LOCUS       NM_001394401            1383 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens stimulated by retinoic acid 8 (STRA8), transcript
            variant 1, mRNA.
ACCESSION   NM_001394401 XM_011516138
VERSION     NM_001394401.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1383)
  AUTHORS   Desimio,M.G., Cesari,E., Sorrenti,M., De Felici,M. and Farini,D.
  TITLE     Stimulated by retinoic acid gene 8 (STRA8) interacts with the germ
            cell specific bHLH factor SOHLH1 and represses c-KIT expression in
            vitro
  JOURNAL   J Cell Mol Med 25 (1), 383-396 (2021)
   PUBMED   33236849
  REMARK    GeneRIF: Stimulated by retinoic acid gene 8 (STRA8) interacts with
            the germ cell specific bHLH factor SOHLH1 and represses c-KIT
            expression in vitro.
REFERENCE   2  (bases 1 to 1383)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1383)
  AUTHORS   Chen,Y., Clarke,O.B., Kim,J., Stowe,S., Kim,Y.K., Assur,Z.,
            Cavalier,M., Godoy-Ruiz,R., von Alpen,D.C., Manzini,C.,
            Blaner,W.S., Frank,J., Quadro,L., Weber,D.J., Shapiro,L.,
            Hendrickson,W.A. and Mancia,F.
  TITLE     Structure of the STRA6 receptor for retinol uptake
  JOURNAL   Science 353 (6302) (2016)
   PUBMED   27563101
REFERENCE   4  (bases 1 to 1383)
  AUTHORS   Lu,C., Xu,M., Wang,Y., Qin,Y., Du,G., Wu,W., Han,X., Ji,C.,
            Yang,Y., Gu,A., Xia,Y., Song,L., Wang,S. and Wang,X.
  TITLE     Genetic variants in meiotic program initiation pathway genes are
            associated with spermatogenic impairment in a Han Chinese
            population
  JOURNAL   PLoS One 8 (1), e53443 (2013)
   PUBMED   23320086
  REMARK    GeneRIF: The genetic variant rs10269148 of STRA8 gene shows higher
            risk of spermatogenic impairment in the groups of abnormospermia
            than the controls
REFERENCE   5  (bases 1 to 1383)
  AUTHORS   Jorgensen,A., Nielsen,J.E., Blomberg Jensen,M., Graem,N. and
            Rajpert-De Meyts,E.
  TITLE     Analysis of meiosis regulators in human gonads: a sexually
            dimorphic spatio-temporal expression pattern suggests involvement
            of DMRT1 in meiotic entry
  JOURNAL   Mol Hum Reprod 18 (11), 523-534 (2012)
   PUBMED   22899867
REFERENCE   6  (bases 1 to 1383)
  AUTHORS   Chen,B., Wang,Y.B., Zhang,Z.L., Xia,W.L., Wang,H.X., Xiang,Z.Q.,
            Hu,K., Han,Y.F., Wang,Y.X., Huang,Y.R. and Wang,Z.
  TITLE     Xeno-free culture of human spermatogonial stem cells supported by
            human embryonic stem cell-derived fibroblast-like cells
  JOURNAL   Asian J Androl 11 (5), 557-565 (2009)
   PUBMED   19734913
REFERENCE   7  (bases 1 to 1383)
  AUTHORS   Houmard,B., Small,C., Yang,L., Naluai-Cecchini,T., Cheng,E.,
            Hassold,T. and Griswold,M.
  TITLE     Global gene expression in the human fetal testis and ovary
  JOURNAL   Biol Reprod 81 (2), 438-443 (2009)
   PUBMED   19369649
REFERENCE   8  (bases 1 to 1383)
  AUTHORS   Anderson,E.L., Baltus,A.E., Roepers-Gajadien,H.L., Hassold,T.J., de
            Rooij,D.G., van Pelt,A.M. and Page,D.C.
  TITLE     Stra8 and its inducer, retinoic acid, regulate meiotic initiation
            in both spermatogenesis and oogenesis in mice
  JOURNAL   Proc Natl Acad Sci U S A 105 (39), 14976-14980 (2008)
   PUBMED   18799751
  REMARK    GeneRIF: Functional characterization of an homologous mouse gene.
REFERENCE   9  (bases 1 to 1383)
  AUTHORS   Nagase,T., Yamakawa,H., Tadokoro,S., Nakajima,D., Inoue,S.,
            Yamaguchi,K., Itokawa,Y., Kikuno,R.F., Koga,H. and Ohara,O.
  TITLE     Exploration of human ORFeome: high-throughput preparation of ORF
            clones and efficient characterization of their protein products
  JOURNAL   DNA Res 15 (3), 137-149 (2008)
   PUBMED   18316326
REFERENCE   10 (bases 1 to 1383)
  AUTHORS   Miyamoto,T., Sengoku,K., Takuma,N., Hasuike,S., Hayashi,H.,
            Yamauchi,T., Yamashita,T. and Ishikawa,M.
  TITLE     Isolation and expression analysis of the testis-specific gene,
            STRA8, stimulated by retinoic acid gene 8
  JOURNAL   J Assist Reprod Genet 19 (11), 531-535 (2002)
   PUBMED   12489526
  REMARK    GeneRIF: Expression restricted to testis (STRA8)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009542.2.
            
            On Apr 19, 2021 this sequence version replaced XM_011516138.2.
            
            Summary: This gene encodes a retinoic acid-responsive protein. A
            homologous protein in mouse has been shown to be involved in the
            regulation of meiotic initiation in both spermatogenesis and
            oogenesis, though feature differences between the mouse and human
            proteins suggest that these homologs are not entirely functionally
            equivalent. It is thought that this gene may play a role in
            spermatogenesis in humans. [provided by RefSeq, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000662584.2/ ENSP00000499386.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC009542.2         79968-80033
            67-264              AC009542.2         86649-86846
            265-340             AC009542.2         88911-88986
            341-425             AC009542.2         89456-89540
            426-665             AC009542.2         91418-91657
            666-951             AC009542.2         92547-92832
            952-1025            AC009542.2         97926-97999
            1026-1137           AC009542.2         101244-101355
            1138-1383           AC009542.2         104548-104793
FEATURES             Location/Qualifiers
     source          1..1383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1383
                     /gene="STRA8"
                     /note="stimulated by retinoic acid 8"
                     /db_xref="GeneID:346673"
                     /db_xref="HGNC:HGNC:30653"
                     /db_xref="MIM:609987"
     exon            1..66
                     /gene="STRA8"
                     /inference="alignment:Splign:2.1.0"
     exon            67..264
                     /gene="STRA8"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1212
                     /gene="STRA8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     stimulated by retinoic acid gene 8 protein homolog"
                     /codon_start=1
                     /product="stimulated by retinoic acid gene 8 protein
                     homolog isoform 1"
                     /protein_id="NP_001381330.1"
                     /db_xref="CCDS:CCDS94209.1"
                     /db_xref="GeneID:346673"
                     /db_xref="HGNC:HGNC:30653"
                     /db_xref="MIM:609987"
                     /translation="MATPEENSNPHDRATPQLPAQLQELEHRVARRRLSQARHRATLA
                     ALFNNLRKTVYSQSDLIASKWQVLNKAKSHIPELEQTLDNLLKLKASFNLEDGHASSL
                     EEVKKEYASMYSGNDSLLSNSFPQNGSSPWCPTEAVRKDAEEEEDEEEEDQEEEEEEE
                     EEEEEEEEEEEEEEEEEEKKVILYSPGTLSPDLMEFERYLNFYKQTMDLLTGSGIITP
                     QEAALPIVSAAISHLWQNLSEERKASLRQAWAQKHRGPATLAEACREPACAEGSVKDS
                     GVDSQGASCSLVSTPEEILFEDAFDVASFLDKSEVPSTSSSSSVLASCNPENPEEKFQ
                     LYMQIINFFKGLSCANTQVKQEASFPVDEEMIMLQCTETFDDEDL"
     exon            265..340
                     /gene="STRA8"
                     /inference="alignment:Splign:2.1.0"
     exon            341..425
                     /gene="STRA8"
                     /inference="alignment:Splign:2.1.0"
     exon            426..665
                     /gene="STRA8"
                     /inference="alignment:Splign:2.1.0"
     exon            666..951
                     /gene="STRA8"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1025
                     /gene="STRA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1137
                     /gene="STRA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1383
                     /gene="STRA8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actccggcgc acgaagccgg gtgactgctg tcccgggagt ggggacgtcg cgtgcaccgt
       61 tggcgactta taatggcaac ccctgaagaa aacagcaatc cccatgacag agcaacaccc
      121 cagctgccag cacagctgca ggagcttgag catcgggtgg cccggagacg gctgtcccag
      181 gcccgccacc gagccaccct ggcagcgctc ttcaacaacc tcaggaagac agtgtactct
      241 cagtctgatc tcatagcctc aaagtggcag gttctgaata aggcaaagag tcatattcca
      301 gaactggagc aaaccctgga taatttgctg aagctgaaag catccttcaa cctggaagat
      361 gggcatgcaa gcagcttaga ggaggtcaag aaagaatatg ccagcatgta ttctggaaat
      421 gacagcctgc tttcaaacag ttttcctcag aatggttcct ccccttggtg cccaactgag
      481 gcagtcagga aggatgctga ggaggaggaa gatgaggaag aggaagatca agaagaagag
      541 gaggaggaag aagaagagga ggaggaggaa gaggaggaag aggaagagga ggaggaggaa
      601 gaggagaaaa aagtgatctt atactcccca ggaactttgt cgcctgacct catggaattt
      661 gaacggtatc tcaactttta caaacagacg atggaccttc tgactggcag cgggatcatt
      721 accccgcagg aggcggcgct gcccatcgtc tccgcggcca tctcccacct gtggcagaac
      781 ctctcggagg agaggaaggc cagcctccgg caggcctggg cgcagaagca ccgcggccct
      841 gcgaccctgg cggaggcctg ccgagagccg gcctgtgccg agggcagcgt gaaggacagc
      901 ggcgtggaca gccagggggc cagctgctcg ctggtctcca cgcccgagga gatccttttt
      961 gaggatgcct ttgatgtggc aagcttcctg gacaaaagtg aggttccgag tacatctagc
     1021 tccagttcag tgcttgccag ctgcaaccca gaaaacccag aggagaagtt tcagctctat
     1081 atgcagatca tcaacttttt taaaggcctt agctgtgcaa acactcaagt aaagcaggaa
     1141 gcatcctttc ccgttgatga agagatgatc atgttgcagt gcacagagac ctttgacgat
     1201 gaagatttgt aatgcagaag aggagctgcg aggggaggga ctgaatgagg tgggcagttc
     1261 ccaaggttga atgctggcag ctaaggttgc acctgccttg gcctccagga ctctttggag
     1321 tgggttgttc cagaagcatt ttgatgattt tagtttctga ttattataaa gtataagaga
     1381 agc
//
