LOCUS       NM_153700               5515 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens stereocilin (STRC), mRNA.
ACCESSION   NM_153700 XM_001715128 XM_001718339
VERSION     NM_153700.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5515)
  AUTHORS   Peart,L., Gonzalez,J., Morel Swols,D., Duman,D., Saridogan,T.,
            Ramzan,M., Zafeer,M.F., Liu,X.Z., Eshraghi,A.A., Hoffer,M.E.,
            Angeli,S.I., Bademci,G., Blanton,S., Smith,C., Telischi,F.F. and
            Tekin,M.
  TITLE     Dispersed DNA variants underlie hearing loss in South Florida's
            minority population
  JOURNAL   Hum Genomics 17 (1), 103 (2023)
   PUBMED   37996878
  REMARK    GeneRIF: Dispersed DNA variants underlie hearing loss in South
            Florida's minority population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5515)
  AUTHORS   Benoit,C., Carlson,R.J., King,M.C., Horn,D.L. and Rubinstein,J.T.
  TITLE     Behavioral characterization of the cochlear amplifier lesion due to
            loss of function of stereocilin (STRC) in human subjects
  JOURNAL   Hear Res 439, 108898 (2023)
   PUBMED   37890241
  REMARK    GeneRIF: Behavioral characterization of the cochlear amplifier
            lesion due to loss of function of stereocilin (STRC) in human
            subjects.
REFERENCE   3  (bases 1 to 5515)
  AUTHORS   Achard,S., Simon,F., Denoyelle,F. and Marlin,S.
  TITLE     Recurrent benign paroxysmal positional vertigo in two DFNB16
            siblings: A CARE case report
  JOURNAL   Eur Ann Otorhinolaryngol Head Neck Dis 140 (3), 127-129 (2023)
   PUBMED   36526540
  REMARK    GeneRIF: Recurrent benign paroxysmal positional vertigo in two
            DFNB16 siblings: A CARE case report.
REFERENCE   4  (bases 1 to 5515)
  AUTHORS   Achard,S., Campion,M., Parodi,M., MacAskill,M., Hochet,B.,
            Simon,F., Rouillon,I., Jonard,L., Serey-Gaut,M., Denoyelle,F.,
            Loundon,N. and Marlin,S.
  TITLE     Recurrent Benign Paroxysmal Positional Vertigo in DFNB16 Patients
            with Biallelic STRC Gene Deletions
  JOURNAL   Otol Neurotol 44 (4), e241-e245 (2023)
   PUBMED   36764706
  REMARK    GeneRIF: Recurrent Benign Paroxysmal Positional Vertigo in DFNB16
            Patients with Biallelic STRC Gene Deletions.
REFERENCE   5  (bases 1 to 5515)
  AUTHORS   Nishio,S.Y. and Usami,S.I.
  TITLE     Frequency of the STRC-CATSPER2 deletion in STRC-associated hearing
            loss patients
  JOURNAL   Sci Rep 12 (1), 634 (2022)
   PUBMED   35022556
  REMARK    GeneRIF: Frequency of the STRC-CATSPER2 deletion in STRC-associated
            hearing loss patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5515)
  AUTHORS   Jovine,L., Park,J. and Wassarman,P.M.
  TITLE     Sequence similarity between stereocilin and otoancorin points to a
            unified mechanism for mechanotransduction in the mammalian inner
            ear
  JOURNAL   BMC Cell Biol 3, 28 (2002)
   PUBMED   12445334
REFERENCE   7  (bases 1 to 5515)
  AUTHORS   Bitner-Glindzicz,M.
  TITLE     Hereditary deafness and phenotyping in humans
  JOURNAL   Br Med Bull 63, 73-94 (2002)
   PUBMED   12324385
  REMARK    Review article
REFERENCE   8  (bases 1 to 5515)
  AUTHORS   Verpy,E., Masmoudi,S., Zwaenepoel,I., Leibovici,M., Hutchin,T.P.,
            Del Castillo,I., Nouaille,S., Blanchard,S., Laine,S., Popot,J.L.,
            Moreno,F., Mueller,R.F. and Petit,C.
  TITLE     Mutations in a new gene encoding a protein of the hair bundle cause
            non-syndromic deafness at the DFNB16 locus
  JOURNAL   Nat Genet 29 (3), 345-349 (2001)
   PUBMED   11687802
REFERENCE   9  (bases 1 to 5515)
  AUTHORS   Villamar,M., del Castillo,I., Valle,N., Romero,L. and Moreno,F.
  TITLE     Deafness locus DFNB16 is located on chromosome 15q13-q21 within a
            5-cM interval flanked by markers D15S994 and D15S132
  JOURNAL   Am J Hum Genet 64 (4), 1238-1241 (1999)
   PUBMED   10090914
REFERENCE   10 (bases 1 to 5515)
  AUTHORS   Campbell,D.A., McHale,D.P., Brown,K.A., Moynihan,L.M., Houseman,M.,
            Karbani,G., Parry,G., Janjua,A.H., Newton,V., al-Gazali,L.,
            Markham,A.F., Lench,N.J. and Mueller,R.F.
  TITLE     A new locus for non-syndromal, autosomal recessive, sensorineural
            hearing loss (DFNB16) maps to human chromosome 15q21-q22
  JOURNAL   J Med Genet 34 (12), 1015-1017 (1997)
   PUBMED   9429146
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BK000138.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Mar 29, 2008 this sequence version replaced
            XM_001715128.1, XM_001718339.1, NM_153700.1.
            
            Summary: This gene encodes a protein that is associated with the
            hair bundle of the sensory hair cells in the inner ear. The hair
            bundle is composed of stiff microvilli called stereocilia and is
            involved with mechanoreception of sound waves. This gene is part of
            a tandem duplication on chromosome 15; the second copy is a
            pseudogene. Mutations in this gene cause autosomal recessive
            non-syndromic deafness. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000138.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450892.7/ ENSP00000401513.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.3"
     gene            1..5515
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /note="stereocilin"
                     /db_xref="GeneID:161497"
                     /db_xref="HGNC:HGNC:16035"
                     /db_xref="MIM:606440"
     exon            1..142
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..5406
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /codon_start=1
                     /product="stereocilin precursor"
                     /protein_id="NP_714544.1"
                     /db_xref="CCDS:CCDS10098.1"
                     /db_xref="GeneID:161497"
                     /db_xref="HGNC:HGNC:16035"
                     /db_xref="MIM:606440"
                     /translation="MALSLWPLLLLLLLLLLLSFAVTLAPTGPHSLDPGLSFLKSLLS
                     TLDQAPQGSLSRSRFFTFLANISSSFEPGRMGEGPVGEPPPLQPPALRLHDFLVTLRG
                     SPDWEPMLGLLGDMLALLGQEQTPRDFLVHQAGVLGGLVEVLLGALVPGGPPTPTRPP
                     CTRDGPSDCVLAADWLPSLLLLLEGTRWQALVQVQPSVDPTNATGLDGREAAPHFLQG
                     LLGLLTPTGELGSKEALWGGLLRTVGAPLYAAFQEGLLRVTHSLQDEVFSILGQPEPD
                     TNGQCQGGNLQQLLLWGVRHNLSWDVQALGFLSGSPPPPPALLHCLSTGVPLPRASQP
                     SAHISPRQRRAITVEALCENHLGPAPPYSISNFSIHLLCQHTKPATPQPHPSTTAICQ
                     TAVWYAVSWAPGAQGWLQACHDQFPDEFLDAICSNLSFSALSGSNRRLVKRLCAGLLP
                     PPTSCPEGLPPVPLTPDIFWGCFLENETLWAERLCGEASLQAVPPSNQAWVQHVCQGP
                     TPDVTASPPCHIGPCGERCPDGGSFLVMVCANDTMYEVLVPFWPWLAGQCRISRGGND
                     TCFLEGLLGPLLPSLPPLGPSPLCLTPGPFLLGMLSQLPRCQSSVPALAHPTRLHYLL
                     RLLTFLLGPGAGGAEAQGMLGRALLLSSLPDNCSFWDAFRPEGRRSVLRTIGEYLEQD
                     EEQPTPSGFEPTVNPSSGISKMELLACFSPVLWDLLQREKSVWALQILVQAYLHMPPE
                     NLQQLVLSAEREAAQGFLTLMLQGKLQGKLQVPPSEEQALGRLTALLLQRYPRLTSQL
                     FIDLSPLIPFLAVSDLMRFPPSLLANDSVLAAIRDYSPGMRPEQKEALAKRLLAPELF
                     GEVPAWPQELLWAVLPLLPHLPLENFLQLSPHQIQALEDSWPAAGLGPGHARHVLRSL
                     VNQSVQDGEEQVRRLGPLACFLSPEELQSLVPLSDPTGPVERGLLECAANGTLSPEGR
                     VAYELLGVLRSSGGAVLSPRELRVWAPLFSQLGLRFLQELSEPQLRAMLPVLQGTSVT
                     PAQAVLLLGRLLPRHDLSLEELCSLHLLLPGLSPQTLQAIPRRVLVGACSCLAPELSR
                     LSACQTAALLQTFRVKDGVKNMGTTGAGPAVCIPGQPIPTTWPDCLLPLLPLKLLQLD
                     SLALLANRRRYWELPWSEQQAQFLWKKMQVPTNLTLRNLQALGTLAGGMSCEFLQQIN
                     SMVDFLEVVHMIYQLPTRVRGSLRACIWAELQRRMAMPEPEWTTVGPELNGLDSKLLL
                     DLPIQLMDRLSNESIMLVVELVQRAPEQLLALTPLHQAALAERALQNLAPKETPVSGE
                     VLETLGPLVGFLGTESTRQIPLQILLSHLSQLQGFCLGETFATELGWLLLQESVLGKP
                     ELWSQDEVEQAGRLVFTLSTEAISLIPREALGPETLERLLEKQQSWEQSRVGQLCREP
                     QLAAKKAALVAGVVRPAAEDLPEPVPNCADVRGTFPAAWSATQIAEMELSDFEDCLTL
                     FAGDPGLGPEELRAAMGKAKQLWGPPRGFRPEQILQLGRLLIGLGDRELQELILVDWG
                     VLSTLGQIDGWSTTQLRIVVSSFLRQSGRHVSHLDFVHLTALGYTLCGLRPEELQHIS
                     SWEFSQAALFLGTLHLQCSEEQLEVLAHLLVLPGGFGPISNWGPEIFTEIGTIAAGIP
                     DLALSALLRGQIQGVTPLAISVIPPPKFAVVFSPIQLSSLTSAQAVAVTPEQMAFLSP
                     EQRRAVAWAQHEGKESPEQQGRSTAWGLQDWSRPSWSLVLTISFLGHLL"
     exon            143..928
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            929..953
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            954..2211
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2274
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2391
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2558
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2745
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2861
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2994
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3177
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3216
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3384
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3450
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3451..3576
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3635
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3759
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..3872
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..4008
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4009..4205
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4206..4296
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4297..4453
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4454..4623
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4624..4779
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4780..4922
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4923..5071
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            5072..5169
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            5170..5317
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            5318..5515
                     /gene="STRC"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctgccct cacctggcta tcccacacag gtgagaataa ccagaactca cctccggtac
       61 cagtgttcac ttggaaacat ggctctcagc ctctggcccc tgctgctgct gctgctgctg
      121 ctgctgctgc tgtcctttgc agtgactctg gcccctactg ggcctcattc cctggaccct
      181 ggtctctcct tcctgaagtc attgctctcc actctggacc aggctcccca gggctccctg
      241 agccgctcac ggttctttac attcctggcc aacatttctt cttcctttga gcctgggaga
      301 atgggggaag gaccagtagg agagccccca cctctccagc cgcctgctct gcggctccat
      361 gattttctag tgacactgag aggtagcccc gactgggagc caatgctagg gctgctaggg
      421 gatatgctgg cactgctggg acaggagcag actccccgag atttcctggt gcaccaggca
      481 ggggtgctgg gtggacttgt ggaggtgctg ctgggagcct tagttcctgg gggcccccct
      541 accccaactc ggcccccatg cacccgtgat gggccgtctg actgtgtcct ggctgctgac
      601 tggttgcctt ctctgctgct gttgttagag ggcacacgct ggcaagctct ggtgcaggtg
      661 cagcccagtg tggaccccac caatgccaca ggcctcgatg ggagggaggc agctcctcac
      721 tttttgcagg gtctgttggg tttgcttacc ccaacagggg agctaggctc caaggaggct
      781 ctttggggcg gtctgctacg cacagtgggg gcccccctct atgctgcctt tcaggagggg
      841 ctgctccgtg tcactcactc cctgcaggat gaggtcttct ccattttggg gcagccagag
      901 cctgatacca atgggcagtg ccagggaggt aaccttcaac agctgctctt atggggcgtc
      961 cggcacaacc tttcctggga tgtccaggcg ctgggctttc tgtctggatc accaccccca
     1021 ccccctgccc tccttcactg cctgagcacg ggcgtgcctc tgcccagagc ttctcagccg
     1081 tcagcccaca tcagcccacg ccaacggcga gccatcactg tggaggccct ctgtgagaac
     1141 cacttaggcc cagcaccacc ctacagcatt tccaacttct ccatccactt gctctgccag
     1201 cacaccaagc ctgccactcc acagccccat cccagcacca ctgccatctg ccagacagct
     1261 gtgtggtatg cagtgtcctg ggcaccaggt gcccaaggct ggctacaggc ctgccacgac
     1321 cagtttcctg atgagttttt ggatgcgatc tgcagtaacc tctccttttc agccctgtct
     1381 ggctccaacc gccgcctggt gaagcggctc tgtgctggcc tgctcccacc ccctaccagc
     1441 tgccctgaag gcctgccccc tgttcccctc accccagaca tcttttgggg ctgcttcttg
     1501 gagaatgaga ctctgtgggc tgagcgactg tgtggggagg caagtctaca ggctgtgccc
     1561 cccagcaacc aggcttgggt ccagcatgtg tgccagggcc ccaccccaga tgtcactgcc
     1621 tccccaccat gccacattgg accctgtggg gaacgctgcc cggatggggg cagcttcctg
     1681 gtgatggtct gtgccaatga caccatgtat gaggtcctgg tgcccttctg gccttggcta
     1741 gcaggccaat gcaggataag tcgtgggggc aatgacactt gcttcctaga agggctgctg
     1801 ggcccccttc tgccctctct gccaccactg ggaccatccc cactctgtct gacccctggc
     1861 cccttcctcc ttggcatgct atcccagttg ccacgctgtc agtcctctgt cccagctctt
     1921 gctcacccca cacgcctaca ctatctcctc cgcctgctga ccttcctctt gggtccaggg
     1981 gctgggggcg ctgaggccca ggggatgctg ggtcgggccc tactgctctc cagtctccca
     2041 gacaactgct ccttctggga tgcctttcgc ccagagggcc ggcgcagtgt gctacggacg
     2101 attggggaat acctggaaca agatgaggag cagccaaccc catcaggctt tgaacccact
     2161 gtcaacccca gctctggtat aagcaagatg gagctgctgg cctgctttag tcctgtgctg
     2221 tgggatctgc tccagaggga aaagagtgtt tgggccctgc agattctagt gcaggcgtac
     2281 ctgcatatgc ccccagaaaa cctccagcag ctggtgcttt cagcagagag ggaggctgca
     2341 cagggcttcc tgacactcat gctgcagggg aagctgcagg ggaagctgca ggtaccacca
     2401 tccgaggagc aggccctggg tcgcctgaca gccctgctgc tccagcggta cccacgcctc
     2461 acctcccagc tcttcattga cctgtcacca ctcatccctt tcttggctgt ctctgacctg
     2521 atgcgcttcc caccatccct gttagccaac gacagtgtcc tggctgccat ccgggattac
     2581 agcccaggaa tgaggcctga acagaaggag gctctggcaa agcgactgct ggcccctgaa
     2641 ctgtttgggg aagtgcctgc ctggccccag gagctgctgt gggcagtgct gcccctgctc
     2701 ccccacctcc ctctggagaa ctttttgcag ctcagccctc accagatcca ggccctggag
     2761 gatagctggc cagcagcagg tctggggcca gggcatgccc gccatgtgct gcgcagcctg
     2821 gtaaaccaga gtgtccagga tggtgaggag caggtacgca ggcttgggcc cctcgcctgt
     2881 ttcctgagcc ctgaggagct gcagagccta gtgcccctga gtgatccaac ggggccagta
     2941 gaacgggggc tgctggaatg tgcagccaat gggaccctca gcccagaagg acgggtggca
     3001 tatgaacttc tgggtgtgtt gcgctcatct ggaggagcgg tgctgagccc ccgggagctg
     3061 cgggtctggg cccctctctt ctctcagctg ggcctccgct tccttcagga gctgtcagag
     3121 ccccagctta gagccatgct tcctgtcctg cagggaacta gtgttacacc tgctcaggct
     3181 gtcctgctgc ttggacggct ccttcctagg cacgatctat ccctggagga actctgctcc
     3241 ttgcaccttc tgctaccagg cctcagcccc cagacactcc aggccatccc taggcgagtc
     3301 ctggtcgggg cttgttcctg cctggcccct gaactgtcac gcctctcagc ctgccagacc
     3361 gcagcactgc tgcagacctt tcgggttaaa gatggtgtta aaaatatggg tacaacaggt
     3421 gctggtccag ctgtgtgtat ccctggtcag cctattccca ccacctggcc agactgcctg
     3481 cttcccctgc tcccattaaa gctgctacaa ctggattcct tggctcttct ggcaaatcga
     3541 agacgctact gggagctgcc ctggtctgag cagcaggcac agtttctctg gaagaagatg
     3601 caagtaccca ccaaccttac cctcaggaat ctgcaggctc tgggcaccct ggcaggaggc
     3661 atgtcctgtg agtttctgca gcagatcaac tccatggtag acttccttga agtggtgcac
     3721 atgatctatc agctgcccac tagagttcga gggagcctga gggcctgtat ctgggcagag
     3781 ctacagcgga ggatggcaat gccagaacca gaatggacaa ctgtagggcc agaactgaac
     3841 gggctggata gcaagctact cctggactta ccgatccagt tgatggacag actatccaat
     3901 gaatccatta tgttggtggt ggagctggtg caaagagctc cagagcagct gctggcactg
     3961 acccccctcc accaggcagc cctggcagag agggcactac aaaacctggc tccaaaggag
     4021 actccagtct caggggaagt gctggagacc ttaggccctt tggttggatt cctggggaca
     4081 gagagcacac gacagatccc cctacagatc ctgctgtccc atctcagtca gctgcaaggc
     4141 ttctgcctag gagagacatt tgccacagag ctgggatggc tgctattgca ggagtctgtt
     4201 cttgggaaac cagagttgtg gagccaggat gaagtagagc aagctggacg cctagtattc
     4261 actctgtcta ctgaggcaat ttccttgatc cccagggagg ccttgggtcc agagaccctg
     4321 gagcggcttc tagaaaagca gcagagctgg gagcagagca gagttggaca gctgtgtagg
     4381 gagccacagc ttgctgccaa gaaagcagcc ctggtagcag gggtggtgcg accagctgct
     4441 gaggatcttc cagaacctgt gccaaattgt gcagatgtac gagggacatt cccagcagcc
     4501 tggtctgcaa cccagattgc agagatggag ctctcagact ttgaggactg cctgacatta
     4561 tttgcaggag acccaggact tgggcctgag gaactgcggg cagccatggg caaagcaaaa
     4621 cagttgtggg gtcccccccg gggatttcgt cctgagcaga tcctgcagct tggtaggctc
     4681 ttaataggtc taggagatcg ggaactacag gagctgatcc tagtggactg gggagtgctg
     4741 agcaccctgg ggcagataga tggctggagc accactcagc tccgcattgt ggtctccagt
     4801 ttcctacggc agagtggtcg gcatgtgagc cacctggact tcgttcatct gacagcgctg
     4861 ggttatactc tctgtggact gcggccagag gagctccagc acatcagcag ttgggagttc
     4921 agccaagcag ctctcttcct cggcaccctg catctccagt gctctgagga acaactggag
     4981 gttctggccc acctacttgt actgcctggt gggtttggcc caatcagtaa ctgggggcct
     5041 gagatcttca ctgaaattgg caccatagca gctgggatcc cagacctggc tctttcagca
     5101 ctgctgcggg gacagatcca gggcgttact cctcttgcca tttctgtcat ccctcctcct
     5161 aaatttgctg tggtgtttag tcccatccaa ctatctagtc tcaccagtgc tcaggctgtg
     5221 gctgtcactc ctgagcaaat ggcctttctg agtcctgagc agcgacgagc agttgcatgg
     5281 gcccaacatg agggaaagga gagcccagaa cagcaaggtc gaagtacagc ctggggcctc
     5341 caggactggt cacgaccttc ctggtccctg gtattgacta tcagcttcct tggccacctg
     5401 ctatgagcct gtctctacag tagaaggaga ttgtggggag agaaatctta agtcataatg
     5461 aataaagtgc aaacagaagt gcatcctgat tattttcaga agctgatgag gaata
//
