LOCUS       NM_033088               3257 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens striatin interacting protein 1 (STRIP1), transcript
            variant 1, mRNA.
ACCESSION   NM_033088
VERSION     NM_033088.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3257)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3257)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3257)
  AUTHORS   Jeong,B.C., Bae,S.J., Ni,L., Zhang,X., Bai,X.C. and Luo,X.
  TITLE     Cryo-EM structure of the Hippo signaling integrator human STRIPAK
  JOURNAL   Nat Struct Mol Biol 28 (3), 290-299 (2021)
   PUBMED   33633399
REFERENCE   4  (bases 1 to 3257)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 3257)
  AUTHORS   Tang,Y., Chen,M., Zhou,L., Ma,J., Li,Y., Zhang,H., Shi,Z., Xu,Q.,
            Zhang,X., Gao,Z., Zhao,Y., Cheng,Y., Jiao,S. and Zhou,Z.
  TITLE     Architecture, substructures, and dynamic assembly of STRIPAK
            complexes in Hippo signaling
  JOURNAL   Cell Discov 5, 3 (2019)
   PUBMED   30622739
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3257)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3257)
  AUTHORS   Kean,M.J., Ceccarelli,D.F., Goudreault,M., Sanches,M., Tate,S.,
            Larsen,B., Gibson,L.C., Derry,W.B., Scott,I.C., Pelletier,L.,
            Baillie,G.S., Sicheri,F. and Gingras,A.C.
  TITLE     Structure-function analysis of core STRIPAK Proteins: a signaling
            complex implicated in Golgi polarization
  JOURNAL   J Biol Chem 286 (28), 25065-25075 (2011)
   PUBMED   21561862
REFERENCE   8  (bases 1 to 3257)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 3257)
  AUTHORS   Goudreault,M., D'Ambrosio,L.M., Kean,M.J., Mullin,M.J.,
            Larsen,B.G., Sanchez,A., Chaudhry,S., Chen,G.I., Sicheri,F.,
            Nesvizhskii,A.I., Aebersold,R., Raught,B. and Gingras,A.C.
  TITLE     A PP2A phosphatase high density interaction network identifies a
            novel striatin-interacting phosphatase and kinase complex linked to
            the cerebral cavernous malformation 3 (CCM3) protein
  JOURNAL   Mol Cell Proteomics 8 (1), 157-171 (2009)
   PUBMED   18782753
REFERENCE   10 (bases 1 to 3257)
  AUTHORS   Glatter,T., Wepf,A., Aebersold,R. and Gstaiger,M.
  TITLE     An integrated workflow for charting the human interaction proteome:
            insights into the PP2A system
  JOURNAL   Mol Syst Biol 5, 237 (2009)
   PUBMED   19156129
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB960147.1, AB051548.2 and
            BC040142.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033088.3.
            
            Summary: This gene encodes a member of the striatin-interacting
            phosphatase and kinase complex, which is involved in localization
            of the Golgi body. The encoded protein participates in cytosketelal
            organization. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094786.1, SRR1660803.13925.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369795.8/ ENSP00000358810.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                CB960147.1         32-51
            21-2562             AB051548.2         9-2550
            2563-3257           BC040142.1         812-1506
FEATURES             Location/Qualifiers
     source          1..3257
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..3257
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /note="striatin interacting protein 1"
                     /db_xref="GeneID:85369"
                     /db_xref="HGNC:HGNC:25916"
                     /db_xref="MIM:617918"
     exon            1..194
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..2528
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homolog of yeast FAR11 protein 1; protein FAM40A; family
                     with sequence similarity 40, member A; FAR11 factor arrest
                     11 homolog A"
                     /codon_start=1
                     /product="striatin-interacting protein 1 isoform 1"
                     /protein_id="NP_149079.2"
                     /db_xref="CCDS:CCDS30798.1"
                     /db_xref="GeneID:85369"
                     /db_xref="HGNC:HGNC:25916"
                     /db_xref="MIM:617918"
                     /translation="MEPAVGGPGPLIVNNKQPQPPPPPPPAAAQPPPGAPRAAAGLLP
                     GGKAREFNRNQRKDSEGYSESPDLEFEYADTDKWAAELSELYSYTEGPEFLMNRKCFE
                     EDFRIHVTDKKWTELDTNQHRTHAMRLLDGLEVTAREKRLKVARAILYVAQGTFGECS
                     SEAEVQSWMRYNIFLLLEVGTFNALVELLNMEIDNSAACSSAVRKPAISLADSTDLRV
                     LLNIMYLIVETVHQECEGDKAEWRTMRQTFRAELGSPLYNNEPFAIMLFGMVTKFCSG
                     HAPHFPMKKVLLLLWKTVLCTLGGFEELQSMKAEKRSILGLPPLPEDSIKVIRNMRAA
                     SPPASASDLIEQQQKRGRREHKALIKQDNLDAFNERDPYKADDSREEEEENDDDNSLE
                     GETFPLERDEVMPPPLQHPQTDRLTCPKGLPWAPKVREKDIEMFLESSRSKFIGYTLG
                     SDTNTVVGLPRPIHESIKTLKQHKYTSIAEVQAQMEEEYLRSPLSGGEEEVEQVPAET
                     LYQGLLPSLPQYMIALLKILLAAAPTSKAKTDSINILADVLPEEMPTTVLQSMKLGVD
                     VNRHKEVIVKAISAVLLLLLKHFKLNHVYQFEYMAQHLVFANCIPLILKFFNQNIMSY
                     ITAKNSISVLDYPHCVVHELPELTAESLEAGDSNQFCWRNLFSCINLLRILNKLTKWK
                     HSRTMMLVVFKSAPILKRALKVKQAMMQLYVLKLLKVQTKYLGRQWRKSNMKTMSAIY
                     QKVRHRLNDDWAYGNDLDARPWDFQAEECALRANIERFNARRYDRAHSNPDFLPVDNC
                     LQSVLGQRVDLPEDFQMNYDLWLEREVFSKPISWEELLQ"
     exon            195..264
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            265..339
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            340..474
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            475..595
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            596..664
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            665..771
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            772..899
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1082
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1300
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1366
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1430
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1502
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1577
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1675
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1802
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1903
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1970
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2075
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2280
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..3257
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3237..3242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /note="hexamer: ATTAAA"
     polyA_site      3257
                     /gene="STRIP1"
                     /gene_synonym="FAM40A; FAR11A"
                     /note="major polyA site"
ORIGIN      
        1 gtggagcagc caagatggag ccggcagtcg gcggtccggg cccactgatc gtgaacaaca
       61 aacagcccca gcccccgcca cctccgccgc cggcagccgc acagccacca cccggggcac
      121 cgcgggccgc cgcgggcctc ctgcctgggg gcaaagcccg cgagttcaac cgcaaccagc
      181 gcaaagactc agagggctat tcggagtcac cagacctgga gtttgagtat gctgacacag
      241 acaagtgggc tgcagagctc tcggagcttt acagctacac ggaagggcca gaattcctga
      301 tgaatcgaaa atgctttgag gaggacttcc ggatccatgt gacagacaag aagtggactg
      361 agctggatac caaccagcac cggacccatg ccatgaggct cctggatggc ttggaagtca
      421 ctgccaggga gaagagactc aaggtggctc gagcaattct ctatgttgct caaggcacgt
      481 ttggggagtg cagctcggag gcagaggtgc agtcctggat gcgctacaac atctttctcc
      541 tcctggaggt gggcacgttc aatgctttgg tggagcttct gaacatggaa atagacaaca
      601 gtgccgcctg cagcagtgct gtgaggaagc ctgccatctc cctggctgac agcacagacc
      661 tcagggtcct gctcaacatc atgtacctga tagtggagac cgttcatcag gagtgtgagg
      721 gtgacaaggc tgagtggagg accatgcggc agaccttcag agccgagctg ggctccccgc
      781 tgtacaacaa tgagccattt gccatcatgc tgtttgggat ggtgaccaaa ttttgcagtg
      841 gtcacgcccc tcactttccc atgaagaaag ttctcttgct gctctggaag acagtattgt
      901 gcacgctagg cggctttgag gagctgcaga gcatgaaggc tgagaagcgc agcatcctgg
      961 gcctcccccc gcttcctgag gacagcatca aagtgattcg caacatgaga gcagcctctc
     1021 caccagcatc tgcttcagac ttgattgagc agcagcagaa acggggccgc cgagagcaca
     1081 aggctctgat aaagcaggac aacctagatg ccttcaacga gcgggatccc tacaaggctg
     1141 atgactctcg agaagaggaa gaggagaatg atgatgacaa cagtctggag ggggagacgt
     1201 ttcccctgga acgggatgaa gtgatgcctc ccccgctaca gcacccacag actgacaggc
     1261 tgacttgccc caaagggctc ccgtgggctc ccaaggtcag agagaaagac attgagatgt
     1321 tccttgagtc cagccgcagc aaatttatag gttacactct aggcagtgac acgaacacag
     1381 tggtggggct gcccaggcca atccacgaaa gcatcaagac tctgaaacag cacaagtaca
     1441 cgtcgattgc agaggtccag gcacagatgg aggaggaata cctccgctcc cctctctcag
     1501 ggggagaaga agaagttgag caagtccctg cagaaaccct ctaccaaggc ttgctcccca
     1561 gcctgcctca gtatatgatt gccctcctga agatcctgtt ggctgcagca cccacctcaa
     1621 aagccaaaac agactcaatc aacatcctag cggacgtctt gcctgaggag atgcccacca
     1681 cagtgttgca gagcatgaag ctgggggtgg atgtaaaccg ccacaaagag gtcattgtta
     1741 aggccatttc tgctgtcctg ctgctgctgc tcaagcactt taagttgaac catgtctacc
     1801 agtttgaata catggcccag cacctggtgt ttgccaactg cattcctttg atcctaaagt
     1861 tcttcaatca aaacatcatg tcctacatca ctgccaagaa cagcatttct gtcctggatt
     1921 accctcactg cgtggtgcat gagctgccag agctgacggc ggagagtttg gaagcaggtg
     1981 acagtaacca attttgctgg aggaacctct tttcttgtat caatctgctt cggatcttga
     2041 acaagctgac aaagtggaag cattcaagga caatgatgct ggtggtgttc aagtcagccc
     2101 ccatcttgaa gcgggcccta aaggtgaaac aagccatgat gcagctctat gtgctgaagc
     2161 tgctcaaggt acagaccaaa tacttggggc ggcagtggcg aaagagcaac atgaagacca
     2221 tgtctgccat ctaccagaag gtgcggcatc ggctgaacga cgactgggca tacggcaatg
     2281 atcttgatgc ccggccttgg gacttccagg cagaggagtg tgcccttcgt gccaacattg
     2341 aacgcttcaa cgcccggcgc tatgaccggg cccacagcaa ccctgacttc ctgccagtgg
     2401 acaactgcct gcagagtgtc ctgggccaac gggtggacct ccctgaggac tttcagatga
     2461 actatgacct ctggttagaa agggaggtct tctccaagcc catttcctgg gaagagctgc
     2521 tgcagtgagg ctgttggtta ggggactgaa atggagagaa aagatgatct gaaggtacct
     2581 gtgggactgt cctagttcat tgctgcagtg ctcccatccc ccaccaggtg gcagcacagc
     2641 cccactgtgt cttccgcagt ctgtcctggg cttgggtgag cccagcttga cctccccttg
     2701 gttcccaggg tcctgctccg aagcagtcat ctctgcctga gatccattct tcctttactt
     2761 cccccaccct cctctcttgg atatggttgg ttttggctca tttcacaatc agcccaaggc
     2821 tgggaaagct ggaatgggat gggaacccct ccgccgtgca tctgaatttc aggggtcatg
     2881 ctgatgcctc tcgagacata caaatccttg ctttgtcagc ttgcaaagga ggagagttta
     2941 ggattagggc cagggccaga aagtcggtat cttggttgtg ctctggggtg ggggtggggt
     3001 gtttctgatg ttattccagc ctcctgctac attatatcca gaagtaattg cggaggctcc
     3061 ttcagctgcc tcagcacttt gattttggac agggacaagg taggaagaga agcttccctt
     3121 aaccagaggg gccatttttc cttttggctt tcgagggcct gtaaatatct atatataatt
     3181 ctgtgtgtat tctgtgtcat gttggggttt ttaatgtgat tgtgtattct gtttacatta
     3241 aaaagaagca aaaataa
//
