LOCUS       NM_018571               2222 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens STE20 related adaptor beta (STRADB), transcript
            variant 1, mRNA.
ACCESSION   NM_018571
VERSION     NM_018571.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2222)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2222)
  AUTHORS   Kim,M., Park,J., Bouhaddou,M., Kim,K., Rojc,A., Modak,M.,
            Soucheray,M., McGregor,M.J., O'Leary,P., Wolf,D., Stevenson,E.,
            Foo,T.K., Mitchell,D., Herrington,K.A., Munoz,D.P., Tutuncuoglu,B.,
            Chen,K.H., Zheng,F., Kreisberg,J.F., Diolaiti,M.E., Gordan,J.D.,
            Coppe,J.P., Swaney,D.L., Xia,B., van 't Veer,L., Ashworth,A.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein interaction landscape of breast cancer
  JOURNAL   Science 374 (6563), eabf3066 (2021)
   PUBMED   34591612
REFERENCE   3  (bases 1 to 2222)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2222)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 2222)
  AUTHORS   Blandin,G., Marchand,S., Charton,K., Daniele,N., Gicquel,E.,
            Boucheteil,J.B., Bentaib,A., Barrault,L., Stockholm,D., Bartoli,M.
            and Richard,I.
  TITLE     A human skeletal muscle interactome centered on proteins involved
            in muscular dystrophies: LGMD interactome
  JOURNAL   Skelet Muscle 3 (1), 3 (2013)
   PUBMED   23414517
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2222)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   7  (bases 1 to 2222)
  AUTHORS   Boudeau,J., Baas,A.F., Deak,M., Morrice,N.A., Kieloch,A.,
            Schutkowski,M., Prescott,A.R., Clevers,H.C. and Alessi,D.R.
  TITLE     MO25alpha/beta interact with STRADalpha/beta enhancing their
            ability to bind, activate and localize LKB1 in the cytoplasm
  JOURNAL   EMBO J 22 (19), 5102-5114 (2003)
   PUBMED   14517248
REFERENCE   8  (bases 1 to 2222)
  AUTHORS   Hawley,S.A., Boudeau,J., Reid,J.L., Mustard,K.J., Udd,L.,
            Makela,T.P., Alessi,D.R. and Hardie,D.G.
  TITLE     Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and
            MO25 alpha/beta are upstream kinases in the AMP-activated protein
            kinase cascade
  JOURNAL   J Biol 2 (4), 28 (2003)
   PUBMED   14511394
REFERENCE   9  (bases 1 to 2222)
  AUTHORS   Sanna,M.G., da Silva Correia,J., Luo,Y., Chuang,B., Paulson,L.M.,
            Nguyen,B., Deveraux,Q.L. and Ulevitch,R.J.
  TITLE     ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated
            activation of JNK1 and protection against apoptosis
  JOURNAL   J Biol Chem 277 (34), 30454-30462 (2002)
   PUBMED   12048196
  REMARK    GeneRIF: a novel XIAP-interacting protein that acts as a co-factor
            enhancing XIAP-mediated activation of JNK1 and the
            caspase-independent protection of XIAP against apoptosis
REFERENCE   10 (bases 1 to 2222)
  AUTHORS   Hadano,S., Yanagisawa,Y., Skaug,J., Fichter,K., Nasir,J.,
            Martindale,D., Koop,B.F., Scherer,S.W., Nicholson,D.W.,
            Rouleau,G.A., Ikeda,J. and Hayden,M.R.
  TITLE     Cloning and characterization of three novel genes, ALS2CR1,
            ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis
            (ALS2) critical region at chromosome 2q33-q34: candidate genes for
            ALS2
  JOURNAL   Genomics 71 (2), 200-213 (2001)
   PUBMED   11161814
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007282.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018571.5.
            
            Summary: This gene encodes a protein that belongs to the
            serine/threonine protein kinase STE20 subfamily. One of the active
            site residues in the protein kinase domain of this protein is
            altered, and it is thus a pseudokinase. This protein is a component
            of a complex involved in the activation of serine/threonine kinase
            11, a master kinase that regulates cell polarity and
            energy-generating metabolism. This complex regulates the relocation
            of this kinase from the nucleus to the cytoplasm, and it is
            essential for G1 cell cycle arrest mediated by this kinase. The
            protein encoded by this gene can also interact with the X
            chromosome-linked inhibitor of apoptosis protein, and this
            interaction enhances the anti-apoptotic activity of this protein
            via the JNK1 signal transduction pathway. Two pseudogenes, located
            on chromosomes 1 and 7, have been found for this gene.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.130218.1,
                                           SRR1803615.39799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000194530.8/ ENSP00000194530.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AC007282.4         175573-175771       c
            200-306             AC007282.4         172659-172765       c
            307-387             AC007282.4         168647-168727       c
            388-487             AC007282.4         157459-157558       c
            488-609             AC007282.4         154435-154556       c
            610-718             AC007282.4         152756-152864       c
            719-842             AC007282.4         151769-151892       c
            843-1014            AC007282.4         149721-149892       c
            1015-1119           AC007282.4         149320-149424       c
            1120-1364           AC007282.4         148910-149154       c
            1365-1407           AC007282.4         147980-148022       c
            1408-2222           AC007282.4         146665-147479       c
FEATURES             Location/Qualifiers
     source          1..2222
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..2222
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /note="STE20 related adaptor beta"
                     /db_xref="GeneID:55437"
                     /db_xref="HGNC:HGNC:13205"
                     /db_xref="MIM:607333"
     exon            1..199
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /inference="alignment:Splign:2.1.0"
     exon            200..306
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1551
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /note="isoform 1 is encoded by transcript variant 1;
                     amyotrophic lateral sclerosis 2 (juvenile) chromosome
                     region, candidate 2; STRAD beta; pseudokinase ALS2CR2;
                     ILP-interacting protein ILPIPA; STE20-related kinase
                     adaptor beta; amyotrophic lateral sclerosis 2 chromosomal
                     region candidate gene 2 protein"
                     /codon_start=1
                     /product="STE20-related kinase adapter protein beta
                     isoform 1"
                     /protein_id="NP_061041.2"
                     /db_xref="CCDS:CCDS2348.1"
                     /db_xref="GeneID:55437"
                     /db_xref="HGNC:HGNC:13205"
                     /db_xref="MIM:607333"
                     /translation="MSLLDCFCTSRTQVESLRPEKQSETSIHQYLVDEPTLSWSRPST
                     RASEVLCSTNVSHYELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLK
                     ALQKAVILSHFFRHPNITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETL
                     IRNILFGAVRGLNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRA
                     VYDFPQFSTSVQPWLSPELLRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQM
                     LLQKLKGPPYSPLDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPS
                     SKTFSPAFFSLVQLCLQQDPEKRPSASSLLSHVFFKQMKEESQDSILSLLPPAYNKPS
                     ISLPPVLPWTEPECDFPDEKDSYWEF"
     exon            307..387
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /inference="alignment:Splign:2.1.0"
     exon            388..487
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /inference="alignment:Splign:2.1.0"
     exon            488..609
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /inference="alignment:Splign:2.1.0"
     exon            610..718
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /inference="alignment:Splign:2.1.0"
     exon            719..842
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1014
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1119
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1364
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1407
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..2222
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2202..2207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /note="hexamer: AATAAA"
     polyA_site      2222
                     /gene="STRADB"
                     /gene_synonym="ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK;
                     PRO1038"
                     /note="major polyA site"
ORIGIN      
        1 gttcccagcg ggtagcctgg gactggtgca gagttccaag cccacggccc cggtcgcggc
       61 ctcgccgccc tcccgcgccc cgcgccggga gcgggcctag agcgctcgcc tcgcccctcc
      121 gcgagcaggg ctctggcgcc cgcccctgtc cgcaccgctg gcagcctgaa gagagtcgct
      181 ggccgtggtc gccgctaggt aggatatatc tgcatcttga aaggaagata aaacaaaagc
      241 cttctttgga atagatggat ttttgtcact ttctgtgtga actaaagtga ttcaatgtct
      301 cttttggatt gcttctgcac ttcaagaaca caagttgaat cactcagacc tgaaaaacag
      361 tctgaaacca gtatccatca atacttggtt gatgagccaa ccctttcctg gtcacgtcca
      421 tccactagag ccagtgaagt actatgttcc accaacgttt ctcactatga gctccaagta
      481 gaaataggaa gaggatttga caacttgact tctgtccatc ttgcacggca tactcccaca
      541 ggaacactgg taactataaa aattacaaat ctggaaaact gcaatgaaga acgcctgaaa
      601 gctttacaga aagccgtgat tctatcccac tttttccggc atcccaatat tacaacttat
      661 tggacagttt tcactgttgg cagctggctt tgggttattt ctccatttat ggcctatggt
      721 tcagcaagtc aactcttgag gacctatttt cctgaaggaa tgagtgaaac tttaataaga
      781 aacattctct ttggagccgt gagagggttg aactatctgc accaaaatgg ctgtattcac
      841 aggagtatta aagccagcca tatcctcatt tctggtgatg gcctagtgac cctctctggc
      901 ctgtcccatc tgcatagttt ggttaagcat ggacagaggc atagggctgt gtatgatttc
      961 ccacagttca gcacatcagt gcagccgtgg ctgagtccag aactactgag acaggattta
     1021 catgggtata atgtgaagtc agatatttac agtgttggga ttacagcatg tgaattagcc
     1081 agtgggcagg tgcctttcca ggacatgcat agaactcaga tgctgttaca gaaactgaaa
     1141 ggtcctcctt atagcccatt ggatatcagt attttccctc aatcagaatc cagaatgaaa
     1201 aattcccagt caggtgtaga ctctgggatt ggagaaagtg tgcttgtctc cagtggaact
     1261 cacacagtaa atagtgaccg attacacaca ccatcctcaa aaactttctc tcctgccttc
     1321 tttagcttgg tacagctctg tttgcaacaa gatcctgaga aaaggccatc agcaagcagt
     1381 ttattgtccc atgttttctt caaacagatg aaagaagaaa gccaggattc aatactttca
     1441 ctgttgcctc ctgcttataa caagccatca atatcattgc ctccagtgtt accttggact
     1501 gagccagaat gtgattttcc tgatgaaaaa gactcatact gggaattcta gggctgccaa
     1561 atcattttat gtcctatata cttgacactt tctccttgct gctttttctt ctgtatttct
     1621 aggtacaaat accagaatta tacttgaaaa tacagttggt gcactggaga atctattatt
     1681 taaaaccact ctgttcaaag gggcaccagt ttgtagtccc tctgtttcgc acagagtact
     1741 atgacaagga aacatcagaa ttactaatct agctagtgtc atttattctg gaattttttt
     1801 ctaagctgtg actaactctt tttatctctc aatataattt ttgagccagt taattttttt
     1861 cagtattttg ctgtcccttg ggaatgggcc ctcagaggac agtgcttcca agtacatctt
     1921 ctcccagatt ctctggcctt tttaatgagc tattgttaaa ccaacaggct agtttatctt
     1981 acatcagacc cttttctggt agagggaaaa tgtttgtgct ttcccttttt cttctgttaa
     2041 tacttatggt aacacctaac tgagcctcac tcacattaaa tgattcactt gaaatatata
     2101 cagaaattgt aatttgcttt tttttaaaca agggggctaa agtaacactt tcctacttat
     2161 gtaaattata gatcctaaat tcacgcaccc cgtgggagct caataaagat ttactgaatt
     2221 ga
//
