LOCUS       NM_024928               6369 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens STN1 subunit of CST complex (STN1), mRNA.
ACCESSION   NM_024928
VERSION     NM_024928.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6369)
  AUTHORS   Takai,H., Aria,V., Borges,P., Yeeles,J.T.P. and de Lange,T.
  TITLE     CST-polymerase alpha-primase solves a second telomere
            end-replication problem
  JOURNAL   Nature 627 (8004), 664-670 (2024)
   PUBMED   38418884
  REMARK    GeneRIF: CST-polymerase alpha-primase solves a second telomere
            end-replication problem.
REFERENCE   2  (bases 1 to 6369)
  AUTHORS   Jaiswal,R.K., Lei,K.H., Chastain,M., Wang,Y., Shiva,O., Li,S.,
            You,Z., Chi,P. and Chai,W.
  TITLE     CaMKK2 and CHK1 phosphorylate human STN1 in response to replication
            stress to protect stalled forks from aberrant resection
  JOURNAL   Nat Commun 14 (1), 7882 (2023)
   PUBMED   38036565
  REMARK    GeneRIF: CaMKK2 and CHK1 phosphorylate human STN1 in response to
            replication stress to protect stalled forks from aberrant
            resection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6369)
  AUTHORS   Zaug,A.J., Goodrich,K.J., Song,J.J., Sullivan,A.E. and Cech,T.R.
  TITLE     Reconstitution of a telomeric replicon organized by CST
  JOURNAL   Nature 608 (7924), 819-825 (2022)
   PUBMED   35831508
  REMARK    GeneRIF: Reconstitution of a telomeric replicon organized by CST.
REFERENCE   4  (bases 1 to 6369)
  AUTHORS   He,Q., Lin,X., Chavez,B.L., Agrawal,S., Lusk,B.L. and Lim,C.J.
  TITLE     Structures of the human CST-Polalpha-primase complex bound to
            telomere templates
  JOURNAL   Nature 608 (7924), 826-832 (2022)
   PUBMED   35830881
  REMARK    GeneRIF: Structures of the human CST-Polalpha-primase complex bound
            to telomere templates.
REFERENCE   5  (bases 1 to 6369)
  AUTHORS   Dos Santos,G.A., Viana,N.I., Pimenta,R., de Camargo,J.A.,
            Guimaraes,V.R., Romao,P., Candido,P., Ghazarian,V., Reis,S.T.,
            Leite,K.R.M. and Srougi,M.
  TITLE     Pan-cancer analysis reveals that CTC1-STN1-TEN1 (CST) complex may
            have a key position in oncology
  JOURNAL   Cancer Genet 262-263, 80-90 (2022)
   PUBMED   35134616
  REMARK    GeneRIF: Pan-cancer analysis reveals that CTC1-STN1-TEN1 (CST)
            complex may have a key position in oncology.
REFERENCE   6  (bases 1 to 6369)
  AUTHORS   Vasan,R.S., Larson,M.G., Aragam,J., Wang,T.J., Mitchell,G.F.,
            Kathiresan,S., Newton-Cheh,C., Vita,J.A., Keyes,M.J.,
            O'Donnell,C.J., Levy,D. and Benjamin,E.J.
  TITLE     Genome-wide association of echocardiographic dimensions, brachial
            artery endothelial function and treadmill exercise responses in the
            Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S2 (2007)
   PUBMED   17903301
  REMARK    GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6369)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 6369)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 6369)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   10 (bases 1 to 6369)
  AUTHORS   Savage,S.A. and Niewisch,M.R.
  TITLE     Dyskeratosis Congenita and Related Telomere Biology Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133355.13.
            
            On Nov 22, 2018 this sequence version replaced NM_024928.4.
            
            Summary: OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha
            accessory factor (AAF) that stimulates the activity of DNA
            polymerase-alpha-primase (see MIM 176636), the enzyme that
            initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]).
            OBFC1 also appears to function in a telomere-associated complex
            with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009
            [PubMed 19854130]).[supplied by OMIM, Nov 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.4137.1,
                                           SRR14038195.2732492.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000224950.8/ ENSP00000224950.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL133355.13        188674-188758       c
            86-280              AL133355.13        188036-188230       c
            281-376             AL133355.13        181101-181196       c
            377-442             AL133355.13        175665-175730       c
            443-604             AL133355.13        170636-170797       c
            605-728             AL133355.13        169451-169574       c
            729-900             AL133355.13        168122-168293       c
            901-1023            AL133355.13        162704-162826       c
            1024-1096           AL133355.13        159646-159718       c
            1097-6369           AL133355.13        148143-153415       c
FEATURES             Location/Qualifiers
     source          1..6369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.33"
     gene            1..6369
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /note="STN1 subunit of CST complex"
                     /db_xref="GeneID:79991"
                     /db_xref="HGNC:HGNC:26200"
                     /db_xref="MIM:613128"
     exon            1..85
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            86..280
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1254
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /note="oligonucleotide/oligosaccharide-binding
                     fold-containing protein 1; alpha accessory factor 44;
                     replication protein A 32 kDa subunit; suppressor of cdc
                     thirteen homolog; oligonucleotide/oligosaccharide binding
                     fold containing 1; STN1, CST complex subunit"
                     /codon_start=1
                     /product="CST complex subunit STN1"
                     /protein_id="NP_079204.2"
                     /db_xref="CCDS:CCDS7552.1"
                     /db_xref="GeneID:79991"
                     /db_xref="HGNC:HGNC:26200"
                     /db_xref="MIM:613128"
                     /translation="MQPGSSRCEEETPSLLWGLDPVFLAFAKLYIRDILDMKESRQVP
                     GVFLYNGHPIKQVDVLGTVIGVRERDAFYSYGVDDSTGVINCICWKKLNTESVSAAPS
                     AARELSLTSQLKKLQETIEQKTKIEIGDTIRVRGSIRTYREEREIHATTYYKVDDPVW
                     NIQIARMLELPTIYRKVYDQPFHSSALEKEEALSNPGALDLPSLTSLLSEKAKEFLME
                     NRVQSFYQQELEMVESLLSLANQPVIHSASSDQVNFKKDTTSKAIHSIFKNAIQLLQE
                     KGLVFQKDDGFDNLYYVTREDKDLHRKIHRIIQQDCQKPNHMEKGCHFLHILACARLS
                     IRPGLSEAVLQQVLELLEDQSDIVSTMEHYYTAF"
     exon            281..376
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            377..442
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            443..604
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            605..728
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            729..900
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1023
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1096
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..6369
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1378..1383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /note="hexamer: AATATA"
     polyA_site      1408
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /note="major polyA site"
     regulatory      1842..1847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /note="hexamer: AATAAA"
     polyA_site      1865
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /note="major polyA site"
     regulatory      2204..2209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /note="hexamer: AATAAA"
     polyA_site      2222
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
     regulatory      3778..3783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /note="hexamer: AATAAA"
     polyA_site      3803
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
     regulatory      6345..6350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
                     /note="hexamer: AATAAA"
     polyA_site      6369
                     /gene="STN1"
                     /gene_synonym="AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32"
ORIGIN      
        1 ggggtcgtcg ccgccagcgg ctccgagcgc cggaagggcc aggtctcagg gctcctggag
       61 ctgcaggcgg cgggaggggc tacaaatgct tgactcagtg atgcagaacc tttcagagtt
      121 agctggaagc cacagccctg cctcttgatg cagcctggat ccagccggtg tgaagaggag
      181 accccttccc tcttgtgggg tttggatcct gtgtttctag cctttgcaaa actctacatc
      241 agggatatcc tggacatgaa ggagtcccgc caggtgccag gtgtattttt gtacaatgga
      301 catccaataa aacaggtaga tgtcttggga actgtcattg gagtgagaga aagagatgct
      361 ttctacagtt atggagtgga tgacagcact ggagttataa actgcatctg ctggaaaaag
      421 ttgaatactg agtctgtatc agctgctcca agtgcagcaa gagagctcag cttaacctca
      481 caacttaaga agctacaaga gaccattgag cagaaaacaa agatagagat cggggacacg
      541 atccgagtca gaggcagtat ccgcacatac agagaagagc gagagattca tgccaccact
      601 tactataaag tggacgaccc agtgtggaac attcaaattg caaggatgct tgagctgccc
      661 actatctaca ggaaagttta tgaccagcct tttcacagct cagccctaga gaaagaagag
      721 gcactaagca atccaggcgc cctggacctc cccagtctca cgagtttgct gagtgaaaaa
      781 gccaaagaat tcctcatgga gaacagagtg cagagctttt accagcagga gctggaaatg
      841 gtggagtctt tgctgtccct tgccaatcag cctgtgattc acagtgcctc ctccgaccaa
      901 gtgaatttta agaaggacac cacttccaag gcaattcata gtatatttaa gaatgctata
      961 caactgctgc aggaaaaagg acttgttttc cagaaagatg atggttttga taacctatac
     1021 tatgtaacca gagaagacaa agacctgcac agaaagatcc accggatcat tcagcaggac
     1081 tgccagaaac caaatcacat ggagaagggc tgtcacttcc tgcacatctt ggcctgtgct
     1141 cgcctgagca tccgcccggg cctgagcgag gctgtgctgc agcaagttct ggagctcctg
     1201 gaggaccaga gtgacattgt cagcacaatg gagcactact acacagcgtt ctgagcagag
     1261 acacgcagac cagctgagga ggacaaagat aaggtggcat tcacccccag gctctgactt
     1321 tcagcatcat gcaggggctt atctgtctgg aggcagttac ctcataataa actataaaat
     1381 atagtcatct tgggaatggg atttggcata aatgttgttg gctcccttct gtccactatg
     1441 tccttggtgt acaatgactt tgatctcagc catgacacaa caagaaaacc ctccctgttg
     1501 agctcctggc tggactgtgc gttgttcgca gagcagaatg gggaggaaac agtgttggca
     1561 gcttaactga tgtgtgtggt tggagtctct tccatggcaa agggacacca cagggtagtg
     1621 aacattcagg aactgagggg catatggcct gatcacacag ttctaagctt ttcaaaactt
     1681 caggttatca gagaccttcc tgtgggcctc tcttgctggc taagaaccgg tttaggggag
     1741 tagttctccc tggatgagtg cttacagttt ctgtggctca gttaccagca gtggggttga
     1801 gacctgggtc gatgctcttt acaggcctgc ccagagatgg gaataaacag ggatccacag
     1861 cgtgactatg tgtttgtcat tttcctttta tttccttggg aatcgaaagg tgtcccagta
     1921 catttccctg cacttacaga ggtgcatgac taaatacatt gtccctcgat gcccctgaag
     1981 atcacggagg cagtcagcca attgcctggc aggtggtaga tgttattttc agggttgccg
     2041 ctgagtgtgc aggatgtgct gacaccatcc agacaaagac tcggtatgtg cccagacagg
     2101 tgatggagtc atgcttttgc tcagaatgac aaggtaaagg aaaaacatct gaggtatgtt
     2161 gtaggcctgt tctgacagca aaatgacaaa tccagccagc aaaaataaag tgtggagaaa
     2221 gatttggagt taattacagt catttcacag aaggcactgc cttcgtctgc tgcatttgct
     2281 cttgatgtga taagctcttc gtggctcagc tggagatcct ttaggcctgg agagttgctc
     2341 ctctctccgt ggaaacagga cagtctttat acgcagaagt ccgctgcagc tcgatacgtc
     2401 aggctgagag ctagaaccag tagattgcct cctgtcatag acttttgtaa tgatgcaaac
     2461 ctttgctgat ttctaacagt gattatgtag tggctgccct gcatcttctc tgtgtacaga
     2521 agggtcccta gcatagagtc tgcctggaat gatgtcctgg gcagttcttc cttgaggtca
     2581 gcagctgttc cacgttgaat gcatctgatt agtggggctg cccaggaagg agttcagaat
     2641 cagaaggtaa aaagggcata cccttgccta tagcaactct gctcttaggg gtttatctca
     2701 aggagatggc tacacaagtg tgaaaggatg gttgcacaag gtgttcattg ctgtataatc
     2761 tagaattcta tattggggaa aatacctata gggaaaaagt taattacggt tcttgggcac
     2821 aatgaaatac tatgcagcta tgaaaaaaat gatgaaagca gacagacagt gttgccatgg
     2881 cacactgtcc ctagtagatt tagtgggaag tagatagagt tatagatctg tttctatagt
     2941 ataacaccat tatctacagc tccctgtgtg tatgtatata tccgtagaga gagtgtatat
     3001 ttctgcatgg aggtctttat aaatgtagca catgtacata tatatatata tacacacaca
     3061 cagtcgacca ctcccttctc ctggaagtac tttccgcgtt tggctttcag gacaccaagc
     3121 tctctggttg ctccttctca ggttcctttg ttcagtgctc tgcctccctg aggactcagt
     3181 cccagacctc ttttctatct ggcttgctca ctggggtgtc tccagcagcc acatggatta
     3241 taccatctac atgctgtcta acacctcagt ttaaacccag aatgggcctc ttccctgaac
     3301 tgcagacccc tatattcagt ttgctactga catctccact taggtctcta atggacatct
     3361 cagatttcac aggcccaaag ccaggctccc aattactcct gaccccaggc ttgctcctga
     3421 tagtgacatg aggcagccaa atgcctaggc agagagggga gggtcccaaa tgaaacccca
     3481 cgttcaagca aagatcagcc tgaaggctaa aagaccagat tgctggtcct ggatgaaacc
     3541 caccacgcag agtgggaact tctgttcctg tttgcccacc ctttcccaat tgttctttct
     3601 gaataacgcc ttaaccaatc gaatgttgcc ttttccagta atacctacag cctgcccctc
     3661 cccccattct gagcccataa aaagacccag actcccccat attaagggga ctttcctgcc
     3721 tttgggtagg gggaccaccc ccacgtctcc tctctgttga aaactgtttc atcactcaat
     3781 aaaactccca gctttgctca ctcttccact gtcagcacat tctcattctt ctttggtgct
     3841 gggcaagaac tcaaccagtg tggaagccat acttggccca ggcgggtgaa gtgggcgggc
     3901 cgtctcctgc agcaggtagc atggtcaagc gaggcccagg tgggccgtca ccagccagag
     3961 gtccctggct tgcaaagtga ccgagaaaaa aatcctgtgc cactcctttg gaaaatgtcc
     4021 ctgattcagg aagaggtagc tccatccagt tgctcaaacc aaatccattg gcttctttct
     4081 ttctatcata cctcacatcc aatctgtctg caagtctttt ggctctacct tcagaatatc
     4141 tccagaatct taactgcttc accctcctcc ccggcctcct cagtcctctc tgcttccgcc
     4201 ctggcccctc ttgggctgtt cacagcacag cagctgttgc caccctgtta atgctcccac
     4261 tctcctacag ccttcggtct tgccccaggt aggagcctga ggctgcacag aggtcagcac
     4321 ggccccgctt accctgccct cccagcccag ccgcacgggc cttgcacaca tgcctcggca
     4381 tattcctgcc ttagggctgg tgctcctgct atttcctctt cccaggtaac catgtgaagt
     4441 gcctccctct gccctctttc cagcctttac ttgagtgtca ccttctcagt gaggcctgcc
     4501 ctcattcctc tttcgctgtt tgcaacccat ctcctgtccc ccttcccaga actccctttc
     4561 ctacttcgtt tttcttcaca gtacttgata ctgcctaaca cactccatgg tttcttactt
     4621 gccctgttta ttattttccc ccaatagaca gaatgttcca tgatggcaga attctctgtt
     4681 ttgtttcctt ccatgtcccc agcacctaga acagtgcctg acgcatctcc taagcaatac
     4741 gaccaataag tatgtgtctg gctgccttcc ggctgccagt gtctgcctct ttcctagggg
     4801 cagtggttgc gggggtgctt tctcacatgt cttagtaggc tgtgcaggct ggaagtgctc
     4861 agaagtcaca cccccaggga gcagcctcag ccaacagcac cttggctgta aatgccccag
     4921 ctccctcgcc ctcaggtaag cattgctgag gcacacgttc catactcttt tccacagttc
     4981 ctccgtggga ctgagcacca cccagccacc cacaggagca gctaacctga taaccaccag
     5041 cctcaccctc cctgccttac ttccccgctc ccctttacca catgctgacc tcccagatgc
     5101 atttcttgct ttccggtctc tgtctcagga ttggctcctg gatgaacaca aactaacact
     5161 atgttcacaa atatatttgg gaaatgctgg atgaataatt atacacatca gacagattac
     5221 tagaaattct caccaaaggg atgcacatgt tacctctgca tggtgagatc tcaggtgctt
     5281 tttaccccac atagctatcc tttggcattt ttataattag caagtgctca ctcttccact
     5341 gtcagtacat tctcattctt cttgggcgct ggacaagaat tcaaccggtg tgtaagccag
     5401 actcggcccg ggcagtctca aactcctgac tccttatata atttctacaa aaattataaa
     5461 gctatttccc actccccacc ccacattcat gtaacctgaa gcatgagtaa accaagaatg
     5521 aggtaggcct ctgtcttcta agcaacatca gaactctaag aacatgaggg actcttagaa
     5581 aactctctgg agctaaccac agctgggtca ctgctcatgt actgaagacc agccagaggg
     5641 ttcccctgaa aaggagggaa actgagcaaa cattctccag ttctcttagt gtgcacatgt
     5701 ttcaggaggt gtgaacccca catgtagctt gtgtaggcaa gaagacaaat agtgctactg
     5761 tctggtcaag gatttgtttg aagagccatg attatgccca tatggtaagc caccagtgct
     5821 ccccatccct gtaagacact tctttctcat tattttctcc tctgatggtg tgccaggatg
     5881 ctggccaaga gaagccaagt ggaaagaagg ctgttcagtg acaaggaacc taagacttag
     5941 tgccaaggac tgaaaccaag taaacttgta attttccatg atggaaacat ctacactttc
     6001 tcattagtgg cctctacagc agttgcccca aagaagcgtc tcattgtttt tttactacat
     6061 ttatgtgaag catacaggca aactcagaaa gactgtgata aggctcgcca gagatgcctg
     6121 cacaggtgct gggggaaaag caggaccatc ctgaagggag atggtgtctg tggacaaaga
     6181 actctgcagt ggttcttatt tgcatgattt ctgctggtgg aggctgtaaa tgtgagctca
     6241 aactcccaca taagtgagtt ttcattgtaa tccagaatgt ttttaaatca ccctacttct
     6301 attgaacttg cactatcatc tgttaacctc tactgtattt attaaataaa cctgaatagg
     6361 taaatcaca
//
