LOCUS       NM_018387               6451 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens spermatid perinuclear RNA binding protein (STRBP),
            transcript variant 1, mRNA.
ACCESSION   NM_018387
VERSION     NM_018387.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6451)
  AUTHORS   Chen,S.Y., Zhang,F.L., Zhang,Y.L., Liao,L., Deng,L., Shao,Z.M.,
            Liu,G.Y. and Li,D.Q.
  TITLE     Spermatid perinuclear RNA-binding protein promotes UBR5-mediated
            proteolysis of Dicer to accelerate triple-negative breast cancer
            progression
  JOURNAL   Cancer Lett 586, 216672 (2024)
   PUBMED   38280476
  REMARK    GeneRIF: Spermatid perinuclear RNA-binding protein promotes
            UBR5-mediated proteolysis of Dicer to accelerate triple-negative
            breast cancer progression.
REFERENCE   2  (bases 1 to 6451)
  AUTHORS   Li,D., Che,X., Gao,N. and Li,J.
  TITLE     CircSTRBP contributes to H2O2-induced lens epithelium cell
            dysfunction through increasing NOX4 mRNA stability by recruiting
            IGF2BP1
  JOURNAL   Exp Eye Res 241, 109817 (2024)
   PUBMED   38340945
  REMARK    GeneRIF: CircSTRBP contributes to H2O2-induced lens epithelium cell
            dysfunction through increasing NOX4 mRNA stability by recruiting
            IGF2BP1.
REFERENCE   3  (bases 1 to 6451)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6451)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6451)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 6451)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   7  (bases 1 to 6451)
  AUTHORS   Coolidge,C.J. and Patton,J.G.
  TITLE     A new double-stranded RNA-binding protein that interacts with PKR
  JOURNAL   Nucleic Acids Res 28 (6), 1407-1417 (2000)
   PUBMED   10684936
REFERENCE   8  (bases 1 to 6451)
  AUTHORS   Schumacher,J.M., Artzt,K. and Braun,R.E.
  TITLE     Spermatid perinuclear ribonucleic acid-binding protein binds
            microtubules in vitro and associates with abnormal manchettes in
            vivo in mice
  JOURNAL   Biol Reprod 59 (1), 69-76 (1998)
   PUBMED   9674995
REFERENCE   9  (bases 1 to 6451)
  AUTHORS   Schumacher,J.M., Lee,K., Edelhoff,S. and Braun,R.E.
  TITLE     Spnr, a murine RNA-binding protein that is localized to cytoplasmic
            microtubules
  JOURNAL   J Cell Biol 129 (4), 1023-1032 (1995)
   PUBMED   7744952
REFERENCE   10 (bases 1 to 6451)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL365504.33, BC017732.1, BC002693.2 and AL365338.17.
            
            On May 17, 2019 this sequence version replaced NM_018387.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1954245.1,
                                           SRR14038193.1957701.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348403.10/ ENSP00000321347.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL365504.33        63941-63962         c
            23-1411             BC017732.1         1-1389
            1412-2657           BC002693.2         789-2034
            2658-6451           AL365338.17        67123-70916         c
FEATURES             Location/Qualifiers
     source          1..6451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..6451
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /note="spermatid perinuclear RNA binding protein"
                     /db_xref="GeneID:55342"
                     /db_xref="HGNC:HGNC:16462"
                     /db_xref="MIM:611138"
     exon            1..151
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            152..288
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            289..455
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..2471
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     epididymis luminal protein 162; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="spermatid perinuclear RNA-binding protein
                     isoform 1"
                     /protein_id="NP_060857.2"
                     /db_xref="CCDS:CCDS6851.1"
                     /db_xref="GeneID:55342"
                     /db_xref="HGNC:HGNC:16462"
                     /db_xref="MIM:611138"
                     /translation="MRSIRSFANDDRHVMVKHSTIYPSPEELEAVQNMVSTVECALKH
                     VSDWLDETNKGTKTEGETEVKKDEAGENYSKDQGGRTLCGVMRIGLVAKGLLIKDDMD
                     LELVLMCKDKPTETLLNTVKDNLPIQIQKLTEEKYQVEQCVNEASIIIRNTKEPTLTL
                     KVILTSPLIRDELEKKDGENVSMKDPPDLLDRQKCLNALASLRHAKWFQARANGLKSC
                     VIVLRILRDLCNRVPTWAPLKGWPLELICEKSIGTCNRPLGAGEALRRVMECLASGIL
                     LPGGPGLHDPCERDPTDALSYMTIQQKEDITHSAQHALRLSAFGQIYKVLEMDPLPSS
                     KPFQKYSWSVTDKEGAGSSALKRPFEDGLGDDKDPNKKMKRNLRKILDSKAIDLMNAL
                     MRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTTYEASGPSKKTAKLHVAVKVLQA
                     MGYPTGFDADIECMSSDEKSDNESKNETVSSNSSNNTGNSTTETSSTLEVRTQGPILT
                     ASGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFRGAGPNKKVAKASA
                     ALAALEKLFSGPNAANNKKKKIIPQAKGVVNTAVSAAVQAVRGRGRGTLTRGAFVGAT
                     AAPGYIAPGYGTPYGYSTAAPAYGLPKRMVLLPVMKFPTYPVPHYSFF"
     exon            456..676
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            677..842
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            843..987
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1079
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1175
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1287
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1385
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1497
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1590
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1790
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1949
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2084
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2225
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2349
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2394
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..6451
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2829..2834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /note="hexamer: AATAAA"
     polyA_site      2852
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /note="major polyA site"
     regulatory      3011..3016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /note="hexamer: AATAAA"
     polyA_site      3029
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /note="major polyA site"
     regulatory      3338..3343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /note="hexamer: AATAAA"
     polyA_site      3360
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /note="major polyA site"
     regulatory      3955..3960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
                     /note="hexamer: AATAAA"
     polyA_site      3985
                     /gene="STRBP"
                     /gene_synonym="HEL162; ILF3L; p74; SPNR"
ORIGIN      
        1 gaagcggaga ccggagccgc gagcgccacc agggcagcag ccgccgcagc cgccgccgct
       61 gggcagagga gccggagacg cgagcgggcg aggtggcggc ggcggcggag cgggagcggg
      121 taccgggcgc gggcagagcg cggcggcgcg gagacggggt tttgccatgt tgacctggct
      181 ggtctcgaac tcctgaacgc aagtgatccg cctgcctcag cctcccaagg tgctgggatt
      241 acaggcacga gccactgtgc ctggcctcaa ctgttgcttc ttataaaggt gtgttccaga
      301 gaacaagcct tcagacattt gctatattga cgctgagctg tcaggggact caggcttatg
      361 aggaggtatt gttacacaaa acagtgtcta gtgaagacga caagaaagag gggaaaggat
      421 cggaaaaaga agctaaaata ctatagaaaa ccatgagatc tattcgatct tttgctaatg
      481 atgatcgcca tgttatggtg aaacattcaa caatctatcc atctccggag gaacttgaag
      541 ctgttcagaa tatggtatct actgttgaat gtgctcttaa acatgtctca gattggttgg
      601 atgaaacaaa taaaggcaca aaaacagagg gtgagacaga agtgaagaaa gatgaggccg
      661 gagaaaacta ttccaaggat caaggtggtc ggacattgtg tggtgtaatg aggattggcc
      721 tggttgcaaa aggcttgctg attaaagatg atatggactt ggagctggtt ttaatgtgca
      781 aagacaaacc cacagagacc ctgttaaata cagtcaaaga taatcttcct attcagattc
      841 agaaactcac agaagagaaa tatcaagtgg aacaatgtgt aaatgaggca tctattataa
      901 ttcggaatac aaaagagccc acgctaactt tgaaggtgat acttacctca cctctaatta
      961 gggacgaatt ggagaagaag gatggagaaa atgtttcgat gaaagatcct ccggacttat
     1021 tggacaggca gaaatgcctg aacgccttgg cgtctcttcg acatgccaaa tggtttcagg
     1081 caagggcaaa tggattaaaa tcatgtgtaa ttgtcctccg cattctgcgt gatttgtgca
     1141 acagagtccc cacatgggca ccattgaaag gatggccact agaacttata tgtgaaaagt
     1201 ctataggtac ttgtaataga cctttgggcg ctggggaggc cttgagacga gtaatggagt
     1261 gtttggcatc tggaatacta cttcctgggg gtcctggtct tcatgatcct tgtgagcgag
     1321 acccaacaga tgctctgagc tatatgacca tccagcaaaa agaagatatt acccacagtg
     1381 cacagcatgc actcagacta tcagcctttg gccagattta caaagtgctg gagatggacc
     1441 cccttccatc tagtaagcct tttcagaagt attcctggtc agttactgat aaagaaggtg
     1501 ctgggtcttc agctctaaag aggccatttg aagatggatt aggggatgat aaagacccca
     1561 acaagaagat gaaacgaaac ttaaggaaaa ttctggatag taaagcaata gaccttatga
     1621 atgcactaat gaggctaaat cagatcaggc ctgggcttca gtataagctc ctatctcagt
     1681 ctggccccgt tcatgcccca gtcttcacaa tgtctgtaga tgtggatggc acaacatatg
     1741 aagcctcagg accatccaag aaaacagcaa aacttcacgt agcggtgaag gtattgcagg
     1801 caatgggata tccaacaggc tttgatgcag atattgaatg tatgagttcc gatgaaaaat
     1861 cagataatga aagtaaaaat gaaacagtgt cttcaaactc aagcaataat actggaaatt
     1921 ctacaactga aacctccagt accttagagg taagaactca gggccctatc ctcacagcaa
     1981 gtggcaaaaa ccctgtaatg gagctcaatg aaaaaagaag aggtctcaag tatgaactca
     2041 tctcagagac tggtggaagc catgacaagc gctttgtaat ggaggtagaa gtagatggac
     2101 agaaattcag aggcgcaggt ccaaataaga aagtggcaaa ggcgagtgca gctttagctg
     2161 ccttggagaa actgttttct ggacccaatg cggcaaataa taagaaaaag aagattatcc
     2221 ctcaggcaaa gggcgttgtg aatacagctg tgtctgcagc agtccaagct gttcggggca
     2281 gaggaagagg aactctaaca aggggagctt ttgttggggc gacagctgct cctggctaca
     2341 tagctccagg ctatggaaca ccatatggtt acagcacagc tgcccctgcc tatggtttac
     2401 ccaagagaat ggttctgtta cccgttatga aatttccaac atatcctgtt ccccactact
     2461 cattctttta gcaaatgaca gaagctaatt cctattgaac aacaatacag tacaacacag
     2521 aatgttagag aaaaagcctt tttatcctgc tttctttgaa cacatacttg atcaaaatta
     2581 tttgtaaaga acatctttcc tactttttga ttttaacaaa tgcaaattta gttctctaaa
     2641 acttgaaaaa aaaaaaagaa accagttctg tgaaaacggt acctcatttc tggaaaataa
     2701 cttataccag cccttctgtt ctagggaaat aaaagtctag cagttcaaag tttaagtttt
     2761 aagagacgta tcagattatg taaaattaaa tttgtgaagg atgtatagag tctcaaacac
     2821 tgatcacaaa taaactgctt tgttgtaaca cagagtactg cctggttcct gatgcagtca
     2881 ctgattctta gttgattgat atgtatttgc cccagggcac tttaatttgg gctgtagtta
     2941 ttttttttaa tacaatagag acttttcatt taactttaac tttgtaaata ttgaagtgtg
     3001 taataaagcc aataaaatat gggtttgaat attgttttag cttattattt ttgatatgtt
     3061 ttggtatcaa attacaagga attgaaaact aataacttag ccctagaagc ccattcactt
     3121 gtaagcaaag tgctaaaaca aagcaaaggt gattgttagt ttgagccagt ctactcactt
     3181 tgtaagccct ttgtactcct gttgtacaag ggccatcccc atgataaagg ttccattctg
     3241 ttatttgagc attgcttatt aaaatgatgg cactacccag agatggggaa ggagaatgtg
     3301 attatcctag tttatgaatt tccaagtttt taaaaataat aaattaatca atcaatcacc
     3361 ctctcttgtt cttgtggcct tcttcactct gtaagatatt gtgttcactc cctggctttt
     3421 ttcatgcaga tagaagatta gtgattttgc tgggattcat tgaagggtct cctttcctct
     3481 tcaattacat cagaatctaa agcagcaaca gggtccccat aaaaacttgc tcttcgattg
     3541 tcccagttct tgttgagtgc tgctgtgaaa agtgacaggt ttcagccatg ggtcagcatt
     3601 tctttttaag acacctgatg atgctggtgg aaatggatca gtgggtaaca ttgtgctgtt
     3661 ctgtaaaggg tgcagaccta agtcctccac ttgcattctc accttgtttg gaaagccaat
     3721 gatgttacta ggtcaatggt ttcattaagg tactcacccc catgaaggag cagcagtgtg
     3781 gtcccctgtc aatatttata aggcaccatg tcttaaaaat gtctgttttt agtatgaatt
     3841 agctttcatt ttccctattc agttctgctt ttgggaactt gacagggccc atccatgaga
     3901 atgggcttca caaaatatgg caaatgtatg taccaaattc cttcgggacc actaaataaa
     3961 ggtgaaatgg gcaatgtaca acaaatgtta gtgtcacttc tcagatatat attacacaat
     4021 gattagtttg tttcttctcc ttggtctttt gtctttatta gtggtgggtg atactttaat
     4081 aaaacctcat cacttgctgg aaatagctgt aacttatcat tctcatcctg tgcattagtg
     4141 gctagacata aacaagaggg cccatttcag ctgggagttt tcatgtttca ttgatgcgtt
     4201 ttgctgacct atggatgaaa cagagccatc actgagaaga aaaagcatgg ctgatagtgt
     4261 ccagttttta ttaattaaat ctttacagta gtcctcattg tctttggaat actattaatt
     4321 ggcagctgcg gctgtattgt tatttgaaat tggtcatcaa atttggattc cacgttggaa
     4381 tctctagata tttctcgtta gaaaattctt ttgaagtagc tgactctgct tcataactca
     4441 cgcgctctgt aatggtgaaa agggagctgt gctgttttcc aacatgatgg cagtcatttc
     4501 aaatggtttc taccaagtct tttttttttt tttttaattt tgttgtttgt tggaagttac
     4561 taaccatgtt gtaaacctgc ccagttgctg caaactttta catttctctg ctttacttaa
     4621 aataatcgag ctgtcagtcc tttgttagaa gtggtaacca tgcaagttca actgtttaaa
     4681 ttctgtaatg aattaagtgt ccccccacct gttgcccttc ccacccttcc attttgtaat
     4741 gaaaattcca cttacagctg aaagagcaga gaaatataaa tgaagctctt ggcttcacca
     4801 aattgcctga gattaacatg aagttttgct tctctgctct tttctccact gtaggtggtt
     4861 ttttcattga cagcccctat tgccagcctc tgagcgtcgc accatttatt attcacttgg
     4921 gccctcaaga tttcttctct gacttctaga accatcaggt tgtctggctt gaaatggcaa
     4981 tttctatgtc ttggtcttaa gagcaatgtg acaccctgag gctatccagc tttcagacac
     5041 tccactctga caccctcttt ttgaaagcaa tgactgatca ttttaaagaa gagcaatact
     5101 ttgttcaaag ccacggtgtc tgttttaaaa cttttccttt ggaaacctag caatatctgt
     5161 acttaacccc tttttagcat agtttcttgt cagggagttt acaggtcagt gtagagctta
     5221 aaattagcgt gtgagctgtg ctatgttctg acagtttttt acacttttta gcacataaat
     5281 agttacattc ctgactgcgt cagttagcgt tactataatt tctcagagat aggggtcctc
     5341 cttgaagcca tatcctctgc acggggactg gcccctagcc agggatgtgg cttgcagctt
     5401 gtgtttcttc aggctgcagg agtaccccat ctcttgtgca aggtaattgg tccagtagat
     5461 ttccaacata cctcatgctg actagatgaa gtgcatgggt ggtgaagtaa ggagttgagt
     5521 ttatatagtt ctgaagtcgt ttgtagtctc tctcaaattg ttagcctggg gaacaaacca
     5581 ctgagagatt ttgctggtat tggccttttc tttttttttt tttttttaat tttgggtgaa
     5641 tgtttgaaaa tcatgaatca gccaccatta ttaattgaag agctgggaat acctcgttaa
     5701 tgtattttta aaactggtgt tggaccctct gtgtatttca ggttaatact tttaagcagt
     5761 tttcagcacg tttatctcac tttattctcg ttctcctcgg accttcgtag ccatatcact
     5821 tgtataaaat aggctgagat atagtgactg taagctgtga tctcagtata caaaggtaag
     5881 ctcttttatt ttctgattaa agagaaaaat agtcaattaa gacaacatgc atatatgaca
     5941 atcatatatg atgtatttga tctcttaggt catatgtcat cgcattacct ttaaaaattg
     6001 tatggtctaa atgtaaaata gttatttttc aacatttgtt ttaataccct tgtaactgct
     6061 ttttactcaa gacagacatt tcacttacac taagtgtgtg tgtgtgtgtg tgtgtgtgta
     6121 gaaacttagg atataacacg tatgtaaatt acacacacat acctgtttaa atgtaagaat
     6181 tcagtgatag gaacagttca tctaagaaga ttttaatgac agggcactct tttggccaaa
     6241 gcagtggaat ttcctaagca gcaaggttgg taatagtgct ggtaggatct gtatgtgtaa
     6301 gctgttacac aagctgagga tcaaagtgcc aatttctcaa ggagaaaaac ttctccgaga
     6361 aatgaaagtc tctgatctgt gttgtatgcc ctaatacaac aacagcaaga agccatagaa
     6421 aaaagcaata gaaaatgaaa aaaaaaaaaa a
//
