LOCUS       NM_022369               2708 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens signaling receptor and transporter of retinol STRA6
            (STRA6), transcript variant 2, mRNA.
ACCESSION   NM_022369
VERSION     NM_022369.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2708)
  AUTHORS   Zhou,C., Haneke,T., Rohner,E., Sohlmer,J., Kameneva,P., Artemov,A.,
            Adameyko,I. and Sahara,M.
  TITLE     STRA6 is essential for induction of vascular smooth muscle lineages
            in human embryonic cardiac outflow tract development
  JOURNAL   Cardiovasc Res 119 (5), 1202-1217 (2023)
   PUBMED   36635482
  REMARK    GeneRIF: STRA6 is essential for induction of vascular smooth muscle
            lineages in human embryonic cardiac outflow tract development.
REFERENCE   2  (bases 1 to 2708)
  AUTHORS   Yang,F., Xu,P., Yao,S., Li,M., Bian,Z. and Huang,Z.
  TITLE     Up-regulation of STRA6 predicts poor prognosis and contributes to
            oxaliplatin resistance in colorectal cancer
  JOURNAL   Pathol Res Pract 243, 154352 (2023)
   PUBMED   36758416
  REMARK    GeneRIF: Up-regulation of STRA6 predicts poor prognosis and
            contributes to oxaliplatin resistance in colorectal cancer.
REFERENCE   3  (bases 1 to 2708)
  AUTHORS   He,W., Sun,Y., Ge,J., Wang,X., Lin,B., Yu,S., Li,Y., Hong,S. and
            Xiao,H.
  TITLE     STRA6 regulates tumor immune microenvironment and is a prognostic
            marker in BRAF-mutant papillary thyroid carcinoma
  JOURNAL   Front Endocrinol (Lausanne) 14, 1076640 (2023)
   PUBMED   36843593
  REMARK    GeneRIF: STRA6 regulates tumor immune microenvironment and is a
            prognostic marker in BRAF-mutant papillary thyroid carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2708)
  AUTHORS   Nakamura,S., Kanda,M., Shimizu,D., Sawaki,K., Tanaka,C.,
            Hattori,N., Hayashi,M., Yamada,S., Nakayama,G., Omae,K., Koike,M.
            and Kodera,Y.
  TITLE     STRA6 Expression Serves as a Prognostic Biomarker of Gastric Cancer
  JOURNAL   Cancer Genomics Proteomics 17 (5), 509-516 (2020)
   PUBMED   32859629
  REMARK    GeneRIF: STRA6 Expression Serves as a Prognostic Biomarker of
            Gastric Cancer.
REFERENCE   5  (bases 1 to 2708)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   6  (bases 1 to 2708)
  AUTHORS   Szeto,W., Jiang,W., Tice,D.A., Rubinfeld,B., Hollingshead,P.G.,
            Fong,S.E., Dugger,D.L., Pham,T., Yansura,D.G., Wong,T.A.,
            Grimaldi,J.C., Corpuz,R.T., Singh,J.S., Frantz,G.D., Devaux,B.,
            Crowley,C.W., Schwall,R.H., Eberhard,D.A., Rastelli,L., Polakis,P.
            and Pennica,D.
  TITLE     Overexpression of the retinoic acid-responsive gene Stra6 in human
            cancers and its synergistic induction by Wnt-1 and retinoic acid
  JOURNAL   Cancer Res 61 (10), 4197-4205 (2001)
   PUBMED   11358845
REFERENCE   7  (bases 1 to 2708)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   8  (bases 1 to 2708)
  AUTHORS   Bouillet,P., Sapin,V., Chazaud,C., Messaddeq,N., Decimo,D.,
            Dolle,P. and Chambon,P.
  TITLE     Developmental expression pattern of Stra6, a retinoic
            acid-responsive gene encoding a new type of membrane protein
  JOURNAL   Mech Dev 63 (2), 173-186 (1997)
   PUBMED   9203140
REFERENCE   9  (bases 1 to 2708)
  AUTHORS   Bardakjian,T., Weiss,A. and Schneider,A.
  TITLE     Microphthalmia/Anophthalmia/Coloboma Spectrum - RETIRED CHAPTER,
            FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301552
REFERENCE   10 (bases 1 to 2708)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC025256.1, AF352729.1 and
            AK056125.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022369.3.
            
            Summary: The protein encoded by this gene is a membrane protein
            involved in the metabolism of retinol. The encoded protein acts as
            a receptor for retinol/retinol binding protein complexes. This
            protein removes the retinol from the complex and transports it
            across the cell membrane. Defects in this gene are a cause of
            syndromic microphthalmia type 9 (MCOPS9). Several transcript
            variants encoding a few different isoforms have been found for this
            gene. [provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 8. The resulting isoform (a) is
            shorter at the N-terminus compared to isoform f. Variants 1, 2, and
            3 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025256.1, AF370419.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395105.9/ ENSP00000378537.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1104              BC025256.1         65-1168
            1105-1670           AF352729.1         1173-1738
            1671-2119           AK056125.1         1824-2272
            2120-2708           AF352729.1         2188-2776
FEATURES             Location/Qualifiers
     source          1..2708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..2708
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /note="signaling receptor and transporter of retinol
                     STRA6"
                     /db_xref="GeneID:64220"
                     /db_xref="HGNC:HGNC:30650"
                     /db_xref="MIM:610745"
     exon            1..75
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            76..203
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2094
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /note="isoform a is encoded by transcript variant 2;
                     stimulated by retinoic acid gene 6 protein homolog;
                     stimulated by retinoic acid gene 6 homolog; stimulated by
                     retinoic acid 6 homolog; retinol binding protein 4
                     receptor; retinol-binding protein receptor STRA6; receptor
                     for retinol uptake STRA6; RBP receptor"
                     /codon_start=1
                     /product="receptor for retinol uptake STRA6 isoform a"
                     /protein_id="NP_071764.3"
                     /db_xref="CCDS:CCDS10261.1"
                     /db_xref="GeneID:64220"
                     /db_xref="HGNC:HGNC:30650"
                     /db_xref="MIM:610745"
                     /translation="MSSQPAGNQTSPGATEDYSYGSWYIDEPQGGEELQPEGEVPSCH
                     TSIPPGLYHACLASLSILVLLLLAMLVRRRQLWPDCVRGRPGLPSPVDFLAGDRPRAV
                     PAAVFMVLLSSLCLLLPDEDALPFLTLASAPSQDGKTEAPRGAWKILGLFYYAALYYP
                     LAACATAGHTAAHLLGSTLSWAHLGVQVWQRAECPQVPKIYKYYSLLASLPLLLGLGF
                     LSLWYPVQLVRSFSRRTGAGSKGLQSSYSEEYLRNLLCRKKLGSSYHTSKHGFLSWAR
                     VCLRHCIYTPQPGFHLPLKLVLSATLTGTAIYQVALLLLVGVVPTIQKVRAGVTTDVS
                     YLLAGFGIVLSEDKQEVVELVKHHLWALEVCYISALVLSCLLTFLVLMRSLVTHRTNL
                     RALHRGAALDLSPLHRSPHPSRQAIFCWMSFSAYQTAFICLGLLVQQIIFFLGTTALA
                     FLVLMPVLHGRNLLLFRSLESSWPFWLTLALAVILQNMAAHWVFLETHDGHPQLTNRR
                     VLYAATFLLFPLNVLVGAMVATWRVLLSALYNAIHLGQMDLSLLPPRAATLDPGYYTY
                     RNFLKIEVSQSHPAMTAFCSLLLQAQSLLPRTMAAPQDSLRPGEEDEGMQLLQTKDSM
                     AKGARPGASRGRARWGLAYTLLHNPTLQVFRKTALLGANGAQP"
     exon            204..270
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..356
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..496
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..520
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..687
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..810
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..878
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..955
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1017
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1180
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1256
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1390
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1508
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1610
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1774
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1930
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2708
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2688..2693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /note="hexamer: AATAAA"
     polyA_site      2708
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /note="major polyA site"
ORIGIN      
        1 aggcagtgcg gagctggccg tgggctgcct accctttcat ctctgcaact ccttcctccc
       61 tgggcctccc ttctggagaa gggccagaga atgtcgtccc agccagcagg gaaccagacc
      121 tcccccgggg ccacagagga ctactcctat ggcagctggt acatcgatga gccccagggg
      181 ggcgaggagc tccagccaga gggggaagtg ccctcctgcc acaccagcat accacccggc
      241 ctgtaccacg cctgcctggc ctcgctgtca atccttgtgc tgctgctcct ggccatgctg
      301 gtgaggcgcc gccagctctg gcctgactgt gtgcgtggca ggcccggcct gcccagccct
      361 gtggatttct tggctgggga caggccccgg gcagtgcctg ctgctgtttt catggtcctc
      421 ctgagctccc tgtgtttgct gctccccgac gaggacgcat tgcccttcct gactctcgcc
      481 tcagcaccca gccaagatgg gaaaactgag gctccaagag gggcctggaa gatactggga
      541 ctgttctatt atgctgccct ctactaccct ctggctgcct gtgccacggc tggccacaca
      601 gctgcacacc tgctcggcag cacgctgtcc tgggcccacc ttggggtcca ggtctggcag
      661 agggcagagt gtccccaggt gcccaagatc tacaagtact actccctgct ggcctccctg
      721 cctctcctgc tgggcctcgg attcctgagc ctttggtacc ctgtgcagct ggtgagaagc
      781 ttcagccgta ggacaggagc aggctccaag gggctgcaga gcagctactc tgaggaatat
      841 ctgaggaacc tcctttgcag gaagaagctg ggaagcagct accacacctc caagcatggc
      901 ttcctgtcct gggcccgcgt ctgcttgaga cactgcatct acactccaca gccaggattc
      961 catctcccgc tgaagctggt gctttcagct acactgacag ggacggccat ttaccaggtg
     1021 gccctgctgc tgctggtggg cgtggtaccc actatccaga aggtgagggc aggggtcacc
     1081 acggatgtct cctacctgct ggccggcttt ggaatcgtgc tctccgagga caagcaggag
     1141 gtggtggagc tggtgaagca ccatctgtgg gctctggaag tgtgctacat ctcagccttg
     1201 gtcttgtcct gcttactcac cttcctggtc ctgatgcgct cactggtgac acacaggacc
     1261 aaccttcgag ctctgcaccg aggagctgcc ctggacttga gtcccttgca tcggagtccc
     1321 catccctccc gccaagccat attctgttgg atgagcttca gtgcctacca gacagccttt
     1381 atctgccttg ggctcctggt gcagcagatc atcttcttcc tgggaaccac ggccctggcc
     1441 ttcctggtgc tcatgcctgt gctccatggc aggaacctcc tgctcttccg ttccctggag
     1501 tcctcgtggc ccttctggct gactttggcc ctggctgtga tcctgcagaa catggcagcc
     1561 cattgggtct tcctggagac tcatgatgga cacccacagc tgaccaaccg gcgagtgctc
     1621 tatgcagcca cctttcttct cttccccctc aatgtgctgg tgggtgccat ggtggccacc
     1681 tggcgagtgc tcctctctgc cctctacaac gccatccacc ttggccagat ggacctcagc
     1741 ctgctgccac cgagagccgc cactctcgac cccggctact acacgtaccg aaacttcttg
     1801 aagattgaag tcagccagtc gcatccagcc atgacagcct tctgctccct gctcctgcaa
     1861 gcgcagagcc tcctacccag gaccatggca gccccccagg acagcctcag accaggggag
     1921 gaagacgaag ggatgcagct gctacagaca aaggactcca tggccaaggg agctaggccc
     1981 ggggccagcc gcggcagggc tcgctggggt ctggcctaca cgctgctgca caacccaacc
     2041 ctgcaggtct tccgcaagac ggccctgttg ggtgccaatg gtgcccagcc ctgagggcag
     2101 ggaaggtcaa cccacctgcc catctgtgct gaggcatgtt cctgcctacc atcctcctcc
     2161 ctccccggct ctcctcccag catcacacca gccatgcagc cagcaggtcc tccggatcac
     2221 tgtggttggg tggaggtctg tctgcactgg gagcctcagg agggctctgc tccacccact
     2281 tggctatggg agagccagca ggggttctgg agaaagaaac tggtgggtta gggccttggt
     2341 ccaggagcca gttgagccag ggcagccaca tccaggcgtc tccctaccct ggctctgcca
     2401 tcagccttga agggcctcga tgaagccttc tctggaacca ctccagccca gctccacctc
     2461 agccttggcc ttcacgctgt ggaagcagcc aaggcacttc ctcaccccct cagcgccacg
     2521 gacctctctg gggagtggcc ggaaagctcc cgggcctctg gcctgcaggg cagcccaagt
     2581 catgactcag accaggtccc acactgagct gcccacactc gagagccaga tatttttgta
     2641 gtttttatgc ctttggctat tatgaaagag gttagtgtgt tccctgcaat aaacttgttc
     2701 ctgagaaa
//
