LOCUS       NM_173575               2096 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens serine/threonine kinase 32C (STK32C), transcript
            variant 2, mRNA.
ACCESSION   NM_173575
VERSION     NM_173575.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2096)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 2096)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2096)
  AUTHORS   Sun,E., Liu,K., Zhao,K. and Wang,L.
  TITLE     Serine/threonine kinase 32C is overexpressed in bladder cancer and
            contributes to tumor progression
  JOURNAL   Cancer Biol Ther 20 (3), 307-320 (2019)
   PUBMED   30359551
  REMARK    GeneRIF: Silencing of STK32C inhibited the activity of the HMGB1
            pathway and regulated the expression of key genes in this pathway.
REFERENCE   5  (bases 1 to 2096)
  AUTHORS   Dempster,E.L., Wong,C.C., Lester,K.J., Burrage,J., Gregory,A.M.,
            Mill,J. and Eley,T.C.
  TITLE     Genome-wide methylomic analysis of monozygotic twins discordant for
            adolescent depression
  JOURNAL   Biol Psychiatry 76 (12), 977-983 (2014)
   PUBMED   24929637
REFERENCE   6  (bases 1 to 2096)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
REFERENCE   7  (bases 1 to 2096)
  AUTHORS   Chidambaram,M., Radha,V. and Mohan,V.
  TITLE     Replication of recently described type 2 diabetes gene variants in
            a South Indian population
  JOURNAL   Metabolism 59 (12), 1760-1766 (2010)
   PUBMED   20580033
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2096)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 2096)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    Review article
REFERENCE   10 (bases 1 to 2096)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY098866.1, AK302102.1 and
            CD369442.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173575.3.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. It is thought that this
            family member is functional in brain due to its high expression
            levels there. DNA methylation differences have been found in this
            gene in monozygotic twins that are discordant for adolescent
            depression. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon, and it thus differs in the 5' UTR and 5' coding
            region, compared to variant 1. The encoded isoform (b) has a
            distinct N-terminus and is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY098866.1, ERR279836.5267.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298630.8/ ENSP00000298630.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-692               AY098866.1         24-715
            693-1972            AK302102.1         701-1980
            1973-2096           CD369442.1         28-151              c
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..2096
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /note="serine/threonine kinase 32C"
                     /db_xref="GeneID:282974"
                     /db_xref="HGNC:HGNC:21332"
     exon            1..379
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1578
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /EC_number="2.7.11.1"
                     /note="isoform b is encoded by transcript variant 2; PKE
                     protein kinase; serine/threonine-protein kinase 32C; yet
                     another novel kinase 3; testicular tissue protein Li 187"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 32C isoform b"
                     /protein_id="NP_775846.2"
                     /db_xref="CCDS:CCDS7666.1"
                     /db_xref="GeneID:282974"
                     /db_xref="HGNC:HGNC:21332"
                     /translation="MRSGAERRGSSAAASPGSPPPGRARPAGSDAPSALPPPAAGQPR
                     ARDSGDVRSQPRPLFQWSKWKKRMGSSMSAATARRPVFDDKEDVNFDHFQILRAIGKG
                     SFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSF
                     QDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQHIIHRDVK
                     PDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNGGTGYSFEV
                     DWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLT
                     VNPEHRLSSLQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGRLHCDPTFELEEMILES
                     RPLHKKKKRLAKNKSRDNSRDSSQSENDYLQDCLDAIQQDFVIFNREKLKRSQDLPRE
                     PLPAPESRDAAEPVEDEAERSALPMCGPICPSAGSG"
     exon            380..435
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..587
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..761
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            762..799
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            800..889
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            890..993
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1110
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1236
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1368
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1436
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..2096
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2077..2082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /note="hexamer: ATTACA"
     polyA_site      2096
                     /gene="STK32C"
                     /gene_synonym="PKE; YANK3"
                     /note="major polyA site"
ORIGIN      
        1 agaagagcgc acggcgggcg ctgccggccc cgagcgctcc cgctaccact gccgctcccg
       61 gccctgccgg ccggccatgc cccgagttcc ggctgccgcg cgcacccaga cccggcgatg
      121 aggagtggcg ccgagcgcag gggcagcagc gccgcggcgt ccccgggctc gccgcccccc
      181 ggccgcgcgc gccccgccgg ctccgacgcg ccctcggccc tgccgccgcc cgctgctggc
      241 cagccccggg cccgggactc gggcgatgtc cgctcgcagc cgcgccccct gtttcagtgg
      301 agcaagtgga agaagaggat gggctcgtcc atgtcggcgg ccaccgcgcg gaggccggtg
      361 tttgacgaca aggaggacgt gaacttcgac cacttccaga tccttcgggc cattgggaag
      421 ggcagctttg gcaaggtgtg cattgtgcag aagcgggaca cggagaagat gtacgccatg
      481 aagtacatga acaagcagca gtgcatcgag cgcgacgagg tccgcaacgt cttccgggag
      541 ctggagatcc tgcaggagat cgagcacgtc ttcctggtga acctctggta ctccttccag
      601 gacgaggagg acatgttcat ggtcgtggac ctgctactgg gcggggacct gcgctaccac
      661 ctgcagcaga acgtgcagtt ctccgaggac acggtgaggc tgtacatctg cgagatggca
      721 ctggctctgg actacctgcg cggccagcac atcatccaca gagatgtcaa gcctgacaac
      781 attctcctgg atgagagagg acatgcacac ctgaccgact tcaacattgc caccatcatc
      841 aaggacgggg agcgggcgac ggcattagca ggcaccaagc cgtacatggc tccggagatc
      901 ttccactctt ttgtcaacgg cgggaccggc tactccttcg aggtggactg gtggtcggtg
      961 ggggtgatgg cctatgagct gctgcgagga tggaggccct atgacatcca ctccagcaac
     1021 gccgtggagt ccctggtgca gctgttcagc accgtgagcg tccagtatgt ccccacgtgg
     1081 tccaaggaga tggtggcctt gctgcggaag ctcctcactg tgaaccccga gcaccggctc
     1141 tccagcctcc aggacgtgca ggcagccccg gcgctggccg gcgtgctgtg ggaccacctg
     1201 agcgagaaga gggtggagcc gggcttcgtg cccaacaaag gccgtctgca ctgcgacccc
     1261 acctttgagc tggaggagat gatcctggag tccaggcccc tgcacaagaa gaagaagcgt
     1321 ctggccaaga acaagtcccg ggacaacagc agggacagct cccagtccga gaatgactat
     1381 cttcaagact gcctcgatgc catccagcaa gacttcgtga tttttaacag agaaaagctg
     1441 aagaggagcc aggacctccc gagggagcct ctccccgccc ctgagtccag ggatgctgcg
     1501 gagcctgtgg aggacgaggc ggaacgctcc gccctgccca tgtgcggccc catttgcccc
     1561 tcggccggga gcggctaggc cgggacgccc gtggtcctca ccccttgagc tgctttggag
     1621 actcggctgc cagagggagg gccatgggcc gaggcctggc attcacgttc ccacccagcc
     1681 tggctggcgg tgcccacagt gccccggaca catttcacac ctcaggctcg tggtggtgca
     1741 ggggacaaga ggctgtgggt gcaggggaca cctgtggagg gcatttcccg tgggcccccg
     1801 agacccgcct agatggagga agcgctgctg ggcgccctct taccgctcac ggggagctgg
     1861 ggccatggat gggacaggag tctttgtccc tgctcagccc ggaggctgtg cacggccctc
     1921 gtcacaaggt gacccttgca gcacaggccg cgggtgcccc aggctcggct caggtcttgg
     1981 aggtcaaggg catgggttgg ggtagtgggt ggggaggtga atgttttcta gagattcaaa
     2041 ctgctccagc aatttctgta gttttcacct ctgagaatta caatgtgaga accgct
//
