LOCUS       NM_001004353            1166 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens sperm-tail PG-rich repeat containing 3 (STPG3),
            transcript variant 3, mRNA.
ACCESSION   NM_001004353 XM_497086
VERSION     NM_001004353.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1166)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 1166)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat Genet 36 (1), 40-45 (2004)
   PUBMED   14702039
REFERENCE   3  (bases 1 to 1166)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX255925.17.
            
            On Apr 21, 2021 this sequence version replaced NM_001004353.3.
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. It encodes isoform c, which has a shorter and distinct
            C-terminus, compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144308.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412566.6/ ENSP00000391218.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               BX255925.17        46666-46776
            112-269             BX255925.17        47118-47275
            270-404             BX255925.17        47381-47515
            405-493             BX255925.17        47817-47905
            494-797             BX255925.17        48042-48345
            798-1166            BX255925.17        48495-48863
FEATURES             Location/Qualifiers
     source          1..1166
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1166
                     /gene="STPG3"
                     /gene_synonym="C9orf173"
                     /note="sperm-tail PG-rich repeat containing 3"
                     /db_xref="GeneID:441476"
                     /db_xref="HGNC:HGNC:37285"
     exon            1..111
                     /gene="STPG3"
                     /gene_synonym="C9orf173"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..928
                     /gene="STPG3"
                     /gene_synonym="C9orf173"
                     /note="isoform c is encoded by transcript variant 3;
                     sperm-tail PG-rich repeat-containing protein 3; protein
                     STPG3"
                     /codon_start=1
                     /product="protein STPG3 isoform c"
                     /protein_id="NP_001004353.2"
                     /db_xref="CCDS:CCDS48065.1"
                     /db_xref="GeneID:441476"
                     /db_xref="HGNC:HGNC:37285"
                     /translation="MMNSDQKAVKFLANFYINGGKHWTHGHLRQTQPEPTQPKASVLL
                     LGPEPGMAWDETQPPKMKEIPVGLRLQTGTPQESLPTYTQTLRELLLEQRPLITADLE
                     VPSPTRYQVPSPSVRESSPHPHYSIGCKHQGREGGGRRAWQTLWFQSESPFTQKADFD
                     QEQKWPSPAHYQLLSRPAFPAFSFRGCHSASKTPEGHTHLGLPGARGLGLRVQPQSLL
                     QASLQAPGKRCPGPNTYNILPGSRLQSPRSPAFSMSRSPAFTSWLSTSRTPGPAAYHV
                     EDCNSRFPSAPGVVIQGVRRPKRHDTGPFCTL"
     exon            112..269
                     /gene="STPG3"
                     /gene_synonym="C9orf173"
                     /inference="alignment:Splign:2.1.0"
     exon            270..404
                     /gene="STPG3"
                     /gene_synonym="C9orf173"
                     /inference="alignment:Splign:2.1.0"
     exon            405..493
                     /gene="STPG3"
                     /gene_synonym="C9orf173"
                     /inference="alignment:Splign:2.1.0"
     exon            494..797
                     /gene="STPG3"
                     /gene_synonym="C9orf173"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1166
                     /gene="STPG3"
                     /gene_synonym="C9orf173"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1166
                     /gene="STPG3"
                     /gene_synonym="C9orf173"
                     /note="major polyA site"
ORIGIN      
        1 gatgatgaat tctgaccaga aggcagtgaa attcctggca aatttttaca tcaatggagg
       61 caaacactgg acccatggtc acctgaggca gacacaacca gagcccaccc agcccaaggc
      121 atctgtgctg ttgttgggcc cggagccggg gatggcctgg gatgagacac agcccccaaa
      181 gatgaaggag atcccagttg gcctcaggtt acagacgggc accccccagg agtccctgcc
      241 cacctacacc cagaccctga gggaactatt gctggagcaa cgccccctga tcacagctga
      301 cctggaagtc cccagcccca ccaggtacca ggtgccgagc ccgtccgtac gagagtcctc
      361 cccacacccc cactacagca tcggctgcaa gcaccagggc cgagagggcg gtggccgcag
      421 ggcatggcag actttgtggt tccagagcga aagccccttc acgcagaaag ctgacttcga
      481 ccaagagcaa aagtggccct cgccagccca ctaccagctg ctcagccggc ccgccttccc
      541 cgccttcagc ttcagaggct gccactccgc ttccaagaca cctgaaggcc acacccacct
      601 agggctgcct ggggctaggg ggctgggcct cagggtgcag ccccagtccc tgcttcaggc
      661 ctctttgcag gcacctggca agagatgccc tggccccaac acctacaata tccttcctgg
      721 gagccgcctg cagagccccc gctcgccggc cttctcgatg agccgctccc ctgcgttcac
      781 ctcctggctc agcacctccc gaacccctgg cccagccgcc taccacgtgg aggactgcaa
      841 ctcacgcttc ccttcggcgc ctggcgtggt catccagggt gtacgcagac ccaagcgcca
      901 cgacacaggc cccttctgca cgctctagag ccagctgggc acaacctgct tggcccggcc
      961 accgagtgga accatggcct cccccggggc tttcccaggc ctcccctggg acttggggcc
     1021 ccagcctggc cttctgaccc tctgggcacc ccgatgcacc cttctggctg gccaaccctt
     1081 ctatgggctg tggacaaggc tggcccagcc tggatccccc atctgcccat ctccccgcta
     1141 cactgagatg ctgttggttt tcccga
//
