LOCUS       NM_001190766            1536 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens stathmin domain containing 1 (STMND1), mRNA.
ACCESSION   NM_001190766 XM_001725362 XM_376469 XM_939163
VERSION     NM_001190766.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1536)
  AUTHORS   Deng,X., Seguinot,B.O., Bradshaw,G., Lee,J.S., Coy,S., Kalocsay,M.,
            Santagata,S. and Mitchison,T.
  TITLE     STMND1 is a phylogenetically ancient stathmin which localizes to
            motile cilia and exhibits nuclear translocation that is inhibited
            when soluble tubulin concentration increases
  JOURNAL   Mol Biol Cell 35 (6), ar82 (2024)
   PUBMED   38630521
  REMARK    GeneRIF: STMND1 is a phylogenetically ancient stathmin which
            localizes to motile cilia and exhibits nuclear translocation that
            is inhibited when soluble tubulin concentration increases.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL138740.10.
            
            On Aug 7, 2019 this sequence version replaced NM_001190766.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The genomic coordinates used for the
            transcript record were based on transcript alignments and
            orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279857.2139.1,
                                           DRR138524.1093194.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000536551.6/ ENSP00000455698.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AL138740.10        19965-20253
            290-467             AL138740.10        32877-33054
            468-619             AL138740.10        38522-38673
            620-751             AL138740.10        47027-47158
            752-1536            AL138740.10        48509-49293
FEATURES             Location/Qualifiers
     source          1..1536
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..1536
                     /gene="STMND1"
                     /note="stathmin domain containing 1"
                     /db_xref="GeneID:401236"
                     /db_xref="HGNC:HGNC:44668"
     exon            1..289
                     /gene="STMND1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1039
                     /gene="STMND1"
                     /codon_start=1
                     /product="stathmin domain-containing protein 1"
                     /protein_id="NP_001177695.1"
                     /db_xref="CCDS:CCDS58997.1"
                     /db_xref="GeneID:401236"
                     /db_xref="HGNC:HGNC:44668"
                     /translation="MGCGPSQPAEDRRRVRAPKKGWKEEFKADVSVPHTGENCSPRME
                     AALTKNTVDIAEGLEQVQMGSLPGTISENSPSPSERNRRVNSDLVTNGLINKPQSLES
                     RERQKSSDILEELIVQGIIQSHSKVFRNGESYDVTLTTTEKPLRKPPSRLKKLKIKKQ
                     VKDFTMKDIEEKMEAAEERRKTKEEEIRKRLRSDRLLPSANHSDSAELDGAEVAFAKG
                     LQRVRSAGFEPSDLQGGKPLKRKKSKCDATLIDRNESDESFGVVESDMSYNQADDIVY
                     "
     exon            290..467
                     /gene="STMND1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..619
                     /gene="STMND1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..751
                     /gene="STMND1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1536
                     /gene="STMND1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1518..1523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STMND1"
                     /note="hexamer: AATAAA"
     polyA_site      1536
                     /gene="STMND1"
                     /note="major polyA site"
ORIGIN      
        1 attcctggcg actgcccaga aactcagtgc gtcctgcccg gggtttaagc gcgggaagtg
       61 ggagaggcgg gtggcgcccg agcgcagtag caggggcgta gggcgcaggg cgcaggagcg
      121 cgggaccacc ggcgccggag cgcggcaggg agcgctcgcg ggggcgcaca gcagccaagc
      181 ccgcggagga ggagcgcgcg cgcgcagcat gggctgtgga ccttcccaac ctgctgaaga
      241 ccggagacgt gtacgcgcgc ccaagaaggg ctggaaagag gaattcaagg ctgatgtcag
      301 tgtgcctcat actggggaaa attgcagccc ccggatggaa gctgctctga ccaagaatac
      361 tgtggacatt gcagaaggcc tggaacaagt ccagatggga agcttacctg gaaccatttc
      421 agaaaattct ccatctccta gtgaaagaaa cagacgagta aattcagacc tagtgaccaa
      481 tggattaatc aataaacccc aatccctaga gagtcgagag cgacagaagt catcagatat
      541 cctggaggaa ctaattgttc aaggaattat acaaagccac agcaaagtat ttagaaatgg
      601 agaatcatat gatgtcacgt tgactacgac tgagaagcca ttgagaaagc caccttccag
      661 actgaaaaaa ctcaagatca aaaagcaagt gaaggatttc acaatgaagg acatcgagga
      721 gaagatggag gctgccgagg agcgcaggaa gactaaagaa gaagaaataa gaaaaaggct
      781 acggagtgac cgacttttgc cttcagccaa tcactcagat tcagctgaat tagatggggc
      841 cgaggttgca tttgccaaag gacttcaaag ggtgaggtct gctggatttg aaccatctga
      901 cctgcaggga ggaaaaccat tgaagaggaa gaagagtaaa tgtgatgcaa ccttgattga
      961 tagaaacgaa agtgatgaaa gttttggggt cgtggagtca gacatgtcct acaaccaagc
     1021 agatgacata gtctactaag ccattttttg tgaatttcat aagaaagcat tcattctccc
     1081 catttgtgac atttgtagta tgtctcatat tctttgactg actgacctca ttccactggg
     1141 atttctgcct tgggcttaag gatgattgtg tgggctgcac aggctgaagg ttagttgagt
     1201 aaattaagta gctatgctag cttttaaaaa aagagcgagg gggagacttg accagcatag
     1261 atatttggca ctctcctttg tgtggcttca aacattatgg agatgtcttt aattcattta
     1321 taagtgcctt cagtttacat taataagttc gtgccaaatg aaatccttcc tgtttactcc
     1381 tgccttgtgg cggggtccat cctctgctgc tcctttaaaa caaattgcat ggatttgtat
     1441 taagtatttt aatggcttat atgtttttta tgctgtatgt ctatggtttt ataatttttt
     1501 tctctgtgtt gtgaaggaat aaagcaatgt cttgaa
//
