LOCUS       NM_030795               2321 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens stathmin 4 (STMN4), transcript variant 1, mRNA.
ACCESSION   NM_030795
VERSION     NM_030795.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2321)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2321)
  AUTHORS   Bieche,I., Maucuer,A., Laurendeau,I., Lachkar,S., Spano,A.J.,
            Frankfurter,A., Levy,P., Manceau,V., Sobel,A., Vidaud,M. and
            Curmi,P.A.
  TITLE     Expression of stathmin family genes in human tissues:
            non-neural-restricted expression for SCLIP
  JOURNAL   Genomics 81 (4), 400-410 (2003)
   PUBMED   12676564
REFERENCE   3  (bases 1 to 2321)
  AUTHORS   Gavet,O., Ozon,S., Manceau,V., Lawler,S., Curmi,P. and Sobel,A.
  TITLE     The stathmin phosphoprotein family: intracellular localization and
            effects on the microtubule network
  JOURNAL   J Cell Sci 111 (Pt 22), 3333-3346 (1998)
   PUBMED   9788875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090150.9, BC011520.1 and AI638208.1.
            
            On Jun 2, 2019 this sequence version replaced NM_030795.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011520.1, SRR1803613.146820.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350889.9/ ENSP00000342538.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC090150.9         190336-190353       c
            19-1332             BC011520.1         1-1314
            1333-2036           AC090150.9         167542-168245       c
            2037-2306           AI638208.1         12-281              c
            2307-2321           AC090150.9         167257-167271       c
FEATURES             Location/Qualifiers
     source          1..2321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..2321
                     /gene="STMN4"
                     /gene_synonym="RB3"
                     /note="stathmin 4"
                     /db_xref="GeneID:81551"
                     /db_xref="HGNC:HGNC:16078"
                     /db_xref="MIM:620740"
     exon            1..54
                     /gene="STMN4"
                     /gene_synonym="RB3"
                     /inference="alignment:Splign:2.1.0"
     exon            55..145
                     /gene="STMN4"
                     /gene_synonym="RB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..783
                     /gene="STMN4"
                     /gene_synonym="RB3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     stathmin-like-protein RB3; stathmin-like protein B3;
                     stathmin-like 4"
                     /codon_start=1
                     /product="stathmin-4 isoform 1"
                     /protein_id="NP_110422.2"
                     /db_xref="CCDS:CCDS6055.1"
                     /db_xref="GeneID:81551"
                     /db_xref="HGNC:HGNC:16078"
                     /db_xref="MIM:620740"
                     /translation="MTLAAYKEKMKELPLVSLFCSCFLADPLNKSSYKYEGWCGRQCR
                     RKDESQRKDSADWRERRAQADTVDLNWCVISDMEVIELNKCTSGQSFEVILKPPSFDG
                     VPEFNASLPRRRDPSLEEIQKKLEAAEERRKYQEAELLKHLAEKREHEREVIQKAIEE
                     NNNFIKMAKEKLAQKMESNKENREAHLAAMLERLQEKDKHAEEVRKNKELKEEASR"
     exon            146..241
                     /gene="STMN4"
                     /gene_synonym="RB3"
                     /inference="alignment:Splign:2.1.0"
     exon            242..322
                     /gene="STMN4"
                     /gene_synonym="RB3"
                     /inference="alignment:Splign:2.1.0"
     exon            323..531
                     /gene="STMN4"
                     /gene_synonym="RB3"
                     /inference="alignment:Splign:2.1.0"
     exon            532..723
                     /gene="STMN4"
                     /gene_synonym="RB3"
                     /inference="alignment:Splign:2.1.0"
     exon            724..2321
                     /gene="STMN4"
                     /gene_synonym="RB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1314..1319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STMN4"
                     /gene_synonym="RB3"
                     /note="hexamer: AATGAA"
     polyA_site      1326
                     /gene="STMN4"
                     /gene_synonym="RB3"
                     /note="major polyA site"
     polyA_site      1332
                     /gene="STMN4"
                     /gene_synonym="RB3"
     regulatory      2283..2288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STMN4"
                     /gene_synonym="RB3"
                     /note="hexamer: AATAAA"
     polyA_site      2321
                     /gene="STMN4"
                     /gene_synonym="RB3"
ORIGIN      
        1 accactaatt gagggagtga ggaagagagc agctcgcttc taactggact gcacgttggt
       61 gacagcgtcc caagctggtg acagacccac tctgtaactt tcagctagat tcagccacca
      121 gatcccagaa acatgaccct tgctgcctac aaagagaaga tgaaggagct cccgctggtg
      181 tccttgttct gctcctgctt cctggccgat cccctgaata agtcgtccta caaatatgaa
      241 ggctggtgtg ggagacagtg taggaggaag gatgaaagcc agcggaaaga cagtgctgac
      301 tggagagaaa gaagagctca ggcagacacg gtggacctga attggtgcgt catttccgac
      361 atggaagtca tcgagctgaa caaatgcacc tcgggccaat cctttgaagt catcctgaag
      421 ccaccctcct ttgatggggt tcccgagttc aacgcctccc tgccaaggcg gcgagaccca
      481 tccctggaag agatccagaa gaaactagaa gcggctgagg agcgaaggaa gtaccaggaa
      541 gcggagctcc tgaaacacct agcagagaaa cgggaacatg agagagaggt gatccaaaag
      601 gccattgagg aaaacaacaa cttcatcaag atggctaagg aaaaactggc ccagaagatg
      661 gaatccaaca aggagaacag ggaggcccac ctcgccgcca tgttggaacg gctgcaagag
      721 aaggacaagc acgccgagga ggtgcggaaa aacaaggagc tgaaggaaga ggcctccagg
      781 taaagcctag aggccaaaga actttccagg tcagccggac agctccagca gctccacgtt
      841 ccaggcagcc tcgcccgccg gctgcgctcc cagcactggg gtttgggggg aggggggtgg
      901 ccaaggggcg tttcctctgc ttttggtgtt tgtacatgtt aagaattgac cagtgaagcc
      961 atcctatttg tttccgggga acaatgacgg ggtgggagag gggagaggag agagtttggg
     1021 aaagggagat ggagaagaac tcaaggacat tgcaaccctg cccggcgcag atctgatttt
     1081 cacatctcta cctggacatt gagcctccag gcaccatgtt gaggagagat gaaaaccagg
     1141 gcggtagaac ttcagggtga aggacagagt cctgggtggg gcagcggctg cagggcgcac
     1201 cagagaaccc agccagaggg gttgtgagta ccagtggtgt tgcttccacc ctgcagcagg
     1261 tgggatgagg tctgtgtgtg tgtgtgaacc atcatttttt gatcatcatg accaatgaaa
     1321 cattgactcc aagtgtccag ttctttattt cccaaatgtg tcctttgggt aattgttaaa
     1381 aagttctcga aacctggctt tcatccatct gatggcagat gcccctttgc ttccttaatt
     1441 ctgccattca agcatctgga gcctgggtga ggtgggttga atcaggccag cctttggcat
     1501 aattgaaagg ttttctcttc tgttttttaa aatcccctct gtgggctaat ctttattgga
     1561 tagcatgcac taaattgatg agaaaagaaa ctcaatcttc ctttcaatga actgacatcc
     1621 taatatggtc cccaagatgc actgtaagaa ggaatttgtc ttagtcacaa ccgttcagac
     1681 tgctgtaaca aaatacctta gactaagtaa ttgataacag aaattgattg ctcacagttt
     1741 tggaggctgg gaagtccaat atcaaggtgc cagcagattc agtgtctggt gagggcttgc
     1801 catctgcttc aaagatgatg cctttttgct gcatcctcac atggcagaag ggaagggcaa
     1861 aagggcttcc ttgagccttt tctttaaggc actaatccca ttcatgaagg tggagtcctc
     1921 atgatctcac ctcttaaggc cctatctctt aattctgtag tgtcgggatt aggattcaac
     1981 ctgtatattg ggggagacag caacattcac accatagcag aagtcctcca tgctttgggg
     2041 gtttgagatt ctaggtagat tagaaaatac gagcaaggaa ataaagtgtt tgctagtaga
     2101 aggcaaagga ggcatccaga cccagcagtc ttggtctcca ggacactgaa ccatggctgg
     2161 aaaagaagct ctcctcctcc cttcccctgc aaacatgagt gcaggggctg cctgtgttaa
     2221 ccgggtccca ggacctcttc ccactctgct ctgcacactg tgtagttttt tacagctttg
     2281 caaataaacc ctttggtata gccttttttt ctttcttctc a
//
