LOCUS       NM_007271               3585 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens serine/threonine kinase 38 (STK38), transcript variant
            1, mRNA.
ACCESSION   NM_007271
VERSION     NM_007271.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3585)
  AUTHORS   Ogura,M., Kaminishi,T., Shima,T., Torigata,M., Bekku,N., Tabata,K.,
            Minami,S., Nishino,K., Nezu,A., Hamasaki,M., Kosako,H.,
            Yoshimori,T. and Nakamura,S.
  TITLE     Microautophagy regulated by STK38 and GABARAPs is essential to
            repair lysosomes and prevent aging
  JOURNAL   EMBO Rep 24 (12), e57300 (2023)
   PUBMED   37987447
  REMARK    GeneRIF: Microautophagy regulated by STK38 and GABARAPs is
            essential to repair lysosomes and prevent aging.
REFERENCE   2  (bases 1 to 3585)
  AUTHORS   Liu,Y., Shi,Z., Zheng,Z., Li,J., Yang,K., Xu,C., Liu,Q., Gong,Z.,
            Yang,Y., Zhao,Y., Xuan,Z., Sun,H. and Shao,C.
  TITLE     Prognostic and Immunological Role of STK38 across Cancers: Friend
            or Foe?
  JOURNAL   Int J Mol Sci 23 (19), 11590 (2022)
   PUBMED   36232893
  REMARK    GeneRIF: Prognostic and Immunological Role of STK38 across Cancers:
            Friend or Foe?
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3585)
  AUTHORS   Wang,L.L., Wan,X.Y., Liu,C.Q. and Zheng,F.M.
  TITLE     NDR1 increases NOTCH1 signaling activity by impairing Fbw7 mediated
            NICD degradation to enhance breast cancer stem cell properties
  JOURNAL   Mol Med 28 (1), 49 (2022)
   PUBMED   35508987
  REMARK    GeneRIF: NDR1 increases NOTCH1 signaling activity by impairing Fbw7
            mediated NICD degradation to enhance breast cancer stem cell
            properties.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3585)
  AUTHORS   Qian,K., Yu,D., Wang,W., Jiang,M., Yang,R., Brown,R. and Gong,D.W.
  TITLE     STK38 is a PPARgamma-interacting protein promoting adipogenesis
  JOURNAL   Adipocyte 10 (1), 524-531 (2021)
   PUBMED   34670478
  REMARK    GeneRIF: STK38 is a PPARgamma-interacting protein promoting
            adipogenesis.
REFERENCE   5  (bases 1 to 3585)
  AUTHORS   Hergovich,A.
  TITLE     Regulation and functions of mammalian LATS/NDR kinases: looking
            beyond canonical Hippo signalling
  JOURNAL   Cell Biosci 3 (1), 32 (2013)
   PUBMED   23985307
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3585)
  AUTHORS   Devroe,E., Erdjument-Bromage,H., Tempst,P. and Silver,P.A.
  TITLE     Human Mob proteins regulate the NDR1 and NDR2 serine-threonine
            kinases
  JOURNAL   J Biol Chem 279 (23), 24444-24451 (2004)
   PUBMED   15067004
  REMARK    GeneRIF: NDR1 and NDR2 serine-threonine kinases are regulated by
            mob proteins
REFERENCE   7  (bases 1 to 3585)
  AUTHORS   Bhattacharya,S., Large,E., Heizmann,C.W., Hemmings,B. and
            Chazin,W.J.
  TITLE     Structure of the Ca2+/S100B/NDR kinase peptide complex: insights
            into S100 target specificity and activation of the kinase
  JOURNAL   Biochemistry 42 (49), 14416-14426 (2003)
   PUBMED   14661952
REFERENCE   8  (bases 1 to 3585)
  AUTHORS   Tamaskovic,R., Bichsel,S.J., Rogniaux,H., Stegert,M.R. and
            Hemmings,B.A.
  TITLE     Mechanism of Ca2+-mediated regulation of NDR protein kinase through
            autophosphorylation and phosphorylation by an upstream kinase
  JOURNAL   J Biol Chem 278 (9), 6710-6718 (2003)
   PUBMED   12493777
REFERENCE   9  (bases 1 to 3585)
  AUTHORS   Millward,T.A., Heizmann,C.W., Schafer,B.W. and Hemmings,B.A.
  TITLE     Calcium regulation of Ndr protein kinase mediated by S100
            calcium-binding proteins
  JOURNAL   EMBO J 17 (20), 5913-5922 (1998)
   PUBMED   9774336
REFERENCE   10 (bases 1 to 3585)
  AUTHORS   Millward,T., Cron,P. and Hemmings,B.A.
  TITLE     Molecular cloning and characterization of a conserved nuclear
            serine(threonine) protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 92 (11), 5022-5026 (1995)
   PUBMED   7761441
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA459946.1, BC012085.1 and
            CB852856.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007271.3.
            
            Summary: This gene encodes a member of the AGC serine/threonine
            kinase family of proteins. The kinase activity of this protein is
            regulated by autophosphorylation and phosphorylation by other
            upstream kinases. This protein has been shown to function in the
            cell cycle and apoptosis. This protein has also been found to
            regulate the protein stability and transcriptional activity of the
            MYC oncogene. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Feb 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012085.1, SRR1803616.179486.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229812.8/ ENSP00000229812.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA459946.1         38-46
            10-3584             BC012085.1         1-3575
            3585-3585           CB852856.1         26-26               c
FEATURES             Location/Qualifiers
     source          1..3585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..3585
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /note="serine/threonine kinase 38"
                     /db_xref="GeneID:11329"
                     /db_xref="HGNC:HGNC:17847"
                     /db_xref="MIM:606964"
     exon            1..290
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..426
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1693
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /EC_number="2.7.11.1"
                     /note="Ndr Ser/Thr kinase-like protein; NDR1 protein
                     kinase; nuclear Dbf2-related kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 38"
                     /protein_id="NP_009202.1"
                     /db_xref="CCDS:CCDS4822.1"
                     /db_xref="GeneID:11329"
                     /db_xref="HGNC:HGNC:17847"
                     /db_xref="MIM:606964"
                     /translation="MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMR
                     QKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGE
                     VRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKL
                     NLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNL
                     LLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRR
                     QLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKV
                     MNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRE
                     RPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPETDYKNKDWVFINYTYKRFEG
                     LTARGAIPSYMKAAK"
     exon            427..478
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..601
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..685
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..809
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..964
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1067
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1129
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1247
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1371
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1467
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1562
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..3585
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3567..3572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /note="hexamer: AATAAA"
     polyA_site      3585
                     /gene="STK38"
                     /gene_synonym="NDR; NDR1"
                     /note="major polyA site"
ORIGIN      
        1 atgcgtagtc tcggccccgg gctgccgcgc cagcccgtct ccgcggcggg ggaccgggct
       61 gccttggccc ctcagcgctc gcgtcttttc cggcagttgg aacgcttcct gttgtcctca
      121 cccgtaaccg cctgttgccc cctgtctcag agtccctcac gcgtcccctc ccgtctttgg
      181 ctcgttggct gccgccgccg gggcttcgcc agccttcaag tcgagactac tggccgaagg
      241 ggcgtctgcg gctctccgcc gtccccagcc ctgcctctcc ctgggctctg cagccatggc
      301 aatgacaggc tcaacacctt gctcatccat gagtaaccac acaaaggaaa gggtgacaat
      361 gaccaaagtg acactggaga atttttatag caaccttatc gctcaacatg aagaacgaga
      421 aatgagacaa aagaagttag aaaaggtgat ggaagaagaa ggcctaaaag atgaggagaa
      481 acgactccgg agatcagcac atgctcggaa ggaaacagag tttcttcgtt tgaagagaac
      541 aagacttgga ttggaagatt ttgagtcctt aaaagtaata ggcagaggag catttggtga
      601 ggtacggctt gttcagaaga aagatacggg acatgtgtat gcaatgaaaa tactccgtaa
      661 agcagatatg cttgaaaaag agcaggttgg ccacattcgt gcggagcgtg acattctagt
      721 ggaggcagac agtttgtggg ttgtgaaaat gttctatagt tttcaggata agctaaacct
      781 ctacctaatc atggagttcc tgcctggagg ggacatgatg accttgttga tgaaaaaaga
      841 cactctgaca gaagaggaga ctcagtttta tatagcagaa acagtattag ccatagactc
      901 tattcaccaa cttggattca tccacagaga catcaaacca gacaaccttc ttttggacag
      961 caagggccat gtgaaacttt ctgactttgg tctttgcaca ggactgaaaa aagcacatag
     1021 gacagaattt tataggaatc tgaaccacag cctccccagt gatttcactt tccagaacat
     1081 gaattccaaa aggaaagcag aaacctggaa aagaaataga cgtcagctag ccttctccac
     1141 agtaggcact cctgactaca ttgctcctga ggtgttcatg cagaccgggt acaacaagct
     1201 ctgtgattgg tggtcgcttg gggtgatcat gtatgagatg ctcatcggct acccaccttt
     1261 ctgttctgag acccctcaag agacatataa gaaggtgatg aactggaaag aaactttgac
     1321 ttttcctcca gaagttccca tctctgagaa agccaaggat ctaattttga ggttctgctg
     1381 tgaatgggaa catagaattg gagctcctgg agttgaggaa ataaaaagta actctttttt
     1441 tgaaggcgtt gactgggaac atatcagaga gagacctgct gcaatatcta ttgaaatcaa
     1501 aagcattgat gatacctcaa acttcgatga gtttccagaa tctgatattc ttaagccaac
     1561 agtggccaca agtaatcatc ctgagactga ctacaagaac aaagactggg tcttcatcaa
     1621 ttacacgtac aagcgctttg agggcctgac tgcaaggggg gcaatacctt cctacatgaa
     1681 agcagcaaaa tagtactctt gccacggaat cctatgtgga gcagagttct ttgtataaca
     1741 tcatgctttt cctctcacac tcttgaagag cttccaagaa gttgatggaa cccaccaata
     1801 tgtcatagta aagtctcctg aaatgtggta gtaagaggat tttcttccat aatgcatctg
     1861 aaaaactgta aacaaagaca accatttcta ctacgtcggc cataaacagc tatcctgctt
     1921 tggaagagaa gcatcatgag ccaatttgat aggtgtttta aaaataactt gagttttcct
     1981 aagttcatca gaatgaaggg gaaaaacagc catcatccaa cattattgag attgtcgtgt
     2041 atagtcatcg aatatcagcc agttcctgta attttgtgac acgctctctg ccaagcccac
     2101 caagtatttc ctttatagct aaaagttcca tagtactaag gaaataaagc aataaagaca
     2161 gtctcagcag ccaggattct ggctgaagga aatgatccgc caccctgagg gtggtgatgg
     2221 tagtttctac ccatacctca gcctcaggcg agtggcttat agcctccatt catggtgcac
     2281 tttatttatg gtactaagat aaagactgtc aatccattga tttatctcct cctgtccccc
     2341 atctaaaata cccatgctgc ttttctgagt gttgatgggg gttaccagct tgatccactg
     2401 ttgctcttag aaggcccaga aagtctttgg gcattgccaa gaaatcccgg attatgtgga
     2461 aaaccctcac tttctcttca cggctgtacc agaaaatccc taagacagat cttgccgtgg
     2521 actagcaata cctgcaagtg ctgccaatgg gaactcaatt tattcctggg aacctaacga
     2581 ggagagccca ggcctaggca ggaggcctgg aaccctcttg gctaaggtgc tgttcctgtt
     2641 cctgcaaggt ctccagaacc cctttggaaa tggtgaagga accagcccaa tagaagtaca
     2701 gagccagctg acaagtcctt gtaaagctca ctcctcagtc cttggcacag ccatgttttg
     2761 tcttctctct tggtatttct tctctcccaa ctttagccat tttgccttgg aatcatgatt
     2821 acaatttttt cctttgcaga tgccttcctg ggggatactc ctccccaccc taaagggtcg
     2881 cctgcaactt aggcggattg ggtctctctg ctgtggcgtt ctctcttgag agaccctctg
     2941 aattttagca caaagtgcct tctgtttcac agctgccacc acctttagag gaatttcgtc
     3001 agaaaaatgt ggaggctcca tattaatgca ttatttttta aaaagttttg ataactctta
     3061 aagcatcatt tgcacctatg tgggaacttt gcctgttgca aagtattgtg gccgagctgc
     3121 agctgggagc ctgctttctg ccagtcttga ggttctgaag atcagctttg aaaggaaagt
     3181 atgtcctagc ttagccattc agaagagaaa aatggaatat cagagttaca gttgtcagtg
     3241 aaactacttt ggattttaac ctcttagagg aagaaaaaag gttagggaag tgtcaactct
     3301 ggatgaaggt gatgtgtttg cctctcagtc tttcattcat agcctgctag tgaaaaggaa
     3361 gtaaatgaga ttcttttgtg tgactttgta gtctctttgt attaccaaat agttggggtg
     3421 ttgactcctg tgtgttttgc aagaatgtgt ggtaagcctg ggtaaagaga aggaactgcg
     3481 gtgttgggag agtctttgtg ttggggagtg gcaggggatg atttgtttca ggggaaaatg
     3541 cccacatttt aacttttaaa cttctgaata aactgtgtaa aaaca
//
