LOCUS       NM_007178               1874 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens serine/threonine kinase receptor associated protein
            (STRAP), mRNA.
ACCESSION   NM_007178
VERSION     NM_007178.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1874)
  AUTHORS   Bownes,L.V., Marayati,R., Quinn,C.H., Hutchins,S.C., Stewart,J.E.,
            Anderson,J.C., Willey,C.D., Datta,P.K. and Beierle,E.A.
  TITLE     Serine-Threonine Kinase Receptor Associate Protein (STRAP) confers
            an aggressive phenotype in neuroblastoma via regulation of Focal
            Adhesion Kinase (FAK)
  JOURNAL   J Pediatr Surg 57 (6), 1026-1032 (2022)
   PUBMED   35272839
  REMARK    GeneRIF: Serine-Threonine Kinase Receptor Associate Protein (STRAP)
            confers an aggressive phenotype in neuroblastoma via regulation of
            Focal Adhesion Kinase (FAK).
REFERENCE   2  (bases 1 to 1874)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1874)
  AUTHORS   Vu,T., Datta,A., Banister,C., Jin,L., Yuan,G., Samuel,T., Bae,S.,
            Eltoum,I.E., Manne,U., Zhang,B., Welner,R.S., Mitra,K.,
            Buckhaults,P. and Datta,P.K.
  TITLE     Serine-threonine Kinase Receptor-Associated Protein is a Critical
            Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a
            Feed-Forward Mechanism
  JOURNAL   Gastroenterology 162 (1), 193-208 (2022)
   PUBMED   34520730
  REMARK    GeneRIF: Serine-threonine Kinase Receptor-Associated Protein is a
            Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis
            Through a Feed-Forward Mechanism.
REFERENCE   4  (bases 1 to 1874)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1874)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1874)
  AUTHORS   Iriyama,C., Matsuda,S., Katsumata,R. and Hamaguchi,M.
  TITLE     Cloning and sequencing of a novel human gene which encodes a
            putative hydroxylase
  JOURNAL   J Hum Genet 46 (5), 289-292 (2001)
   PUBMED   11355021
REFERENCE   7  (bases 1 to 1874)
  AUTHORS   Datta,P.K. and Moses,H.L.
  TITLE     STRAP and Smad7 synergize in the inhibition of transforming growth
            factor beta signaling
  JOURNAL   Mol Cell Biol 20 (9), 3157-3167 (2000)
   PUBMED   10757800
REFERENCE   8  (bases 1 to 1874)
  AUTHORS   Matsuda,S., Katsumata,R., Okuda,T., Yamamoto,T., Miyazaki,K.,
            Senga,T., Machida,K., Thant,A.A., Nakatsugawa,S. and Hamaguchi,M.
  TITLE     Molecular cloning and characterization of human MAWD, a novel
            protein containing WD-40 repeats frequently overexpressed in breast
            cancer
  JOURNAL   Cancer Res 60 (1), 13-17 (2000)
   PUBMED   10646843
REFERENCE   9  (bases 1 to 1874)
  AUTHORS   Hunt,S.L., Hsuan,J.J., Totty,N. and Jackson,R.J.
  TITLE     unr, a cellular cytoplasmic RNA-binding protein with five
            cold-shock domains, is required for internal initiation of
            translation of human rhinovirus RNA
  JOURNAL   Genes Dev 13 (4), 437-448 (1999)
   PUBMED   10049359
REFERENCE   10 (bases 1 to 1874)
  AUTHORS   Datta,P.K., Chytil,A., Gorska,A.E. and Moses,H.L.
  TITLE     Identification of STRAP, a novel WD domain protein in transforming
            growth factor-beta signaling
  JOURNAL   J Biol Chem 273 (52), 34671-34674 (1998)
   PUBMED   9856985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022073.13.
            
            On Nov 24, 2018 this sequence version replaced NM_007178.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1099325.1,
                                           SRR3476690.102734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419869.7/ ENSP00000392270.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               AC022073.13        22558-22990
            434-569             AC022073.13        23712-23847
            570-651             AC022073.13        30099-30180
            652-724             AC022073.13        30768-30840
            725-821             AC022073.13        34218-34314
            822-959             AC022073.13        35530-35667
            960-1096            AC022073.13        38053-38189
            1097-1246           AC022073.13        40075-40224
            1247-1312           AC022073.13        41118-41183
            1313-1874           AC022073.13        43088-43649
FEATURES             Location/Qualifiers
     source          1..1874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..1874
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /note="serine/threonine kinase receptor associated
                     protein"
                     /db_xref="GeneID:11171"
                     /db_xref="HGNC:HGNC:30796"
                     /db_xref="MIM:605986"
     exon            1..433
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1374
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /note="unr-interacting protein; WD-40 repeat protein
                     PT-WD; MAP activator with WD repeats; mitogen-activated
                     protein kinase activator with WD repeats; MAPK activator
                     with WD repeats"
                     /codon_start=1
                     /product="serine-threonine kinase receptor-associated
                     protein"
                     /protein_id="NP_009109.3"
                     /db_xref="CCDS:CCDS8676.1"
                     /db_xref="GeneID:11171"
                     /db_xref="HGNC:HGNC:30796"
                     /db_xref="MIM:605986"
                     /translation="MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLR
                     QGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHI
                     VKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILS
                     ADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIK
                     SFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPD
                     GELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIA
                     SENSDCIFPSAPDVKA"
     exon            434..569
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            570..651
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            652..724
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            725..821
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            822..959
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1096
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1246
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1312
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1874
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1852..1857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /note="hexamer: AATAAA"
     polyA_site      1874
                     /gene="STRAP"
                     /gene_synonym="MAWD; PT-WD; UNRIP"
                     /note="major polyA site"
ORIGIN      
        1 cgtcgtcact tcctgccgat gccggtgtgg acgctgtgaa tcgtggctgg cccggttctc
       61 cgcttctccc catcccctac tttcctccct ccctcccttt ccctccctcg tcgactgttg
      121 cttgctggtc gcagactccc tgacccctcc ctcacccctc cctaacctcg gtgccaccgg
      181 attgcccttc ttttcctgtt gcccagccca gccctagtgt cagggcgggg gcctggagca
      241 gcccgaggca ctgcagcaga agagagaaaa gacaacgacg accctcagct cgccagtccg
      301 gtcgctggct tcgccgccgc catggcaatg agacagacgc cgctcacctg ctctggccac
      361 acgcgacccg tggttgattt ggccttcagt ggcatcacgc cttatgggta tttcttaatc
      421 agcgcttgca aagatggtaa acctatgcta cgccagggag atacaggaga ctggattgga
      481 acatttttgg gtcataaagg tgctgtttgg ggtgcaacac tgaataagga tgccaccaaa
      541 gcagctacag cagctgcaga tttcacagcc aaagtgtggg atgctgtctc aggagatgaa
      601 ttgatgaccc tggctcataa acacattgtc aagactgtgg atttcacgca ggatagtaat
      661 tatttgttaa ccgggggaca ggataaactg ttacgcatat atgacttgaa caaacctgaa
      721 gcagaaccta aggaaattag tggtcatact tctggtataa aaaaagctct gtggtgcagt
      781 gaggataaac agattctttc tgctgatgac aaaactgttc gactttggga tcatgctact
      841 atgacagaag tgaaatctct aaattttaat atgtctgtta gtagtatgga atatattcct
      901 gagggagaga ttttggttat aacttatgga cgatctattg cttttcatag tgcagtaagt
      961 ttggacccaa ttaaatcctt tgaagctcct gcaaccatca attctgcatc tcttcatcct
     1021 gagaaagaat ttcttgttgc aggcggtgaa gattttaaac tttataagta tgattataat
     1081 agtggagaag aattagaatc ctacaaggga cactttggtc ctattcactg tgtgagattt
     1141 agtcctgatg gagaactcta tgccagtggt tcagaagatg gaacattgag actatggcaa
     1201 actgtggtag gaaaaacgta tggcctttgg aaatgtgtgc ttcctgaaga agatagtggt
     1261 gagctggcaa agccaaagat tggttttcca gagacaacag aagaggagct agaagaaatt
     1321 gcttcagaga attcagattg catctttcct tcagctcctg atgttaaggc ctgagcgtca
     1381 atcatatgtg cagttagtat acaactgact aaaacaagca agcagagaaa agcatcagcc
     1441 ttccagagtt actgtctgct taaggcagaa acagcagtaa ataatgagga aaatgaatta
     1501 gctccagtgc tggaacaact aactaacttg gtgttacctg taagtgaaaa ctcaagtgtc
     1561 agatgaaggg aggtggagtt atcctcttat agtacagtgg cctgttatct ttttaatgaa
     1621 tatatacaag ccaacatcca atttctatta ttacaattag ggttcttgta gctgtttatg
     1681 ttaatatgga gaagaaaact atattggctg attttttctg atcttaaagc agaatgcctt
     1741 ttcttttttt gcttcagttg taaagaagag ggaatacatg ataaagtaac tggtttgatt
     1801 tctcgttcat tgtacactgc ctctgaacat ctaattgttt ttagttgtct aaataaaatg
     1861 cctctaaaac aaaa
//
