LOCUS       NM_001394390           10874 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens stonin 2 (STON2), transcript variant 5, mRNA.
ACCESSION   NM_001394390
VERSION     NM_001394390.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10874)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   2  (bases 1 to 10874)
  AUTHORS   Mahapatra,K.K., Mishra,S.R., Dhiman,R. and Bhutia,S.K.
  TITLE     Stonin 2 activates lysosomal-mTOR axis for cell survival in oral
            cancer
  JOURNAL   Toxicol In Vitro 88, 105561 (2023)
   PUBMED   36702439
  REMARK    GeneRIF: Stonin 2 activates lysosomal-mTOR axis for cell survival
            in oral cancer.
REFERENCE   3  (bases 1 to 10874)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 10874)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 10874)
  AUTHORS   Hosoda,Y., Miyake,M., Meguro,A., Tabara,Y., Iwai,S.,
            Ueda-Arakawa,N., Nakano,E., Mori,Y., Yoshikawa,M., Nakanishi,H.,
            Khor,C.C., Saw,S.M., Yamada,R., Matsuda,F., Cheng,C.Y., Mizuki,N.,
            Tsujikawa,A. and Yamashiro,K.
  CONSRTM   Nagahama Study Group
  TITLE     Keratoconus-susceptibility gene identification by corneal thickness
            genome-wide association study and artificial intelligence IBM
            Watson
  JOURNAL   Commun Biol 3 (1), 410 (2020)
   PUBMED   32737415
  REMARK    GeneRIF: Keratoconus-susceptibility gene identification by corneal
            thickness genome-wide association study and artificial intelligence
            IBM Watson.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10874)
  AUTHORS   Jung,N., Wienisch,M., Gu,M., Rand,J.B., Muller,S.L., Krause,G.,
            Jorgensen,E.M., Klingauf,J. and Haucke,V.
  TITLE     Molecular basis of synaptic vesicle cargo recognition by the
            endocytic sorting adaptor stonin 2
  JOURNAL   J Cell Biol 179 (7), 1497-1510 (2007)
   PUBMED   18166656
  REMARK    GeneRIF: Our data identify the molecular determinants for
            recognition of synaptotagmin by stonin 2 or its Caenorhabditis
            elegans orthologue UNC-41B.
REFERENCE   7  (bases 1 to 10874)
  AUTHORS   Diril,M.K., Wienisch,M., Jung,N., Klingauf,J. and Haucke,V.
  TITLE     Stonin 2 is an AP-2-dependent endocytic sorting adaptor for
            synaptotagmin internalization and recycling
  JOURNAL   Dev Cell 10 (2), 233-244 (2006)
   PUBMED   16459302
  REMARK    GeneRIF: The ability of stonin 2 to facilitate endocytosis of
            synaptotagmin is dependent on its association with AP-2, an intact
            mu-homology domain, and functional AP-2 heterotetramers.
REFERENCE   8  (bases 1 to 10874)
  AUTHORS   Walther,K., Diril,M.K., Jung,N. and Haucke,V.
  TITLE     Functional dissection of the interactions of stonin 2 with the
            adaptor complex AP-2 and synaptotagmin
  JOURNAL   Proc Natl Acad Sci U S A 101 (4), 964-969 (2004)
   PUBMED   14726597
REFERENCE   9  (bases 1 to 10874)
  AUTHORS   Walther,K., Krauss,M., Diril,M.K., Lemke,S., Ricotta,D., Honing,S.,
            Kaiser,S. and Haucke,V.
  TITLE     Human stoned B interacts with AP-2 and synaptotagmin and
            facilitates clathrin-coated vesicle uncoating
  JOURNAL   EMBO Rep 2 (7), 634-640 (2001)
   PUBMED   11454741
  REMARK    Erratum:[EMBO Rep 2002 Feb;3(2):197]
REFERENCE   10 (bases 1 to 10874)
  AUTHORS   Martina,J.A., Bonangelino,C.J., Aguilar,R.C. and Bonifacino,J.S.
  TITLE     Stonin 2: an adaptor-like protein that interacts with components of
            the endocytic machinery
  JOURNAL   J Cell Biol 153 (5), 1111-1120 (2001)
   PUBMED   11381094
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121769.4 and AL136040.5.
            
            Summary: This gene encodes a protein which is a membrane protein
            involved in regulating endocytotic complexes. The protein product
            is described as one of the clathrin-associated sorting proteins,
            adaptor molecules which ensure specific proteins are internalized.
            The encoded protein has also been shown to participate in synaptic
            vesicle recycling through interaction with synaptotagmin 1 required
            for neurotransmission. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jan 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.101382.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614646.5/ ENSP00000477736.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AL121769.4         87316-87361
            47-332              AL121769.4         89060-89345
            333-617             AL121769.4         91462-91746
            618-815             AL121769.4         116455-116652
            816-986             AL121769.4         163453-163623
            987-2825            AL136040.5         42657-44495
            2826-3028           AL136040.5         50524-50726
            3029-10874          AL136040.5         52899-60744
FEATURES             Location/Qualifiers
     source          1..10874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31.1"
     gene            1..10874
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /note="stonin 2"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
     exon            1..46
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /inference="alignment:Splign:2.1.0"
     exon            47..332
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..3112
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /note="isoform 5 is encoded by transcript variant 5;
                     stoned B homolog 2"
                     /codon_start=1
                     /product="stonin-2 isoform 5"
                     /protein_id="NP_001381319.1"
                     /db_xref="CCDS:CCDS91915.1"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
                     /translation="MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPD
                     QSESSSGENHVVDGGSQDHSHSEQDDSSEKMGLISEAASPPGSPEQPPPDLASAISNW
                     VQFEDDTPWASTSPPHQETAETALPLTMPCWTCPSFDSLGRCPLTSESSWTTHSEDTS
                     SPSFGCSYTDLQLINAEEQTSGQASGADSTDKRTEWQTGRQTAVSPVQACSEHTSTRT
                     HRLDPSPPSPQPKRSQNPGEGPEGASAPNDNSSSLQEDEEVEMEAISWQASSPAMNGH
                     PAPPVTSARFPSWVTFDDNEVSCPLPPVTSPLKPNTPPSASVIPDVPYNSMGSFKKRD
                     RPKSTLMNFSKVQKLDISSLNRTPSVTEASPWRATNPFLNETLQDVQPSPINPFSAFF
                     EEQERRSQNSSISSTTGKSQRDSLIVIYQDAISFDDSSKTQSHSDAVEKLKQLQIDDP
                     DHFGSATLPDDDPVAWIELDAHPPGSARSQPRDGWPMMLRIPEKKNIMSSRHWGPIFV
                     KLTDTGYLQLYYEQGLEKPFREFKLEICHEISEPRLQNYDENGRIHSLRIDRVTYKEK
                     KKYQPKPAVAHTAEREQVIKLGTTNYDDFLSFIHAVQDRLMDLPVLSMDLSTVGLNYL
                     EEEITVDVRDEFSGIVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILVKGNEI
                     VLRQDIMPTTTTKWIKLHECRFHGCVDEDVFHNSRVILFNPLDACRFELMRFRTVFAE
                     KTLPFTLRTATSVNGAEVEVQSWLRMSTGFSANRDPLTQVPCENVMIRYPVPSEWVKN
                     FRRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLGTAKYEHAFNSIVWRINRLP
                     DKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKASVRSISVEDKTD
                     VRKWVNYSAHYSYQVEIEQKKSLKPDFEGDEMENPKECGVQ"
     exon            333..617
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /inference="alignment:Splign:2.1.0"
     exon            618..815
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /inference="alignment:Splign:2.1.0"
     exon            816..986
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /inference="alignment:Splign:2.1.0"
     exon            987..2825
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..3028
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..10874
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10755..10760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /note="hexamer: AATAAA"
     polyA_site      10774
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /note="major polyA site"
     regulatory      10853..10858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /note="hexamer: AATAAA"
     polyA_site      10874
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /note="major polyA site"
ORIGIN      
        1 agtgggaatc agctctttgt gcttgtggac cctgcactgc tctctgattt ctgcctggca
       61 gattaaccaa cggcaagaga ggctgatctg tctacattct gagtactgcc cttggcaaga
      121 cacctagaac agaccctgga cccaagtcta ccgtactacc atacccctac tccagcccac
      181 cccagacagt attctggggt tcacctgagg tcagcagtgt gaagatgacc agtgcctttt
      241 tagcatgacg actttggacc atgtgattgc cacccaccag tcagaatggg tctccttcaa
      301 tgaagagcca ccctttcctg cccactcgca ggggggcacg gaagagcacc tcccaggact
      361 gtcatcttcc ccagaccagt ccgagagctc ctccggggag aaccatgtgg tggatggagg
      421 ctctcaagac cattcccact cggagcagga tgactcctct gaaaagatgg gcctcatctc
      481 tgaagcagct tccccacctg ggagccctga gcagccccca cctgacctgg cctcggccat
      541 cagcaactgg gttcagtttg aagatgacac accctgggcc agcacatctc cacctcatca
      601 ggaaacagct gagacagccc taccattgac catgccctgc tggacatgcc cttcctttga
      661 ctccctgggg agatgccctc tgacttctga gagcagctgg accacccatt ctgaagacac
      721 cagcagtcct agctttggat gttcgtatac agatctgcag ctcatcaatg ctgaggagca
      781 gacgagtggc caggcttctg gggctgactc aactgacaag aggacggagt ggcagacagg
      841 caggcagacg gcagtgagtc ctgttcaagc atgctcggag catacctcca cccgcaccca
      901 ccgcctggac ccctcgccac cctcacccca gcccaagagg agccagaacc ccggcgaggg
      961 tccggagggg gcctctgctc ccaatgacaa ttcctcctcg cttcaagaag atgaagaagt
     1021 agagatggag gccatcagct ggcaggccag cagtccagcc atgaatgggc accctgcccc
     1081 tccagtgacc tctgctcgtt ttcccagctg ggtcaccttt gatgacaatg aagtcagctg
     1141 ccctttacca ccagtcacct ctcctctgaa gccaaataca ccaccaagtg catctgtgat
     1201 cccagatgta ccttataatt caatgggatc atttaagaag agggaccgtc ccaagagcac
     1261 tttgatgaac ttctccaaag ttcagaagct ggatatttcc tctttaaacc gcacgccttc
     1321 tgtaactgag gcttcacctt ggagggcaac caaccctttc ctgaatgaga ctctgcagga
     1381 tgtacagccc tcccctatca accctttcag tgctttcttt gaggagcagg agaggcgctc
     1441 ccaaaacagt tccatttcca gtaccacggg caaaagccaa agagattccc tcattgtcat
     1501 ctaccaggat gccatcagtt ttgatgattc aagcaaaacc cagtcacact ctgatgctgt
     1561 tgaaaaactc aaacaactcc aaattgatga ccctgatcac tttggcagtg caactctacc
     1621 tgatgatgac ccagtagcct ggattgaact agatgctcac ccgcctggat cagcacggtc
     1681 ccagcctcgt gacgggtggc caatgatgtt gaggatccct gagaagaaaa acatcatgtc
     1741 ctccaggcac tggggaccga tcttcgtcaa actgacagac actggttacc tgcagctgta
     1801 ttatgagcag ggcctagaaa aaccattccg tgagttcaag ctggagatct gtcatgagat
     1861 ttcagaaccc cggcttcaaa actatgatga gaatggcaga atccacagct tgcggataga
     1921 ccgtgtcacc tataaagaga agaagaaata ccagcccaaa cctgctgtgg cccacacagc
     1981 agagagggaa caggtgatta agctgggcac caccaattac gatgacttcc tgagtttcat
     2041 ccatgcagtt caggaccgtc tcatggatct gccagtgttg tcaatggact tgagcacagt
     2101 tggcctcaac taccttgaag aggagattac agtggatgtc agagatgaat tctctggcat
     2161 tgtgagcaaa ggagacaacc agattctcca gcaccatgtc ttgacacgga tccacatcct
     2221 gagtttcctg tctgggctcg cagagtgccg cctgggcctc aatgacatcc tcgtcaaagg
     2281 gaatgaaata gttttgaggc aggacatcat gcccaccacc accacaaagt ggatcaagct
     2341 ccatgagtgc cgtttccatg ggtgtgtgga tgaggatgtt ttccacaact cacgggtcat
     2401 tctgttcaac cctttggatg cgtgccggtt tgagctaatg cggttcagga cagtgtttgc
     2461 tgagaagacc ttgcctttca cactcaggac ggccacaagt gtcaatgggg cagaggtgga
     2521 ggtgcagagc tggctgagga tgtcaactgg cttctccgcc aatcgtgacc ccctcactca
     2581 ggttccctgt gagaatgtga tgatccgtta ccctgtgccc agtgagtggg tgaaaaactt
     2641 ccgcagggaa agtgtcctgg gggaaaagtc tttgaaagcc aaagtgaacc ggggggcaag
     2701 ttttggctcc actagtgttt ctggctctga gcctgtcatg agagtaactc tgggaactgc
     2761 caagtacgag catgccttca actccattgt gtggaggata aaccgactgc cggacaaaaa
     2821 ctcagcttcc ggtcacccac actgtttctt ttgccacctt gaactcggct ctgaccggga
     2881 agtgccttcc agatttgcca atcacgtgaa tgtcgagttc agcatgccca caacttctgc
     2941 ctccaaagcc agcgtgagat ctatctctgt agaagacaag actgacgtca ggaagtgggt
     3001 caattattct gcacactaca gctaccaggt ggaaattgag caaaaaaaga gtttgaagcc
     3061 ggactttgaa ggagatgaaa tggaaaatcc caaggagtgt ggagtgcagt gacaaagcct
     3121 tgcggcaagg aatcctgatc ccagagtcat gatagggtgt cttcctgagt catgataggg
     3181 tgtcttcctg agtagctgaa gttgcagtca atacctgctg tggccactgc atgttgggaa
     3241 cagtatacca gatcttcctg tttgcagtta cttgtatttt accaggaaac cctgagaatg
     3301 gtggcttttg gagaggctct ttgattctgg tcatgcctaa agcacgaggt tcacctgact
     3361 gttggagctt actgtataat taagcctcct tgtcttgtct ctgcttatct cacagcactg
     3421 gtatgtggtt tgttgtgact gttacagtca ggaaaagaac ctcccacatc agtgttagca
     3481 cgattgcctt ctgatgttca tctgtcactc gcataacttt ctggcaaagg cagtcttgag
     3541 aagttaatta agaatccatc tctttcactc tgtctagaaa aggttcagaa aaggtgcaaa
     3601 acaaatttcc tctttgggtc ttactagacc tttttgaggt gtctccattc tttaactgtt
     3661 aagctttcaa gacatttccc tcctggctct agatcgttta gattggaaca ctttttccat
     3721 ctctctaagg tttcagtcac aggatttgct atcctgagtc acaatagaca atggaaaaag
     3781 gcacaatagg agacttttta attttgtgaa tggacccaca ttctgcaaaa tgggtgttga
     3841 ggggaaggca aaattaatct tagttttctt cattttggag aaaagagaca ttaaatataa
     3901 gatgatgttc agttcaagag gtagattcaa tctcagtgaa ttcccaaatt cacactgaaa
     3961 aatacagtcc acttctgatt cctgaaacaa atatacataa tacctgaggc atttgtaagg
     4021 ggcatttggg agttcttttt atacctcatg accaatagac agttgcatgt ccctttaacc
     4081 caactttata ggaaatttaa gctgcaaaga taatttttaa agctgtttta aaattaagct
     4141 tgaatgagct ttcccccaaa attcagagtt tgataatcac agtattggat tggattgaaa
     4201 aggcatctct agggtagaga cgtggaaaag ccatattttt ctaatgttgg gaacattata
     4261 ttctgattcc aagagtcaga acgctcactc catcttcttt ttcttcatct gtttctggga
     4321 caattaatct tcttttcctt catccgttcc tactcacctc tgcttcttat ttgtatctta
     4381 gtgttttctc ccatgaagaa tacaagtcgg gggacagaaa gcacacttca ttggatttgt
     4441 agatgatgca gaaatgaaaa atatctccag tttttggctg atggattcaa gattaatgta
     4501 ttcaatgaac aatcattgga gtctaaatgt gtattgacac tgggatatag aaatagttac
     4561 agtattttga aatatctgaa ctaagactga aagtaaaatg atgattgaat aggcattaat
     4621 gagaaaccct atattctggg tttttaaaat gcaaccctct aagtacagag tggagtgtgt
     4681 gtttgtggat gtgtgtgttt gtgtgtgttt atgtgtgtgg tgttgatggg aacggtgtta
     4741 ggaagacctg gtttcacggt agtttataga gaaatatttc cttacagaaa tggaggttca
     4801 atgttgaatc agaaatatat catggctatt cacaaagcta atgtagtcag ctggtgttaa
     4861 taaaagcctt acatgctttt attaaccctc catctagtcc atatctaaat ggagggttga
     4921 gttcaattat gggtatcata ttttaagaga gacattaata agttgattgt gtccataggg
     4981 aggtgaccag ggttgtaaag ggtctgatga tgcaagaaca agggagtagc ttccctgaag
     5041 gaacagaagg tatagctgga aagggagtgc agacaaggag ggaatgatac aatagctgcc
     5101 tagaaatttc tattgagcta tgaaaaggaa gaggaattag atttattctg tgtagcttca
     5161 aagggcaaaa ataagaacaa agaggaactt tacaggtgac aaatgtttgc ttcaatataa
     5221 ggaagaattg tctaataaga gttgttctaa agaggaatag actcaagtta gtaagatttc
     5281 ctgttcctgt gaatgcccaa cagttaaaat aaccacctat cccacgtgct gtgaaaggga
     5341 atcttacatt ggatttggtc tatatgtcta ccaagattcc ttctaaatat aggtttagtc
     5401 tcaatagtaa taagactctc taacttcatt tgtctttttc ttcataagtg gtttttcatg
     5461 ctctttgaaa tacagtggag ttcctttgag gtttttgtca aggaatttca acgcatatct
     5521 cttcccctgt tgtactgaag gcttttgaga ttaattcctc atagaacatc taaatggatt
     5581 ggagagttgg caagggaaat gaagctcatc ccagcacctt ccttagtcac tcacgcttag
     5641 cactctgtca agatctctgc ctcatctgct agcataacat gtggattgct tgttggagct
     5701 tatttccccg ccccccatgg taaattctca tttcctgtgt acatgcacct ggactttttt
     5761 gtttttttta ccaagagttg ggaaaaatcc cttctatgct atctatattc tgcaaacaaa
     5821 ttattattat tattattatt gagacagagt attattatta ttattattat tattattact
     5881 gagacaaagt ttcgctcttg tcgcccaggc tggagtgcaa tggcgtgatc tcggctcatt
     5941 gcaacctctg cctcccaaat ctcctgcctc agcctcctga gtagctggga ttacaggcgc
     6001 ctgccaccat gcaccactaa tttatgtatt tttagtagag atggggtttc accatgttgg
     6061 ccaggctggt ctcgaatgtc tgacctcagg tgataagcct gcctcagtct cccaaagctc
     6121 tgggattaca ggcgtgagcc accatgctgg acccacaaat tattattaat ttttaaaaac
     6181 ctaacatctt aatttcatca aatttgtttt ccctctactg tttttaggaa actgattatg
     6241 ggtagcattt aggggtttgg ggataataat actatatatt tttagacgta atgagtgttt
     6301 tactaggttt aaataacttc taaagaaaat acaagtgggc aaattagcta tgtaataacc
     6361 tacatagaaa acagttgggc aaattacctg tggatatgca gattctactt ttgcaaccct
     6421 ggacctggac tttttatttt ttttttttgt ggtcacaaat aatctttgtt atcaataatg
     6481 tgaaaatatt aaaaatgaat tcattttacc agtacatagt attactctta gaacataaat
     6541 tagatatcac gtggtatcaa gagctgtgct ttcttttgag tctagggcct gctttttgac
     6601 tttacagcaa aaagataaga aatgtactca tgacatgtca gacaagacaa tgtgaggcac
     6661 tttgtgggga gaccattaga tgatccccct tgcctgctct tgcagacata gtactagtta
     6721 ttccttatca aaagtttgca tttcattcat attaaatatt atctggacag tttcattttt
     6781 tctatttggc tcttccctta ctgtgccttc ctgcattatt ggcagggttc ataatccttg
     6841 agaacattgt ttgatttaaa atatttttta tttgaaatga gactgatttc tattcaaatc
     6901 cagtggctgg gagtaagagt ttatttccct agaaacttat gtttctgata aatgggatcc
     6961 atgaaggcaa ggactatata taattttttg tgtttccaac acctagcaca aagcttggaa
     7021 tataataggg ttcagccacc ttaaatgctt gccaggaggg caaacgtata ctcatgaaat
     7081 aaaggaaaat gagtatgtat tcaataaatg tttgctgaaa gaatactgac cctgagactc
     7141 gaaggctact taacccttac ttatcatcaa atactcataa taaagccagc aagcatgctt
     7201 ttatttcctg aaggacttaa ataattttgc tttcctttta ctcctgcctc cagagtcaag
     7261 taataaaacc tgtcagcatt taggcactta atatgctgct gaatttgaac tacaatgtac
     7321 ctcattcaca ttgaaaaaca tttttgtgcc ccaaagcata gtagcataga tgctgtccat
     7381 agtcacggtg attgattgct ttgttcctgc aagtcaaaca gatccatgag cctgagcctt
     7441 gcccatttca atggtcagta ggaaaagaaa gcatttgata gagtgcacaa ccagtcttca
     7501 tgcagtaggt ctttgttctt ccagcactaa ccgctgaccg ttactttgca tttattttgt
     7561 caccacagta agatggaggt ctgagatagt aaggtcaaaa tttgtgagat aaagtcatga
     7621 tttcagaggt gatatatatt tcaccataag tttagtggtg ggaaaacaga atgagctgaa
     7681 gttttttctt aaaagccttg ggaatattaa attggtttaa gtaggaagca ctaccatcca
     7741 gcctgcttat agaaatgctc ccagttcgag tggtaacttt aactcttcta aaaatgagga
     7801 ttatatgtta attccagcat atctagacct tagtcaggga ggtccaatct tttggcttcc
     7861 ctgggccaca taggaagaag aattgtcttg ggtcacacat aaaatacagt aacaacagct
     7921 gatgagcttt aaaaacatgg ccaaaaaata gcattttctt ttttgttttt tttttttttt
     7981 ttttttttga gacggagtct cagtctgtca cccaggctag agtgcagtgg cacgacatcg
     8041 gctcactgca acctccgcct cccgggttca agtgattctc ctgcctcaac ctcccgagta
     8101 gctgggacta caggcatgtg ccaccacgcc tgactaattt ttgtattttt agtagagatg
     8161 ggatttcatt atgttggcca gctggtcttg aacttctgag ctcaggtgat ccacccgcct
     8221 tagcctccca gagtgctagg ataacaggca tgagccgccg cgcctggcca aaatagcata
     8281 atgttttaag aaagtttacg aatttgtctt gggccacatt caaaaccatc atgggccaag
     8341 ggttggacaa gctagcctta ggtcatgtcc agaatgcaat ttaacaggaa tttcaagcaa
     8401 aactaacaaa aaattaaatc cacaaaaaaa tatcatttgg taaatgcact gtctcacaca
     8461 ctttactact aagtcccatt caaaccatga cgacccttta cataaaatta gggcattctc
     8521 accaagtttc taaagatgat ttctaaacat taccaaggtc taagtgctaa ttccccacaa
     8581 accatttctt atcttgttta aatgagactg gctttagata tcatgactca tatttatgtg
     8641 tttaaggaat taaacgtgaa ggagatgtat aaggcaacca caaatgtaga aaacaaatgt
     8701 atgtattagt aatattctcc catgtattaa ctagaacaag aatgtgagat ttttacattt
     8761 cttctagtgt gccttagcaa atctgctgga aagagtctag ttgttttgag aattgaaaaa
     8821 aaaatgtgtc tctcaatttg tcaattctaa gcctgtaaag gcagaaacta tccacagtaa
     8881 tgagtttggt agtgcctgga gagaggcaaa tgatcattgg atgtaacaaa agctacaaga
     8941 gaatagacta aaaaaagaat ttcaatatga aaaagtaaaa tctagagaga tgacaaatca
     9001 gcattgggta ccaagcctca aaatacttga actagaagcc atctcttaaa gttaaaagta
     9061 agaagctcca ggaaaaataa agattgcata gtaaaaaggg atagatggca ggattaattc
     9121 aactcaacaa atatttatca aatgtctact ctggtcaggt gctgtgttag cagccagctt
     9181 ccctaaaggg aggaaaggct agacacgagg acattgagga ttgtttattt aaagtcactc
     9241 ataggcatgc cataatggat ttattaaggg gaaattgggg tttctgtgaa tctttacagg
     9301 acatagccat ggagacaatc actatgttaa gtaagttgct gttttcccaa ttgggcttca
     9361 gtttcctgag acaaaaaagt gaggaagttg gattaattgt ttcttcaagt cctttccagc
     9421 tctaaagttg tgggttattt tacaaaatat ccattggtgc cacctttcag tgactcttcc
     9481 tatgtttata agaaccaaga aatttaaatt ttgaagattg gaaaaatcac ctggtccatc
     9541 tttttccttt tcacatctct ctcttttttt tttttttttt tatcatttcc ccagacaaca
     9601 gaaacagaca accttccaaa tcctctatat tgcagttgcc ttccacacac agatttaaaa
     9661 agaggatcaa agagggtggt gaagatcagg tggaatgctt ctttggaagt tccactggca
     9721 tcatctatca gaacaatggt gtgagcatga agaggcacag acaggtctcc aaaatagatg
     9781 ttaggatttg ggtgctacct gacacagaag taggtctaac cctccaagta ctggggatga
     9841 taggataatc aatgaggtat atatatattt gtcattttgt ataaaatatt gtgaaaattg
     9901 aaggaggaca ctcagtaaac atcctgggac tatttgtaag ttatggcaaa accagatgag
     9961 agaaaaggga cagtcccctc tgtatcctcg ttgtctctta gtaacatcaa attgtagtta
    10021 aaaaaatttt aaactatgta caagctacaa aatagcatct ctttcatggt atgtttgagt
    10081 gtgtaatttt agtttctttt ctggttgtat ttgtggtagt cagatgtgtt ggattgattc
    10141 caactggaca gagtaaggaa ttccagcatc ctcttcctgc ttgctcgtgt taccccacag
    10201 atcaaaccct caattctagt tggggatgct gtctagcccc acaccatgac tgaagcctta
    10261 agcactgttg cgcctccatg tgctttggat cagcaacccc agtggtattc taccagagca
    10321 ttgtgggaaa gcagatgtat agtcaggtcc caacagcaaa ttgttgggtg tgagagttct
    10381 aaagtatagg ggtgagggaa gagaaggata tgaactcctc tgaccttaag ccagcattca
    10441 tttaactttt atgtctactt aacaagagaa cctggagaaa actaccgtat tcaagagatt
    10501 aatcaaaatc agtgttttag ccaggcgatg acagagaagc accattcctc accctccatt
    10561 cttgtaatgt ctgtaataaa tttcagtgcg tcaggatgga tgaacccaag atccagtgaa
    10621 tgattcagct gttccaagcc ttacattttc catcattcat catccattct cattcagtgt
    10681 aacctcttgc actattgtgg ttaattttat gtaaaaccag tttatgtttt ttttttttta
    10741 atatgtgcct atgtaataaa gtctacacac tggctatctc tgtagaggtg aggttttgtt
    10801 tttagttgtt ctactgatta tatccttttc tgagctatga aaatgaatta ttaataaaaa
    10861 atttttgaac aaaa
//
