LOCUS       NM_001130929            2461 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens short transmembrane mitochondrial protein 1 (STMP1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001130929 XM_930101 XM_935586 XM_938850
VERSION     NM_001130929.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2461)
  AUTHORS   Sang,Y., Liu,J.Y., Wang,F.Y., Luo,X.Y., Chen,Z.Q., Zhuang,S.M. and
            Zhu,Y.
  TITLE     Mitochondrial micropeptide STMP1 promotes G1/S transition by
            enhancing mitochondrial complex IV activity
  JOURNAL   Mol Ther 30 (8), 2844-2855 (2022)
   PUBMED   35450818
REFERENCE   2  (bases 1 to 2461)
  AUTHORS   Xie,C., Wang,F.Y., Sang,Y., Chen,B., Huang,J.H., He,F.J., Li,H.,
            Zhu,Y., Liu,X., Zhuang,S.M. and Fang,J.H.
  TITLE     Mitochondrial Micropeptide STMP1 Enhances Mitochondrial Fission to
            Promote Tumor Metastasis
  JOURNAL   Cancer Res 82 (13), 2431-2443 (2022)
   PUBMED   35544764
  REMARK    GeneRIF: Mitochondrial Micropeptide STMP1 Enhances Mitochondrial
            Fission to Promote Tumor Metastasis.
REFERENCE   3  (bases 1 to 2461)
  AUTHORS   Clemente,T.M., Ratnayake,R., Samanta,D., Augusto,L., Beare,P.A.,
            Heinzen,R.A. and Gilk,S.D.
  TITLE     Coxiella burnetii Sterol-Modifying Protein Stmp1 Regulates
            Cholesterol in the Intracellular Niche
  JOURNAL   mBio 13 (1), e0307321 (2022)
   PUBMED   35073737
  REMARK    GeneRIF: Coxiella burnetii Sterol-Modifying Protein Stmp1 Regulates
            Cholesterol in the Intracellular Niche.
REFERENCE   4  (bases 1 to 2461)
  AUTHORS   Makarewich,C.A., Munir,A.Z., Bezprozvannaya,S., Gibson,A.M., Young
            Kim,S., Martin-Sandoval,M.S., Mathews,T.P., Szweda,L.I.,
            Bassel-Duby,R. and Olson,E.N.
  TITLE     The cardiac-enriched microprotein mitolamban regulates
            mitochondrial respiratory complex assembly and function in mice
  JOURNAL   Proc Natl Acad Sci U S A 119 (6) (2022)
   PUBMED   35101990
REFERENCE   5  (bases 1 to 2461)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2461)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 2461)
  AUTHORS   Mullin,B.H., Zhu,K., Brown,S.J., Mullin,S., Tickner,J.,
            Pavlos,N.J., Dudbridge,F., Xu,J., Walsh,J.P. and Wilson,S.G.
  TITLE     Genetic regulatory mechanisms in human osteoclasts suggest a role
            for the STMP1 and DCSTAMP genes in Paget's disease of bone
  JOURNAL   Sci Rep 9 (1), 1052 (2019)
   PUBMED   30705363
  REMARK    GeneRIF: Genetic regulatory mechanisms in human osteoclasts suggest
            a role for the STMP1 and DCSTAMP genes in Paget's disease of bone.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2461)
  AUTHORS   Zhang,D., Xi,Y., Coccimiglio,M.L., Mennigen,J.A., Jonz,M.G.,
            Ekker,M. and Trudeau,V.L.
  TITLE     Functional prediction and physiological characterization of a novel
            short trans-membrane protein 1 as a subunit of mitochondrial
            respiratory complexes
  JOURNAL   Physiol Genomics 44 (23), 1133-1140 (2012)
   PUBMED   23073385
REFERENCE   9  (bases 1 to 2461)
  AUTHORS   Carroll,J., Altman,M.C., Fearnley,I.M. and Walker,J.E.
  TITLE     Identification of membrane proteins by tandem mass spectrometry of
            protein ions
  JOURNAL   Proc Natl Acad Sci U S A 104 (36), 14330-14335 (2007)
   PUBMED   17720804
  REMARK    GeneRIF: reports the identification by tandem mass spec of a novel
            protein, proteolipid with a mass of 5,283 Da, (PL-5283).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC073942.1, AC091736.2 and BM979743.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001130929.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.402922.1,
                                           SRR1803616.122336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000507606.3/
                                                  ENSP00000425996.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1215              BC073942.1         16-1230
            1216-2255           AC091736.2         10548-11587
            2256-2457           BM979743.1         18-219              c
            2458-2461           AC091736.2         11790-11793
FEATURES             Location/Qualifiers
     source          1..2461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2461
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
                     /note="short transmembrane mitochondrial protein 1"
                     /db_xref="GeneID:647087"
                     /db_xref="HGNC:HGNC:41909"
                     /db_xref="MIM:618755"
     exon            1..81
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..210
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
                     /note="uncharacterized protein C7orf73; mitolamban"
                     /codon_start=1
                     /product="short transmembrane mitochondrial protein 1
                     precursor"
                     /protein_id="NP_001124401.1"
                     /db_xref="CCDS:CCDS55168.1"
                     /db_xref="GeneID:647087"
                     /db_xref="HGNC:HGNC:41909"
                     /db_xref="MIM:618755"
                     /translation="MLQFLLGFTLGNVVGMYLAQNYDIPNLAKKLEEIKKDLDAKKKP
                     PSA"
     exon            82..135
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
                     /inference="alignment:Splign:2.1.0"
     exon            136..2461
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
                     /inference="alignment:Splign:2.1.0"
     regulatory      473..478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
                     /note="hexamer: AGTAAA"
     polyA_site      493
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
                     /note="major polyA site"
     regulatory      658..663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
                     /note="hexamer: ATTAAA"
     polyA_site      680
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
     regulatory      1191..1196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
                     /note="hexamer: ATTAAA"
     polyA_site      1215
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
     regulatory      1251..1256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
                     /note="hexamer: TATAAA"
     polyA_site      1283
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
     regulatory      2437..2442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
                     /note="hexamer: AATAAA"
     polyA_site      2461
                     /gene="STMP1"
                     /gene_synonym="C7orf73; Mm47; Mtlbn; PL-5283"
ORIGIN      
        1 aggctcggac cggcccgcgg agctgctgca gtccttcgcg ccctcctcgc cctccccacc
       61 gacatcatgc tccagttcct gcttggattt acactgggca acgtggttgg aatgtatctg
      121 gctcagaact atgatatacc aaacctggct aaaaaacttg aagaaattaa aaaggacttg
      181 gatgccaaga agaaaccccc tagtgcatga gactgcctcc agcactgcct tcaggatata
      241 ctgattctac tgctcttgag ggcctcgttt actatctgaa ccaaaagctt ttgttttcgt
      301 ctccagcctc agcacttctc ttctttgcta gaccctgtgt tttttgcttt aaagcaagca
      361 aaatggggcc ccaatttgag aactacccga catttccaac atactcacct cttcccataa
      421 tccctttcca actgcatggg aggttctaag actggaatta tggtgctaga ttagtaaaca
      481 tgacttttaa tgagtagtgt cttctttatc gtttgcgatt tttactacct tttttcaaaa
      541 gaaaaattga tgagttttgt atagctggtc agatacaaat aatagtgact tcacagttta
      601 gtaattataa tgggtacttg ttaaacattt ggtactaaat tatgttgctg caaagtaatt
      661 aaaattagta tctagagcta gtttctggtg aattattcat ttattttgta ctgttgttag
      721 gcagctctgt agttgctaat ttaaccaata agtcaatttg ctattcatga agaaacgatt
      781 ctgagaatcc tgtcaggaat tggggaatga aaaaatacac aaaataatgg tctttgtccc
      841 agtagagttc atagtctatt tagtgtgcat gtttttcctt aatgatgtat ttgatctgac
      901 ttttttcctt ctcaaaagaa tcatacttgg gattacaggt acatttgatg ttatatgatg
      961 gataagtgaa aagtttttaa aggagatttt ataccttttc acattaaaaa aggtatttat
     1021 attattactt tgtagtgatt gtcttaagaa aaaatatagc ccaaatgtat agtaaaatca
     1081 gcagctcaag aagaatttct gcttctcttt gtagttgatg ctttgttttt tcctgcagtc
     1141 agaaattcct tgtatttgtc aaatgtataa tcagcttgta ttgtttttaa attaaaaaaa
     1201 aatttgaata attaactttt gccatgggac aagatacaaa agtaatttca tataaagggc
     1261 ctctcccacc cctgttctct ggctcctggc tcctgtttga caagttactg ttaccacttc
     1321 gccttatact tttgagaaag agtctgtgcc taaacaaaca cgtgtaacac aaatagtaac
     1381 tatacatgga ggtctagccc tcgccttttt tttttctttt tttctttttt aatggagatc
     1441 attctatacc agcatgtaag tagcaaggaa cctcattctt tttttggctg cctaaaattt
     1501 ttttgaatag atataacata attgatttaa tctgctactg gtgaatgctt aggttgttct
     1561 tttgctatta cagtgataac ttcaatccta atgttattaa gcatatcgat tcagggtata
     1621 gctataagat gaagtcctaa aagtataatt tagactaaat acaaataccc atttcgctag
     1681 ctgttttgtt tcagaggact tgttgagcag cttcactaat aatgccattt ttgaagacat
     1741 ggcaggttca gaatcaataa actggaagaa ttgttcagag catctttttt cagacagtga
     1801 tgacattgat tctgtatatg ataaagtgat tctgcttctc tttgacaact tgcatctctc
     1861 ctacatggaa gtaagtttta ttcctgtcaa tgttgtcttt gtgtgtgaca gattaggatt
     1921 aaattatggt ttgacttttc ctagcagcgt gatcatgggc aagtggcttt tttttttttt
     1981 tttttttgag acagagtctc actctgctgc ccaggctgga gtgcagtggc acagtcttgg
     2041 ctcactgcaa ctcctgcctc ccggtccaag tgattctcgt gctgcagctt ctcaagtagc
     2101 tggcatcacc accacacctg gctaattttt gtatttttag taacgacgag gtttcaccat
     2161 gttggcaaag ctggtctcaa attcctggcc tcaagtgatc tgcccacttc agcctcccaa
     2221 agtgttggga ttacaggcgt gagccactgc gcccagcttt tttaaacttt tagattcatt
     2281 taataggtaa attgcatgtc acgggtttgt agcttattct ttcagaaact cttgcattat
     2341 ctgtagacgt ggacgtaaat atccacctca tagggttttc ataaaaaata attgagataa
     2401 tgtatgtaat gtttcacagt gctttgcaga ctatctaata aatagtagct attagtacaa
     2461 a
//
