LOCUS       NM_153710               2826 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens serine/threonine kinase like domain containing 1
            (STKLD1), transcript variant 1, mRNA.
ACCESSION   NM_153710 XM_376921
VERSION     NM_153710.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2826)
  AUTHORS   Umair,M., Bilal,M., Ali,R.H., Alhaddad,B., Ahmad,F., Abdullah,
            Haack,T.B., Alfadhel,M., Ansar,M., Meitinger,T. and Ahmad,W.
  TITLE     Whole-exome sequencing revealed a nonsense mutation in STKLD1
            causing non-syndromic pre-axial polydactyly type A affecting only
            upper limb
  JOURNAL   Clin Genet 96 (2), 134-139 (2019)
   PUBMED   30945277
REFERENCE   2  (bases 1 to 2826)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    GeneRIF: Also known as SgK071, a unique kinase belonging to no
            group or family. Single orthologs have been found in other
            vertebrates and lower metazoans including Nematostella, but are
            absent from Drosophila and C. elegans.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL593848.15, BC036504.2 and AK131545.1.
            
            On May 17, 2019 this sequence version replaced NM_153710.4.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036504.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371957.4/ ENSP00000361025.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AL593848.15        27881-27927
            48-1478             BC036504.2         1-1431
            1479-1479           AL593848.15        54424-54424
            1480-2239           BC036504.2         1433-2192
            2240-2643           AK131545.1         2718-3121
            2644-2826           BC036504.2         2596-2778
FEATURES             Location/Qualifiers
     source          1..2826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..2826
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /note="serine/threonine kinase like domain containing 1"
                     /db_xref="GeneID:169436"
                     /db_xref="HGNC:HGNC:28669"
                     /db_xref="MIM:618530"
     exon            1..195
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2151
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /note="sugen kinase 071; probable inactive protein
                     kinase-like protein SgK071; serine/threonine kinase-like
                     domain-containing protein 1"
                     /codon_start=1
                     /product="serine/threonine kinase-like domain-containing
                     protein STKLD1"
                     /protein_id="NP_714921.4"
                     /db_xref="CCDS:CCDS35169.1"
                     /db_xref="GeneID:169436"
                     /db_xref="HGNC:HGNC:28669"
                     /db_xref="MIM:618530"
                     /translation="MLGPGSNRRRPTQGERGPGSPGEPMEKYQVLYQLNPGALGVNLV
                     VEEMETKVKHVIKQVECMDDHYASQALEELMPLLKLRHAHISVYQELFITWNGEISSL
                     YLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKP
                     SNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKSWMAPEALNFSFSQKSDIW
                     SLGCIILDMTSCSFMDGTEAMHLRKSLRQSPGSLKAVLKTMEEKQIPDVETFRNLLPL
                     MLQIDPSDRITIKDVVHITFLRGSFKSSCVSLTLHRQMVPASITDMLLEGNVASILEV
                     MQKFSGWPEVQLRAMKRLLKMPADQLGLPWPPELVEVVVTTMELHDRVLDVQLCACSL
                     LLHLLGQALVHHPEAKAPCNQAITSTLLSALQSHPEEEPLLVMVYSLLAITTTQESES
                     LSEELQNAGLLEHILEHLNSSLESRDVCASGLGLLWALLLDGIIVNKAPLEKVPDLIS
                     QVLATYPADGEMAEASCGVFWLLSLLGCIKEQQFEQVVALLLQSIRLCQDRALLVNNA
                     YRGLASLVKVSELAAFKVVVQEEGGSGLSLIKETYQLHRDDPEVVENVGMLLVHLASY
                     EEILPELVSSSMKALLQEIKERFTSSLVSDSSAFSKPGLPPGGSPQLGCTTSGGLE"
     exon            196..282
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            283..327
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            328..402
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            403..504
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            505..575
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            576..691
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            692..810
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            811..974
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1105
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1189
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1306
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1447
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1582
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1711
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1840
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1981
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2826
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /note="hexamer: AATAAA"
     polyA_site      2644
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /note="major polyA site"
     regulatory      2797..2802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /note="hexamer: AGTAAA"
     polyA_site      2826
                     /gene="STKLD1"
                     /gene_synonym="C9orf96; SgK071; Sk521"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcctcg agggcgccgt tcgggcgggg aggatcccgc gggtcccact gacccacgcg
       61 gggtggggcc aggggtggac gctcgcccgt acgcggtcgc tactgatcat gcttgggcca
      121 gggtccaatc gcaggcgccc cacgcagggg gagcgaggcc cagggtcccc cggagagccc
      181 atggagaagt accaggtttt gtaccagctg aatcctgggg ccttgggggt gaacctggtg
      241 gtggaggaaa tggaaaccaa agtcaagcat gtgataaagc aggtggaatg catggatgac
      301 cattacgcca gtcaggccct ggaggagctg atgccactgc tgaagctgcg gcacgcccac
      361 atctctgtgt accaggagct gttcatcacg tggaatgggg agatctcttc tctgtacctc
      421 tgcctggtga tggagttcaa tgagctcagc ttccaggagg tcattgagga taagaggaag
      481 gcaaagaaaa tcattgactc tgagtggatg cagaatgtgc tgggccaggt gctggacgcg
      541 ctggaatacc tgcaccattt ggacatcatc cacaggaatc tcaaaccctc caacatcatc
      601 ctcatcagca gtgaccactg caaactgcag gacctgagtt ccaatgtgct aatgacagac
      661 aaagccaaat ggaatattcg tgcggaggaa gacccctttc gtaagtcctg gatggcccct
      721 gaagccctca acttctcctt cagccagaaa tcagacatct ggtccctggg ctgcatcatt
      781 ctggacatga ccagctgctc cttcatggat ggcacagaag ccatgcatct gcggaagtcc
      841 ctccgccaga gcccaggcag cctgaaggcc gtcctgaaga caatggagga gaagcagatc
      901 ccggatgtgg aaaccttcag gaatcttctg cccttgatgc tccagatcga cccctcggat
      961 cgaataacga taaaggacgt ggtgcacatc accttcttga gaggctcctt caagtcctcg
     1021 tgcgtctctc tgaccctgca ccggcagatg gtgcctgcgt ccatcaccga catgctgtta
     1081 gaaggcaacg tggccagcat tttagaggtc atgcagaaat tctctggctg gcccgaagtc
     1141 cagctcaggg ccatgaagag gcttctgaaa atgcctgcag atcagctagg tctgccgtgg
     1201 cccccggagc tggtggaggt ggtggtcacg accatggagc tacatgacag ggtcctcgat
     1261 gtccagctgt gtgcctgctc cctgctgctg cacctcctgg gccaagcgct ggtgcaccac
     1321 ccggaagcca aggctccctg caaccaagcc atcacctcca ccctgctgag tgctcttcag
     1381 agccaccccg aggaggagcc acttcttgtc atggtctaca gcctgctagc catcaccaca
     1441 acccaggagt cagagtcact gtcagaggag ctgcagaatg ctgggctgct ggagcacatc
     1501 ctggagcacc tcaacagctc cctcgaaagc agggacgtct gcgccagcgg cctgggcctg
     1561 ctctgggccc tcctgctgga cggtatcatt gtgaacaagg cccccttgga gaaggtcccg
     1621 gacctcatca gccaggtgtt ggccacctac cctgcggatg gggaaatggc agaagccagc
     1681 tgcggagtct tctggctgct gtccctgctg ggctgcatca aggagcagca gtttgaacaa
     1741 gtggtggcgc tgctcctgca aagcatccgg ctgtgccagg acagagccct gctggtgaac
     1801 aatgcctacc ggggactggc cagcctggtg aaggtgtcag agctggcggc cttcaaggtg
     1861 gtggtgcagg aggagggcgg cagtggcctc agcctcatca aggagaccta ccagctccac
     1921 agggacgacc cggaggtggt ggagaacgtg ggcatgctgc tggtccacct ggcttcctat
     1981 gaggagatcc tgccggagct ggtgtccagt agtatgaagg ccctgctcca ggagatcaag
     2041 gagcgcttca cctccagcct ggtgagtgac agcagcgcct tcagcaaacc aggcctccct
     2101 ccaggtggaa gcccccagct ggggtgcacc acgtctgggg gactggaata gatgtttgta
     2161 tggaactgac cttgatctcc acgtgtatag ttttcaagac tgctctcctg cctgcctatt
     2221 atcccatctc tatgactggg ccaaaatcaa tcttaaacgg gaggggtaat cagacctctc
     2281 caaagagttt cctgtccatg actgctggat tgagtcacat gagtaactgc tcctggaccc
     2341 ggggactgtc cacgaaaact gacttgcctg cttcctcctt ccaggaactg gtttcttgcg
     2401 cggaaaaagt gctcttgagg ctggaggcag ccacctctcc cagcccactg ggtggggaag
     2461 cagctcagcc ctgatgcggg ggagaagaca gataccccac aggcccctcc ctccacgtgt
     2521 gccctctccc tgtccttcct ttccatgggc cactgtttcc cttggggtgg ggggaagggt
     2581 catccagcac cagaatgcgc atctcacact cctcttaggt gactaataaa gaggcccaag
     2641 gccagtttct gccttaatca tttctggcaa gaggctgtga ctggccagtg ggatacttaa
     2701 ttctgcagtc tctatagacc tcgcccctgg acagagcagt ccttccagac cattctagat
     2761 gagagtcaac actgagcctc cacaggctcc attccaagta aacatctgca tttattttaa
     2821 atcgca
//
