LOCUS       NM_005563               1443 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens stathmin 1 (STMN1), transcript variant 3, mRNA.
ACCESSION   NM_005563 XM_005245871 XR_042017 XR_042018 XR_042019
VERSION     NM_005563.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1443)
  AUTHORS   Aksoy,A., Varoglu,A., Onalan,E.E., Tektemur,A., Artas,G., Koc,M.,
            Cakmak,M., Aydin,S., Kilic,M. and Ulas,M.
  TITLE     The knockdown of stathmin with si-RNA inhibits invasion of
            mesothelioma
  JOURNAL   Tissue Cell 87, 102303 (2024)
   PUBMED   38244401
  REMARK    GeneRIF: The knockdown of stathmin with si-RNA inhibits invasion of
            mesothelioma.
REFERENCE   2  (bases 1 to 1443)
  AUTHORS   Wang,L., Cao,J., Tao,J. and Liang,Y.
  TITLE     STMN1 promotes cell malignancy and bortezomib resistance of
            multiple myeloma cell lines via PI3K/AKT signaling
  JOURNAL   Expert Opin Drug Saf 23 (3), 277-286 (2024)
   PUBMED   37642368
  REMARK    GeneRIF: STMN1 promotes cell malignancy and bortezomib resistance
            of multiple myeloma cell lines via PI3K/AKT signaling.
REFERENCE   3  (bases 1 to 1443)
  AUTHORS   Handa,T., Yokobori,T., Obayashi,S., Fujii,T., Shirabe,K. and
            Oyama,T.
  TITLE     Association Between High Expression of Phosphorylated-STMN1 and
            Mesenchymal Marker Expression and Cancer Stemness in Breast Cancer
  JOURNAL   Anticancer Res 43 (12), 5341-5348 (2023)
   PUBMED   38030185
  REMARK    GeneRIF: Association Between High Expression of
            Phosphorylated-STMN1 and Mesenchymal Marker Expression and Cancer
            Stemness in Breast Cancer.
REFERENCE   4  (bases 1 to 1443)
  AUTHORS   Lombardo,C., Broggi,G., Vitale,E., Ledda,C., Loreto,C., Matera,S.,
            Hagnas,M., Caltabiano,R. and Filetti,V.
  TITLE     Expression of stathmin in asbestos-like fibers-induced
            mesothelioma: A preliminary report
  JOURNAL   Histol Histopathol 38 (11), 1249-1256 (2023)
   PUBMED   37466108
  REMARK    GeneRIF: Expression of stathmin in asbestos-like fibers-induced
            mesothelioma: A preliminary report.
REFERENCE   5  (bases 1 to 1443)
  AUTHORS   Ozge,Z., Sevil,K., Ahmet,Y., Hulya,A. and Sema,A.
  TITLE     Stathmin 1 and p53 Expression in Cutaneous Squamous Cell Carcinoma
            and Precursor Lesions
  JOURNAL   Am J Dermatopathol 45 (3), 170-175 (2023)
   PUBMED   36749137
  REMARK    GeneRIF: Stathmin 1 and p53 Expression in Cutaneous Squamous Cell
            Carcinoma and Precursor Lesions.
REFERENCE   6  (bases 1 to 1443)
  AUTHORS   Doye,V., Le Gouvello,S., Dobransky,T., Chneiweiss,H., Beretta,L.
            and Sobel,A.
  TITLE     Expression of transfected stathmin cDNA reveals novel
            phosphorylated forms associated with developmental and functional
            cell regulation
  JOURNAL   Biochem J 287 (Pt 2) (Pt 2), 549-554 (1992)
   PUBMED   1445213
REFERENCE   7  (bases 1 to 1443)
  AUTHORS   Labdon,J.E., Nieves,E. and Schubart,U.K.
  TITLE     Analysis of phosphoprotein p19 by liquid chromatography/mass
            spectrometry. Identification of two proline-directed serine
            phosphorylation sites and a blocked amino terminus
  JOURNAL   J Biol Chem 267 (5), 3506-3513 (1992)
   PUBMED   1737801
REFERENCE   8  (bases 1 to 1443)
  AUTHORS   Melhem,R.F., Zhu,X.X., Hailat,N., Strahler,J.R. and Hanash,S.M.
  TITLE     Characterization of the gene for a proliferation-related
            phosphoprotein (oncoprotein 18) expressed in high amounts in acute
            leukemia
  JOURNAL   J Biol Chem 266 (27), 17747-17753 (1991)
   PUBMED   1917919
REFERENCE   9  (bases 1 to 1443)
  AUTHORS   Sobel,A.
  TITLE     Stathmin: a relay phosphoprotein for multiple signal transduction?
  JOURNAL   Trends Biochem Sci 16 (8), 301-305 (1991)
   PUBMED   1957351
  REMARK    Review article
REFERENCE   10 (bases 1 to 1443)
  AUTHORS   Ferrari,A.C., Seuanez,H.N., Hanash,S.M. and Atweh,G.F.
  TITLE     A gene that encodes for a leukemia-associated phosphoprotein (p18)
            maps to chromosome bands 1p35-36.1
  JOURNAL   Genes Chromosomes Cancer 2 (2), 125-129 (1990)
   PUBMED   2278968
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG030679.1, AK054594.1 and
            BQ772197.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005563.3.
            
            Summary: This gene belongs to the stathmin family of genes. It
            encodes a ubiquitous cytosolic phosphoprotein proposed to function
            as an intracellular relay integrating regulatory signals of the
            cellular environment. The encoded protein is involved in the
            regulation of the microtubule filament system by destabilizing
            microtubules. It prevents assembly and promotes disassembly of
            microtubules. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Feb
            2009].
            
            Transcript Variant: This variant (3) uses an alternate terminal
            exon, compared to variant 4. The resulting isoform (a) has a
            shorter and distinct C-terminus, compared to isoform b. Variants 1,
            2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.230008.1,
                                           SRR3476690.775749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455785.7/ ENSP00000387858.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-561               BG030679.1         55-615
            562-1438            AK054594.1         541-1417
            1439-1443           BQ772197.1         17-21               c
FEATURES             Location/Qualifiers
     source          1..1443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1443
                     /gene="STMN1"
                     /gene_synonym="C1orf215; Lag; LAP18; OP18; PP17; PP19;
                     PR22; SMN"
                     /note="stathmin 1"
                     /db_xref="GeneID:3925"
                     /db_xref="HGNC:HGNC:6510"
                     /db_xref="MIM:151442"
     exon            1..31
                     /gene="STMN1"
                     /gene_synonym="C1orf215; Lag; LAP18; OP18; PP17; PP19;
                     PR22; SMN"
                     /inference="alignment:Splign:2.1.0"
     exon            32..106
                     /gene="STMN1"
                     /gene_synonym="C1orf215; Lag; LAP18; OP18; PP17; PP19;
                     PR22; SMN"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..543
                     /gene="STMN1"
                     /gene_synonym="C1orf215; Lag; LAP18; OP18; PP17; PP19;
                     PR22; SMN"
                     /note="isoform a is encoded by transcript variant 3;
                     stathmin 1/oncoprotein 18; metablastin; prosolin;
                     phosphoprotein 19; transmembrane protein C1orf215;
                     leukemia-associated phosphoprotein p18; phosphoprotein
                     p19; testicular tissue protein Li 189"
                     /codon_start=1
                     /product="stathmin isoform a"
                     /protein_id="NP_005554.1"
                     /db_xref="CCDS:CCDS269.1"
                     /db_xref="GeneID:3925"
                     /db_xref="HGNC:HGNC:6510"
                     /db_xref="MIM:151442"
                     /translation="MASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKD
                     LSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLT
                     HKMEANKENREAQMAAKLERLREKDKHIEEVRKNKESKDPADETEAD"
     exon            107..279
                     /gene="STMN1"
                     /gene_synonym="C1orf215; Lag; LAP18; OP18; PP17; PP19;
                     PR22; SMN"
                     /inference="alignment:Splign:2.1.0"
     exon            280..471
                     /gene="STMN1"
                     /gene_synonym="C1orf215; Lag; LAP18; OP18; PP17; PP19;
                     PR22; SMN"
                     /inference="alignment:Splign:2.1.0"
     exon            472..1443
                     /gene="STMN1"
                     /gene_synonym="C1orf215; Lag; LAP18; OP18; PP17; PP19;
                     PR22; SMN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      970..975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STMN1"
                     /gene_synonym="C1orf215; Lag; LAP18; OP18; PP17; PP19;
                     PR22; SMN"
                     /note="hexamer: AATAAA"
     polyA_site      1002
                     /gene="STMN1"
                     /gene_synonym="C1orf215; Lag; LAP18; OP18; PP17; PP19;
                     PR22; SMN"
                     /note="major polyA site"
     regulatory      1416..1421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STMN1"
                     /gene_synonym="C1orf215; Lag; LAP18; OP18; PP17; PP19;
                     PR22; SMN"
                     /note="hexamer: AATAAA"
     polyA_site      1443
                     /gene="STMN1"
                     /gene_synonym="C1orf215; Lag; LAP18; OP18; PP17; PP19;
                     PR22; SMN"
ORIGIN      
        1 agagtgtggt caggcggctc ggactgagca ggactttcct tatcccagtt gattgtgcag
       61 aatacactgc ctgtcgcttg tcttctattc accatggctt cttctgatat ccaggtgaaa
      121 gaactggaga agcgtgcctc aggccaggct tttgagctga ttctcagccc tcggtcaaaa
      181 gaatctgttc cagaattccc cctttcccct ccaaagaaga aggatctttc cctggaggaa
      241 attcagaaga aattagaagc tgcagaagaa agacgcaagt cccatgaagc tgaggtcttg
      301 aagcagctgg ctgagaaacg agagcacgag aaagaagtgc ttcagaaggc aatagaagag
      361 aacaacaact tcagtaaaat ggcagaagag aaactgaccc acaaaatgga agctaataaa
      421 gagaaccgag aggcacaaat ggctgccaaa ctggaacgtt tgcgagagaa ggataagcac
      481 attgaagaag tgcggaagaa caaagaatcc aaagaccctg ctgacgagac tgaagctgac
      541 taatttgttc tgagaactga ctttctcccc atccccttcc taaatatcca aagactgtac
      601 tggccagtgt cattttattt tttccctcct gacaaatatt ttagaagcta atgtaggact
      661 gtataggtag atccagatcc agactgtaag atgttgtttt aggggctaaa ggggagaaac
      721 tgaaagtgtt ttactctttt tctaaagtgt tggtctttct aatgtagcta tttttcttgt
      781 tgcatctttt ctacttcagt acacttggtg tactgggtta atggctagta ctgtattggc
      841 tctgtgaaaa catatttgtg aaaagagtat gtagtggctt cttttgaact gttagatgct
      901 gaatatctgt tcacttttca atcccaattc tgtcccaatc ttaccagatg ctactggact
      961 tgaatggtta ataaaactgc acagtgctgt tggtggcagt gacttctttt gagttaggtt
     1021 aataaatcaa gccatagagc ccctcctggt tgatacttgt tccagatggg gcctttgggg
     1081 ctggtagaaa tacccaacgc acaaatgacc gcacgttctc tgccccgttt cttgccccag
     1141 tgtggtttgc attgtctcct tccacaatga ctgctttgtt tggatgcctc agcccaggtc
     1201 agctgttact ttctttcaga tgtttatttg caaacaacca ttttttgttc tgtgtccctt
     1261 ttaaaaggca gattaaaagc acaagcgtgt ttctagagaa cagttgagag agaatctcaa
     1321 gattctactt ggtggtttgc ttgctctacg ttacaggtgg ggcatgtcct catcctttcc
     1381 tgccataaaa gctatgacac gagaatcaga atattaataa aactttatgt actgctgtag
     1441 caa
//
