LOCUS       NM_004809               6280 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens stomatin like 1 (STOML1), transcript variant 1, mRNA.
ACCESSION   NM_004809
VERSION     NM_004809.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6280)
  AUTHORS   Lapatsina,L., Brand,J., Poole,K., Daumke,O. and Lewin,G.R.
  TITLE     Stomatin-domain proteins
  JOURNAL   Eur J Cell Biol 91 (4), 240-245 (2012)
   PUBMED   21501885
  REMARK    GeneRIF: [review] Stomatin family member STOML1 is oligomeric; it
            mostly localizes to membrane domains and has been shown to modulate
            ion channel activity.
            Review article
REFERENCE   2  (bases 1 to 6280)
  AUTHORS   Zhang,W., MacDonald,E.M. and Koepp,D.M.
  TITLE     The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box
            protein Fbw7-gamma
  JOURNAL   PLoS One 7 (10), e47736 (2012)
   PUBMED   23082202
REFERENCE   3  (bases 1 to 6280)
  AUTHORS   Mairhofer,M., Steiner,M., Salzer,U. and Prohaska,R.
  TITLE     Stomatin-like protein-1 interacts with stomatin and is targeted to
            late endosomes
  JOURNAL   J Biol Chem 284 (42), 29218-29229 (2009)
   PUBMED   19696025
  REMARK    GeneRIF: Stomatin-like protein-1 interacts with stomatin and is
            targeted to late endosomes
REFERENCE   4  (bases 1 to 6280)
  AUTHORS   Gilles,F., Glenn,M., Goy,A., Remache,Y. and Zelenetz,A.D.
  TITLE     A novel gene STORP (STOmatin-Related Protein) is localized 2 kb
            upstream of the promyelocytic gene on chromosome 15q22
  JOURNAL   Eur J Haematol 64 (2), 104-113 (2000)
   PUBMED   10997330
REFERENCE   5  (bases 1 to 6280)
  AUTHORS   Seidel,G. and Prohaska,R.
  TITLE     Molecular cloning of hSLP-1, a novel human brain-specific member of
            the band 7/MEC-2 family similar to Caenorhabditis elegans UNC-24
  JOURNAL   Gene 225 (1-2), 23-29 (1998)
   PUBMED   9931417
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF156557.1, AK302051.1 and AC108137.8.
            
            On Nov 22, 2018 this sequence version replaced NM_004809.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.198621.1, AF156557.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000541638.6/ ENSP00000442478.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1987              AF156557.1         62-2048
            1988-1988           AK302051.1         1846-1846
            1989-6280           AC108137.8         115282-119573       c
FEATURES             Location/Qualifiers
     source          1..6280
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..6280
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
                     /note="stomatin like 1"
                     /db_xref="GeneID:9399"
                     /db_xref="HGNC:HGNC:14560"
                     /db_xref="MIM:608326"
     exon            1..205
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1269
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     stomatin (EBP72)-like 1; stomatin-like protein 1;
                     EPB72-like 1; EPB72-like protein 1; protein unc-24
                     homolog; stomatin-related protein; stomatin (EPB72)-like
                     1"
                     /codon_start=1
                     /product="stomatin-like protein 1 isoform 1"
                     /protein_id="NP_004800.2"
                     /db_xref="CCDS:CCDS10254.1"
                     /db_xref="GeneID:9399"
                     /db_xref="HGNC:HGNC:14560"
                     /db_xref="MIM:608326"
                     /translation="MLGRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPERGGVGTGA
                     DVPQSWPSCLCHGLISFLGFLLLLVTFPISGWFALKIVPTYERMIVFRLGRIRTPQGP
                     GMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVK
                     DLNTATRMTAQNAMTKALLKRPLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELA
                     VEAVLQPPQDSPAGPNLDSTLQQLALHFLGGSMNSMAGGAPSPGPADTVEMVSEVEPP
                     APQVGARSSPKQPLAEGLLTALQPFLSEALVSQVGACYQFNVVLPSGTQSAYFLDLTT
                     GRGRVGHGVPDGIPDVVVEMAEADLRALLCRELRPLGAYMSGRLKVKGDLAMAMKLEA
                     VLRALK"
     exon            206..312
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
                     /inference="alignment:Splign:2.1.0"
     exon            313..462
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
                     /inference="alignment:Splign:2.1.0"
     exon            463..666
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
                     /inference="alignment:Splign:2.1.0"
     exon            667..862
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1075
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..6280
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1964..1969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
                     /note="hexamer: AATAAA"
     polyA_site      1987
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
                     /note="major polyA site"
     regulatory      5061..5066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
                     /note="hexamer: ATTAAA"
     polyA_site      5100
                     /gene="STOML1"
                     /gene_synonym="hUNC-24; SLP-1; STORP"
ORIGIN      
        1 ggggccgcgt agggcccact ggccagggag ggcgccgcgc ggaggcgcgg ggcgtgtctc
       61 ctgtcaaaag ccatgctcgg caggtctggg taccgggcgc tgcccctggg tgattttgac
      121 cgcttccagc agtcgagctt cggctttctg ggctcgcaga agggctgctt gtccccggag
      181 cggggcggcg tggggacagg ggccgatgta ccccagagct ggccctcctg cctctgtcat
      241 ggcctcatca gtttcctggg gttcttgctg ctgttggtca ccttccccat ttctggctgg
      301 tttgccctga agattgtgcc cacctacgag cggatgattg tgttccgcct gggccggatc
      361 cgcacccccc agggacctgg catggttctg ctcttgccct tcattgactc ctttcagagg
      421 gtggatctga ggacacgagc cttcaacgtc cctccctgca agctggcctc taaggacggg
      481 gctgtgctgt ccgtgggagc cgatgtccag tttcgcatct gggacccggt gctgtcggtg
      541 atgactgtga aagacctgaa cacagccaca cgcatgacag cccagaacgc catgaccaag
      601 gccctgctca agaggccgct gcgggagatc cagatggaga agctcaagat cagcgaccag
      661 cttctgctgg agatcaacga tgtgaccagg gcctgggggc tggaggtaga ccgcgtggag
      721 ctggcagtgg aggccgtgct ccagccgccc caggacagcc cagctgggcc caacctggac
      781 agcaccctcc agcagctggc cctgcacttc ctgggaggaa gcatgaactc aatggcagga
      841 ggtgccccgt ccccggggcc agcagacacc gtggagatgg tgagtgaagt tgagccacct
      901 gcccctcaag ttggtgccag gtccagtccg aagcagcctc tggcggaggg gctactgact
      961 gctctacagc ccttcctgtc tgaggccctg gtcagccaag tcggggcctg ctaccagttc
     1021 aatgtcgtcc tgcccagcgg cacccaaagc gcctacttcc tggacctcac tacaggacga
     1081 ggaagagtgg gacacggggt gcctgatggc atccctgatg tggtggtgga gatggccgag
     1141 gcagacctgc gggccctgct atgcagagag ctgcggcccc tgggggccta catgagtgga
     1201 cggctgaagg tgaagggcga cctggctatg gccatgaagc tggaggctgt cctcagggcc
     1261 ttgaagtagc agccttggct gactttccag agcccagtcc caagcctggc accaagcctg
     1321 aggggcctct tggaggagga ggtgttcatc tgcaccacag agagttgagg ccctaacaaa
     1381 tttcaggccc agccaagagc ccatgaatgg aggctgcagg aggctgagtc cggctgccat
     1441 gcacgtctcc cctacagtgg ttctctggac aaggctttgt ccatcccggt ccccagctga
     1501 gtgcccagcg ctgagctggg tgcacggtgt gattccagga ggagagccag gcctgccctg
     1561 ccctgctggc ttcctgactg gagagacagg acccacagaa acagcctgac agcagctggt
     1621 ttggtccttg tgtgagggac caagcatgtg gcccaggctc taagctctgc ggggattgga
     1681 gagggatggg gagggaaggg aaggcagctc caagaagagg tccctgtggc gaagttacct
     1741 ggggatcctg gctggcccac cttcctggct gcagtccagg cccgtgctgg cgggattggg
     1801 catgggaagg agcagggcct gctgcttccc tggcgctgct cccaaagatt tctgactcat
     1861 ctgccagctc tgtcctgcat gcctggcgag ctggggccca gggcagcatg aaggagagcc
     1921 ctgcgttctg tgcttcttac cagaggtttg caagcctcag acaaataaat gtggtgttta
     1981 caatgtataa aagagaagaa gccaagcggg gctcctgggg gcatggggtg ggctaggagg
     2041 gtccacaagg tccatgctgc cagcccaggc agggattgac atcctggtgg ctgacacaga
     2101 cagaccctca caatatttga agctccttct cctgagtgtc tcaaagcccc tggaagcaag
     2161 ggtggggctg ggtggggagt tctgttcctc tttgtagtgg gatacaggtt caccaggaaa
     2221 ggaaggcatg agtgtgccag agtgtcctgc aaacactgag gggcaggtgg ggtggtcata
     2281 tcccattcaa gagaggagtt ggggccaccg tcagcttccc ctcctggtac actctgtcac
     2341 tgcttctccg ctcgctgacg ggaaggaaac agtcattgag gtctggcccc aggcccagcc
     2401 cagccctgct ttctgctcca gtactctcgc ccaaacccca ggggccccag agaagggggc
     2461 ctctgacttc ttgagtccta agaaaggaat cttactcctt ggagagactt ctgggaaaaa
     2521 caaaaccaca aaaatcaaag cctcccctta agaacagccc ccagcctgtc ctgtggcacc
     2581 gcaacttccc tctcccccaa ggggtctctg cccttcctgg gtgcctggct ctgtcttgtt
     2641 tgctgtctgt ccctgccttt gccagacact gccttgtccc gcctcctgga ggtcctccac
     2701 attgcctgag gcacctccct aaagcccagc acagacccct ctgtcactgc catggccatt
     2761 gaggttcagg tttccagggc cccttcctag agtcccaggc tgctgcacct gctgttgccc
     2821 ctttgcctac ttggaggcct ctcatgggcc ctcccagggc tttctagctg aggctgtctg
     2881 ttccaaagcc tgccctccaa tccccgcagc cacactgtgg ccaccctttg aggcccagtg
     2941 agacttgtcc tctgtgccct tgcctggctc tctgcaccca ttccacattg tgtgtttctg
     3001 ctccttgcat atatggctgc cctccctgct ggactgggag cttcctgcat cagcattcac
     3061 ctgtggattc cttccattgc tattacacag tatatgaagg gctgcccagg aaaccccagg
     3121 catcttcacc atgaaagctg gcacggcccc ttggctgggg tagggctgga gggtagggaa
     3181 gacaggaaaa atgagatcac aacttagggg aaacccaaac tcttctttgt gagcatggga
     3241 agatcaacat aacgtttagg ggaaaccgaa acttttctgg atgtctgtgt aggtggagag
     3301 taaggcctgc ccctgccatg aatccccacc ctgtggaggg gagctcgatc cttggccagc
     3361 actccaggac tacagaggac tgagcagacc ctgcagtcca caggggagga aggacaaggg
     3421 ccacctaaag ggtcggtgtg aagagggagg aggagggtgt gtgtcaatca gagaaggctt
     3481 tcctgaggag gtgatgtcct ccacatccca gctaccaagt aggtggacaa taagaagaga
     3541 tggggaaaat cattcagcag aggagaagtc cctgcaaggg cacagctgga agaggcagtc
     3601 aggcaactgg gcttcgggga actagaacct gaagtaccag acaggttgtg tgcgggcatt
     3661 tgaggggcag ggtatagaaa tagtaaccat tactgtgtgc caaatatgtc cttataccgg
     3721 actagacact tcttattata tttttcttca agataacctg gtgaataatg ataatagttt
     3781 aagtatccta gttaatatat taatatataa tgtgttattt tgatgttatt gaaaagtatt
     3841 ttattttttt ttgaaacaag agtcttactc tgttgcccat gttagagtac agtacaatct
     3901 cagctcactg caacctctac ctcccggatt caagtgattc tcctgcctca gacacctgag
     3961 tagccaggat tataggcgca taccaccaca cctggttaat ttttgtattt ttagtagaga
     4021 tgggatttca ccatgttgac caggctggtc tcgaactcct gacctcaagt gatctgcctg
     4081 cctaggcctc ccaaagtgct gggattatag gtgtgagcca ccgcacctgg ccttattttt
     4141 aagcatttaa aaaaaatttt ttagaccgtc ttgctctatc acccaggctg gagtgcagtg
     4201 gcatgatcat agctcactgt agccttgaac tctggggctc aaacgatcct cttgcctcag
     4261 cttcctgagt agctgggacc acaggttgtg ccaccacaac cggctaattt ttaaaatctc
     4321 ttttgtagag ataaggatgt ctccccatgt tgctcaggct ggtcttgaac tcctgggctc
     4381 gcaggatcct cccaccacag cctcccaaag tgctgggatt acaggtgtga gccactgtac
     4441 ccagccaata tttaaatttt ggttggctaa acatttaaaa agataggaaa gcatattatg
     4501 aaaattctcc ctccacacat atttcccatg ccttccccca tcccctgcga ttagtttctt
     4561 ggtaattctt cctgaaggtt ttgtttttta aaaaaaaata tatgcaagaa aatccaaata
     4621 tgtatcttct gggtttttgt tgttcctgtt tttatacaaa tggcaacata gaaacacaat
     4681 gttgcctttt tcacttaaca ttacccactg aggatctttc catgttacca cagacagcct
     4741 ttccctgtgc tttcttgtac ttacatagga ttccacagta tggatgtatc ataaattatt
     4801 caacctgtcg tggaccgata gacattttga ttatttcttg tgttttgcta ttttaaatac
     4861 ttttgcaatg aataaccttt aacatgtgct atttgtggta gagtttatct ataagataaa
     4921 atcctagaag tggaattgct aaatcaaagc atttataatt tagtaaatat tgccagaata
     4981 ccttctctgg ggattatacc aatttacact cccattgtca gtggtgtttt tttctcatag
     5041 tcatgtcaat acactgtgtt attaaacttt tgggtctttt gacattctgg aaagtgaaaa
     5101 tttgtatctc agtgtaattt ttttgtttat tgttcaagtt atttttttgt tttttgtttg
     5161 tttgttttga gacagggtct cactctgtct cccaggctgg agtgcagtgc agtgattgtg
     5221 gctcactgca gcctcaacct cccaggctta aaggatcacc atgcctggct tttttttttt
     5281 tttttttttt gtagagacag ggccttctca agctggtctc taactcctgg cctcaagtga
     5341 tcctcccacc tggccctggc ccgctaactg ctaggattac aggcatgagc catctagccc
     5401 agcctgttta ttgtccaatt gtttattgct ttgtaagtct tggatttcta gctccagcaa
     5461 agaacagggt ttggtttggt ttggtttctc ttcccctagc atttacatat tttttaaagg
     5521 tgtaatttac atacaacaaa caccctttta aaatgtatta tttggctggc ttgcgcctct
     5581 aatcccagca ctttgggagg ccgaggcagg tggatcacct gaggtcagga gtttgagacc
     5641 agcctgaccg atatggtgaa accccatctc tactaaaaat acaaaattta gccaggcatg
     5701 gtggtacacg gctgtagtcc cagctactcg ggaggctgag acaggagaat tgcttgaacc
     5761 caggaggtgg aagttgcagt gagttgagat catgccactg cactttagcc tgggcaacag
     5821 agtgagactc catctcaaaa ttaaataaat aaagataaaa taaaaagtgt catctgaggt
     5881 gctttgacaa atgtgaacac ctgagtaacc accaccccct acaatcaaat acaaaacatt
     5941 cccatccact cacaaagttc tccacgtcac ttcccgtcag tgcttgccac ctccagcttt
     6001 gagcagccac tgacctttcc ataaccgctg atcacatttc acttttctag catttcatat
     6061 gaatgaaatg agtgcacagt actcttctgt gtctagcttt ttccccctca ctgtaatggt
     6121 tttgagagta atacatgtta ttctgtgtat ctgtagtttg ttgtattgcc aacacattcc
     6181 attgtctaga tagaggcaca atgtattcat tcatccattg atgaacattt gagtagtttt
     6241 caggtttggt tattaaataa agctcctcca gacatctgtg
//
