LOCUS       NM_152709               3387 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens storkhead box 1 (STOX1), transcript variant 1, mRNA.
ACCESSION   NM_152709
VERSION     NM_152709.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Sammar,M., Apicella,C., Altevogt,P., Meiri,H. and Vaiman,D.
  TITLE     Modeling Preeclampsia In Vitro: Polymorphic Variants of STOX1-A/B
            Genes Can Downregulate CD24 in Trophoblast Cell Lines
  JOURNAL   Int J Mol Sci 23 (24), 15927 (2022)
   PUBMED   36555567
  REMARK    GeneRIF: Modeling Preeclampsia In Vitro: Polymorphic Variants of
            STOX1-A/B Genes Can Downregulate CD24 in Trophoblast Cell Lines.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3387)
  AUTHORS   Akin,S., Pinarbasi,E., Bildirici,A.E. and Cekin,N.
  TITLE     STOX1 promotor region -922 T > C polymorphism is associated with
            Early-Onset preeclampsia
  JOURNAL   J Obstet Gynaecol 42 (8), 3464-3470 (2022)
   PUBMED   36369889
  REMARK    GeneRIF: STOX1 promotor region -922 T > C polymorphism is
            associated with Early-Onset preeclampsia.
REFERENCE   3  (bases 1 to 3387)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   4  (bases 1 to 3387)
  AUTHORS   Dunk,C.E., van Dijk,M., Choudhury,R., Wright,T.J., Cox,B.,
            Leavey,K., Harris,L.K., Jones,R.L. and Lye,S.J.
  TITLE     Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in
            Placentation, Preeclampsia, and Preterm Birth
  JOURNAL   Hypertension 77 (2), 475-490 (2021)
   PUBMED   33356399
  REMARK    GeneRIF: Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1)
            in Placentation, Preeclampsia, and Preterm Birth.
REFERENCE   5  (bases 1 to 3387)
  AUTHORS   Li,Z., Zhou,G., Tao,F., Cao,Y., Han,W. and Li,Q.
  TITLE     circ-ZUFSP regulates trophoblasts migration and invasion through
            sponging miR-203 to regulate STOX1 expression
  JOURNAL   Biochem Biophys Res Commun 531 (4), 472-479 (2020)
   PUBMED   32807495
  REMARK    GeneRIF: circ-ZUFSP regulates trophoblasts migration and invasion
            through sponging miR-203 to regulate STOX1 expression.
REFERENCE   6  (bases 1 to 3387)
  AUTHORS   Rigourd,V., Chauvet,C., Chelbi,S.T., Rebourcet,R., Mondon,F.,
            Letourneur,F., Mignot,T.M., Barbaux,S. and Vaiman,D.
  TITLE     STOX1 overexpression in choriocarcinoma cells mimics
            transcriptional alterations observed in preeclamptic placentas
  JOURNAL   PLoS One 3 (12), e3905 (2008)
   PUBMED   19079545
  REMARK    GeneRIF: Anomalies in STOX1 expression are associated with the
            onset of preeclampsia.
REFERENCE   7  (bases 1 to 3387)
  AUTHORS   Berends,A.L., Bertoli-Avella,A.M., de Groot,C.J., van Duijn,C.M.,
            Oostra,B.A. and Steegers,E.A.
  TITLE     STOX1 gene in pre-eclampsia and intrauterine growth restriction
  JOURNAL   BJOG 114 (9), 1163-1167 (2007)
   PUBMED   17617193
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3387)
  AUTHORS   Kivinen,K., Peterson,H., Hiltunen,L., Laivuori,H., Heino,S.,
            Tiala,I., Knuutila,S., Rasi,V. and Kere,J.
  TITLE     Evaluation of STOX1 as a preeclampsia candidate gene in a
            population-wide sample
  JOURNAL   Eur J Hum Genet 15 (4), 494-497 (2007)
   PUBMED   17290274
  REMARK    GeneRIF: In conclusion, we are unable to validate STOX1 as a common
            preeclampsia susceptibility gene.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3387)
  AUTHORS   van Dijk,M., Mulders,J., Poutsma,A., Konst,A.A., Lachmeijer,A.M.,
            Dekker,G.A., Blankenstein,M.A. and Oudejans,C.B.
  TITLE     Maternal segregation of the Dutch preeclampsia locus at 10q22 with
            a new member of the winged helix gene family
  JOURNAL   Nat Genet 37 (5), 514-519 (2005)
   PUBMED   15806103
REFERENCE   10 (bases 1 to 3387)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391539.27, BC140011.1 and
            AY842014.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_152709.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY842014.1, ERR3218373.84465.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298596.11/ ENSP00000298596.6
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL391539.27        39920-39925
            7-549               BC140011.1         1-543
            550-3386            AY842014.1         457-3293
            3387-3387           BC140011.1         1222-1222
FEATURES             Location/Qualifiers
     source          1..3387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..3387
                     /gene="STOX1"
                     /gene_synonym="C10orf24"
                     /note="storkhead box 1"
                     /db_xref="GeneID:219736"
                     /db_xref="HGNC:HGNC:23508"
                     /db_xref="MIM:609397"
     exon            1..403
                     /gene="STOX1"
                     /gene_synonym="C10orf24"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..3063
                     /gene="STOX1"
                     /gene_synonym="C10orf24"
                     /note="isoform a is encoded by transcript variant 1;
                     storkhead-box protein 1; winged-helix domain-containing
                     protein"
                     /codon_start=1
                     /product="storkhead-box protein 1 isoform a"
                     /protein_id="NP_689922.3"
                     /db_xref="CCDS:CCDS41535.1"
                     /db_xref="GeneID:219736"
                     /db_xref="HGNC:HGNC:23508"
                     /db_xref="MIM:609397"
                     /translation="MARPVQLAPGSLALVLCRLEAQKAAGAAEEPGGRAVFRAFRRAN
                     ARCFWNARLARAASRLAFQGWLRRGVLLVRAPPACLQVLRDAWRRRALRPPRGFRIRA
                     VGDVFPVQMNPITQSQFVPLGEVLCCAISDMNTAQIVVTQESLLERLMKHYPGIAIPS
                     EDILYTTLGTLIKERKIYHTGEGYFIVTPQTYFITNTTTQENKRMLPSDESRLMPASM
                     TYLVSMESCAESAQENAAPISHCQSCQCFRDMHTQDVQEAPVAAEVTRKSHRGLGESV
                     SWVQNGAVSVSAEHHICESTKPLPYTRDKEKGKKFGFSLLWRSLSRKEKPKTEHSSFS
                     AQFPPEEWPVRDEDDLDNIPRDVEHEIIKRINPILTVDNLIKHTVLMQKYEEQKKYNS
                     QGTSTDMLTIGHKYPSKEGVKKRQGLSAKPQGQGHSRRDRHKARNQGSEFQPGSIRLE
                     KHPKLPATQPIPRIKSPNEMVGQKPLGEITTVLGSHLIYKKRISNPFQGLSHRGSTIS
                     KGHKIQKTSDLKPSQTGPKEKPFQKPRSLDSSRIFDGKAKEPYAEQPNDKMEAESIYI
                     NDPTVKPINDDFRGHLFSHPQQSMLQNDGKCCPFMESMLRYEVYGGENEVIPEVLRKS
                     HSHFDKLGETKQTPHSLPSRGASFSDRTPSACRLVDNTIHQFQNLGLLDYPVGVNPLR
                     QAARQDKDSEELLRKGFVQDAETTSLENEQLSNDDQALYQNEVEDDDGACSSLYLEED
                     DISENDDLRQMLPGHSQYSFTGGSQGNHLGKQKVIERSLTEYNSTMERVESQVLKRNE
                     CYKPTGLHATPGESQEPNLSAESCGLNSGAQFGFNYEEEPSVAKCVQASAPADERIFD
                     YYSARKASFEAEVIQDTIGDTGKKPASWSQSPQNQEMRKHFPQKFQLFNTSHMPVLAQ
                     DVQYEHSHLEGTENHSMAGDSGIDSPRTQSLGSNNSVILDGLKRRQNFLQNVEGTKSS
                     QPLTSNSLLPLTPVINV"
     exon            404..556
                     /gene="STOX1"
                     /gene_synonym="C10orf24"
                     /inference="alignment:Splign:2.1.0"
     exon            557..2915
                     /gene="STOX1"
                     /gene_synonym="C10orf24"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3387
                     /gene="STOX1"
                     /gene_synonym="C10orf24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3367..3372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STOX1"
                     /gene_synonym="C10orf24"
                     /note="hexamer: AATATA"
     polyA_site      3387
                     /gene="STOX1"
                     /gene_synonym="C10orf24"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcggcc gatcctcccg ccgagcgagc ggcgtcgtag ccgccgcgct cgccgaggcc
       61 ctgcgttgcg ggctcccggc cgccggcgaa agcatggccc ggcccgtgca gctggcgccg
      121 ggctcgctgg cgctagtgct gtgccggctg gaggcgcaga aggcggcggg ggccgcggag
      181 gagcctggtg ggcgcgcggt gttccgcgct ttccgtcgcg ccaacgcgcg ctgcttctgg
      241 aacgcgcggc tggcgcgcgc cgcctcgcgg ctggccttcc agggctggct gcggcggggg
      301 gtgctgctgg tgcgcgcgcc ccccgcctgc ctgcaggtgc tgcgcgatgc ctggcggcgc
      361 cgggccctgc ggccgccgcg cggcttccgc atcagggcgg tgggtgatgt ctttccagtg
      421 caaatgaatc caataactca atctcagttc gtacctttgg gtgaagttct ttgctgtgct
      481 atatctgata tgaatacagc tcagattgta gtaacgcagg aatcactttt ggagcgtttg
      541 atgaaacatt acccaggcat tgcaattcca tcggaagata ttctttatac cactctggga
      601 acgctgatta aagaaaggaa gatttatcac actggagaag gatacttcat agttactcct
      661 cagacttact tcattacaaa tacaaccacc caggaaaata agagaatgct gccatcagat
      721 gaaagtcgcc tgatgccagc ttccatgaca tatctggtga gcatggagag ctgtgcagag
      781 tcagcccaag agaatgctgc ccccatatcc cactgtcagt cttgccagtg tttccgggac
      841 atgcacactc aggatgttca ggaagcacca gttgctgcag aagtgactag gaagagtcac
      901 agaggtcttg gggaatccgt atcttgggta cagaatgggg cagtttcagt gtctgcggag
      961 caccacattt gtgagagcac caaaccttta ccatacacaa gagataaaga aaaaggcaag
     1021 aagtttggtt ttagtctctt atggcgcagc ttatctagaa aggagaagcc caaaacagaa
     1081 cacagcagtt tctctgctca gttcccacct gaagaatggc ccgtccgaga tgaagatgac
     1141 ttggacaata tccctcgaga tgttgaacat gagataatca aacgaattaa ccccattttg
     1201 actgttgaca atttaatcaa acacactgtc ctaatgcaaa aatacgaaga acagaaaaaa
     1261 tataatagcc agggcacttc cactgacatg ctgacaatcg ggcataagta tccttcaaaa
     1321 gagggggtta agaaaaggca gggtctgtct gcaaaacctc aagggcaggg ccattctcga
     1381 agggatagac acaaagccag gaatcaggga agtgagtttc agccaggaag cattagactg
     1441 gagaaacacc ccaagctccc tgctacacag cccatcccca gaattaaaag cccaaatgaa
     1501 atggtaggtc agaaaccact tggtgagatt acaacagtgc taggttccca tttgatttac
     1561 aaaaagcgaa tcagtaatcc tttccagggt ttgtctcacc gaggaagcac aatatccaaa
     1621 gggcacaaaa ttcagaagac gagtgatctg aaacccagcc agactggacc aaaggaaaag
     1681 cctttccaaa agcctaggtc cttggattcc tcaagaatct ttgatggtaa agccaaagag
     1741 ccatatgctg aacaacctaa tgataaaatg gaagcagaat ccatttacat aaatgaccct
     1801 actgtcaaac ccatcaatga tgacttcaga ggtcacctct tcagtcaccc tcaacagagc
     1861 atgttgcaaa atgatggtaa atgctgtccc tttatggaaa gcatgttgag atatgaagtg
     1921 tatggtggag aaaatgaggt aattcctgaa gtcttgagga aaagtcattc ccactttgac
     1981 aaattagggg agaccaaaca gactccgcat agtctgccat cacgaggtgc ctccttttca
     2041 gaccgaacac cctctgcttg tagattagtg gataacacaa tacaccagtt tcaaaatctt
     2101 ggccttttgg attacccagt tggcgtgaac cctttaagac aagctgcaag acaagacaaa
     2161 gactcagaag aattattgag aaaaggattt gtccaggatg cagagactac aagcctagaa
     2221 aatgaacagc tttctaacga tgaccaggcc ttgtatcaga atgaagtgga agatgatgat
     2281 ggtgcctgta gttcattata tctagaggag gatgacattt ctgagaatga cgacttacgt
     2341 caaatgctgc ctggccacag tcagtattcc ttcacaggtg gaagccaggg aaatcattta
     2401 ggaaaacaaa aagtgattga gagatctctg accgagtaca acagcacaat ggagagggtt
     2461 gagtctcagg tgcttaaaag aaatgaatgc tacaaaccca ctgggctgca tgctacccca
     2521 ggtgaaagcc aagaacctaa cctctctgct gaaagttgtg gcctaaattc aggggcccag
     2581 tttggtttta actacgaaga agaacccagt gttgctaaat gtgtacaggc ctcagcacct
     2641 gctgatgaaa gaatctttga ttactatagc gcaagaaaag ccagttttga agctgaagtc
     2701 atacaagaca ctattggtga cacaggaaag aagccagcta gctggagtca gagtcctcag
     2761 aatcaggaaa tgagaaaaca tttcccacaa aagttccaac ttttcaacac ttcacatatg
     2821 ccagtgttgg ctcaggatgt ccaatatgaa cacagtcact tggaagggac agaaaatcac
     2881 agcatggcag gagatagtgg aatagattct ccacggacac agagtctggg atctaataat
     2941 tcagtcattt tggatggact aaaaagaaga cagaattttc tgcaaaatgt cgaaggcaca
     3001 aagagcagtc aaccactcac atctaattcc ttactaccgc taactccagt cataaacgtt
     3061 taattttctt ttggaaacct acttttttct ttataaaaag gtagagcatt attacagaat
     3121 ctttcaatca tgtaagaatt gagtatataa gaattgtcta aaggcaagca tatctatact
     3181 attaaccaca ttacacattt tgttctaatt actggctttt tttcctcttt tggtgtctta
     3241 aggctttttg aagcttattt tactgtgagt ttattgggag tatatagatt attttcgatt
     3301 aaaaagtgga attattggtc cccttccaat tgtaattatc ttgaattttt atacattagt
     3361 ttctcaaata tatagaatgc caattta
//
