LOCUS       NM_020225              10507 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens storkhead box 2 (STOX2), transcript variant 1, mRNA.
ACCESSION   NM_020225 XM_048721
VERSION     NM_020225.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10507)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 10507)
  AUTHORS   Renz,P.F., Spies,D., Tsikrika,P., Wutz,A., Beyer,T.A. and Ciaudo,C.
  TITLE     Inhibition of FGF and TGF-beta Pathways in hESCs Identify STOX2 as
            a Novel SMAD2/4 Cofactor
  JOURNAL   Biology (Basel) 9 (12), 470 (2020)
   PUBMED   33339109
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10507)
  AUTHORS   Oudejans,C.B., Poutsma,A., Michel,O.J., Thulluru,H.K., Mulders,J.,
            van de Vrugt,H.J., Sistermans,E.A. and van Dijk,M.
  TITLE     Noncoding RNA-regulated gain-of-function of STOX2 in Finnish
            pre-eclamptic families
  JOURNAL   Sci Rep 6, 32129 (2016)
   PUBMED   27555360
  REMARK    GeneRIF: A long non-coding RNA within intron 3 of the STOX2 gene on
            4q35.1 acts as a permissive cis-acting regulator of alternative
            splicing of STOX2.Non-coding RNA-directed splicing of STOX2 is
            affected in Finnish pre-eclamptic patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10507)
  AUTHORS   Sasahira,T., Nishiguchi,Y., Fujiwara,R., Kurihara,M., Kirita,T.,
            Bosserhoff,A.K. and Kuniyasu,H.
  TITLE     Storkhead box 2 and melanoma inhibitory activity promote oral
            squamous cell carcinoma progression
  JOURNAL   Oncotarget 7 (18), 26751-26764 (2016)
   PUBMED   27050375
  REMARK    GeneRIF: Our results suggest that MIA-STOX2 signaling may be a
            useful diagnostic and therapeutic target in oral squamous cell
            carcinoma
REFERENCE   5  (bases 1 to 10507)
  AUTHORS   Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
            Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
            Johnson,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association analyses suggest NELL1 influences adverse
            metabolic response to HCTZ in African Americans
  JOURNAL   Pharmacogenomics J 14 (1), 35-40 (2014)
   PUBMED   23400010
REFERENCE   6  (bases 1 to 10507)
  AUTHORS   Fenstad,M.H., Johnson,M.P., Loset,M., Mundal,S.B., Roten,L.T.,
            Eide,I.P., Bjorge,L., Sande,R.K., Johansson,A.K., Dyer,T.D.,
            Forsmo,S., Blangero,J., Moses,E.K. and Austgulen,R.
  TITLE     STOX2 but not STOX1 is differentially expressed in decidua from
            pre-eclamptic women: data from the Second Nord-Trondelag Health
            Study
  JOURNAL   Mol Hum Reprod 16 (12), 960-968 (2010)
   PUBMED   20643876
  REMARK    GeneRIF: STOX2 shows significantly lower expression in deciduas
            from pregnancies complicated by both pre-eclampsia and FGR as
            compared with controls.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074194.6, AB037813.1 and
            R42234.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020225.2.
            
            Summary: This gene encodes a Storkhead-box_winged-helix domain
            containing protein. This protein is differentially expressed in
            decidual tissue and may be involved in the susceptibility to
            pre-eclampsia with fetal growth restriction. Alternate splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146754.1, AB037813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308497.9/ ENSP00000311257.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC074194.6         34052-34100
            50-4703             AB037813.1         1-4654
            4704-10330          AC074194.6         146468-152094
            10331-10507         R42234.1           17-193              c
FEATURES             Location/Qualifiers
     source          1..10507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..10507
                     /gene="STOX2"
                     /note="storkhead box 2"
                     /db_xref="GeneID:56977"
                     /db_xref="HGNC:HGNC:25450"
                     /db_xref="MIM:617359"
     exon            1..1650
                     /gene="STOX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1485..4265
                     /gene="STOX2"
                     /codon_start=1
                     /product="storkhead-box protein 2"
                     /protein_id="NP_064610.1"
                     /db_xref="CCDS:CCDS47167.1"
                     /db_xref="GeneID:56977"
                     /db_xref="HGNC:HGNC:25450"
                     /db_xref="MIM:617359"
                     /translation="MKKTRSTTLRRAWPSSDFSDRASDRMRSRSEKDYRLHKRFPAAF
                     APQASRGYMTSGDVSPISMSPISQSQFIPLGEILCLAISAMNSARKPVTQEALMEHLT
                     TCFPGVPTPSQEILRHTLNTLVRERKIYPTPDGYFIVTPQTYFITPSLIRTNSKWYHL
                     DERIPDRSQCTSPQPGTITPSASGCVRERTLPRNHCDSCHCCREDVHSTHAPTLQRKS
                     AKDCKDPYCPPSLCQVPPTEKSKSTVNFSYKTETLSKPKDSEKQSKKFGLKLFRLSFK
                     KDKTKQLANFSAQFPPEEWPLRDEDTPATIPREVEMEIIRRINPDLTVENVMRHTALM
                     KKLEEEKAQRSKAGSSAHHSGRSKKSRTHRKSHGKSRSHSKTRVSKGDPSDGSHLDIP
                     AEREYDFCDPLTRVPREGCFIIEHKGDNFIMHSNTNVLESHFPMTPEWDVSGELAKRR
                     TEMPFPEPSRGSSHSKVHRSHSHTQDRRSRNERSNKAKERSRSMDNSKGPLGASSLGT
                     PEDLAEGCSQDDQTPSQSYIDDSTLRPAQTVSLQRAHISSTSYKEVCIPEIVSGSKEP
                     SSACSLLEPGKPPESLPSYGELNSCPTKTATDDYFQCNTSSETVLTAPSPLGKNKEDH
                     DTLTLAEGVKKLSPSDRQVPHSSREPVGHKEESPKGPGGGPAASGGVAEGIANGRLVQ
                     HHGAEPSSLDKRKEIFSKDTLFKPLHSTLSVNSYHKSSLSLLKSHPKTPADTLPGRCE
                     KLEPSLGTSAAQAMPASQRQQESGGNQEASFDYYNVSDDDDSEEGANKNTEEEKNRED
                     VGTMQWLLEREKERDLQRKFEKNLTLLAPKETDSSSNQRATHSARLDSMDSSSITVDS
                     GFNSPRTRESLASNTSSIVESNRRQNPALSPAHGGAGPAFNFRASAEPPTNEAEKLQK
                     PSNCLQASVTSV"
     exon            1651..1803
                     /gene="STOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..4069
                     /gene="STOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4070..10507
                     /gene="STOX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10487..10492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STOX2"
                     /note="hexamer: ATTAAA"
     polyA_site      10507
                     /gene="STOX2"
                     /note="major polyA site"
ORIGIN      
        1 agaaacagct gtgcagagcc gtgccatcta aagagctgtg gacctgaatg cagcgtagcg
       61 ggctggcggt gacttacacc gggactccag agggagagag gaagcgctgc aggccacttg
      121 cattgcgtct tccaggctgc gtggacccgg cgccccggcg tgtgcggttg tgggggagct
      181 cgccgtggcc tcccctccct ctggctttag cttcctttgg ggttggcgca ggtgggccag
      241 gcagcgcacc gcagatctcc ccgttcccac gaaggctggc tcgctgtctc tctccgagcg
      301 ggagggacca tcctaaaaat atgtaaatat ccaagcgctg gctccaggct ggggcagctg
      361 ccaaggtccc cgcgccgccg ccgggtgttt tacatgaaaa tgagaagcct gatgggaacc
      421 gcgttctaac ttaaggcagc ctggtgatta gcatgagact gggcggctgt cctgcttcct
      481 gcccttcaat agccgttccg cgcgctcgcg ccggagcagc gctgccgccg cgcgggggtc
      541 gatcgcaggc tcggcgtcct tggcagccat ggctccggcg ccgcctcggc cagtaagtag
      601 gagcatgcat gtgtaggggg cacatgcgtg tcggcgcacc cacccagcca tccacccgcg
      661 cgcacgcaca gcgcccggag cctcggcaag gggaagattg acgaggcgct gcagtcgcgg
      721 ggacgacgcg ggctcttcct ggattccgca ggagcccgcc cgccgcagct gctgtctgca
      781 gagcctgctc ggatcctgtg cacacgcgcc ccccgctcga gcctctgtga tgaagactgt
      841 ctcccgggga ctgcagcgga ggcagagcca gccagcgccg gggactgcgg gccgtgcggc
      901 tgataggccc gcggggacac gactcggaca ctgtcatccc cacgcctcgc gctgagctgc
      961 ccggcgcgga gggtctgccg ccgcccctcc ggcctcccgc acgcccgatc ccgggtcagc
     1021 cccggaggcc tcggctgcct catttgtttg ggtcttttgt gccgtggctc ccagttggcc
     1081 aagcactcct gcgctgaatc gggccattgt ctgcgctccc attgccttca cgctgcaagt
     1141 ctcggcgccc ccaccccgcc cgccccctcc ccgcctcctc ccggccgggg agcctcctaa
     1201 cgtgcctttc cccccaggaa tctggaagct ataagccggg cggattgcaa atgaagtgta
     1261 atgcattgtg ggacgtgtgt aaaatcggag ccttcgccgt gggggtgtgg gggggcgtgg
     1321 ggagggccgg acccgccgct ggcggtgtag acgccgacga ggaggggctg ggaaaatgtg
     1381 cgcagagtcc gcccgggtcg tgcccgccgt agacggatga aggagcgcgc tgcgccccgg
     1441 cgctgaggcc ccgaggatcg gggcggcagg tcgccctccc caccatgaag aagacccgga
     1501 gcacaacctt gcggcgagcc tggcctagct cggatttctc ggaccgggcc tcggaccgca
     1561 tgaggtcccg cagcgagaag gactaccgcc tgcacaagcg tttccccgcg gccttcgcgc
     1621 cccaggcttc gcggggctac atgacatcag gtgatgtatc acccatcagt atgtctccca
     1681 tcagtcagtc tcagtttatt ccactcgggg agatcctctg cttggccatc tcagcaatga
     1741 actcggcaag aaagcctgtc acccaagaag cactgatgga gcacctgacc acgtgcttcc
     1801 caggtgttcc aacgccaagc caagaaattc tgcggcacac gctgaacacg ctggtacggg
     1861 agaggaagat ctacccaact ccagatggct acttcatcgt gaccccacag acttatttca
     1921 taactccttc cctcataaga actaacagta aatggtacca tttggacgag aggatacctg
     1981 accggtctca gtgcacctct ccgcaacccg ggaccatcac gccctctgcc tcaggctgtg
     2041 tcagggaaag gacattgccc cgaaaccact gcgactcttg ccactgctgc agagaagacg
     2101 tgcacagcac gcatgcaccc accctgcaaa ggaagtctgc caaggactgc aaagaccctt
     2161 actgtccccc ttctctgtgc caggtgccac ccactgaaaa gagcaaaagt actgtaaatt
     2221 tttcctataa gacagaaact ctctcaaaac ctaaagatag tgaaaagcag tcaaaaaaat
     2281 tcgggctaaa gttattccgg ttaagtttta aaaaagacaa gaccaaacag ctggccaatt
     2341 tttctgccca gtttcctcct gaagagtggc ccctgcgaga cgaggacacg ccagctacga
     2401 tccctcggga agtagagatg gaaatcatta ggcgcattaa cccagacctg accgtggaaa
     2461 atgtcatgcg gcacaccgcg ctcatgaaga aactggaaga agaaaaggcc cagaggagta
     2521 aagccgggtc ctctgcccat cacagcggaa ggagtaaaaa gagtaggact catcggaagt
     2581 cccatggaaa gtctcggtct cacagcaaga cacgggtgtc taaaggagac ccttccgacg
     2641 gttcacatct ggatatccca gctgaaagag agtatgactt ttgtgatcct cttaccaggg
     2701 tgcccaggga gggctgcttc atcattgaac acaaaggaga taacttcatc atgcacagca
     2761 acacaaacgt gctcgagtcc cacttcccca tgacaccaga atgggatgtg tctggtgaat
     2821 tggctaaaag gagaactgag atgccttttc ctgaaccttc taggggaagc tcccactcaa
     2881 aagtgcaccg aagccacagc catacacagg accggaggtc caggaatgag agatccaaca
     2941 aagccaagga gagatccagg tcgatggata actccaaagg ccctctgggt gcttcttctc
     3001 tagggacgcc ggaagacctt gctgaaggct gcagccaaga cgaccagacc cccagccaat
     3061 cctacattga cgacagtact ttaaggcctg cacagaccgt tagtctccaa agggctcaca
     3121 tttcgtccac aagctataaa gaggtgtgta ttccagagat agtcagtggc agcaaggaac
     3181 cgtccagcgc ttgcagcctt ttggagccag gaaaaccacc cgagagtttg ccatcctatg
     3241 gcgaactcaa ctcttgtcca acaaaaacag ccacagatga ctatttccag tgcaacacct
     3301 ctagtgagac ggtgctcacg gcaccatcac ctctgggaaa gaataaggag gaccatgaca
     3361 ctctgacttt ggcagaaggg gtgaaaaagc tctccccttc tgataggcag gtcccccact
     3421 cctccaggga gcctgtgggg cacaaggagg agtcaccaaa agggccgggt gggggccccg
     3481 ctgcttcggg aggagtggct gaagggatcg ccaacggacg cctcgtccag caccatggtg
     3541 ccgagcccag cagcttggac aagaggaaag agatatttag caaagacaca ctgttcaaac
     3601 ctcttcacag caccttgtct gtaaacagct atcacaagtc gagcctgtcc ctcctcaaat
     3661 ctcacccgaa gacacctgct gacacattgc caggccgatg tgagaaactg gaaccgtccc
     3721 tggggacctc ggcggcacaa gccatgcctg cttcccagcg tcagcaggag tcaggaggga
     3781 accaggaagc ctcttttgac tattacaacg tctctgatga tgacgactct gaggaagggg
     3841 caaacaagaa cacagaggag gagaaaaata gagaggacgt aggcaccatg cagtggctcc
     3901 tcgagcggga gaaggaaaga gacttgcaga ggaaatttga aaagaacctc acccttcttg
     3961 ctccaaaaga aaccgacagc agcagcaacc agagagccac ccattcagcc cggctcgaca
     4021 gcatggacag cagcagcatc acagtggaca gtggattcaa ctccccacgt actcgggaga
     4081 gcctggcttc caacacatca agcattgttg aaagtaaccg tcgtcagaac cccgctttga
     4141 gcccggccca tggtggagct ggtccagcct tcaacttccg agcgagcgcg gagcccccga
     4201 caaatgaagc tgagaagcta cagaaacctt ccaactgctt gcaagcttct gttactagcg
     4261 tgtgattgtc cttctgcctc agatcttctg tctcattcga tacagcaaag tttacgacac
     4321 tgggactgat gtttacatct ttggaaagac aagcatctca accacagttt ttgtgtttac
     4381 ttaaactgtg ctgctaagta gggctagggc aaaaaaacaa aaaatcttta tttcagagta
     4441 ttgcttttca catttatggc tctgtagcaa ctgagtaaca gtaggggtga tatgtatact
     4501 tttgcttcac taattgtatc tgagcacaca taggaaagtc tagacactgt aagtgtaata
     4561 cgcattttca atgtcatgca gttgccaatt ccattttaaa atgccacaga tgcgtgttgc
     4621 tcccagtctg tggttaaacg gtgccacaga actgatcctt gacacttcca aaaaaaaaaa
     4681 aacaaaacaa aacaaaaaaa atttaaaaaa aaaaaacaaa aaacaaaact aagctaccac
     4741 gaaatgtcaa atgcaagggt ccaccttgag ggaaatagat gccaaactaa ctagaaggga
     4801 ccccggccct ttgtgtgtga attgtttatg caccagtcat ttttcactgt gagttttcgt
     4861 gacactattt tgcaggagcc catggaagtg tgtgagaagg ggtcgcaatg gagatcactg
     4921 ggagtgaatg ttttcagggt tttgttttga agtgtcacag atgcttgtct gattttttta
     4981 accttccgtg atcacaaaca ggaatatagg cctttgaatc tgaagtggac aaaggaaagc
     5041 aatttccagt ctggctgggg cacagcatta ggtgattgaa aaggtgatgt ggacttgtaa
     5101 aaggtgttac tcaaatattg aaggaagaga atttcctcct tgtgatactt aggatgaccc
     5161 tatcttactc taatagatac aataattagt ttgtttaaaa gcaaaatgtt ctttgtgata
     5221 caaatgaaga gtagggcctg aggatgttat tctttctaat ggaaggacat aaatctattt
     5281 tatgtagttt taaatagaat gcctaaatta ggctgtggga gataattttt agtggttgta
     5341 ggaaagagca aatttaggga gtgttgaact tcaggccttt tattcctggg aagatatgta
     5401 tagagaaaac ttttaaaata atttttgatt agaaatatac atgtgcccat gtaataaaca
     5461 acagaatgtg ctcattctgc tagtgcggta taatccgaat ttgtactccc ctaaaattta
     5521 tcagaataac aattatgcat acatgaacta tgccagagta atgtttacag atactttgta
     5581 accaatttca ggaggcgttt ttagctggat gtgtagttaa ttagaccaac ttatttccaa
     5641 atggtttgtt aacattttgc tttggtttac aatgtcatgt tgaacacaaa gaagacccag
     5701 cagcaaaggg atgaccaata atttcatctt atagcaagga gacattccaa cgttcccatg
     5761 ttttattttc tgagaacagt gggacagatc tgtagtaatg gaatattatt tgcaaaaggg
     5821 ttacatatga cacaagtaag tgttctgaca taaagtttta tttagttcag tggcatgtgc
     5881 tgttgggagc catacaccat aaaatatata tatcccaaaa taaatctaga atattttcac
     5941 ctccaatttc agtaattggc atatgatttg tgagacgcat ctgtttttgt atgaggttta
     6001 atcactagca atctgtttaa agaatccagt cctatacaca gttggactca ttcttgaaac
     6061 ctttaaatgc tccctcatag tttttcagtt atttggaagt tgcattgggt caaactgaac
     6121 tccttgagtt tggtgtaaat tccttttttc tgcttattat agtgaaactt cagcatgttt
     6181 cttagtaaac tcccatacca ttgaaatgct taagccagtt ggctttcagt ctcatgcctt
     6241 atttcctcca aggcatgcct caacgcattg tttgtctcat tgcttaaata tgtccagaag
     6301 gaatgatcat gtatctaata gactacatag ttggttccct tggggagtta tatatcatac
     6361 agttactaaa tatttgtcta aattcatttt ttccaaaaac ctgctctcaa atttttcttc
     6421 tactctcagt tcataaataa tataaccatt gaaacaacac atcagcctct agctgatcct
     6481 ctgaaagtag ccattgaaat aatcgaatac tgtgtgaaca ggaaaggaaa gcgttacctt
     6541 taagagaagc tttaaaatag gaatttattg atatttcaca agatataggt ttacagaaga
     6601 cattattcaa ataaatatgt acactatttg cctgatgcta tggggtacat aattttttaa
     6661 aaactccctt agaccagcag ccattagtgt agaaatgatg gactttaaag gtgataccat
     6721 gtaagcagat gttgcatata aaaatattcc tgcctgaatc tgatcgagat tcttgaatgg
     6781 gggaggagtg gcagccggca gcacattgca aatgtcattc gaggtcacgg tgaggctctc
     6841 ggtcccggaa cagtgggggc ctcgccaggc gttgccagta tccctttcct cctgtaaaat
     6901 catagctttg tgttacacga ctgcttatcc agtcttaggg tttagcagct gaaaggttta
     6961 caaaactgaa tctggttgaa tctctgtgaa agggtcaaca catctgtcgg cattttgcac
     7021 acttatgtat tattatgata caacatatta ctttatggta atttttattt ttacatataa
     7081 ctacctccat aaatttgatg aaatggcagc cgtgtgttaa agtgtatcgt tcagaagagc
     7141 aaagttgaac acttccttca acattagggc atggcgtgct gtgtgtgtca gtgattgcct
     7201 ctgtggactc atgactttcc atcgccatgg ctttctctta cgccgctgtt tggctttcag
     7261 atgtaatcct gtcttctcct ctcttcccca cgaaagcgca ctcgattttg ttaggaatga
     7321 acggaagttt aaaaattctt gtgcccaccc ccgccctcca cccattcctg ttaaaagttc
     7381 tctggcgaag agccaatggg tgaacgtaat tgaaagagct atttactctt ttggaaatct
     7441 gatttgaagt ctaagttttc agtaacagaa gacacacaag caatgtggac tgccaagctt
     7501 gaagcacttc gggctctgcc ttcactcgca tgctaccatg tcgagcccaa actccacttt
     7561 aattaaaaga gctgtgctgt gaattccaca acttctgtta aataatttgt attccattat
     7621 atatattttg cacatctcag gggaccataa tgaacatatg aaaggggggg gggtgccatc
     7681 aaatagagaa aacaaataga agaggtgaat ggagactagc tggataaaaa taacaaatta
     7741 cttcttctct gatgttgtga aggtcaggtt caggaagcat caattcacag ttaatccgga
     7801 gtaacaatga tctgaacacc agctgttccc aggtccctct ttttcatagc ccaaccagca
     7861 tctaaaatgt aaatttaaat tacattgcag tcaccatggg gagaagaaac ctgttcagtg
     7921 gaagcagaag cattgttcct tttttaggtt ggcgcagctt tgcaaaactc tacccaggat
     7981 aaaccactta tcaccaccaa gtgtacttga aaataaagtt tttaacttaa attacaagca
     8041 tattgctcat aatacaatag tgatcatttt ttgaaagtct tgccatttat aacatgggca
     8101 gtatttggag cttcatttaa aaaccaacaa caaccgataa tgactttgca cgattcactt
     8161 tgggatctca aagtgcttcc aaagcattca gatttacaaa caattcacaa gacaggtcat
     8221 ctttgtaata cgcatactta caacgaatta acaaaaggag tgacttaaga ttctccagga
     8281 acacagtggc agctattgat gatctgtttt ctatctgttt gatagagcat catgagaaat
     8341 cacaaaatac aatgctattt ttctgatgtg tgctaataaa gtcaaagaaa acaaatacat
     8401 cttgacactt ttgtccattt tcattaaaaa aaaaaaagtt cagggtgttt ggaattttac
     8461 atctcagcac accttactgg tatcaatgga taaagcgggt gattgacaga tccacccaaa
     8521 tgccactgca gtcagaagca gatctggaca cacccttgtt tacagtttca tattgggttg
     8581 ctatagttcc cgtgctaaat caccagcttt caggaacatg actgctcctg gcagtggaag
     8641 gtgctgaaac agaaatttta attaaaaact ttatcaagta ctcttcacag tgctgcttgg
     8701 caccatagaa aatcagtaca atatatcgag ccctactttg gaggagctgg atttctgagg
     8761 gagctgatcc agttctaagt gtcttctcga attaggagat agatgatctt tgatggggat
     8821 ctcctccgtc accacaggcc agtcacagaa ccaactagcc acgtgctgcc agacctcagt
     8881 gggcccaagc aggagcaatc tcttctatcc cccatctccc ccaggaccat cccgcccatt
     8941 gtcaacgtca tccagggctc ttctggtagt gagtgacttt tctgcacatg tttagggctt
     9001 gggggagcta gaacacagga aacatgaatg caaaaggcat ggaaaacact gttttgcttt
     9061 gggttagtaa aatgtgggca ggacaaagat tactattggt ctgagctttg ccaagtgaga
     9121 tagaatcaac tgtcacccca ttcctttccc agaaggtctt atggtattaa ggatacatcc
     9181 agtattttcc cacagatttt tattcaggcg atgtttcata aattacatat atgaaaacat
     9241 tcattattac atttccttgt gtgtttcaaa cagacattgg caccttccta ttgagttaat
     9301 tctctgcatc ttttgcagca gcagcccaca aggagattcc cagagatggc tcccctaaca
     9361 cacagtcctg tgattttaca gttctatgac ttacagttga tgattcacaa gattcaggat
     9421 tctacaagac tcaaggggga actaaacttt cttacgattg tacatgatca gttatagggc
     9481 tgtaatcatt aattgttggc ttcaaatgtg gacacacaca cacacacatc atgccaagga
     9541 gggaatgggg tgtttcaagt caggcagcga tgattctgga aggttggaaa tgtaaggtta
     9601 gaagcttggc tggtcttagt aaacttgttc ccttgctccc accaagaaga ggtaccaaat
     9661 gtgagacctg agatctcctc caatatctgt cctctgcagt tccgggaaac taatcatgaa
     9721 gtacacatgc agcagctcct ccacttcctt tcctccgagg tcctcctttc cattctccca
     9781 cctagatact gacacaccgc cacggtttcc acattggaag ggcagaacac tgtgcagtat
     9841 cgtgcacact tgctgggtta ggaatagagc tgccctaggg tcaccttcat gcaagtattg
     9901 acagctacaa attaaagtcc ttagagcagt tgacacagat actacgttct agaagagaat
     9961 taaatttaaa cgtcaagttt aaagggatca taattctgca ggtatctttc tctgagtgac
    10021 tgaatgtgac tattgcatta gggtaaatga attaagacgt gcaagtggga tttactgtat
    10081 gttagaaagg agttttgcag ccaagactgc cttgaataaa atgtgtttgc actgaaaaaa
    10141 aattttaaat tacttggtct ctggttgctg taaaggtcat ccaagatgga tgttctgttt
    10201 atattgtata gtatttcata tgaaataatt acagttcatg aaatgtcttc cctaatgtta
    10261 ctgatttata acagcacatt tgtaacatgg tttttatcgt gtcagtgtac catactgtaa
    10321 atgatgatta cttgtcatgc ttagtataat aacttaaaag aaaaaaaagg acagggattt
    10381 ttgtaagtct atatttgaaa gtccctccct atggtgatac tgtgttcatg ttgtttatgt
    10441 agtgttgtgt gaaatatcca ttttggattg tgttactttt taagatatta aataacattt
    10501 ggttata
//
