LOCUS       NM_007029               1903 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens stathmin 2 (STMN2), transcript variant 2, mRNA.
ACCESSION   NM_007029
VERSION     NM_007029.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Agra Almeida Quadros,A.R., Li,Z., Wang,X., Ndayambaje,I.S.,
            Aryal,S., Ramesh,N., Nolan,M., Jayakumar,R., Han,Y., Stillman,H.,
            Aguilar,C., Wheeler,H.J., Connors,T., Lopez-Erauskin,J.,
            Baughn,M.W., Melamed,Z., Beccari,M.S., Olmedo Martinez,L.,
            Canori,M., Lee,C.Z., Moran,L., Draper,I., Kopin,A.S., Oakley,D.H.,
            Dickson,D.W., Cleveland,D.W., Hyman,B.T., Das,S., Ertekin-Taner,N.
            and Lagier-Tourenne,C.
  TITLE     Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological
            hallmark of TDP-43-associated Alzheimer's disease
  JOURNAL   Acta Neuropathol 147 (1), 9 (2024)
   PUBMED   38175301
  REMARK    GeneRIF: Cryptic splicing of stathmin-2 and UNC13A mRNAs is a
            pathological hallmark of TDP-43-associated Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Wood,H.
  TITLE     TDP43 blocks misprocessing of STMN2 RNA
  JOURNAL   Nat Rev Neurol 19 (6), 326 (2023)
   PUBMED   37012364
  REMARK    GeneRIF: TDP43 blocks misprocessing of STMN2 RNA.
REFERENCE   3  (bases 1 to 1903)
  AUTHORS   Shao,M., Wang,L., Zhang,Q., Wang,T. and Wang,S.
  TITLE     STMN2 overexpression promotes cell proliferation and EMT in
            pancreatic cancer mediated by WNT/beta-catenin signaling
  JOURNAL   Cancer Gene Ther 30 (3), 472-480 (2023)
   PUBMED   36460804
  REMARK    GeneRIF: STMN2 overexpression promotes cell proliferation and EMT
            in pancreatic cancer mediated by WNT/beta-catenin signaling.
REFERENCE   4  (bases 1 to 1903)
  AUTHORS   Doronzio,P.N., Lattante,S., Marangi,G., Martello,F., Conte,A.,
            Bisogni,G., Bernardo,D., Patanella,A.K., Meleo,E., Zollino,M. and
            Sabatelli,M.
  TITLE     Analysis of STMN2 CA repeats in italian ALS patients shows no
            association
  JOURNAL   Amyotroph Lateral Scler Frontotemporal Degener 24 (1-2), 152-154
            (2023)
   PUBMED   35876065
  REMARK    GeneRIF: Analysis of STMN2 CA repeats in italian ALS patients shows
            no association.
REFERENCE   5  (bases 1 to 1903)
  AUTHORS   Grima,N., Henden,L., Fearnley,L.G., Rowe,D.B., D'Silva,S.,
            Pamphlett,R., Adams,L., Kiernan,M.C., Mazumder,S., Timmins,H.C.,
            Zoing,M., Bahlo,M., Blair,I.P. and Williams,K.L.
  TITLE     NEK1 and STMN2 short tandem repeat lengths are not associated with
            Australian amyotrophic lateral sclerosis risk
  JOURNAL   Neurobiol Aging 116, 92-95 (2022)
   PUBMED   35613520
  REMARK    GeneRIF: NEK1 and STMN2 short tandem repeat lengths are not
            associated with Australian amyotrophic lateral sclerosis risk.
REFERENCE   6  (bases 1 to 1903)
  AUTHORS   Antonsson,B., Kassel,D.B., Di Paolo,G., Lutjens,R., Riederer,B.M.
            and Grenningloh,G.
  TITLE     Identification of in vitro phosphorylation sites in the growth cone
            protein SCG10. Effect Of phosphorylation site mutants on
            microtubule-destabilizing activity
  JOURNAL   J Biol Chem 273 (14), 8439-8446 (1998)
   PUBMED   9525956
REFERENCE   7  (bases 1 to 1903)
  AUTHORS   Antonsson,B., Lutjens,R., Di Paolo,G., Kassel,D., Allet,B.,
            Bernard,A., Catsicas,S. and Grenningloh,G.
  TITLE     Purification, characterization, and in vitro phosphorylation of the
            neuron-specific membrane-associated protein SCG10
  JOURNAL   Protein Expr Purif 9 (3), 363-371 (1997)
   PUBMED   9126608
REFERENCE   8  (bases 1 to 1903)
  AUTHORS   Di Paolo,G., Lutjens,R., Pellier,V., Stimpson,S.A., Beuchat,M.H.,
            Catsicas,S. and Grenningloh,G.
  TITLE     Targeting of SCG10 to the area of the Golgi complex is mediated by
            its NH2-terminal region
  JOURNAL   J Biol Chem 272 (8), 5175-5182 (1997)
   PUBMED   9030585
REFERENCE   9  (bases 1 to 1903)
  AUTHORS   Okazaki,T., Wang,H., Masliah,E., Cao,M., Johnson,S.A., Sundsmo,M.,
            Saitoh,T. and Mori,N.
  TITLE     SCG10, a neuron-specific growth-associated protein in Alzheimer's
            disease
  JOURNAL   Neurobiol Aging 16 (6), 883-894 (1995)
   PUBMED   8622778
REFERENCE   10 (bases 1 to 1903)
  AUTHORS   Schoenherr,C.J. and Anderson,D.J.
  TITLE     The neuron-restrictive silencer factor (NRSF): a coordinate
            repressor of multiple neuron-specific genes
  JOURNAL   Science 267 (5202), 1360-1363 (1995)
   PUBMED   7871435
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC319376.1, AC025599.8 and
            AC016240.23.
            
            On Jun 2, 2019 this sequence version replaced NM_007029.3.
            
            Summary: This gene encodes a member of the stathmin family of
            phosphoproteins. Stathmin proteins function in microtubule dynamics
            and signal transduction. The encoded protein plays a regulatory
            role in neuronal growth and is also thought to be involved in
            osteogenesis. Reductions in the expression of this gene have been
            associated with Down's syndrome and Alzheimer's disease.
            Alternatively spliced transcript variants have been observed for
            this gene. A pseudogene of this gene is located on the long arm of
            chromosome 6. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (2) lacks an alternate exon, which
            results in a frameshift in the 3' coding region, compared to
            variant 1. The encoded isoform (2) is shorter and has a distinct
            C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.13183.1,
                                           SRR5189652.248641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220876.12/ ENSP00000220876.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                DC319376.1         304-359
            57-98               AC025599.8         107528-107569
            99-194              AC025599.8         133157-133252
            195-367             AC025599.8         137733-137905
            368-559             AC025599.8         151226-151417
            560-1903            AC016240.23        152855-154198       c
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..1903
                     /gene="STMN2"
                     /gene_synonym="SCG10; SCGN10"
                     /note="stathmin 2"
                     /db_xref="GeneID:11075"
                     /db_xref="HGNC:HGNC:10577"
                     /db_xref="MIM:600621"
     exon            1..98
                     /gene="STMN2"
                     /gene_synonym="SCG10; SCGN10"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..619
                     /gene="STMN2"
                     /gene_synonym="SCG10; SCGN10"
                     /note="isoform 2 is encoded by transcript variant 2;
                     neuronal growth-associated protein (silencer element);
                     stathmin-like 2; superior cervical ganglia, neural
                     specific 10; neuron-specific growth-associated protein;
                     superior cervical ganglion-10 protein"
                     /codon_start=1
                     /product="stathmin-2 isoform 2"
                     /protein_id="NP_008960.2"
                     /db_xref="CCDS:CCDS43748.1"
                     /db_xref="GeneID:11075"
                     /db_xref="HGNC:HGNC:10577"
                     /db_xref="MIM:600621"
                     /translation="MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQ
                     INKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQV
                     LKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEK
                     ERHAAEVRRNKELQVELSG"
     exon            99..194
                     /gene="STMN2"
                     /gene_synonym="SCG10; SCGN10"
                     /inference="alignment:Splign:2.1.0"
     exon            195..367
                     /gene="STMN2"
                     /gene_synonym="SCG10; SCGN10"
                     /inference="alignment:Splign:2.1.0"
     exon            368..559
                     /gene="STMN2"
                     /gene_synonym="SCG10; SCGN10"
                     /inference="alignment:Splign:2.1.0"
     exon            560..1903
                     /gene="STMN2"
                     /gene_synonym="SCG10; SCGN10"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1903
                     /gene="STMN2"
                     /gene_synonym="SCG10; SCGN10"
                     /note="major polyA site"
ORIGIN      
        1 agtcttctct ctcgctctct ccgctgctgt agccggaccc tttgccttcg ccactgctca
       61 gcgtctgcac atccctacaa tggctaaaac agcaatggcc tacaaggaaa aaatgaagga
      121 gctgtccatg ctgtcactga tctgctcttg cttttacccg gaacctcgca acatcaacat
      181 ctatacttac gatgatatgg aagtgaagca aatcaacaaa cgtgcctctg gccaggcttt
      241 tgagctgatc ttgaagccac catctcctat ctcagaagcc ccacgaactt tagcttctcc
      301 aaagaagaaa gacctgtccc tggaggagat ccagaagaaa ctggaggctg cagaggaaag
      361 aagaaagtct caggaggccc aggtgctgaa acaattggca gagaagaggg aacacgagcg
      421 agaagtcctt cagaaggctt tggaggagaa caacaacttc agcaagatgg cggaggaaaa
      481 gctgatcctg aaaatggaac aaattaagga aaaccgtgag gctaatctag ctgctattat
      541 tgaacgtctg caggaaaagg agaggcatgc tgcggaggtg cgcaggaaca aggaactcca
      601 ggttgaactg tctggctgaa gcaagggagg gtctggcacg ccccaccaat agtaaatccc
      661 cctgcctata ttataatgga tcatgcgata tcaggatggg gaatgtatga catggtttaa
      721 aaagaactca ttataaaaaa aaaaaaacaa aaaaaatcaa aaattaaaaa aaatcaatgc
      781 ggtctctttg cagaatgttt tgcttgatgt ttaaaaaata ccttggatct tattttgtaa
      841 atacttacat ttttgttaaa aaatacaagt attgcattat gcaagttatt tcataatctt
      901 acatgtcctg taacaggctt ttgatgttgt gtctttccac tcaaatgaat ttgctaggtc
      961 tgttcttttt gaagctcccc atgtctaact ccattccaaa agaaaaatga ggtcagtaga
     1021 cagtctatgg tgctagaaac ccaccattgc ctaatgacct agaaggcttt gttgtctctg
     1081 agcttgacta agaccatacc tagatcacag gtattatgac tccacatgaa ccttcacatt
     1141 tgttcgctca taatctactt actgcctaaa aactacaaaa ccaggctaag aaataccacc
     1201 agtcatagca tttacttctg cttctcctgg attatgtgct acaaatgtgc tttggcttta
     1261 gaaagggatg gatgagaaga cagacctgag accaatctgg gtagaagcaa aaagttgaac
     1321 cttttaaagt gctgaacaca aatccaaatt cgaatggttc aagcagccgt gaaatcgctc
     1381 ttcataaagt gggcttaatt ctctagttta agttcttttg atggaatgaa ttaattaatg
     1441 tgtcaggtgg cttatttgtg gatgccatga ttgatgatgt tcattttaag ctcttaccta
     1501 tagtacaagt acatgatgct actgaatatt tttccacttg gaaactgtga gctggttgtt
     1561 gcattaaaac acacatacaa acaaaatcaa aaacactgcg gactttcact caagctggtc
     1621 tttcttcccc agtgtaaggc aatcctgcct actaacaaca ccaacaacaa aacactccat
     1681 ctgtgaagct gacgcagtta agggggctag gcagggcatt tgtgccaact aagaatcacc
     1741 agatacccac cataagtacc tatcgcagtt ttgaagtcgt ttctccccaa ctcccaactc
     1801 ctgaaggttg ctgcctgcat atttactctt cattagtgct attttcctgt atgtcattgt
     1861 gagcaagctg tgattaataa agaattggag ttctgtgaac taa
//
