LOCUS       NM_001282547            3645 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens serine/threonine kinase 40 (STK40), transcript variant
            2, mRNA.
ACCESSION   NM_001282547 XM_005271249
VERSION     NM_001282547.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3645)
  AUTHORS   Li,X., Shao,L.Z., Li,Z.H., Wang,Y.H., Cai,Q.Y., Wang,S., Chen,H.,
            Sheng,J., Luo,X., Chen,X.M., Wang,Y.X., Ding,Y.B. and Liu,T.H.
  TITLE     STK40 inhibits trophoblast fusion by mediating COP1 ubiquitination
            to degrade P57Kip2
  JOURNAL   J Transl Med 22 (1), 852 (2024)
   PUBMED   39304928
  REMARK    GeneRIF: STK40 inhibits trophoblast fusion by mediating COP1
            ubiquitination to degrade P57[Kip2].
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3645)
  AUTHORS   Sun,W., Yuan,Y., Chen,J., Bao,Q., Shang,M., Sun,P. and Peng,H.
  TITLE     Construction and validation of a novel senescence-related risk
            score can help predict the prognosis and tumor microenvironment of
            gastric cancer patients and determine that STK40 can affect the ROS
            accumulation and proliferation ability of gastric cancer cells
  JOURNAL   Front Immunol 14, 1259231 (2023)
   PUBMED   37915566
  REMARK    GeneRIF: Construction and validation of a novel senescence-related
            risk score can help predict the prognosis and tumor
            microenvironment of gastric cancer patients and determine that
            STK40 can affect the ROS accumulation and proliferation ability of
            gastric cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3645)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3645)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 3645)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3645)
  AUTHORS   So,J., Pasculescu,A., Dai,A.Y., Williton,K., James,A., Nguyen,V.,
            Creixell,P., Schoof,E.M., Sinclair,J., Barrios-Rodiles,M., Gu,J.,
            Krizus,A., Williams,R., Olhovsky,M., Dennis,J.W., Wrana,J.L.,
            Linding,R., Jorgensen,C., Pawson,T. and Colwill,K.
  TITLE     Integrative analysis of kinase networks in TRAIL-induced apoptosis
            provides a source of potential targets for combination therapy
  JOURNAL   Sci Signal 8 (371), rs3 (2015)
   PUBMED   25852190
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3645)
  AUTHORS   Xu,N., Meisgen,F., Butler,L.M., Han,G., Wang,X.J.,
            Soderberg-Naucler,C., Stahle,M., Pivarcsi,A. and Sonkoly,E.
  TITLE     MicroRNA-31 is overexpressed in psoriasis and modulates
            inflammatory cytokine and chemokine production in keratinocytes via
            targeting serine/threonine kinase 40
  JOURNAL   J Immunol 190 (2), 678-688 (2013)
   PUBMED   23233723
REFERENCE   8  (bases 1 to 3645)
  AUTHORS   Makrantonaki,E., Brink,T.C., Zampeli,V., Elewa,R.M., Mlody,B.,
            Hossini,A.M., Hermes,B., Krause,U., Knolle,J., Abdallah,M.,
            Adjaye,J. and Zouboulis,C.C.
  TITLE     Identification of biomarkers of human skin ageing in both genders.
            Wnt signalling - a label of skin ageing?
  JOURNAL   PLoS One 7 (11), e50393 (2012)
   PUBMED   23226273
REFERENCE   9  (bases 1 to 3645)
  AUTHORS   Kang,J.G., Amar,M.J., Remaley,A.T., Kwon,J., Blackshear,P.J.,
            Wang,P.Y. and Hwang,P.M.
  TITLE     Zinc finger protein tristetraprolin interacts with CCL3 mRNA and
            regulates tissue inflammation
  JOURNAL   J Immunol 187 (5), 2696-2701 (2011)
   PUBMED   21784977
REFERENCE   10 (bases 1 to 3645)
  AUTHORS   Huang,J., Teng,L., Liu,T., Li,L., Chen,D., Li,F., Xu,L.G., Zhai,Z.
            and Shu,H.B.
  TITLE     Identification of a novel serine/threonine kinase that inhibits
            TNF-induced NF-kappaB activation and p53-induced transcription
  JOURNAL   Biochem Biophys Res Commun 309 (4), 774-778 (2003)
   PUBMED   13679039
  REMARK    GeneRIF: identification as a negative regulator of NF-kappaB- and
            p53-mediated gene transcription [SINK-homologous serine-threonine
            kinase]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA375448.1 and BC007835.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001282547.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (2) is shorter, compared to isoform 1. Both
            variants 2 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007835.2, AY198395.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373132.4/ ENSP00000362224.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DA375448.1         4-32
            30-3645             BC007835.2         1-3616
FEATURES             Location/Qualifiers
     source          1..3645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..3645
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /note="serine/threonine kinase 40"
                     /db_xref="GeneID:83931"
                     /db_xref="HGNC:HGNC:21373"
                     /db_xref="MIM:609437"
     exon            1..202
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /inference="alignment:Splign:2.1.0"
     exon            203..322
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1518
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Ser/Thr-like kinase; serine/threonine-protein kinase 40;
                     sugen kinase 495; SINK-homologous serine/threonine kinase;
                     SINK-homologous serine/threonine-protein kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 40 isoform 2"
                     /protein_id="NP_001269476.1"
                     /db_xref="CCDS:CCDS407.1"
                     /db_xref="GeneID:83931"
                     /db_xref="HGNC:HGNC:21373"
                     /db_xref="MIM:609437"
                     /translation="MKRRASDRGAGETSARAKALGSGISGNNAKRAGPFILGPRLGNS
                     PVPSIVQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHT
                     QDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQ
                     HYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFC
                     LGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYD
                     SIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIAS
                     WQSLSSLSGPLQVVPDIDDQMSNADSSQEAKVTEECSQYEFENYMRQQLLLAEEKSSI
                     HDARSWVPKRQFGSAPPVRRLGHDAQPMTSLDTAILAQRYLRK"
     exon            323..408
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /inference="alignment:Splign:2.1.0"
     exon            409..552
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /inference="alignment:Splign:2.1.0"
     exon            553..780
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /inference="alignment:Splign:2.1.0"
     exon            781..833
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /inference="alignment:Splign:2.1.0"
     exon            834..949
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1094
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1214
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1299
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..3645
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3624..3629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /note="hexamer: AATAAA"
     polyA_site      3645
                     /gene="STK40"
                     /gene_synonym="SgK495; SHIK"
                     /note="major polyA site"
ORIGIN      
        1 acttccgttg tcaggtggcg gcgccgcagc catggaggga ggcggcggcg gcggcggcgg
       61 cggctcgggt ggctgcgctg ggaggcggcg gtgagaggct cgcacgcctc cagcccggcc
      121 ccggcccccc gggagggaga gccgagcagc cccggctctg ggctacggac tatgggcgaa
      181 tagctctgac cacccggcga agagctgaga atgaagcgga gagcatcaga cagaggagct
      241 ggggaaacgt cggccagggc caaggctcta ggaagtggga tttctggaaa taatgcaaag
      301 agagctggac cattcatcct tggtccccgt ctgggcaact caccggtgcc aagcatagtg
      361 cagtgtttgg cgaggaaaga tggcacggat gacttctatc agctgaagat cctgaccctg
      421 gaggagaggg gggaccaagg catagagagc caggaagagc ggcagggcaa gatgctgctg
      481 cacaccgagt actcactgct gtctctcctg cacacgcagg atggcgtggt gcaccaccac
      541 ggcctcttcc aggaccgcac ctgtgaaatc gttgaggaca cagaatccag ccggatggtt
      601 aagaagatga agaagcgcat ctgcctcgtc ctggactgcc tctgtgctca tgacttcagc
      661 gataagaccg ctgacctcat caacctgcag cactacgtca tcaaggagaa gaggctcagc
      721 gagagggaga ctgtggtaat cttctacgac gtggtccgcg tggtggaggc cctgcaccag
      781 aaaaatatcg tgcacagaga cctgaagctg gggaacatgg tgctcaacaa gaggacacat
      841 cggataacca tcaccaactt ctgcctcggg aagcatctgg tgagcgaggg ggacctgctg
      901 aaggaccaga gagggagccc tgcctacatc agtcccgacg tgctcagcgg ccggccgtac
      961 cgtggcaagc ccagtgacat gtgggccctg ggcgtggtgc tcttcaccat gctgtatggc
     1021 cagttcccct tctacgacag catcccgcag gagctcttcc gcaagatcaa ggctgccgag
     1081 tataccattc ctgaggatgg acgggtttct gagaacaccg tgtgtctcat ccggaagctg
     1141 ctggtccttg acccccagca gcgcctggcc gccgccgacg tcctggaggc cctcagtgcc
     1201 atcattgcat catggcagtc cctgtcatct ctgagtgggc ctttgcaagt ggttcctgac
     1261 attgatgacc aaatgagcaa tgcggatagc tcccaggagg cgaaggtgac ggaggagtgc
     1321 tcccagtacg agtttgagaa ctacatgcgt cagcagctgc tgctggccga ggagaagagc
     1381 tccatccatg acgcccggag ctgggtaccc aagcggcagt tcggcagcgc accaccggtg
     1441 cgacggctgg gccacgacgc acagcccatg acctccttgg acacggccat cctggcgcag
     1501 cgctacctgc ggaaataaca gcctcagccg gggccaccag cactgctgcc acttcttcca
     1561 gccccagcca aaggcgtggc tgtcagggct gggccctgta gtgctggact ctcccgggcc
     1621 acaataggga cagggcaggg acagggacag cccaggtcac acgtggggtc agcagaggta
     1681 ccacgaagct accttttggg atgattgctc gattgtttgg tttttaaatc tgagaagcct
     1741 agataactaa tctgctttta atcacgatgt tttaatctac ctctgtctct ttaaccatgc
     1801 tgtctctgga ctgagcaaga gggaggaggg agcctgctca ccccactcca gggccttccc
     1861 cagcggccac caactgacct ggggcgctgc tccccacagt ccaaataagc tgaaagtgca
     1921 gctcgctgca ggccccagag cgagcttccc ctcctccctg ctctcccagg cccctgccac
     1981 agcctctttc cgtccctctc tttctgatcc aggcccctca gtccaagctt tggaaaacct
     2041 tcacctcatc ttaaaccgaa ctcaaatata tttatttttt taccatacca acttctctcc
     2101 catctctagg tggctcagtc catggccact ccctgccccc agcctggctg gacagcaagg
     2161 aatccacagc ccacacgtga gctccctcct cacccccagg cagggaagcc cctcctgcca
     2221 gtccctgtcc cctttcagcc caccagtccc tctctgctgc cggtgatggg aggcctttct
     2281 agacctggct ctttctctcc cgtctcagtg gcttctctga ggtgctgtac acgcgcgtta
     2341 acctgttccc ttctctatcc ttccccgtgg tactgagctc acgtggactc ccagtgcgaa
     2401 ggggcccatg ggttgggctg caggcctggc cgtgagcggg ggctgcctgc acgctcccct
     2461 agcctactct tgtgtttagg ggatggtggg aacatatccc agtgcccttg cctcataata
     2521 gatgtggtga ctctcccggt agaccctagc aagggtcctc catggtggtg agggactcag
     2581 gagaattgta gggattgggg gaccctgcct gcctggcttg agaacagccc tgctgccctt
     2641 ttgagccgag attttgaagt ggatgcccgt cttgccagaa atgctgttct caccagaatg
     2701 ccccctcccc ttgcccttac tggacttggc cctgcctgat gccaagcaaa gacccttccc
     2761 cagaggccta ccccccatat gtcctcagag aggctgagtg tcccctccag gcagtcatgg
     2821 gccctgaggc ccctcctgcc tggccctgct ccccagtggg gaggtgactg tgtttcccag
     2881 agtgtgagcc gctctcctcc ccctaaaaag ctgactcact gtgagtgacc ttgggcaagt
     2941 tcccaaacct ccttgtgcct cagtttcccc atctggaaaa aatggggcca cctcttgcca
     3001 gcagtagcag ggctgcccac gcccctttct ccccatgccc catccagcac ttgggcgact
     3061 catgcctctg cctcagtggg cctgtgggag cctactggag cccagcactt actccccctg
     3121 agcagcgagc ctgcgtctgt ctcagctgtc cagcgctgag ggccagggtc ttgtgctgtg
     3181 gggctggggg atgccctctt ttctatattt atttcataga aagtctcctg cgggagcgga
     3241 aatgcagtcc ggcctagggc tcccagccct tgactgtcct cctgtgaggg cctgaagctg
     3301 ggccagggcc cgtcgcagcg gagccccctc tcagcagccc accgggtccc tccaggctgc
     3361 tgcccgtgcg tggtctttct cctccttttc aaagcaatag ccgccgggtc tgcaaagccc
     3421 tgtcagacag actgggccct tccaaggtca agccatgtgt ctgatgacat tcctggtgaa
     3481 gcaaaggaga ggaggatggg tcagccctca ctgggtgtca cacactgaga gaagtcctat
     3541 tgtaaagaaa cggaaaaagt cacaaaaaag tttgtataaa gacatatttt tgtactacat
     3601 ggggactctt cctgcatgtc agcaataaaa cttcctgatc tggaa
//
