LOCUS       NM_001352389            2796 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens serine/threonine kinase 33 (STK33), transcript variant
            7, mRNA.
ACCESSION   NM_001352389 XM_017018143
VERSION     NM_001352389.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2796)
  AUTHORS   Yu,W., Li,Y., Chen,H., Cui,Y., Situ,C., Yao,L., Zhang,X., Lu,S.,
            Liu,L., Li,L., Ren,J., Guo,Y., Huo,Z., Chen,Y., Li,H., Jiang,T.,
            Gu,Y., Wang,C., Zhu,T., Li,Y., Hu,Z. and Guo,X.
  TITLE     STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate
            Sperm Flagella Assembly in Spermiogenesis
  JOURNAL   Mol Cell Proteomics 22 (6), 100564 (2023)
   PUBMED   37146716
REFERENCE   2  (bases 1 to 2796)
  AUTHORS   Li,X., Lin,M., Liu,M., Ye,H. and Qin,S.
  TITLE     Interaction between STK33 and autophagy promoted renal cell
            carcinoma metastasis by regulating mTOR/ULK1 signaling pathway
  JOURNAL   Mol Biol Rep 50 (6), 5059-5067 (2023)
   PUBMED   37101009
  REMARK    GeneRIF: Interaction between STK33 and autophagy promoted renal
            cell carcinoma metastasis by regulating mTOR/ULK1 signaling
            pathway.
REFERENCE   3  (bases 1 to 2796)
  AUTHORS   Ma,H., Zhang,B., Khan,A., Zhao,D., Ma,A., Zhou,J., Khan,I.,
            Khan,K., Zhang,H., Zhang,Y., Jiang,X., Dil,S., Zeb,A., Rahim,F. and
            Shi,Q.
  TITLE     Novel frameshift mutation in STK33 is associated with
            asthenozoospermia and multiple morphological abnormalities of the
            flagella
  JOURNAL   Hum Mol Genet 30 (21), 1977-1984 (2021)
   PUBMED   34155512
  REMARK    GeneRIF: Novel frameshift mutation in STK33 is associated with
            asthenozoospermia and multiple morphological abnormalities of the
            flagella.
REFERENCE   4  (bases 1 to 2796)
  AUTHORS   Zhang,S., Wu,H., Wang,K. and Liu,M.
  TITLE     STK33/ERK2 signal pathway contribute the tumorigenesis of
            colorectal cancer HCT15 cells
  JOURNAL   Biosci Rep 39 (3) (2019)
   PUBMED   30760631
  REMARK    GeneRIF: Data show that serine/threonine kinase 33 (STK33) can bind
            with extracellular signal-regulated kinase 2 (ERK2) and take part
            in the regulation of ERKs signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2796)
  AUTHORS   Kong,F., Sun,T., Kong,X., Xie,D., Li,Z. and Xie,K.
  TITLE     Kruppel-like Factor 4 Suppresses Serine/Threonine Kinase 33
            Activation and Metastasis of Gastric Cancer through Reversing
            Epithelial-Mesenchymal Transition
  JOURNAL   Clin Cancer Res 24 (10), 2440-2451 (2018)
   PUBMED   29367428
  REMARK    GeneRIF: STK33 has pro-tumor function and is a critical downstream
            mediator of KLF4 in gastric cancer. STK33 may serve as a potential
            prognostic marker and therapeutic target for gastric cancer.
REFERENCE   6  (bases 1 to 2796)
  AUTHORS   Melen,E., Himes,B.E., Brehm,J.M., Boutaoui,N., Klanderman,B.J.,
            Sylvia,J.S. and Lasky-Su,J.
  TITLE     Analyses of shared genetic factors between asthma and obesity in
            children
  JOURNAL   J Allergy Clin Immunol 126 (3), 631-7 (2010)
   PUBMED   20816195
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2796)
  AUTHORS   Willer,C.J., Speliotes,E.K., Loos,R.J., Li,S., Lindgren,C.M.,
            Heid,I.M., Berndt,S.I., Elliott,A.L., Jackson,A.U., Lamina,C.,
            Lettre,G., Lim,N., Lyon,H.N., McCarroll,S.A., Papadakis,K., Qi,L.,
            Randall,J.C., Roccasecca,R.M., Sanna,S., Scheet,P., Weedon,M.N.,
            Wheeler,E., Zhao,J.H., Jacobs,L.C., Prokopenko,I., Soranzo,N.,
            Tanaka,T., Timpson,N.J., Almgren,P., Bennett,A., Bergman,R.N.,
            Bingham,S.A., Bonnycastle,L.L., Brown,M., Burtt,N.P., Chines,P.,
            Coin,L., Collins,F.S., Connell,J.M., Cooper,C., Smith,G.D.,
            Dennison,E.M., Deodhar,P., Elliott,P., Erdos,M.R., Estrada,K.,
            Evans,D.M., Gianniny,L., Gieger,C., Gillson,C.J., Guiducci,C.,
            Hackett,R., Hadley,D., Hall,A.S., Havulinna,A.S., Hebebrand,J.,
            Hofman,A., Isomaa,B., Jacobs,K.B., Johnson,T., Jousilahti,P.,
            Jovanovic,Z., Khaw,K.T., Kraft,P., Kuokkanen,M., Kuusisto,J.,
            Laitinen,J., Lakatta,E.G., Luan,J., Luben,R.N., Mangino,M.,
            McArdle,W.L., Meitinger,T., Mulas,A., Munroe,P.B., Narisu,N.,
            Ness,A.R., Northstone,K., O'Rahilly,S., Purmann,C., Rees,M.G.,
            Ridderstrale,M., Ring,S.M., Rivadeneira,F., Ruokonen,A.,
            Sandhu,M.S., Saramies,J., Scott,L.J., Scuteri,A., Silander,K.,
            Sims,M.A., Song,K., Stephens,J., Stevens,S., Stringham,H.M.,
            Tung,Y.C., Valle,T.T., Van Duijn,C.M., Vimaleswaran,K.S.,
            Vollenweider,P., Waeber,G., Wallace,C., Watanabe,R.M.,
            Waterworth,D.M., Watkins,N., Witteman,J.C., Zeggini,E., Zhai,G.,
            Zillikens,M.C., Altshuler,D., Caulfield,M.J., Chanock,S.J.,
            Farooqi,I.S., Ferrucci,L., Guralnik,J.M., Hattersley,A.T., Hu,F.B.,
            Jarvelin,M.R., Laakso,M., Mooser,V., Ong,K.K., Ouwehand,W.H.,
            Salomaa,V., Samani,N.J., Spector,T.D., Tuomi,T., Tuomilehto,J.,
            Uda,M., Uitterlinden,A.G., Wareham,N.J., Deloukas,P.,
            Frayling,T.M., Groop,L.C., Hayes,R.B., Hunter,D.J., Mohlke,K.L.,
            Peltonen,L., Schlessinger,D., Strachan,D.P., Wichmann,H.E.,
            McCarthy,M.I., Boehnke,M., Barroso,I., Abecasis,G.R. and
            Hirschhorn,J.N.
  CONSRTM   Wellcome Trust Case Control Consortium; Genetic Investigation of
            ANthropometric Traits Consortium
  TITLE     Six new loci associated with body mass index highlight a neuronal
            influence on body weight regulation
  JOURNAL   Nat Genet 41 (1), 25-34 (2009)
   PUBMED   19079261
REFERENCE   8  (bases 1 to 2796)
  AUTHORS   Mujica,A.O., Brauksiepe,B., Saaler-Reinhardt,S., Reuss,S. and
            Schmidt,E.R.
  TITLE     Differential expression pattern of the novel serine/threonine
            kinase, STK33, in mice and men
  JOURNAL   FEBS J 272 (19), 4884-4898 (2005)
   PUBMED   16176263
  REMARK    GeneRIF: STK33/Stk33 expression pattern resembles those of some
            related members of the calcium/calmodulin dependent kinase group
REFERENCE   9  (bases 1 to 2796)
  AUTHORS   Mujica,A.O., Hankeln,T. and Schmidt,E.R.
  TITLE     A novel serine/threonine kinase gene, STK33, on human chromosome
            11p15.3
  JOURNAL   Gene 280 (1-2), 175-181 (2001)
   PUBMED   11738831
REFERENCE   10 (bases 1 to 2796)
  AUTHORS   Amid,C., Bahr,A., Mujica,A., Sampson,N., Bikar,S.E.,
            Winterpacht,A., Zabel,B., Hankeln,T. and Schmidt,E.R.
  TITLE     Comparative genomic sequencing reveals a strikingly similar
            architecture of a conserved syntenic region on human chromosome
            11p15.3 (including gene ST5) and mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 284-290 (2001)
   PUBMED   11528127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104360.8 and AC105357.7.
            
            On Jun 2, 2019 this sequence version replaced NM_001352389.1.
            
            Transcript Variant: This variant (7), as well as variants 1, 4-6,
            and 8-11, encodes isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.150864.1,
                                           SRR14038196.2108949.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000687296.1/ ENSP00000509322.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC104360.8         153333-153478
            147-351             AC105357.7         94716-94920         c
            352-385             AC105357.7         91556-91589         c
            386-450             AC105357.7         90993-91057         c
            451-836             AC105357.7         88987-89372         c
            837-950             AC105357.7         87469-87582         c
            951-1064            AC105357.7         79015-79128         c
            1065-1169           AC105357.7         76111-76215         c
            1170-1308           AC105357.7         71647-71785         c
            1309-1397           AC105357.7         69050-69138         c
            1398-1482           AC105357.7         67128-67212         c
            1483-1558           AC105357.7         54984-55059         c
            1559-1671           AC105357.7         50333-50445         c
            1672-1757           AC105357.7         49800-49885         c
            1758-1955           AC105357.7         27801-27998         c
            1956-2796           AC105357.7         6176-7016           c
FEATURES             Location/Qualifiers
     source          1..2796
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2796
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /note="serine/threonine kinase 33"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
     exon            1..146
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            147..351
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            352..385
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            386..450
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            451..836
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     CDS             612..2156
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 7;
                     serine/threonine-protein kinase 33"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 33 isoform a"
                     /protein_id="NP_001339318.1"
                     /db_xref="CCDS:CCDS7789.1"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
                     /translation="MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQ
                     TSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVP
                     HIRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLL
                     EREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWI
                     IQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRS
                     EAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFEL
                     IRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPT
                     NVLEMMKEWKNNPESVEENTTEEKNKPSTEEKLKSYQPWGNVPDANYTSDEEEEKQST
                     AYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALS
                     RTKKKL"
     exon            837..950
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1064
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1169
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1308
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1397
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1482
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1558
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1671
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1757
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1955
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2796
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2597..2602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /note="hexamer: AATAAA"
     polyA_site      2623
                     /gene="STK33"
                     /gene_synonym="SPGF93"
     regulatory      2772..2777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /note="hexamer: AATAAA"
     polyA_site      2796
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /note="major polyA site"
ORIGIN      
        1 gctgtttgtc ctcgcgcggc ccccgtccac tgccctgcgg ttgctctgcg ggctgaaaag
       61 tttctcccgg tgcagaattc cgggctcagc gacagcctgc gccgagtgtg cgcacctgtc
      121 ggagacccgc cagtccgccg gccgcggcag ggccactact tctcagcaca tccggccttc
      181 tggctcatct cctccctgca tctcactacg cccctcccca ctccagggta aattccaata
      241 atgctgctct gttccagatg gagttcatgt tgactgaggt gaattttagg gctgtaactg
      301 gtttggtctg atctggatcc ccattataat attgaaatct ctacagtgga ggcctgaagt
      361 taaatcattt tggaaagtga tacaggagag gactctgcta tgaaacttcc tgagtgaaat
      421 gataagtggc atgaagaaaa acaaagcaag ctctcacgtg tgaatatgtg tctagtgcat
      481 ccttaacctg aggacttcac cagttcgaaa ttacagtttt caccatcaac taccttatcc
      541 tttttggcct ggttttcttc ctcaaacagt ggaaacattt ttaaagttgc ttttgttgca
      601 gagttaaaca aatggctgat agtggcttag ataaaaaatc cacaaaatgc cccgactgtt
      661 catctgcttc tcagaaagat gtactttgtg tatgttccag caaaacaagg gttcctccag
      721 ttttggtggt ggaaatgtca cagacatcaa gcattggtag tgcagaatct ttaatttcac
      781 tggagagaaa aaaagaaaaa aatatcaaca gagatataac ctccaggaaa gatttgccct
      841 caagaacctc aaatgtagag agaaaagcat ctcagcaaca atggggtcgg ggcaacttta
      901 cagaaggaaa agttcctcac ataaggattg agaatggagc tgctattgag gaaatctata
      961 cctttggaag aatattggga aaagggagct ttggaatagt cattgaagcg acagacaagg
     1021 aaacagaaac gaagtgggca attaaaaaag tgaacaaaga aaaggctgga agctctgctg
     1081 tgaagttact tgaacgagag gtgaacattc tgaaaagtgt aaaacatgaa cacatcatac
     1141 atctggaaca agtatttgaa acgccaaaga aaatgtacct tgtgatggag ctttgtgagg
     1201 atggagaact caaagaaatt ctggatagga aagggcattt ctcagagaat gagacaaggt
     1261 ggatcattca aagtctcgca tcagctatag catatcttca caataatgat attgtacata
     1321 gagatctgaa actggaaaat ataatggtta aaagcagtct tattgatgat aacaatgaaa
     1381 taaacttaaa cataaaggtg actgattttg gcttagcggt gaagaagcaa agtaggagtg
     1441 aagccatgct gcaggccaca tgtgggactc ctatctatat ggcccctgaa gttatcagtg
     1501 cccacgacta tagccagcag tgtgacattt ggagcatagg cgtcgtaatg tacatgttat
     1561 tacgtggaga accacccttt ttggcaagct cagaagagaa gctttttgag ttaataagaa
     1621 aaggagaact acattttgaa aatgcagtct ggaattccat aagtgactgt gctaaaagtg
     1681 ttttgaaaca acttatgaaa gtagatcctg ctcacagaat cacagctaag gaactactag
     1741 ataaccagtg gttaacaggc aataaacttt cttcggtgag accaaccaat gtattagaga
     1801 tgatgaagga atggaaaaat aacccagaaa gtgttgagga aaacacaaca gaagagaaga
     1861 ataagccgtc cactgaagaa aagttgaaaa gttaccaacc ctggggaaat gtccctgatg
     1921 ccaattacac ttcagatgaa gaggaggaaa aacagtctac tgcttatgaa aagcaatttc
     1981 ctgcaaccag taaggacaac tttgatatgt gcagttcaag tttcacatct agcaaactcc
     2041 ttccagctga aatcaaggga gaaatggaga aaacccctgt gactccaagc caaggaacag
     2101 caaccaagta ccctgctaaa tccggcgccc tgtccagaac caaaaagaaa ctctaaggtt
     2161 ccctccagtg ttggacagta caaaaacaaa gctgctcttg ttagcacttt gatgaggggg
     2221 taggagggga agaagacagc cctatgctga gcttgtagcc ttttagctcc acagagcccc
     2281 gccatgtgtt tgcaccagct taaaattgaa gctgcttatc tccaaagcag cataagctgc
     2341 acatggcatt aaaggacagc caccagtagg cttggcagtg ggctgcagtg gaaatcaact
     2401 caagatgtac acgaaggttt tttagggggg cagatacctt caatttaagg ctgtgggcac
     2461 acttgctcat ttttacttca aattcttatg tttaggcaca gctatttata ggggaaaaca
     2521 agaggccaaa tatagtaatg gaggtgccaa ataattatgt gcactttgca ctagaagact
     2581 ttgttagaaa attactaata aacttgccat acgtattaca gcagaagtgc ttcagtcatt
     2641 cacatgtgtt cgtgagattt taggttgcta tagattgttt aagacagctt attttaaatg
     2701 tagaaaaata ggagattttg taactgcttg ccattaactt gctgctaaat tcccaatgta
     2761 ttgattaaat caataaaaaa cagatgttac tcagca
//
