LOCUS       NM_013442               1365 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens stomatin like 2 (STOML2), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_013442
VERSION     NM_013442.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1365)
  AUTHORS   Gong,H., Chen,S., Liu,S., Hu,Q., Li,Y., Li,Y., Li,G., Huang,K.,
            Li,R. and Fang,L.
  TITLE     Overexpressing lipid raft protein STOML2 modulates the tumor
            microenvironment via NF-kappaB signaling in colorectal cancer
  JOURNAL   Cell Mol Life Sci 81 (1), 39 (2024)
   PUBMED   38214751
  REMARK    GeneRIF: Overexpressing lipid raft protein STOML2 modulates the
            tumor microenvironment via NF-kappaB signaling in colorectal
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1365)
  AUTHORS   Attia,A.S., Hussein,S., Sameh,H., Khalil,A., Waley,A.B., Matar,I.
            and Sameh,R.
  TITLE     Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12
            expression in papillary thyroid carcinoma
  JOURNAL   Cancer Biomark 39 (3), 211-221 (2024)
   PUBMED   38073379
  REMARK    GeneRIF: Diagnostic and prognostic utility of TROP-2, SLP-2, and
            CXCL12 expression in papillary thyroid carcinoma.
REFERENCE   3  (bases 1 to 1365)
  AUTHORS   Qin,C., Wang,Y., Zhao,B., Li,Z., Li,T., Yang,X., Zhao,Y. and
            Wang,W.
  TITLE     STOML2 restricts mitophagy and increases chemosensitivity in
            pancreatic cancer through stabilizing PARL-induced PINK1
            degradation
  JOURNAL   Cell Death Dis 14 (3), 191 (2023)
   PUBMED   36906621
  REMARK    GeneRIF: STOML2 restricts mitophagy and increases chemosensitivity
            in pancreatic cancer through stabilizing PARL-induced PINK1
            degradation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1365)
  AUTHORS   Genin,E.C., Bannwarth,S., Ropert,B., Lespinasse,F.,
            Mauri-Crouzet,A., Auge,G., Fragaki,K., Cochaud,C., Donnarumma,E.,
            Lacas-Gervais,S., Wai,T. and Paquis-Flucklinger,V.
  TITLE     CHCHD10 and SLP2 control the stability of the PHB complex: a key
            factor for motor neuron viability
  JOURNAL   Brain 145 (10), 3415-3430 (2022)
   PUBMED   35656794
  REMARK    GeneRIF: CHCHD10 and SLP2 control the stability of the PHB complex:
            a key factor for motor neuron viability.
REFERENCE   5  (bases 1 to 1365)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 1365)
  AUTHORS   Zhang,L., Ding,F., Cao,W., Liu,Z., Liu,W., Yu,Z., Wu,Y., Li,W.,
            Li,Y. and Liu,Z.
  TITLE     Stomatin-like protein 2 is overexpressed in cancer and involved in
            regulating cell growth and cell adhesion in human esophageal
            squamous cell carcinoma
  JOURNAL   Clin Cancer Res 12 (5), 1639-1646 (2006)
   PUBMED   16533792
  REMARK    GeneRIF: overexpression of stomatin-like protein 2 is associated
            with neoplasms
REFERENCE   7  (bases 1 to 1365)
  AUTHORS   Guo,D., Han,J., Adam,B.L., Colburn,N.H., Wang,M.H., Dong,Z.,
            Eizirik,D.L., She,J.X. and Wang,C.Y.
  TITLE     Proteomic analysis of SUMO4 substrates in HEK293 cells under serum
            starvation-induced stress
  JOURNAL   Biochem Biophys Res Commun 337 (4), 1308-1318 (2005)
   PUBMED   16236267
REFERENCE   8  (bases 1 to 1365)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   9  (bases 1 to 1365)
  AUTHORS   Owczarek,C.M., Treutlein,H.R., Portbury,K.J., Gulluyan,L.M.,
            Kola,I. and Hertzog,P.J.
  TITLE     A novel member of the STOMATIN/EPB72/mec-2 family, stomatin-like 2
            (STOML2), is ubiquitously expressed and localizes to HSA chromosome
            9p13.1
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 196-203 (2001)
   PUBMED   11435687
REFERENCE   10 (bases 1 to 1365)
  AUTHORS   Wang,Y. and Morrow,J.S.
  TITLE     Identification and characterization of human SLP-2, a novel
            homologue of stomatin (band 7.2b) present in erythrocytes and other
            tissues
  JOURNAL   J Biol Chem 275 (11), 8062-8071 (2000)
   PUBMED   10713127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF190167.1, AW273545.1, AA657517.1 and HY367065.1.
            
            On Nov 23, 2018 this sequence version replaced NM_013442.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.63930.1,
                                           SRR5189658.32931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155984 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356493.10/ ENSP00000348886.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1137              AF190167.1         27-1163
            1138-1219           AW273545.1         1-82                c
            1220-1352           AA657517.1         1-133               c
            1353-1365           HY367065.1         3-15                c
FEATURES             Location/Qualifiers
     source          1..1365
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1365
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /note="stomatin like 2"
                     /db_xref="GeneID:30968"
                     /db_xref="HGNC:HGNC:14559"
                     /db_xref="MIM:608292"
     exon            1..82
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1108
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /note="isoform a is encoded by transcript variant 1;
                     paratarg-7; paraprotein target 7; EPB72-like 2;
                     stomatin-like protein 2, mitochondrial; EPB72-like protein
                     2; stomatin (EPB72)-like 2"
                     /codon_start=1
                     /product="stomatin-like protein 2, mitochondrial isoform
                     a"
                     /protein_id="NP_038470.1"
                     /db_xref="CCDS:CCDS6577.1"
                     /db_xref="GeneID:30968"
                     /db_xref="HGNC:HGNC:14559"
                     /db_xref="MIM:608292"
                     /translation="MLARAARGTGALLLRGSLLASGRAPRRASSGLPRNTVVLFVPQQ
                     EAWVVERMGRFHRILEPGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQID
                     GVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNASIVDA
                     INQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAINVA
                     EGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAAALTQHNGDAAASL
                     TVAEQYVSAFSKLAKDSNTILLPSNPGDVTSMVAQAMGVYGALTKAPVPGTPDSLSSG
                     SSRDVQGTDASLDEELDRVKMS"
     exon            83..220
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            221..320
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            321..379
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..481
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..616
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..761
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..841
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..970
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1365
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1225..1230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /note="hexamer: AATAAA"
     polyA_site      1248
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /note="major polyA site"
     regulatory      1337..1342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
                     /note="hexamer: AATAAG"
     polyA_site      1365
                     /gene="STOML2"
                     /gene_synonym="HSPC108; SLP-2"
ORIGIN      
        1 gtctcgttgg ttccggaggt cgctgcggcg gtgggaaatg ctggcgcgcg cggcgcgggg
       61 cactggggcc cttttgctga ggggctctct actggcttct ggccgcgctc cgcgccgcgc
      121 ctcctctgga ttgccccgaa acaccgtggt actgttcgtg ccgcagcagg aggcctgggt
      181 ggtggagcga atgggccgat tccaccggat cctggagcct ggtttgaaca tcctcatccc
      241 tgtgttagac cggatccgat atgtgcagag tctcaaggaa attgtcatca acgtgcctga
      301 gcagtcggct gtgactctcg acaatgtaac tctgcaaatc gatggagtcc tttacctgcg
      361 catcatggac ccttacaagg caagctacgg tgtggaggac cctgagtatg ccgtcaccca
      421 gctagctcaa acaaccatga gatcagagct cggcaaactc tctctggaca aagtcttccg
      481 ggaacgggag tccctgaatg ccagcattgt ggatgccatc aaccaagctg ctgactgctg
      541 gggtatccgc tgcctccgtt atgagatcaa ggatatccat gtgccacccc gggtgaaaga
      601 gtctatgcag atgcaggtgg aggcagagcg gcggaaacgg gccacagttc tagagtctga
      661 ggggacccga gagtcggcca tcaatgtggc agaagggaag aaacaggccc agatcctggc
      721 ctccgaagca gaaaaggctg aacagataaa tcaggcagca ggagaggcca gtgcagttct
      781 ggcgaaggcc aaggctaaag ctgaagctat tcgaatcctg gctgcagctc tgacacaaca
      841 taatggagat gcagcagctt cactgactgt ggccgagcag tatgtcagcg cgttctccaa
      901 actggccaag gactccaaca ctatcctact gccctccaac cctggcgatg tcaccagcat
      961 ggtggctcag gccatgggtg tatatggagc cctcaccaaa gccccagtgc cagggactcc
     1021 agactcactc tccagtggga gcagcagaga tgtccagggt acagatgcaa gtcttgatga
     1081 ggaacttgat cgagtcaaga tgagttagtg gagctgggct tggccaggga gtctgggaac
     1141 aaggaagcag attttcctga ttctggctct agcttccctg ccaagatttt ggtttttatt
     1201 tttttatttg aactttagtc gtgtaataaa ctcaccagtg gcaaaccaga aactgtcctc
     1261 tttgattggg gaatgaagtt gggaaagtca ctagcatttt ccttggatcc agtcctgtca
     1321 gcatgatgcc tccatgaata agagtgaact tcttgtaaag tgaaa
//
