LOCUS       NP_001381330             379 aa            linear   PRI 01-MAY-2025
DEFINITION  stimulated by retinoic acid gene 8 protein homolog isoform 1 [Homo
            sapiens].
ACCESSION   NP_001381330 XP_011514440
VERSION     NP_001381330.1
DBSOURCE    REFSEQ: accession NM_001394401.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 379)
  AUTHORS   Desimio,M.G., Cesari,E., Sorrenti,M., De Felici,M. and Farini,D.
  TITLE     Stimulated by retinoic acid gene 8 (STRA8) interacts with the germ
            cell specific bHLH factor SOHLH1 and represses c-KIT expression in
            vitro
  JOURNAL   J Cell Mol Med 25 (1), 383-396 (2021)
   PUBMED   33236849
  REMARK    GeneRIF: Stimulated by retinoic acid gene 8 (STRA8) interacts with
            the germ cell specific bHLH factor SOHLH1 and represses c-KIT
            expression in vitro.
REFERENCE   2  (residues 1 to 379)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 379)
  AUTHORS   Chen,Y., Clarke,O.B., Kim,J., Stowe,S., Kim,Y.K., Assur,Z.,
            Cavalier,M., Godoy-Ruiz,R., von Alpen,D.C., Manzini,C.,
            Blaner,W.S., Frank,J., Quadro,L., Weber,D.J., Shapiro,L.,
            Hendrickson,W.A. and Mancia,F.
  TITLE     Structure of the STRA6 receptor for retinol uptake
  JOURNAL   Science 353 (6302) (2016)
   PUBMED   27563101
REFERENCE   4  (residues 1 to 379)
  AUTHORS   Lu,C., Xu,M., Wang,Y., Qin,Y., Du,G., Wu,W., Han,X., Ji,C.,
            Yang,Y., Gu,A., Xia,Y., Song,L., Wang,S. and Wang,X.
  TITLE     Genetic variants in meiotic program initiation pathway genes are
            associated with spermatogenic impairment in a Han Chinese
            population
  JOURNAL   PLoS One 8 (1), e53443 (2013)
   PUBMED   23320086
  REMARK    GeneRIF: The genetic variant rs10269148 of STRA8 gene shows higher
            risk of spermatogenic impairment in the groups of abnormospermia
            than the controls
REFERENCE   5  (residues 1 to 379)
  AUTHORS   Jorgensen,A., Nielsen,J.E., Blomberg Jensen,M., Graem,N. and
            Rajpert-De Meyts,E.
  TITLE     Analysis of meiosis regulators in human gonads: a sexually
            dimorphic spatio-temporal expression pattern suggests involvement
            of DMRT1 in meiotic entry
  JOURNAL   Mol Hum Reprod 18 (11), 523-534 (2012)
   PUBMED   22899867
REFERENCE   6  (residues 1 to 379)
  AUTHORS   Chen,B., Wang,Y.B., Zhang,Z.L., Xia,W.L., Wang,H.X., Xiang,Z.Q.,
            Hu,K., Han,Y.F., Wang,Y.X., Huang,Y.R. and Wang,Z.
  TITLE     Xeno-free culture of human spermatogonial stem cells supported by
            human embryonic stem cell-derived fibroblast-like cells
  JOURNAL   Asian J Androl 11 (5), 557-565 (2009)
   PUBMED   19734913
REFERENCE   7  (residues 1 to 379)
  AUTHORS   Houmard,B., Small,C., Yang,L., Naluai-Cecchini,T., Cheng,E.,
            Hassold,T. and Griswold,M.
  TITLE     Global gene expression in the human fetal testis and ovary
  JOURNAL   Biol Reprod 81 (2), 438-443 (2009)
   PUBMED   19369649
REFERENCE   8  (residues 1 to 379)
  AUTHORS   Anderson,E.L., Baltus,A.E., Roepers-Gajadien,H.L., Hassold,T.J., de
            Rooij,D.G., van Pelt,A.M. and Page,D.C.
  TITLE     Stra8 and its inducer, retinoic acid, regulate meiotic initiation
            in both spermatogenesis and oogenesis in mice
  JOURNAL   Proc Natl Acad Sci U S A 105 (39), 14976-14980 (2008)
   PUBMED   18799751
  REMARK    GeneRIF: Functional characterization of an homologous mouse gene.
REFERENCE   9  (residues 1 to 379)
  AUTHORS   Nagase,T., Yamakawa,H., Tadokoro,S., Nakajima,D., Inoue,S.,
            Yamaguchi,K., Itokawa,Y., Kikuno,R.F., Koga,H. and Ohara,O.
  TITLE     Exploration of human ORFeome: high-throughput preparation of ORF
            clones and efficient characterization of their protein products
  JOURNAL   DNA Res 15 (3), 137-149 (2008)
   PUBMED   18316326
REFERENCE   10 (residues 1 to 379)
  AUTHORS   Miyamoto,T., Sengoku,K., Takuma,N., Hasuike,S., Hayashi,H.,
            Yamauchi,T., Yamashita,T. and Ishikawa,M.
  TITLE     Isolation and expression analysis of the testis-specific gene,
            STRA8, stimulated by retinoic acid gene 8
  JOURNAL   J Assist Reprod Genet 19 (11), 531-535 (2002)
   PUBMED   12489526
  REMARK    GeneRIF: Expression restricted to testis (STRA8)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009542.2.
            
            On Apr 19, 2021 this sequence version replaced XP_011514440.1.
            
            Summary: This gene encodes a retinoic acid-responsive protein. A
            homologous protein in mouse has been shown to be involved in the
            regulation of meiotic initiation in both spermatogenesis and
            oogenesis, though feature differences between the mouse and human
            proteins suggest that these homologs are not entirely functionally
            equivalent. It is thought that this gene may play a role in
            spermatogenesis in humans. [provided by RefSeq, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000662584.2/ ENSP00000499386.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     Protein         1..379
                     /product="stimulated by retinoic acid gene 8 protein
                     homolog isoform 1"
                     /note="stimulated by retinoic acid gene 8 protein homolog"
                     /calculated_mol_wt=42586
     Region          31..90
                     /region_name="bHLH_SF"
                     /note="basic Helix Loop Helix (bHLH) domain superfamily;
                     cl00081"
                     /db_xref="CDD:469605"
     Site            order(36..37,39,44,63..64)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381392"
     Site            order(42..43,46..47,49..50,54,64..65,68..69,72,74..75,
                     78..79)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381392"
     CDS             1..379
                     /gene="STRA8"
                     /coded_by="NM_001394401.1:73..1212"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS94209.1"
                     /db_xref="GeneID:346673"
                     /db_xref="HGNC:HGNC:30653"
                     /db_xref="MIM:609987"
ORIGIN      
        1 matpeensnp hdratpqlpa qlqelehrva rrrlsqarhr atlaalfnnl rktvysqsdl
       61 iaskwqvlnk akshipeleq tldnllklka sfnledghas sleevkkeya smysgndsll
      121 snsfpqngss pwcpteavrk daeeeedeee edqeeeeeee eeeeeeeeee eeeeeeeekk
      181 vilyspgtls pdlmeferyl nfykqtmdll tgsgiitpqe aalpivsaai shlwqnlsee
      241 rkaslrqawa qkhrgpatla eacrepacae gsvkdsgvds qgascslvst peeilfedaf
      301 dvasfldkse vpstsssssv lascnpenpe ekfqlymqii nffkglscan tqvkqeasfp
      361 vdeemimlqc tetfddedl
//
