LOCUS       NM_015000               4957 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens serine/threonine kinase 38 like (STK38L), mRNA.
ACCESSION   NM_015000
VERSION     NM_015000.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4957)
  AUTHORS   Levallet,J., Biojout,T., Bazille,C., Douyere,M., Dubois,F.,
            Ferreira,D.L., Taylor,J., Teulier,S., Toutain,J., Elie,N.,
            Bernaudin,M., Valable,S., Bergot,E. and Levallet,G.
  TITLE     Hypoxia-induced activation of NDR2 underlies brain metastases from
            Non-Small Cell Lung Cancer
  JOURNAL   Cell Death Dis 14 (12), 823 (2023)
   PUBMED   38092743
  REMARK    GeneRIF: Hypoxia-induced activation of NDR2 underlies brain
            metastases from Non-Small Cell Lung Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4957)
  AUTHORS   Yang,Y., Zhu,Y., Zhou,S., Tang,P., Xu,R., Zhang,Y., Wei,D., Wen,J.,
            Thorne,R.F., Zhang,X.D., Guan,J.L., Liu,L., Wu,M. and Chen,S.
  TITLE     TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy
            and promote tumorigenesis
  JOURNAL   EMBO J 41 (14), e109777 (2022)
   PUBMED   35670107
  REMARK    GeneRIF: TRIM27 cooperates with STK38L to inhibit ULK1-mediated
            autophagy and promote tumorigenesis.
REFERENCE   3  (bases 1 to 4957)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4957)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4957)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4957)
  AUTHORS   Devroe,E., Silver,P.A. and Engelman,A.
  TITLE     HIV-1 incorporates and proteolytically processes human NDR1 and
            NDR2 serine-threonine kinases
  JOURNAL   Virology 331 (1), 181-189 (2005)
   PUBMED   15582665
  REMARK    GeneRIF: The NDR1 and NDR2 kinases were incorporated into HIV-1
            particles and were cleaved by the HIV-1 protease.
REFERENCE   7  (bases 1 to 4957)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   8  (bases 1 to 4957)
  AUTHORS   Bichsel,S.J., Tamaskovic,R., Stegert,M.R. and Hemmings,B.A.
  TITLE     Mechanism of activation of NDR (nuclear Dbf2-related) protein
            kinase by the hMOB1 protein
  JOURNAL   J Biol Chem 279 (34), 35228-35235 (2004)
   PUBMED   15197186
REFERENCE   9  (bases 1 to 4957)
  AUTHORS   Devroe,E., Erdjument-Bromage,H., Tempst,P. and Silver,P.A.
  TITLE     Human Mob proteins regulate the NDR1 and NDR2 serine-threonine
            kinases
  JOURNAL   J Biol Chem 279 (23), 24444-24451 (2004)
   PUBMED   15067004
  REMARK    GeneRIF: NDR1 and NDR2 serine-threonine kinases are regulated by
            mob proteins
REFERENCE   10 (bases 1 to 4957)
  AUTHORS   Stegert,M.R., Tamaskovic,R., Bichsel,S.J., Hergovich,A. and
            Hemmings,B.A.
  TITLE     Regulation of NDR2 protein kinase by multi-site phosphorylation and
            the S100B calcium-binding protein
  JOURNAL   J Biol Chem 279 (22), 23806-23812 (2004)
   PUBMED   15037617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB023182.2, BX390969.1 and BU681056.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015000.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023182.2, SRR1660807.139823.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389032.8/ ENSP00000373684.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1050              AB023182.2         227-1276
            1051-1442           BX390969.1         277-668
            1443-3249           AB023182.2         1669-3475
            3250-4934           AB023182.2         3478-5162
            4935-4957           BU681056.1         13-35               c
FEATURES             Location/Qualifiers
     source          1..4957
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.23"
     gene            1..4957
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /note="serine/threonine kinase 38 like"
                     /db_xref="GeneID:23012"
                     /db_xref="HGNC:HGNC:17848"
                     /db_xref="MIM:615836"
     exon            1..47
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            48..192
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1453
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /EC_number="2.7.11.1"
                     /note="nuclear Dbf2-related 2; NDR2 protein kinase;
                     nuclear Dbf2-related kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 38-like"
                     /protein_id="NP_055815.1"
                     /db_xref="CCDS:CCDS31761.1"
                     /db_xref="GeneID:23012"
                     /db_xref="HGNC:HGNC:17848"
                     /db_xref="MIM:615836"
                     /translation="MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERET
                     RQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFG
                     EVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDK
                     RNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDN
                     LLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNR
                     RQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRK
                     VMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIR
                     ERPAAIPIEIKSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLT
                     QRGSIPTYMKAGKL"
     exon            193..244
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            245..367
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..451
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            452..575
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..730
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..833
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..895
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1013
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1137
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1233
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1325
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..4957
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1693..1698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /note="hexamer: AATAAA"
     polyA_site      1720
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /note="major polyA site"
     regulatory      4068..4073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /note="hexamer: ATTAAA"
     polyA_site      4092
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /note="major polyA site"
     regulatory      4936..4941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /note="hexamer: AATAAA"
     polyA_site      4957
                     /gene="STK38L"
                     /gene_synonym="NDR2"
                     /note="major polyA site"
ORIGIN      
        1 gcggtccgtg cggaggctga gccggccgcg ggcgcgaccg gaggcagttt ccgttactat
       61 ggcaatgacg gcagggacta caacaacctt tcctatgagc aaccataccc gggaaagagt
      121 gactgtagcc aagctcacat tggagaattt ttatagcaac ctaattttac agcatgaaga
      181 gagagaaacc aggcagaaga aattagaagt ggccatggaa gaagaaggat tagcagatga
      241 agagaaaaag ttacgtcgat cacaacacgc tcgcaaagaa acagagttct tacggctcaa
      301 aaggaccaga cttggcttgg atgactttga gtctctgaaa gttataggaa gaggagcttt
      361 tggagaggtg cggttggtcc agaagaaaga tacaggccat atctatgcaa tgaagatatt
      421 gagaaagtct gatatgcttg aaaaagagca ggtggcccat atccgagcag aaagagatat
      481 tttggtagaa gcagatggtg cctgggtggt gaagatgttt tacagttttc aggataagag
      541 gaatctttat ctaatcatgg aatttctccc tggaggtgac atgatgacat tgctaatgaa
      601 gaaagacacc ttgacagaag aggaaacaca gttctacatt tcagagactg ttctggcaat
      661 agatgcgatc caccagttgg gtttcatcca tcgggatatt aagccagaca accttttatt
      721 ggatgccaag ggtcatgtaa aattatctga ttttggttta tgtacgggat taaagaaagc
      781 tcacaggact gaattttata gaaatctcac acacaaccca ccaagtgact tctcatttca
      841 gaacatgaac tcaaagagga aagcagaaac ttggaagaag aacaggagac aactggcata
      901 ttccacagtt gggacaccag attacattgc tccagaagta ttcatgcaga ctggttacaa
      961 caaattgtgt gactggtggt ctttgggagt gattatgtat gaaatgctaa taggatatcc
     1021 acctttctgc tctgaaacac ctcaagaaac gtacagaaaa gtgatgaact ggaaagaaac
     1081 tctggtattt cctccagagg tacctatatc tgagaaagcc aaggacttaa ttctcagatt
     1141 ttgtattgat tctgaaaaca gaattggaaa tagtggagta gaagaaataa aaggtcatcc
     1201 cttttttgaa ggtgtcgact gggagcacat aagggaaagg ccagcagcaa tccctataga
     1261 aatcaaaagc attgatgata cttcaaattt tgatgacttc cctgaatctg atattttaca
     1321 accagtgcca aataccacag aaccggacta caaatccaaa gactgggttt ttctcaatta
     1381 tacctataaa aggtttgaag ggttgactca acgtggctct atccccacct acatgaaagc
     1441 tgggaagtta tgaatgaaga taacattcac ccataaccaa gagaactcag gtagctgcat
     1501 caccaggctt gcttggcgta gataacaata cactgaaata ctcctgaaga tggtggtgct
     1561 tattgactac aagaggaaat tctacaggat taggatttct aagactacta taggaattgg
     1621 ttggcagtgc cagctggctc ttttttttaa tattttatta tttttgttaa ctttattata
     1681 tgaaggtact ggaataaaag gaacagacat ccctttctaa ctgcactgcc tacatgcgta
     1741 ttaaggtcca ttctgcctgt gtgtgctgtg gctttgaact gtaacacctc taatcaattc
     1801 aggagaaaca catatcattt aaagcaacat aggctaacct gtaggtaaca ctgcagtatt
     1861 gatgttttac tgcaaatctt atgggtctag ataatcagta aaagccatct tccatagttg
     1921 gtgttagaac attgccctat tggtttggac atctgtagaa tatatatgaa gacaatttct
     1981 gtaatggttt taagagattt aaaaagaaat tcactggttc tttacaaaat agaatttatc
     2041 atcaagttat tacacaaact tcacagtaag gagtgacaag tttataataa ggaagacaaa
     2101 gtttaacacc ttcactcaag cactccacta atatatttac gttgcattca gaaatactga
     2161 tgaccttcat atacgtagtc tgtatactca tagggagatg tactgtatta tataacatgt
     2221 aaagttgatt ttcttgtgac aagagaactt ctttttttaa caagaggaca tggcattatt
     2281 ttaatttgat tatggtgagt tgaatttaag acatgaccat gaaggctgct tgtagaatta
     2341 gtgtattttt attaaactat ttttttaaat gtcaaacttc tatcatgtaa atggacttat
     2401 agagaacaaa aagctattta ctttggtttt ctagaaagtt gttacatatc atggctggtt
     2461 aacttttatt tcttttgatg aaaatttttc ctttgatagt acttgtatta ttgtgccatt
     2521 attttcttat gctccaaatg taccaaagat cttgaacaga gtggatgttc acaactgagt
     2581 agaattttcc tttcctgtgg gcatgctgta ttcagacctg acagatcttt gatagaggtc
     2641 agcttattaa agggcaatat tgttcttgtt tagctacatc actgtggtga atatagatgg
     2701 aattaaggaa gtaaatgcag gccagggggt tgtgatgaga ggatagggga gataatatca
     2761 gcatcaaatt ctttgggtat ctctctaaga attaaataat cttttctagc ttaatatttt
     2821 aattctaatt caaacaactc tgaggttttg gtttcattag taatagttga ggaataatat
     2881 actagcaaag aatggcctaa tgtttgtcat aactgttaat ggatgaaatt ttttaaagat
     2941 acaaccatga taaccattat aaatgatcta tgatcaaaat ctaaagtgat gaattatttg
     3001 taggaatgtc ttcctaatgg ggaagaattg cataggagca ttatgcaaat ctacacaagc
     3061 ttttataaat gttgctgctg ggtagctcca cagtgtttca taaggccatc ctgtttcccc
     3121 caactccccc atttttggtt tgtttctttt taaatatttg ttgagtactt acgtgtttat
     3181 ctaacagttc acttccattt ttctagtctg gattttttga gtatttagga aagagagcta
     3241 ttaaaaactg gggatttctc aatgtgacta actctaattt ttctaattat aactgccttt
     3301 aattaacata atattaactt ttgctgaggt ttatgagatt ttctcacccc acatcgctcc
     3361 ccttttttta aaaaggactg ttttgctagt gtgataatga ataggtaaga tatgagataa
     3421 ttgcaacatt gtctagttct agtatggtaa ctattcttga aatggtattg aaaaataccg
     3481 ttaattcaaa ttgacagaga ttgataaaaa gaaactgatt tacctaagtt tactttttaa
     3541 ttgcataata gagcattttt tgttttgagt tccctcattc ttattaccag aaagagcttg
     3601 caaatagttt tactttcttg gcactggaag ggtagttctg gaaagctact ttgttgagag
     3661 tctcattctt ccctggagtt aatagagtga ttcacaatct ttggggtttt ctcctcatca
     3721 aaagcatttc ttaagtgcct atctaaaagc aattaaagac tgtgtctgcc ctttagaagc
     3781 taagaatttg attcatgatg caaattaact agataatttg caaagtaccc ttgagattga
     3841 attttctcta ttatatattt cccatatttc aggtgaataa tttaatttaa atgacaaaac
     3901 cctatctagt caactgggca taatgacatt ttctttaaat tagactctat tttgaattaa
     3961 aagagtttta ttataaaccg tgtgtttttg gtttttctaa gtatatagaa agcttgtata
     4021 attcagattt atcaatttcc tgatttaatg tagactttga cttttttatt aaaaaccttt
     4081 gtattaaagc aagttatgtt atttttcttt tatgcattta ttactaacat agctttaaat
     4141 ctttaaatgt attgaagcat tgtgctgtct gaaaataagg aattgcttat aaaccagcca
     4201 cttctgaata caatatgtag ctgatttaat aagctagtta gtgaatggaa aataagtgtg
     4261 gagtattaaa aatgttcttt ggttggtaag gcctaagata gggtttcatt tatttctata
     4321 ctttttctgt tttttaaaca cctgcatatt tttatgtaaa tctctaaatt taaaatattt
     4381 taagtacatt tatttttggt gttttattgt ataaaacctt agacaatcaa tcagtcagtc
     4441 tttactgaca ggagcagcag ctatctgtct tttgctgatc tacaaataaa tgaattgaga
     4501 atttagtcca tagaggtccc tggctaccaa acacattctc ctttgaattg ttaaaattca
     4561 gaacattcaa aataactgtt ttgctacaac ccatgattat tttcctgttg tgtttattta
     4621 aatttacttt ctctttagaa gtgcacttat ttctgaaaaa tcttaatgaa acaaacgctt
     4681 agaacaaata taaatatgag acacttggga ctactagaga tattttagat ttttatgaaa
     4741 aaaatgtgag gggatattgc tgctttaaaa aggaataaag taataaaaat atatctcagc
     4801 tattttttta aagcaatata attcagcaat tgtctagaaa agtaatcatg aggctactga
     4861 gtttggtgtt cagttactga gtttcaaaaa tgttttggtg gcatgaggac aaaatttcat
     4921 tgaaggtaag ataagaataa aaactatgtt tacaaaa
//
