LOCUS       XM_005260532           10455 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens serine/threonine kinase 4 (STK4),
            transcript variant X2, mRNA.
ACCESSION   XM_005260532
VERSION     XM_005260532.5
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000020.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005260532.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
     gene            1..10455
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /note="serine/threonine kinase 4; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     mRNAs, 27 ESTs, 1490 long SRA reads, 2 Proteins, and 92%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 10 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:6789"
                     /db_xref="HGNC:HGNC:11408"
                     /db_xref="MIM:604965"
     CDS             4186..5610
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 4 isoform X1"
                     /protein_id="XP_005260589.1"
                     /db_xref="GeneID:6789"
                     /db_xref="HGNC:HGNC:11408"
                     /db_xref="MIM:604965"
                     /translation="MQYMESGILTSCELLEFSLLSGCIGRSYGSVYKAIHKETGQIVA
                     IKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR
                     LRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQ
                     LTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMR
                     AIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSI
                     LRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTM
                     TDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKE
                     NQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIR
                     QKYQSKRQPILDAIEAKKRRQQNF"
ORIGIN      
        1 aggaggtccg cgggaggatg gagcagtgag cgggtctggg cggctgctgg cagcgccatg
       61 gagacggtac agctgaggaa cccgccgcgc cggtgagggg ccactggcta agaggacggg
      121 catggggtca ggggaagaaa aggcgggaac tggttgaggg gatacacctg tgtgggagtc
      181 cccggagcta agcgacccag ccgatggggc acctgctgag tgaggggggg gacgtctggt
      241 gggtgagggt ccggctgagg ggagcatctg ctaaggaggt tagacttggg accggttaga
      301 gggagcactc gctgtggtga gactgtgctg aggaacgtgg ggacaagtta gggagagtac
      361 ctgctgaggc cgggccactc gggggaacgc tatccaagca gggactcacg gaggtggggg
      421 cgaatgctga agcagggtga gaatctgtga gggatctctt taagggggtg gatcgagaac
      481 tggccaagag gaaggccggg tggactttct aagggtctga agtcccactt gaggggtgcg
      541 gtggggggat ctgtggaggg gaaaagcttt gcgcctaagg ctgaaagcat gcgaggaaag
      601 gttgagggtc tagcaaggga ggggatggtg gagggtagca tttcagagga tgctgttggt
      661 ggtgtcccca ctgtaggatg gcatctttta ttactgatgt tcagtgtctt cctaatggtc
      721 ttcacatcct cctcagctct tcagaacctg acattgggag gtaggtaagg aaataagagg
      781 atattttcga gatggggaga ctgaggtcca gagtagttgg gaagtgtttc cttctttact
      841 ccgggtcact gaaccctgcc agtctgtgcc cttttcaggc ctcagttgtt ttgtgaatat
      901 cagcaccaaa tcctagtggt acctggaatt gctttagttc aagatcagga tggtggctga
      961 tcctagaaaa tctcaactcc tggatttccc ttgtggacat cccgggtctt ttgccactct
     1021 accacatctg gagaaaagta gggactagag accgaaggag tcatgcttct ctgaggttca
     1081 gtgtggttac ttctatttca cagagacgtc tgacttcctg cagcagaatg agctctaaag
     1141 aaggaagtgt tcagggtgtg gaagtgcagg gcaaccaaga ggtgaagaga agggattgac
     1201 tgcctgggca gcactcttag gggttgtttg agcttgggga tgtttgaggt gcacaaacat
     1261 tgcagaaggc aaataggtgg ttgggatggg ctttggattc accctagcgt agtgtgctga
     1321 gactgtaata gtaatgatta ttacactcat attgcactta ccgggtgcca ggcactgttc
     1381 taagtgcttt ccatgtgtcc tgctgaagca tatgaaattg ctgatatttg accatttttg
     1441 aaccataaaa acctcatttg aactcatttg aacctcacaa caatcctgtg tggtagatat
     1501 ccctatatgt ctgttttaca gatgataaaa ctgagataca gagggtagtg atttgctggg
     1561 agaagtcata gcaagtaaga gacagagcta ggattttaat gtctatgggg tctggtccaa
     1621 agtccatgtt cttttttttt ttttgagacg gagtctcact ctgtcgccca gtctgaagtg
     1681 cagtggcgca atctcggctc actgctactt ccgccttctg ggttcaagcg attctcctgc
     1741 ctcagcctcc tgtgtaactg ggaccacagg tgcgtgccac cacgcctggc taattttttg
     1801 tagttttagt agagacgggg tttcaccgtg ttagccagga tggtctctat ctcctgacct
     1861 cgtgatccgc ccaccttggc ttctcaaagt ggtgggatta caggcgtgag ccaccgggcc
     1921 cggccatgct cttaactgcc tcactctgat gcctctctaa aagtacccct gtttcacagg
     1981 tctctgtgta tgttagcaga tatttactat agtaccatag tgatccaatt atgaatgcac
     2041 actagttatg tttctttctg aactatgttc gttcgttctt cttggtttct ttctccgagg
     2101 ccttggttta attgaaaaga ggattaggaa tctgagtttt gtttccccct ttgccttgtc
     2161 ttacataatc ttgagcaaag gactaaagtt tcttggcatg ctcattcctg taccttttgg
     2221 attttaaaaa atgtattaaa agcacaagag aagagcattg caggactggg ttctgaagtg
     2281 gctggtgatt cccagctcat tgtaactagt agattgccta atttgaagca gatcaatttt
     2341 attatcacgt gtatcagttt atcaggacaa gacaaagtgt catggagtgg gtggtttaag
     2401 caacgtaaat ttattctctc actgttctga aggctagaga tctgaaatca aggcattgtc
     2461 agagttgttt cttttgacgc ctttgcttga ctcgtagatg gccatctccc tgtgtctcca
     2521 tgttcttcct tctgtacctg tcagtgtcct aatctcctct tataaggaca ccagtcatac
     2581 tggattaggg catgcccata tgacctcatt ttatcttaat tacctcttta aaggccttgt
     2641 ctccaaatac agtcacattc ttaggtggtg ggtattagga cttcagcata tgaattgggg
     2701 taagctgggg acacagtttt attatgtaag attttgtcca tttatcatgt atagttgttg
     2761 taatccatat caaattctgt gtggaaaaag aaatagttac acataaaatg aactttatgg
     2821 gagttctgaa atgggagaaa gctttgagaa ttagccagac ctgtaagtga ctacttcata
     2881 gacaccatta cttgtgtttg gaaagataca ggtgtctttt cagaaattca gatggcatgt
     2941 gtttccaata accccagtgc aggaaatgcc ctttgtgttc gtgagtttga catttgtgtg
     3001 tgtgtgtgat taagtgatga cagattggtg tctcatatag gagttaataa ttttaaaaaa
     3061 tgagttgcca ttagattaat gttatagtgg aaggcgtaga gtgcattcct gggatgctgg
     3121 ccatccacat ggccatctga cttaggagag gagcatccac cagtatttgg tccatggatg
     3181 ctctgttgat caggcttgtt catttatgag caagtgctga aaccgtctgg aacctgggga
     3241 agtcccagat aagagaactg tattatcaga gtcaggctgt tttggtaata gtgttttttc
     3301 tgtgaagagt catggtataa aatattatta tgaatcactt atcaaaatat ttttatagaa
     3361 atgttgataa ttcagtaata cttcttaggt gaaattctgt tttattgtga taattcaaag
     3421 attgctgatg aaattcgtga ttcccatcat tacatttgtg aatccatttc acaaatatat
     3481 tttgaccacc tcttggttat caggcaccag agatgtaata gcgccttaag ttcaagttgt
     3541 ttttaatagc cccggatcaa aaacaaacaa aaaagcactt agattgtttc aaagatgtat
     3601 tcgagccgtc atatgctaaa tgacgagtta atgggtgcag cacaccagca tggcacatgt
     3661 atacatatgt aactaacctg cacattgtgc acatgtaccc taaaacttaa agtataataa
     3721 taattaaaaa aaaagaaaaa aaaagtttgt caaagtatta tcagaggttt gcagctgtct
     3781 atctcaaggc agtggcaatt tcctttgtta tgctgtggtc cctgaagtag ttgaaatagt
     3841 gacttttgca ttttgtaaac cacagagagt caacacttca aagaaacata cttgatcttc
     3901 ctttgtataa gctgtttata caactttgat tatacttgag aagtgaggta ttgtccaatg
     3961 tttatacaat tacaattcag gactttacca aaaaaaccct ggcatatgag atgttcgttc
     4021 tgacttctga gtttatagaa gtttcagttc tgaagtttaa gaggagtttc acttcatccc
     4081 ttttcatttt gaaggcagct gaaaaagttg gatgaagata gtttaaccaa acaaccagaa
     4141 gaagtatttg atgtcttaga gaaacttgga gaaggattac tgtagatgca gtatatggaa
     4201 tcaggaatct taacttcatg tgagctattg gagttttcct tgctatcagg atgcataggg
     4261 aggtcctatg gcagcgtata caaagctatt cataaagaga ccggccagat tgttgctatt
     4321 aagcaagttc ctgtggaatc agacctccag gagataatca aagaaatctc tataatgcag
     4381 caatgtgaca gccctcatgt agtcaaatat tatggcagtt attttaagaa cacagactta
     4441 tggatcgtta tggagtactg tggggctggt tctgtatctg atatcattcg attacgaaat
     4501 aaaacgttaa cagaagatga aatagctaca atattacaat caactcttaa gggacttgaa
     4561 taccttcatt ttatgagaaa aatacaccga gatatcaagg caggaaatat tttgctaaat
     4621 acagaaggac atgcaaaact tgcagatttt ggggtagcag gtcaacttac agataccatg
     4681 gccaagcgga atacagtgat aggaacacca ttttggatgg ctccagaagt gattcaggaa
     4741 attggataca actgtgtagc agacatctgg tccctgggaa taactgccat agaaatggct
     4801 gaaggaaagc ccccttatgc tgatatccat ccaatgaggg caatcttcat gattcctaca
     4861 aatcctcctc ccacattccg aaaaccagag ctatggtcag ataactttac agattttgtg
     4921 aaacagtgtc ttgtaaagag ccctgagcag agggccacag ccactcagct cctgcagcac
     4981 ccatttgtca ggagtgccaa aggagtgtca atactgcgag acttaattaa tgaagccatg
     5041 gatgtgaaac tgaaacgcca ggaatcccag cagcgggaag tggaccagga cgatgaagaa
     5101 aactcagaag aggatgaaat ggattctggc acgatggttc gagcagtggg tgatgagatg
     5161 ggcactgtcc gagtagccag caccatgact gatggagcca atactatgat tgagcacgat
     5221 gacacgttgc catcacaact gggcaccatg gtgatcaatg cagaggatga ggaagaggaa
     5281 ggaactatga aaagaaggga tgagaccatg cagcctgcga aaccatcctt tcttgaatat
     5341 tttgaacaaa aagaaaagga aaaccagatc aacagctttg gcaagagtgt acctggtcca
     5401 ctgaaaaatt cttcagattg gaaaatacca caggatggag actacgagtt tcttaagagt
     5461 tggacagtgg aggaccttca gaagaggctc ttggccctgg accccatgat ggagcaggag
     5521 attgaagaga tccggcagaa gtaccagtcc aagcggcagc ccatcctgga tgccatagag
     5581 gctaagaaga gacggcaaca aaacttctga gcaaggccag gctgtgaggg ccccagctcc
     5641 acccaggctt tgggtgaatt ctggatggct tgcctcatgt ttgttagcca gcacttctgc
     5701 tctgtcgtct ctccacagca cctttgtgaa ctcaggaatg tgcgccagtg ggaagggctc
     5761 tcttgacagt cagcgtgcca tcttgatgtg tgtatgtaca ttggtcaggt atattatctc
     5821 aaaggattta tattggcgct tttaactcag agttttaaac cccaggaaca gagactccta
     5881 gttgagtgat agctgggaaa gttttacatt gtctgttttt cttctcccaa tagctttcaa
     5941 ttgttctttc tggaagactt ttaaaaaaat ataaatatgc atatatatat ataaattata
     6001 aatagattcc ccacgcagtg tggtggcatc tctgtacagg tacagtttta aacggtttgc
     6061 ctcttttctg taagattatg gtactgtgga acatgagggc agaggacacc gggaggctgt
     6121 tagggggtca ctgaatccca ggagccaacc tccccctttg cagggctgca tttaaaaatt
     6181 aggtttggga cagttcttgt accgtggttt cagccttgtg tggtcatcac tggcttctgg
     6241 agctattggt gatgtccaag ggaaagcttt gagagtttat gtttactctt tgagtcccag
     6301 gagaagcctg gcaccctctt tgcaaattgg cctttgctct ttcaatgcct ttcatccatc
     6361 tccactctct caactgccta aagtcacagc acagatactg cccagtgcct taagaggaga
     6421 catgatctct accagggact ctcagcaaac acgggactgt gttcagtcca caaaggaaaa
     6481 gcgtttttga agctctcatt gttcatgtaa aaatcataca cgtggcatgt tgctccacat
     6541 tccttacaca caggggtaga ggggattgct tttgtgaccc acgttcaaat atgtgactgt
     6601 tttcttttct cttttactgc taagcagcct ggaaaggata aatgaatatt agactaagat
     6661 ttgttttcca ggaggctcaa tctgaacaca cagaatgtca gagctggaag ggactataga
     6721 gatcatctga tctgatcctc ttgtacggat gatcgcaaaa ctgaggtgta gagaggggaa
     6781 tggccaaaat cacaaagcaa gttagcgtta agagctgaga ctagaattca gggtcctcac
     6841 tcccaggcca ccgaaccatg cagccccttc tttgggggaa gagacctgtg tcagtcttgg
     6901 ttaattgttc cagggaacct tgctaacaga aacttgctct tgccttggct cttcagtaga
     6961 tgacctggct gtaaagagat tccctggacg agccagatca ttcagtttca gcgagtcctt
     7021 gagctccaca acatctacca gatatagcag acaagcaccc atggaggcag gtttcgggcc
     7081 tgaagcagat cagagggctt tgcaaaagac agcatagagc catcttcctg caactttacc
     7141 tctttccctc agatggggag ccatgactgg gttgcacctc aggatactgt aatttgactc
     7201 cataattgct tttgctcctg aaacctggga atcaatggaa aggcagggaa tgtgcctctt
     7261 ctgtggccag attctgttat ttgcaattaa agcaagtttt taaaaaatgc aagaggcagt
     7321 tgttagtctt cagggcttgg caactgaaat agctatgtgg cggatacgga aaacagagga
     7381 caatttgagg atcttgctgg aataataaat gacagctacc atttgttgag cacctattat
     7441 atatcaggca ctgagctggg taggctctaa acttcacaat aaccctgtga cttaactact
     7501 ttatctccat tttgtagttg aagaaataag ttcagagaga aagattcctt cccaaggtca
     7561 tgcagctagt aaatgataga atcaggattc atagcatcac tatagggggt caatatttac
     7621 acaaaaaagg aaagtcacaa gcctgtttaa aatgaagtga ccaccttttc ttgcatagac
     7681 taaataactc gaactggcat ttttaggttg gaaagacagc tgaattagta gttaagtctg
     7741 atagccaagt aagttttaaa aaccaaagca tccaggatgc acacccctgc accatttgct
     7801 gtgcgaatta atagttctgt ctctctctct ctttcttttt tctttttatt ctttgagatg
     7861 gattttcgct cttgtcgccc aggctggagt acaatggcac gatcttggct cactgcaacc
     7921 tccgcctccc gggttcaagc gattcttctg ctgggattac agcatatgcc accatgccca
     7981 gattattttt ttgtatttgt agtagagacg gggtttcacc atgtcagtca ggctggtctt
     8041 gaactcctga cctcaggtga tccacccgcc tcagcctccc acactgctgg gattacaggc
     8101 atgagccacc gctcctggcc tctctttctt ttttaaacaa agaactttgc acttggccag
     8161 agaggaggag aaagcccatt ttctcccttc ctaagctaga tccaaataaa agaaagttca
     8221 gttttccccc ataactattc ttgggtcatg aactttgatc tggagtttgt tttgtttcag
     8281 gaatgtgtgc acccagcttg ctgatccaac aaagtctatt gcttaccagt ctagcttgat
     8341 gaagcctttt ggccagaagt caatttgttt tggatcagag aaatttcctg acaaggtata
     8401 tttgttttct agtgacagaa aggcaaagga acaagtccta gttgttgttg ttgttgttga
     8461 atactaaatt taagatatgt cagcttgctt tcaatgagcc ttgggcttct gttattgctt
     8521 gagcatttgg aactcgagct tccagagaaa tttgaggtcc tcgcttgttc tctgccttca
     8581 agaaacaatg acctgattct gtctttaaaa aaaaaaatct cagaattctt tttttgtttg
     8641 tgtttttttt tttttttgag acagagtctc actctgttgc ccaggctgga gtgcagtggc
     8701 gccatctcgg ctcactgcaa cctccgcctc ccaggttcaa gcaattctcc tgcctcagcc
     8761 tcccaggtag ctgccactac aggtgctgca ccaccacgcc cggctaattt ttgtattttt
     8821 agtagagaca gggtttcacc atattagcca ggtgggtctt gaactcctga ccttgtgatc
     8881 cacccgcctc ggcctcccaa agtgctggga ttacaggcgt gagccacctt gcctggccaa
     8941 aaatctcaga attctttaag actgttttaa ttgctccatc agtaattttg aagcactttc
     9001 cttttttttt ttttttcccc tttttgtccc tttccccaag ccaccaattg gatggatgaa
     9061 tgtttgacgg ggaagaggaa gggtaggagg atgcatggat gagtggatga gtggatcgat
     9121 ggatgtattg ataaatagat agaaccagtc atctgaagca acttaagaat tgtagccttg
     9181 actccttgag actgtagatt tcgatccagg aaacatttat ttagcacctg ccagatgcca
     9241 gaaatttata ccatttaaaa ctcagtaagt cttttaaata tcaggaagga gagaagcgac
     9301 atcatgatac atcctatggg tattaaaaag ccaatagaat attatgaata attttatgct
     9361 aataaattta acaacttcaa catcataaac aaattccttg aaaaataaaa agtaccaaaa
     9421 ttcattcaag aagaaataga taccagcctg agcaacatgg caaaatccca tctctacaaa
     9481 acatcaaaaa aaaaaaaaat tagtcgggca tggtggtgca cacctgtaat cccagcttgt
     9541 caggaggctg aagtgggagg atcacctgag cccagggagg tcaaggatgc agtgagccat
     9601 ggtctcacca ctgcactcta gcctgggtga cagaatgaga ccccgtctca aaaaaaaaga
     9661 agaagtagat aatctgaata gccctatatc tatagaaact taatagtgct gggagatata
     9721 ggtattatta tcctcatttt acagatgtga aaattgaggc tcagagaagt aaagtctatt
     9781 gctcaaggtc atgtggctag aatatggcag agccatgatt cagatccagg tcttctgatt
     9841 cttattccag tgtcctttct agcataccat gttgcctcta aagattgcag ctccttattt
     9901 actagaaaat tgttcctgcc caatctacat ctccacctca ccccatcttt tcttaagcac
     9961 tatgtttgtg tttttatcag tattatattc attgtctttg gaatacatgt tcttgtttgt
    10021 gtttggaaaa aaaatctctt ttaccagctt gcactcggac caacttggaa aaaaaaaagc
    10081 ttaaatgttt ttgctatgta cagtttaaaa atgtgaagtt tgtagcttta actttttgta
    10141 agaaaatcta ataacactgg cttaagtgct gacttgaaat gctattttgt aaggtttgga
    10201 tgtaagtaat caattgaggt cagcagtttg tatgagacat agcttcctcc attgccccca
    10261 ctcctttttt cttttttaag tttgagatgc ttcctgtgtt tttatgttag aattgttgtt
    10321 ctccttcttt tcttcttcct atacctcatc acgtttgttt taaataaact gtcctttgga
    10381 ccacaaaccc ttattaacga gaacctcaat atatagcctg gataatggtg ttgtgaacaa
    10441 tctttgtgac attga
//
