacattt ggtatttgcc aactgcatcc
     1861 ccttgatcct gaagttcttc aatcaaaata tcttgtcata catcactgcc aaaaacagca
     1921 tctcagtcct ggattatcct tgctgtacca tccaggattt gccggagctt actactgaaa
     1981 gtctggaagc tggagacaac agccagttct gctggaggaa cctcttttcc tgcatcaacc
     2041 tcctgaggct gctcaataaa ctgaccaaat ggaaacattc ccggaccatg atgctggtag
     2101 tgtttaaatc ggcaccaatc ttaaagcggg ccctcaaggt caaacaggcc atgctgcaac
     2161 tttatgtcct aaagctacta aagttacaga ccaagtacct ggggcgccaa tggaggaaaa
     2221 gcaacatgaa aaccatgtca gccatttacc agaaagtgcg tcaccgcatg aacgatgact
     2281 gggcttacgg gaatgacatc gatgccagac catgggactt ccaagcagaa gaatgtacct
     2341 tgagggccaa cattgaggct tttaacagcc gtcgctatga cagaccccag gactctgagt
     2401 tttcacctgt ggataactgc ttgcagagcg tactggggca gaggttggat ctgcctgaag
     2461 atttccacta ttcatatgag ctctggctcg agagagaggt gttttcacag cccatctgtt
     2521 gggaggagct gctccagaat cactgactaa gttcttgtca acaagcatca atagatagag
     2581 gtcagctcca ataaactgtg ctctgcctac cctgtccata caggcgctgt taccagttca
     2641 gggctcttct gggggctctt gggcctaaag atggtgcaag ggtgggatcc tgaatcacaa
     2701 taaaatgatc aacttgccct ggggtcagtt gggtgcccag ttggccttgg aaatcttttg
     2761 gtggatcaat tctagacaag ctctttggta ggaccttttc ctgctttagt cttggctaca
     2821 accaggctag actttgctgg ctctaaaaga ggaaatttgt tatggcattt gacccatggc
     2881 attcatcaca gatagtggga ggtacaagtc ataaaatagg gagaaagttt tcttcttgct
     2941 cacactggat tcctaggact tatcagagat ttggaaaaac caactttgaa attaagtttg
     3001 cattttaaat ttcaaatttg gaagcctctt tctgaaatca ttagctctaa gattatttta
     3061 gagcacctgc accttctttg tgaaggatga tgatttacta ttccctcaat actgcatgtt
     3121 atcgaaaagt gtgttgtgta aagtgttttt ttcctcattc tgtaagagat ctatattcaa
     3181 tgtgaaaatt atttccttgt gtactctgta tagggcatgg aatgctctgc catttttaaa
     3241 gagccacaac caatatgaaa taattaggtc ctctctaagg atgtttcatg tttttcttaa
     3301 atgactccag tcttcaaatg gctgagcata ctgcagaaaa ttatcctttt catctaattc
     3361 attttttaaa tgacaagtta actacaggag gctttattta ttcagatggt atgtccactt
     3421 gtggtcgtga tcaatatatt tttctaattg aaaagtaaaa gcatcacagc ttaccatttt
     3481 tctttttctg cagtgttgat taatgatttt tttcccgttt attgctagca gtttcaaagt
     3541 gtcatgtgga gatttagcaa tactgtctct acttaaaagt attgcacatt tcattgaaaa
     3601 tgtgagagtt gatataccag cctctttata tttctctttt acagcagaat cacatacttc
     3661 tcaagataaa caaggttttt aaaaaagttt ctgatttagt taggatcata tgcttttttt
     3721 tttttttttt tttttttttt tttttttgag acagagtttc gctcttgttg cccaagctgg
     3781 agtgcaatgg cacgatctcg gctcactgca acctccgcct cccgggttca agcgattctc
     3841 ctgcctcagc ctcccaagga gctgggatta caggcacgca ccaccatgcc tggctaattt
     3901 tttgtatttt tagtagaaac agggtttcac catgttagcc aggctgacct caaactcctg
     3961 acctcaggtg atccgcccgc ctccacctcc cagggtgctg ggattacagg tgtgagccac
     4021 catgcccagc ctcttcaagc ttttttacta tacatgttgc ccctctcccc caacttaggc
     4081 actactgaat tttttatgat ggcaccaggt cactttatgc tgggtgatat agtcaaaatt
     4141 tgcttattta ctctgcccct cgtcaaccac agtatcattt caaggacatg aataaaatac
     4201 ttgacagtat ccaaaggagc tataccaaaa tctaacaagt aaattttgga ttttgcctct
     4261 ttgtgcttta aagtaccagg atttctgtct ctatggatag gtcttggaga atgttaagta
     4321 atggatgaaa ctttttaaaa taatttgtaa attttaccta agtaggacag tagtccttac
     4381 tgcaatcaaa ataatttact gagcacaact cctgtaaatt aatctacagt caggctagta
     4441 tgattttaat atgatttgag taaaaagata attttcaagg aaagagtaat catccatcaa
     4501 tttattataa agccagatag tattcaattt atgtcaagaa caaagaaatt gcccttttaa
     4561 aagcatgtac gtgaatgctt tttgaggcac agaagtatgc taagctttaa cattttgtat
     4621 ttatttacaa cccttttcta agggaaggtt acttctcagt gcagatggag aaactgaagc
     4681 actaaggata aatgattagt ttccaatcac atcatttttt tccacagact tgctgggact
     4741 agctttcagg tattgacagc cagccccata tattaaggta accaggttga atcttccaat
     4801 ttgagaaccc atgtatgggt tgcagtgagc cgagatcatg ccactgcact ccatcctggg
     4861 caacaagaac gaaactccgt ctcaaaaaca aagaaggata taataaagtt aatatataaa
     4921 ccatgtatgt ggttaggaat aaattcaaat tcaccagtct ccaatggtga ttacttttac
     4981 tacatagaaa aacattttag tgacttacag aggattttta tttgtgaata tttcagtaaa
     5041 gtttgtgttg attgttgata acactgttca tctactgaag cactttaata aaaataaaat
     5101 gagctggaat tagaaa
//
