LOCUS       NM_006282               6366 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens serine/threonine kinase 4 (STK4), transcript variant
            1, mRNA.
ACCESSION   NM_006282
VERSION     NM_006282.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6366)
  AUTHORS   Ye,H., Cai,T., Shen,Y., Zhao,L., Zhang,H., Yang,J., Li,F., Chen,J.
            and Shui,X.
  TITLE     MST1 knockdown inhibits osteoarthritis progression through
            Parkin-mediated mitophagy and Nrf2/NF-kappaB signalling pathway
  JOURNAL   J Cell Mol Med 28 (11), e18476 (2024)
   PUBMED   38842136
  REMARK    GeneRIF: MST1 knockdown inhibits osteoarthritis progression through
            Parkin-mediated mitophagy and Nrf2/NF-kappaB signalling pathway.
REFERENCE   2  (bases 1 to 6366)
  AUTHORS   Jeong,D.J., Um,J.H., Kim,Y.Y., Shin,D.J., Im,S., Lee,K.M.,
            Lee,Y.H., Lim,D.S., Kim,D. and Yun,J.
  TITLE     The Mst1/2-BNIP3 axis is required for mitophagy induction and
            neuronal viability under mitochondrial stress
  JOURNAL   Exp Mol Med 56 (3), 674-685 (2024)
   PUBMED   38443598
  REMARK    GeneRIF: The Mst1/2-BNIP3 axis is required for mitophagy induction
            and neuronal viability under mitochondrial stress.
REFERENCE   3  (bases 1 to 6366)
  AUTHORS   Ma,L., Gao,F., Dong,W., Song,Q. and Jia,Y.
  TITLE     Association Study between SNPs in MST1 and MST2 and H. pylori
            Infection as well as Noncardia Gastric Carcinogenesis
  JOURNAL   Dig Dis 42 (3), 230-239 (2024)
   PUBMED   38295774
  REMARK    GeneRIF: Association Study between SNPs in MST1 and MST2 and H.
            pylori Infection as well as Noncardia Gastric Carcinogenesis.
REFERENCE   4  (bases 1 to 6366)
  AUTHORS   Xu,Y., Qu,M., He,Y., He,Q., Shen,T., Luo,J., Tan,D., Bao,H., Xu,C.,
            Ji,X., Hu,X., Barkat,M.Q., Zeng,L.H. and Wu,X.
  TITLE     Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to
            attenuate their tumor-suppressor functions
  JOURNAL   J Biol Chem 299 (12), 105395 (2023)
   PUBMED   37890777
  REMARK    GeneRIF: Smurf1 polyubiquitinates on K285/K282 of the kinases
            Mst1/2 to attenuate their tumor-suppressor functions.
REFERENCE   5  (bases 1 to 6366)
  AUTHORS   Bai,Z.Y., Peng,L.S., Li,R.Q., Peng,X. and Yang,Z.
  TITLE     STK4 is a prognostic biomarker correlated with immune infiltrates
            in clear cell renal cell carcinoma
  JOURNAL   Aging (Albany NY) 15 (20), 11286-11297 (2023)
   PUBMED   37870765
  REMARK    GeneRIF: STK4 is a prognostic biomarker correlated with immune
            infiltrates in clear cell renal cell carcinoma.
REFERENCE   6  (bases 1 to 6366)
  AUTHORS   Creasy,C.L. and Chernoff,J.
  TITLE     Cloning and characterization of a member of the MST subfamily of
            Ste20-like kinases
  JOURNAL   Gene 167 (1-2), 303-306 (1995)
   PUBMED   8566796
REFERENCE   7  (bases 1 to 6366)
  AUTHORS   Creasy,C.L. and Chernoff,J.
  TITLE     Cloning and characterization of a human protein kinase with
            homology to Ste20
  JOURNAL   J Biol Chem 270 (37), 21695-21700 (1995)
   PUBMED   7665586
REFERENCE   8  (bases 1 to 6366)
  AUTHORS   Schultz,S.J. and Nigg,E.A.
  TITLE     Identification of 21 novel human protein kinases, including 3
            members of a family related to the cell cycle regulator nimA of
            Aspergillus nidulans
  JOURNAL   Cell Growth Differ 4 (10), 821-830 (1993)
   PUBMED   8274451
REFERENCE   9  (bases 1 to 6366)
  AUTHORS   Han,S., Stuart,L.A. and Degen,S.J.
  TITLE     Characterization of the DNF15S2 locus on human chromosome 3:
            identification of a gene coding for four kringle domains with
            homology to hepatocyte growth factor
  JOURNAL   Biochemistry 30 (40), 9768-9780 (1991)
   PUBMED   1655021
REFERENCE   10 (bases 1 to 6366)
  AUTHORS   Gerber,M.J., Drabkin,H.A., Firnhaber,C., Miller,Y.E., Scoggin,C.H.
            and Smith,D.I.
  TITLE     Regional localization of chromosome 3-specific DNA fragments by
            using a hybrid cell deletion mapping panel
  JOURNAL   Am J Hum Genet 43 (4), 442-451 (1988)
   PUBMED   2902784
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL597960.1, U60207.1, Z93016.2
            and AK027088.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006282.4.
            
            Summary: The protein encoded by this gene is a cytoplasmic kinase
            that is structurally similar to the yeast Ste20p kinase, which acts
            upstream of the stress-induced mitogen-activated protein kinase
            cascade. The encoded protein can phosphorylate myelin basic protein
            and undergoes autophosphorylation. A caspase-cleaved fragment of
            the encoded protein has been shown to be capable of phosphorylating
            histone H2B. The particular phosphorylation catalyzed by this
            protein has been correlated with apoptosis, and it's possible that
            this protein induces the chromatin condensation observed in this
            process. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.261078.1,
                                           SRR1660807.77040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372806.8/ ENSP00000361892.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AL597960.1         39-62
            25-1929             U60207.1           10-1914
            1930-6001           Z93016.2           76369-80440
            6002-6322           AK027088.1         1185-1505
            6323-6366           Z93016.2           80762-80805
FEATURES             Location/Qualifiers
     source          1..6366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..6366
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /note="serine/threonine kinase 4"
                     /db_xref="GeneID:6789"
                     /db_xref="HGNC:HGNC:11408"
                     /db_xref="MIM:604965"
     exon            1..92
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1521
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinase responsive to stress 2; mammalian sterile 20-like
                     1; serine/threonine-protein kinase 4; STE20-like kinase
                     MST1; mammalian STE20-like protein kinase 1;
                     serine/threonine-protein kinase Krs-2; hippo homolog"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 4 isoform 1"
                     /protein_id="NP_006273.1"
                     /db_xref="CCDS:CCDS13341.1"
                     /db_xref="GeneID:6789"
                     /db_xref="HGNC:HGNC:11408"
                     /db_xref="MIM:604965"
                     /translation="METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSV
                     YKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVM
                     EYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTE
                     GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMA
                     EGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLL
                     QHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAV
                     GDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAK
                     PSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLA
                     LDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF"
     exon            93..173
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            174..302
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            303..417
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            418..582
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            583..750
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            751..888
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1017
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1204
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1362
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..6366
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6274..6279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /note="hexamer: AATAAA"
     polyA_site      6298
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /note="major polyA site"
     regulatory      6319..6324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
                     /note="hexamer: AATATA"
     polyA_site      6320
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
     polyA_site      6366
                     /gene="STK4"
                     /gene_synonym="KRS2; MST1; YSK3"
ORIGIN      
        1 aggaggtccg cgggaggatg gagcagtgag cgggtctggg cggctgctgg cagcgccatg
       61 gagacggtac agctgaggaa cccgccgcgc cggcagctga aaaagttgga tgaagatagt
      121 ttaaccaaac aaccagaaga agtatttgat gtcttagaga aacttggaga agggtcctat
      181 ggcagcgtat acaaagctat tcataaagag accggccaga ttgttgctat taagcaagtt
      241 cctgtggaat cagacctcca ggagataatc aaagaaatct ctataatgca gcaatgtgac
      301 agccctcatg tagtcaaata ttatggcagt tattttaaga acacagactt atggatcgtt
      361 atggagtact gtggggctgg ttctgtatct gatatcattc gattacgaaa taaaacgtta
      421 acagaagatg aaatagctac aatattacaa tcaactctta agggacttga ataccttcat
      481 tttatgagaa aaatacaccg agatatcaag gcaggaaata ttttgctaaa tacagaagga
      541 catgcaaaac ttgcagattt tggggtagca ggtcaactta cagataccat ggccaagcgg
      601 aatacagtga taggaacacc attttggatg gctccagaag tgattcagga aattggatac
      661 aactgtgtag cagacatctg gtccctggga ataactgcca tagaaatggc tgaaggaaag
      721 cccccttatg ctgatatcca tccaatgagg gcaatcttca tgattcctac aaatcctcct
      781 cccacattcc gaaaaccaga gctatggtca gataacttta cagattttgt gaaacagtgt
      841 cttgtaaaga gccctgagca gagggccaca gccactcagc tcctgcagca cccatttgtc
      901 aggagtgcca aaggagtgtc aatactgcga gacttaatta atgaagccat ggatgtgaaa
      961 ctgaaacgcc aggaatccca gcagcgggaa gtggaccagg acgatgaaga aaactcagaa
     1021 gaggatgaaa tggattctgg cacgatggtt cgagcagtgg gtgatgagat gggcactgtc
     1081 cgagtagcca gcaccatgac tgatggagcc aatactatga ttgagcacga tgacacgttg
     1141 ccatcacaac tgggcaccat ggtgatcaat gcagaggatg aggaagagga aggaactatg
     1201 aaaagaaggg atgagaccat gcagcctgcg aaaccatcct ttcttgaata ttttgaacaa
     1261 aaagaaaagg aaaaccagat caacagcttt ggcaagagtg tacctggtcc actgaaaaat
     1321 tcttcagatt ggaaaatacc acaggatgga gactacgagt ttcttaagag ttggacagtg
     1381 gaggaccttc agaagaggct cttggccctg gaccccatga tggagcagga gattgaagag
     1441 atccggcaga agtaccagtc caagcggcag cccatcctgg atgccataga ggctaagaag
     1501 agacggcaac aaaacttctg agcaaggcca ggctgtgagg gccccagctc cacccaggct
     1561 ttgggtgaat tctggatggc ttgcctcatg tttgttagcc agcacttctg ctctgtcgtc
     1621 tctccacagc acctttgtga actcaggaat gtgcgccagt gggaagggct ctcttgacag
     1681 tcagcgtgcc atcttgatgt gtgtatgtac attggtcagg tatattatct caaaggattt
     1741 atattggcgc ttttaactca gagttttaaa ccccaggaac agagactcct agttgagtga
     1801 tagctgggaa agttttacat tgtctgtttt tcttctccca atagctttca attgttcttt
     1861 ctggaagact tttaaaaaaa tataaatatg catatatata tataaattat aaatagattc
     1921 cccacgcagt gtggtggcat ctctgtacag gtacagtttt aaacggtttg cctcttttct
     1981 gtaagattat ggtactgtgg aacatgaggg cagaggacac cgggaggctg ttagggggtc
     2041 actgaatccc aggagccaac ctcccccttt gcagggctgc atttaaaaat taggtttggg
     2101 acagttcttg taccgtggtt tcagccttgt gtggtcatca ctggcttctg gagctattgg
     2161 tgatgtccaa gggaaagctt tgagagttta tgtttactct ttgagtccca ggagaagcct
     2221 ggcaccctct ttgcaaattg gcctttgctc tttcaatgcc tttcatccat ctccactctc
     2281 tcaactgcct aaagtcacag cacagatact gcccagtgcc ttaagaggag acatgatctc
     2341 taccagggac tctcagcaaa cacgggactg tgttcagtcc acaaaggaaa agcgtttttg
     2401 aagctctcat tgttcatgta aaaatcatac acgtggcatg ttgctccaca ttccttacac
     2461 acaggggtag aggggattgc ttttgtgacc cacgttcaaa tatgtgactg ttttcttttc
     2521 tcttttactg ctaagcagcc tggaaaggat aaatgaatat tagactaaga tttgttttcc
     2581 aggaggctca atctgaacac acagaatgtc agagctggaa gggactatag agatcatctg
     2641 atctgatcct cttgtacgga tgatcgcaaa actgaggtgt agagagggga atggccaaaa
     2701 tcacaaagca agttagcgtt aagagctgag actagaattc agggtcctca ctcccaggcc
     2761 accgaaccat gcagcccctt ctttggggga agagacctgt gtcagtcttg gttaattgtt
     2821 ccagggaacc ttgctaacag aaacttgctc ttgccttggc tcttcagtag atgacctggc
     2881 tgtaaagaga ttccctggac gagccagatc attcagtttc agcgagtcct tgagctccac
     2941 aacatctacc agatatagca gacaagcacc catggaggca ggtttcgggc ctgaagcaga
     3001 tcagagggct ttgcaaaaga cagcatagag ccatcttcct gcaactttac ctctttccct
     3061 cagatgggga gccatgactg ggttgcacct caggatactg taatttgact ccataattgc
     3121 ttttgctcct gaaacctggg aatcaatgga aaggcaggga atgtgcctct tctgtggcca
     3181 gattctgtta tttgcaatta aagcaagttt ttaaaaaatg caagaggcag ttgttagtct
     3241 tcagggcttg gcaactgaaa tagctatgtg gcggatacgg aaaacagagg acaatttgag
     3301 gatcttgctg gaataataaa tgacagctac catttgttga gcacctatta tatatcaggc
     3361 actgagctgg gtaggctcta aacttcacaa taaccctgtg acttaactac tttatctcca
     3421 ttttgtagtt gaagaaataa gttcagagag aaagattcct tcccaaggtc atgcagctag
     3481 taaatgatag aatcaggatt catagcatca ctataggggg tcaatattta cacaaaaaag
     3541 gaaagtcaca agcctgttta aaatgaagtg accacctttt cttgcataga ctaaataact
     3601 cgaactggca tttttaggtt ggaaagacag ctgaattagt agttaagtct gatagccaag
     3661 taagttttaa aaaccaaagc atccaggatg cacacccctg caccatttgc tgtgcgaatt
     3721 aatagttctg tctctctctc tctttctttt ttctttttat tctttgagat ggattttcgc
     3781 tcttgtcgcc caggctggag tacaatggca cgatcttggc tcactgcaac ctccgcctcc
     3841 cgggttcaag cgattcttct gctgggatta cagcatatgc caccatgccc agattatttt
     3901 tttgtatttg tagtagagac ggggtttcac catgtcagtc aggctggtct tgaactcctg
     3961 acctcaggtg atccacccgc ctcagcctcc cacactgctg ggattacagg catgagccac
     4021 cgctcctggc ctctctttct tttttaaaca aagaactttg cacttggcca gagaggagga
     4081 gaaagcccat tttctccctt cctaagctag atccaaataa aagaaagttc agttttcccc
     4141 cataactatt cttgggtcat gaactttgat ctggagtttg ttttgtttca ggaatgtgtg
     4201 cacccagctt gctgatccaa caaagtctat tgcttaccag tctagcttga tgaagccttt
     4261 tggccagaag tcaatttgtt ttggatcaga gaaatttcct gacaaggtat atttgttttc
     4321 tagtgacaga aaggcaaagg aacaagtcct agttgttgtt gttgttgttg aatactaaat
     4381 ttaagatatg tcagcttgct ttcaatgagc cttgggcttc tgttattgct tgagcatttg
     4441 gaactcgagc ttccagagaa atttgaggtc ctcgcttgtt ctctgccttc aagaaacaat
     4501 gacctgattc tgtctttaaa aaaaaaaatc tcagaattct ttttttgttt gtgttttttt
     4561 ttttttttga gacagagtct cactctgttg cccaggctgg agtgcagtgg cgccatctcg
     4621 gctcactgca acctccgcct cccaggttca agcaattctc ctgcctcagc ctcccaggta
     4681 gctgccacta caggtgctgc accaccacgc ccggctaatt tttgtatttt tagtagagac
     4741 agggtttcac catattagcc aggtgggtct tgaactcctg accttgtgat ccacccgcct
     4801 cggcctccca aagtgctggg attacaggcg tgagccacct tgcctggcca aaaatctcag
     4861 aattctttaa gactgtttta attgctccat cagtaatttt gaagcacttt cctttttttt
     4921 tttttttccc ctttttgtcc ctttccccaa gccaccaatt ggatggatga atgtttgacg
     4981 gggaagagga agggtaggag gatgcatgga tgagtggatg agtggatcga tggatgtatt
     5041 gataaataga tagaaccagt catctgaagc aacttaagaa ttgtagcctt gactccttga
     5101 gactgtagat ttcgatccag gaaacattta tttagcacct gccagatgcc agaaatttat
     5161 accatttaaa actcagtaag tcttttaaat atcaggaagg agagaagcga catcatgata
     5221 catcctatgg gtattaaaaa gccaatagaa tattatgaat aattttatgc taataaattt
     5281 aacaacttca acatcataaa caaattcctt gaaaaataaa aagtaccaaa attcattcaa
     5341 gaagaaatag ataccagcct gagcaacatg gcaaaatccc atctctacaa aacatcaaaa
     5401 aaaaaaaaaa ttagtcgggc atggtggtgc acacctgtaa tcccagcttg tcaggaggct
     5461 gaagtgggag gatcacctga gcccagggag gtcaaggatg cagtgagcca tggtctcacc
     5521 actgcactct agcctgggtg acagaatgag accccgtctc aaaaaaaaag aagaagtaga
     5581 taatctgaat agccctatat ctatagaaac ttaatagtgc tgggagatat aggtattatt
     5641 atcctcattt tacagatgtg aaaattgagg ctcagagaag taaagtctat tgctcaaggt
     5701 catgtggcta gaatatggca gagccatgat tcagatccag gtcttctgat tcttattcca
     5761 gtgtcctttc tagcatacca tgttgcctct aaagattgca gctccttatt tactagaaaa
     5821 ttgttcctgc ccaatctaca tctccacctc accccatctt ttcttaagca ctatgtttgt
     5881 gtttttatca gtattatatt cattgtcttt ggaatacatg ttcttgtttg tgtttggaaa
     5941 aaaaatctct tttaccagct tgcactcgga ccaacttgga aaaaaaaaag cttaaatgtt
     6001 tttgctatgt acagtttaaa aatgtgaagt ttgtagcttt aactttttgt aagaaaatct
     6061 aataacactg gcttaagtgc tgacttgaaa tgctattttg taaggtttgg atgtaagtaa
     6121 tcaattgagg tcagcagttt gtatgagaca tagcttcctc cattgccccc actccttttt
     6181 tcttttttaa gtttgagatg cttcctgtgt ttttatgtta gaattgttgt tctccttctt
     6241 ttcttcttcc tatacctcat cacgtttgtt ttaaataaac tgtcctttgg accacaaacc
     6301 cttattaacg agaacctcaa tatatagcct ggataatggt gttgtgaaca atctttgtga
     6361 cattga
//
