LOCUS       NM_080836               6469 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens serine/threonine kinase 35 (STK35), mRNA.
ACCESSION   NM_080836
VERSION     NM_080836.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6469)
  AUTHORS   Polyanskaya,S.A., Moreno,R.Y., Lu,B., Feng,R., Yao,Y., Irani,S.,
            Klingbeil,O., Yang,Z., Wei,Y., Demerdash,O.E., Benjamin,L.A.,
            Weiss,M.J., Zhang,Y.J. and Vakoc,C.R.
  TITLE     SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling
            dependency in acute myeloid leukemia
  JOURNAL   Cell Rep 38 (2), 110233 (2022)
   PUBMED   35021089
  REMARK    GeneRIF: SCP4-STK35/PDIK1L complex is a dual phospho-catalytic
            signaling dependency in acute myeloid leukemia.
REFERENCE   2  (bases 1 to 6469)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6469)
  AUTHORS   Wu,Z., Liu,J., Hu,S., Zhu,Y. and Li,S.
  TITLE     Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the
            Proliferation and Apoptosis of Osteosarcoma Cells
  JOURNAL   Cell Physiol Biochem 45 (2), 808-818 (2018)
   PUBMED   29414823
  REMARK    GeneRIF: STK35 knockdown enhanced apoptosis. Expression of the
            active forms and the activity of two major executioner caspases,
            caspase 3 and caspase 7, were also increased in osteosarcoma cells
            with STK35 silenced.
REFERENCE   4  (bases 1 to 6469)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Haralambieva,I.H., Lambert,N.D.,
            Pankratz,V.S. and Poland,G.A.
  TITLE     Genome-wide SNP associations with rubella-specific cytokine
            responses in measles-mumps-rubella vaccine recipients
  JOURNAL   Immunogenetics 66 (7-8), 493-499 (2014)
   PUBMED   24811271
REFERENCE   5  (bases 1 to 6469)
  AUTHORS   Yasuda,Y., Miyamoto,Y., Yamashiro,T., Asally,M., Masui,A., Wong,C.,
            Loveland,K.L. and Yoneda,Y.
  TITLE     Nuclear retention of importin alpha coordinates cell fate through
            changes in gene expression
  JOURNAL   EMBO J 31 (1), 83-94 (2012)
   PUBMED   21964068
  REMARK    GeneRIF: constitutive overexpression of STK35 proteins enhances
            caspase-independent cell death under oxidative stress conditions.
REFERENCE   6  (bases 1 to 6469)
  AUTHORS   Goyal,P., Behring,A., Kumar,A. and Siess,W.
  TITLE     Identifying and characterizing a novel protein kinase STK35L1 and
            deciphering its orthologs and close-homologs in vertebrates
  JOURNAL   PLoS One 4 (9), e6981 (2009)
   PUBMED   19756140
  REMARK    GeneRIF: analysis of the STK35L proteins in human and in sea
            squirts
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6469)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 6469)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   9  (bases 1 to 6469)
  AUTHORS   Vallenius,T. and Makela,T.P.
  TITLE     Clik1: a novel kinase targeted to actin stress fibers by the CLP-36
            PDZ-LIM protein
  JOURNAL   J Cell Sci 115 (Pt 10), 2067-2073 (2002)
   PUBMED   11973348
  REMARK    GeneRIF: results establish the CLP-36 PDZ-LIM protein as an
            adapter, recruiting the Clik1 kinase to actin stress fibers in
            nonmuscle cells, and suggest that Clik1 represents a novel
            regulator of actin stress fibers
REFERENCE   10 (bases 1 to 6469)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359916.8, GQ281297.1 and
            BC140884.1.
            
            On May 17, 2019 this sequence version replaced NM_080836.3.
            
            Summary: The protein encoded by this gene is a kinase that is
            predominantly found in the nucleus. However, it can interact with
            PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers.
            The encoded protein may be a regulator of actin stress fibers in
            nonmuscle cells. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: GQ281297.1, AK314728.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968540, SAMEA1968832 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381482.8/ ENSP00000370891.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AL359916.8         77867-77921
            56-1660             GQ281297.1         1-1605
            1661-1883           BC140884.1         1307-1529
            1884-6469           AL359916.8         120010-124595
FEATURES             Location/Qualifiers
     source          1..6469
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..6469
                     /gene="STK35"
                     /gene_synonym="CLIK1; STK35L1"
                     /note="serine/threonine kinase 35"
                     /db_xref="GeneID:140901"
                     /db_xref="HGNC:HGNC:16254"
                     /db_xref="MIM:609370"
     exon            1..349
                     /gene="STK35"
                     /gene_synonym="CLIK1; STK35L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1660
                     /gene="STK35"
                     /gene_synonym="CLIK1; STK35L1"
                     /EC_number="2.7.11.1"
                     /note="CLP-36 interacting kinase; serine threonine kinase
                     35 long form; CLIK-1; CLP-36-interacting kinase 1;
                     PDLIM1-interacting kinase 1; serine/threonine-protein
                     kinase 35 L1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 35"
                     /protein_id="NP_543026.2"
                     /db_xref="CCDS:CCDS13024.2"
                     /db_xref="GeneID:140901"
                     /db_xref="HGNC:HGNC:16254"
                     /db_xref="MIM:609370"
                     /translation="MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASP
                     ASAAAAEGSATRRARAATSRAARSRRQPGPGADHPQAGAPGGKRAARKWRCAGQVTIQ
                     GPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGKDGARRGTQSPERKRRSPVPRAP
                     STKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYE
                     AVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQ
                     RMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDP
                     ATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLA
                     PRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIER
                     ITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKD
                     MLAANPQDRPDAFELETRMDQVTCAA"
     exon            350..947
                     /gene="STK35"
                     /gene_synonym="CLIK1; STK35L1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1697
                     /gene="STK35"
                     /gene_synonym="CLIK1; STK35L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..6469
                     /gene="STK35"
                     /gene_synonym="CLIK1; STK35L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6422..6427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK35"
                     /gene_synonym="CLIK1; STK35L1"
                     /note="hexamer: AATAAA"
     polyA_site      6449
                     /gene="STK35"
                     /gene_synonym="CLIK1; STK35L1"
     polyA_site      6469
                     /gene="STK35"
                     /gene_synonym="CLIK1; STK35L1"
                     /note="major polyA site"
ORIGIN      
        1 gtcgaccttt gcaggaccgg gcggtgcagg gctcactcgg ctggcgtccc gggggatggg
       61 ccaccaggag tctccgctgg cccgggcgcc ggcgggaggt gcagcttatg taaagaggtt
      121 atgtaaaggg ctcagctggc gcgaacacgt ggaaagccac gggagcctag gagcccaggc
      181 ttccccagcg agcgccgcgg cagcagaagg atccgctaca cgccgggctc gggccgccac
      241 ctcccgcgct gctcggtccc ggaggcagcc cgggcccgga gcggaccatc cccaggcagg
      301 ggctccaggg gggaaacggg ccgcccggaa gtggaggtgc gcgggccagg tcacaatcca
      361 aggtccggct cctccgcgtc ccagggccgg acggagggat gaggcagggg gggcccgggc
      421 agcgccgttg ctgctccccc cgccgcccgc agccatggaa acggggaagg acggcgcccg
      481 cagaggtaca caaagcccgg agcggaaaag gcgaagccca gtgccgcggg cgcccagcac
      541 gaagctgagg ccggcggcgg cggcccgggc catggatccg gtggcggccg aggccccggg
      601 cgaggccttc ctggcgcggc gacggcctga gggcggtggc gggtccgcgc ggccgcgtta
      661 cagcctgttg gcggagatcg ggcgcggcag ctacggcgtg gtttatgagg cagtggccgg
      721 gcgcagcggg gcccgggtgg cggtcaagaa gatccgctgc gacgcccccg agaacgtgga
      781 gctggcgctg gctgaattct gggccctcac cagcctcaag cggcgccacc agaacgtcgt
      841 gcagtttgag gagtgcgtcc tgcagcgcaa tgggttagcc cagcgcatga gtcacggcaa
      901 caagagctcg cagctttacc tgcgcctggt ggagacctcg ctgaaaggag aaaggatcct
      961 gggttatgct gaggagccct gctatctctg gtttgtcatg gagttctgtg aaggtggaga
     1021 cctgaatcag tatgtcctgt cccggaggcc agacccagcc accaacaaaa gtttcatgct
     1081 acagctgacg agcgccattg ccttcctgca caaaaaccat attgtgcaca gggacctgaa
     1141 gccagacaac atcctcatca cagagcggtc tggcaccccc atcctcaaag tggccgactt
     1201 tggactaagc aaggtctgtg ctgggctggc accccgaggc aaagagggca atcaagacaa
     1261 caaaaatgtg aatgtgaata agtactggct gtcctcagcc tgcggttcgg acttctacat
     1321 ggctcctgaa gtctgggagg gacactacac agccaaggcg gacatctttg ccctgggcat
     1381 tatcatctgg gcaatgatag aaagaatcac ttttattgac tctgagacca agaaggagct
     1441 cctggggacc tacattaaac aggggactga gatcgtccct gttggtgagg cgctgctaga
     1501 aaacccaaag atggagttgc acatccccca aaaacgcagg acttccatgt ctgaggggat
     1561 caagcagctc ttgaaagata tgttagctgc taacccacag gaccggcctg atgcctttga
     1621 acttgaaacc agaatggacc aggtcacatg tgctgcttaa aattcagggc taagcatttt
     1681 gggtgatttt aaactaggtc gattcctcgg gacccacagt ctcaccacgt ctcctccaga
     1741 ggacggcaga gggtacaggt ggtggcctgg ccggttggcg atctcccgac agctggatcc
     1801 ggcaatgtga agcttttgtt tgggtttccc cgcttctttt tagttttgct ttattttttt
     1861 ccttttcttt tctttttttt ttttcctctt tccttttttt aaatttaaac cattgagact
     1921 tcagaagagc aggacacaat gctgtggaca ggcaccaatt tctttaaaga aattcaatgt
     1981 gggcaaggca tatgtgtaaa tttcactttt actttttata aggggttagg gagctatttt
     2041 tggttttgtc cttcactttc cctctgtctt ccttctttat acttttctca gttctactta
     2101 tgacacctca cttccctaga gaaggcctgc ctccccatag ggaatctggg ggtttcttct
     2161 ggaacggggc gtgaggacac aaggaggcct ctgggccacg cctccctacc agatgcagga
     2221 actcctggac tccttggtgg gctggccctg gctagccctt gggcctcgga gatgatcaga
     2281 ggtgaagaac cgcctggaag aggaaggcca gggtttggcc aggagaacta agaaggtctc
     2341 aactccaggc tttgttgtgt ttaagctatt gagagcccca ggccacacca ggacttgcag
     2401 tggtgggaat ccattcctct tctgccctgt gttgcaggga actaggaggt aagggtggag
     2461 ggcgaccatc tcgctcttgc tggcggtgga gcagccatcc ctgcctttct gttgggaaaa
     2521 actgttgtgc caaactcttg tgtggaacac agctgggtct tcagcaggca tctgtcactg
     2581 ccgtgaggtc agcgcttctc acctaactgc ctcctggatt gtcatcttcc cagatgtgtc
     2641 ccatagtgtc caggtgtcac agagacggcc tgaggcccta agatctggtt gtgactttgc
     2701 catgataaca gggtgtcctg aactggctgc cgttgtcgtg ttctcacagt gaagggcgtg
     2761 ccctgtgtgc cggggtccat ggtgtcatat gcagtgacac acactgtcaa gcgccatttc
     2821 cctcacccct ggagacttac tgttaggtgc ctgccctcag tatagacgta tccaatggga
     2881 aaacagcgga cctgcccaga gcagggaggt gtcgtggaac tgggtagacc ccctgcagcg
     2941 ttaggggccc atttgtgggc tcgccacctt caggcttccc cagccatgac acttcagccc
     3001 cgccacccat gcctgtctgc tgcagccatc cttgcactct ccagcgacac tctcgcacct
     3061 ccctagggga agcttccctc cccctgggct gctgctctga gcccatctgt tctccccctg
     3121 caagaagggg caatgctctt gtgttgtccc tctgtctgga cgcgcctggc cactccgaag
     3181 gcttttcacc ccattatggc caaatagtat agggccactg gggaggggga agggaatcat
     3241 tttgtgttca tttttgtttt ctgtttcacc taaaccagca taggattgat aggggagacg
     3301 gttggcgggc atttccgttt ctatgtgacc aaggcagcag gggcttttac ctgctaagcg
     3361 gcaatccttt ggccctgaga atttgggaga gaacagtgca tcaggccagg ctcagcaata
     3421 tgtttgctca cattctttca gccttctgtc acccccctca acaccaaact ttcttccttg
     3481 tgagcagaag gttggctgct gttagcagga tcccacagtg ataaccaggc ccttcccttc
     3541 ctaagccaaa acccattgtg actgcctgtc tctcctgtct ctgacttctc aggcagcctc
     3601 ctgagtgcac tgagttgtat ccgagagggt gggaacagca gcatccccta attgcagtac
     3661 acggttcctt ttccgcccgc caccctgcct ttccttgggg gcagctgtct ctctgtacat
     3721 gagcaaatgg gcaaaaacag tccccaaacc cagcaccccc ctctccctgg ctgcagccca
     3781 cactgtaaca tccctagtga ggctccagcc taatgagccc cttattttct tttttttccc
     3841 tccccaggtc tagtagctct aactaaaaag ttcttggagc catcgtgctc cccctttgtt
     3901 atttttcttg ctatcagagt agcaagaaac agcacccctg taggtgacag gtgggcagcc
     3961 tggtaggggt cgccagcctc catgccccct catcttccag ttcttgctta gtggcacgac
     4021 ctctttccat agcataaatg caggccagcg ttttagcccc aagtgcctgc ccttgcttct
     4081 tacccctccc ctgctttctc aaacacttgc ccacctcagg cactcagcgg gctccgccgt
     4141 ggtgagagaa ctggccgtgg ctcagccccg ggtagcacct gtagtttcag tgccactctc
     4201 cactgtcccc ttgtggacca gcttccactc actgtcacgt cccccctcct gcgtcttcac
     4261 tgggtctcag gctgccagca gctctctggt gcatcgtctc aacaccacca agtttgtagg
     4321 acctgcccaa gttctagtag tattcaaaac ttcaaacggc agtcatttgt tctcctcggc
     4381 tctgtggcaa ggatagccct ttggaggggg actcttgacc tcggctgtta gggatctgaa
     4441 cttggttttc ccgtcagaag aatcagcagg acagatcgta gtgccttatt ccattgtcct
     4501 cccctggcca ggcctcctgg ctcagctgga agtgcatggc ttctttctcc ctatctgtgt
     4561 cctctgtcac ttgctctttc actctctctc tcattcccag agagccacgg gggagggatc
     4621 accctcaccc ccaacaccct cttcctgagg gctgtagcca ggtccgcatc tccccaccac
     4681 caccagggca ctcactcgca gctatagccc aggacagaaa aactgtgctt tggacaggtg
     4741 cacactctct gcctcttacc tctagccagg aggatgcctc agtctgttca ttcgagactg
     4801 gccccgtctg aaccttctct gggcactggg gactaaggtt gcaggcctta gcctcgtctc
     4861 gtcccagagg cattggatca ggagaatggg aatttttttc ctcccacctg gacatagttt
     4921 gcccctgtgg ctgcctttct gagggagtat actaaatgtt tacttaagaa acaccctgtt
     4981 tacagccaga ggagaaacac ccaacactga gtggagattt gactctggac agggcctggc
     5041 ctccttagtg gcactgccgg ggggccccag agcgaatgag ggcagagatg cccggggcag
     5101 gggcaaacgc cctccgctcc ctctgctccc aaccctgtgg tgctaggacc actccccgcc
     5161 ttccctacgg cctcctcgcc ctgcacattc cccacctcca cattcccctc ctccaagatc
     5221 tcagctcctt aacatatcag ttgtctccta gcctagaaaa ccagtgtttg gagcaataag
     5281 atgattattt ttgcttgaat ctttttctaa gagaaggaaa agagctggca ttgtgggaat
     5341 tttcttttta tgctgttagc tgtttacctt cttagaagac atcctaatag gatggatgtc
     5401 tgggttttag ccttggggta tcttttggaa acttagaaaa gcaggagtca ggctgccacc
     5461 ccctaaggag ggaccctaac gttctgccct tgcctggttc catatggctc cttccagccc
     5521 tgcccaccaa gtgcagctcc cactttccat cctgcccata cgcccctctt cccccgacat
     5581 ctgggggcgc tggtggcact tactctaggt tggtctcaga ctatccctcc ccttggctgg
     5641 ttttccctcc taggcctgtc tggcagcccc cagacagacg tagctcctgg gagtctcggc
     5701 cctggcaacc ttggaagagc caagctgaca ttgtttagct cttcaggcca ctgggttttg
     5761 gaggcagaag tccagagata ctggctctgc caagctgtcg tactgggctg tggcacagcc
     5821 ttcgagacaa cacgggtgta tctctgatcc tgccctacct aggcttcaag gggcttctgt
     5881 ctggagaaat gccctcaaag ggtaaccagt aggtgtggca ttgaattggc cagtgttagc
     5941 atctacagcc atcaccgaga tgagtccact gccgttgcct gcccgagggc cccctaaggt
     6001 tatagacggt atcagcaggg aggccgtccc gctggttttc taggagagcc cacaggagga
     6061 agggagcctc ttcaggggca ctggaatctt ttgtgccagg ggcttctttt catcagagcc
     6121 ggggagtaca ttgcagtgac ttcttaaaca tttgtgtggg acagacgagc gtgagggagg
     6181 ttttaagcca ggcacaaagt tagtttccaa tactagttaa taaatctatt tttcttcatt
     6241 tccttttttt gcacagaagc tggtaatcta ggacctacgt gtgaacaact ttatatgaat
     6301 attttttgta cttggtttac ttgggttggt atgatacatt atatttaagt tccttgaaca
     6361 ctgtggatcc cctaatgtgt atgaatgact gaggctttgt aaattaaggg acgtttgtgt
     6421 gaataaagtt atttgatggg gtcaaagaag ccatatgtga tttgaaaaa
//
