LOCUS       NM_018401               3535 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens serine/threonine kinase 32B (STK32B), transcript
            variant 1, mRNA.
ACCESSION   NM_018401
VERSION     NM_018401.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3535)
  AUTHORS   Shi,Y., Cheng,Y., Wang,W., Tang,L., Li,W., Zhang,L., Yuan,Z.,
            Zhu,F. and Duan,Q.
  TITLE     YANK2 activated by Fyn promotes glioma tumorigenesis via the
            mTOR-independent p70S6K activation pathway
  JOURNAL   Sci Rep 14 (1), 10507 (2024)
   PUBMED   38714727
  REMARK    GeneRIF: YANK2 activated by Fyn promotes glioma tumorigenesis via
            the mTOR-independent p70S6K activation pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3535)
  AUTHORS   Cao,L., Gu,L., Pu,J., Lv,D., Tian,J., Yin,X., Gao,T., Song,Z.,
            Lu,J., Zhao,G., Zhang,B., Yan,Y. and Zhao,G.
  TITLE     Association Analysis of 27 Single Nucleotide Polymorphisms in a
            Chinese Population with Essential Tremor
  JOURNAL   J Mol Neurosci 73 (4-5), 205-213 (2023)
   PUBMED   36929462
  REMARK    GeneRIF: Association Analysis of 27 Single Nucleotide Polymorphisms
            in a Chinese Population with Essential Tremor.
REFERENCE   3  (bases 1 to 3535)
  AUTHORS   Ciuculete,D.M., Bostrom,A.E., Tuunainen,A.K., Sohrabi,F., Kular,L.,
            Jagodic,M., Voisin,S., Mwinyi,J. and Schioth,H.B.
  TITLE     Changes in methylation within the STK32B promoter are associated
            with an increased risk for generalized anxiety disorder in
            adolescents
  JOURNAL   J Psychiatr Res 102, 44-51 (2018)
   PUBMED   29604450
  REMARK    GeneRIF: This results of this study provided evidence that shifts
            in DNA methylation within the STK32B promoter are associated with a
            modulated risk profile for generalized anxiety disorder in
            adolescence.
REFERENCE   4  (bases 1 to 3535)
  AUTHORS   Zhang,Y., Zhao,Y., Zhou,X., Li,K., Yi,M., Guo,J., Yan,X., Tang,B.
            and Sun,Q.
  TITLE     Assessment of Three New Loci from Genome-wide Association Study in
            Essential Tremor in Chinese population
  JOURNAL   Sci Rep 7 (1), 7981 (2017)
   PUBMED   28801652
  REMARK    GeneRIF: C allele of rs10937625 in STK32B is a protective factor
            for essential tremor in Chinese population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3535)
  AUTHORS   Muller,S.H., Girard,S.L., Hopfner,F., Merner,N.D., Bourassa,C.V.,
            Lorenz,D., Clark,L.N., Tittmann,L., Soto-Ortolaza,A.I., Klebe,S.,
            Hallett,M., Schneider,S.A., Hodgkinson,C.A., Lieb,W., Wszolek,Z.K.,
            Pendziwiat,M., Lorenzo-Betancor,O., Poewe,W., Ortega-Cubero,S.,
            Seppi,K., Rajput,A., Hussl,A., Rajput,A.H., Berg,D., Dion,P.A.,
            Wurster,I., Shulman,J.M., Srulijes,K., Haubenberger,D., Pastor,P.,
            Vilarino-Guell,C., Postuma,R.B., Bernard,G., Ladwig,K.H., Dupre,N.,
            Jankovic,J., Strauch,K., Panisset,M., Winkelmann,J., Testa,C.M.,
            Reischl,E., Zeuner,K.E., Ross,O.A., Arzberger,T., Chouinard,S.,
            Deuschl,G., Louis,E.D., Kuhlenbaumer,G. and Rouleau,G.A.
  TITLE     Genome-wide association study in essential tremor identifies three
            new loci
  JOURNAL   Brain 139 (Pt 12), 3163-3169 (2016)
   PUBMED   27797806
  REMARK    GeneRIF: STK32B association with essential tremor.
REFERENCE   6  (bases 1 to 3535)
  AUTHORS   Ingersoll,R.G., Hetmanski,J., Park,J.W., Fallin,M.D., McIntosh,I.,
            Wu-Chou,Y.H., Chen,P.K., Yeow,V., Chong,S.S., Cheah,F., Sull,J.W.,
            Jee,S.H., Wang,H., Wu,T., Murray,T., Huang,S., Ye,X., Jabs,E.W.,
            Redett,R., Raymond,G., Scott,A.F. and Beaty,T.H.
  TITLE     Association between genes on chromosome 4p16 and non-syndromic oral
            clefts in four populations
  JOURNAL   Eur J Hum Genet 18 (6), 726-732 (2010)
   PUBMED   20087401
  REMARK    GeneRIF: STK32B and EVC yielded consistent evidence from cleft lip,
            with or without cleft palate, trios in all four populations.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3535)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3535)
  AUTHORS   Temtamy,S.A., Aglan,M.S., Valencia,M., Cocchi,G., Pacheco,M.,
            Ashour,A.M., Amr,K.S., Helmy,S.M., El-Gammal,M.A., Wright,M.,
            Lapunzina,P., Goodship,J.A. and Ruiz-Perez,V.L.
  TITLE     Long interspersed nuclear element-1 (LINE1)-mediated deletion of
            EVC, EVC2, C4orf6, and STK32B in Ellis-van Creveld syndrome with
            borderline intelligence
  JOURNAL   Hum Mutat 29 (7), 931-938 (2008)
   PUBMED   18454448
  REMARK    GeneRIF: In a consanguineous pedigree diagnosed with EvC and
            borderline intelligence, a 520-kb homozygous deletion comprising
            EVC, EVC2, C4orf6, and STK32B, caused by recombination between
            LINE-1 elements, was detected
REFERENCE   9  (bases 1 to 3535)
  AUTHORS   Ruiz-Perez,V.L., Ide,S.E., Strom,T.M., Lorenz,B., Wilson,D.,
            Woods,K., King,L., Francomano,C., Freisinger,P., Spranger,S.,
            Marino,B., Dallapiccola,B., Wright,M., Meitinger,T.,
            Polymeropoulos,M.H. and Goodship,J.
  TITLE     Mutations in a new gene in Ellis-van Creveld syndrome and Weyers
            acrodental dysostosis
  JOURNAL   Nat Genet 24 (3), 283-286 (2000)
   PUBMED   10700184
  REMARK    Erratum:[Nat Genet 2000 May;25(1):125]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096740.3, AK313846.1,
            BC069203.1, AJ250839.1 and AC004664.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018401.2.
            
            Summary: This gene encodes a serine-threonine protein kinase.
            Serine-threonine kinases transfer phosphate molecules to the oxygen
            atoms of serine and threonine. A genomic deletion affecting this
            gene has been associated with Ellis-van Creveld syndrome, an
            autosomal recessive skeletal dysplasia. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.124175.1,
                                           SRR1803611.264083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282908.10/ ENSP00000282908.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC096740.3         186777-186813       c
            38-116              AK313846.1         1-79
            117-320             BC069203.1         1-204
            321-2653            AJ250839.1         1-2333
            2654-2654           AC004664.1         57250-57250         c
            2655-3535           AJ250839.1         2335-3215
FEATURES             Location/Qualifiers
     source          1..3535
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.2"
     gene            1..3535
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /note="serine/threonine kinase 32B"
                     /db_xref="GeneID:55351"
                     /db_xref="HGNC:HGNC:14217"
     exon            1..436
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1629
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; gene
                     for serine/threonine protein kinase; yet another novel
                     kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 32B isoform 1"
                     /protein_id="NP_060871.1"
                     /db_xref="CCDS:CCDS3380.1"
                     /db_xref="GeneID:55351"
                     /db_xref="HGNC:HGNC:14217"
                     /translation="MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRD
                     TKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDL
                     LLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHV
                     HITDFNIATVVKGAERASSMAGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYEL
                     LRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVALLRKLLTKDPESRVSSLHD
                     IQSVPYLADMNWDAVFKKALMPGFVPNKGRLNCDPTFELEEMILESKPLHKKKKRLAK
                     NRSRDGTKDSCPLNGHLQHCLETVREEFIIFNREKLRRQQGQGSQLLDTDSRGGGQAQ
                     SKLQDGCNNNLLTHTCTRGCSS"
     exon            437..492
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /inference="alignment:Splign:2.1.0"
     exon            493..644
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..818
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..856
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /inference="alignment:Splign:2.1.0"
     exon            857..946
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1050
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1167
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1293
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1425
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1490
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..3535
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3518..3523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /note="hexamer: AATAAA"
     polyA_site      3535
                     /gene="STK32B"
                     /gene_synonym="HSA250839; STK32; STKG6; YANK2"
                     /note="major polyA site"
ORIGIN      
        1 cttcccctcc ttcccctgct cccgcgccgc ctcgcgtctc ccgcccgctg tagccggcga
       61 ggagcgccgc acgttggccc cggcgcgagg agctcccggg ttcccgggcg ggcactggag
      121 taaggagctg cgagcgcagc ccgaggcggg gcacggcgga aggcgcggcg agagcggggt
      181 ccctgcgagc gcagtcggaa gggcgtccag gagaaggggg acgccgtccc cgcccctgca
      241 cggtgctcgg ccccctcggg ctccgcgcgc ggctacaacc cggactgggc gcgcccccgg
      301 catcccgcat ctctgcgcgc gtcccacatc ccgcatccgg catcccagcg gccgggcatg
      361 tagcagcggc agcaacggcg gaatatgggc gggaaccact cccacaagcc ccccgtgttt
      421 gacgagaatg aggaagtcaa ctttgaccat tttcagattc tgcgggccat tggtaaaggg
      481 agttttggaa aggtatgcat cgtgcagaag cgagacacta agaaaatgta tgcaatgaag
      541 tacatgaaca agcagaagtg catcgagagg gatgaggttc ggaatgtttt ccgggagctg
      601 cagatcatgc aagggctgga gcaccccttc ctggtcaatc tgtggtactc cttccaggat
      661 gaggaggaca tgttcatggt ggtggacctg ctcctgggag gcgacctgcg ctaccatctg
      721 cagcagaatg tgcatttcac agaggggact gtgaaactct acatctgtga gctggcactg
      781 gccctggagt atcttcagag gtaccacatc atccacagag acatcaagcc agacaatatc
      841 ctgctggatg aacacggaca tgttcacatt acagacttca acatagcgac ggtagtgaaa
      901 ggagcagaaa gggcttcctc catggctggc accaagccct acatggctcc agaagtattc
      961 caggtgtaca tggacagagg ccccggatac tcgtaccctg tcgactggtg gtccctgggc
     1021 atcacagcct atgagctgct gcggggctgg aggccgtacg aaatccactc ggtcacgccc
     1081 atcgatgaaa tcctcaacat gttcaaggtg gagcgtgtcc actactcctc cacgtggtgc
     1141 aaggggatgg tggccctgct gaggaagctc ctgaccaagg atcctgagag ccgcgtgtcc
     1201 agccttcatg acatacagag cgtgccctac ttggccgaca tgaactggga cgcggtgttc
     1261 aagaaggcac tgatgcccgg ctttgtgccc aataaaggga ggttgaactg cgatcccaca
     1321 tttgagcttg aagagatgat tctagaatcc aagccacttc acaaaaagaa gaagcgattg
     1381 gcaaagaaca gatccaggga tggcacaaag gacagctgcc cgctgaatgg acacctgcag
     1441 cactgtttgg agactgtccg ggaggaattc atcatattca acagagagaa gctcaggagg
     1501 cagcagggac agggcagcca gctcttggac accgacagcc gagggggagg ccaggcccaa
     1561 agcaagctcc aggacgggtg caacaacaac ctcctcaccc acacctgcac ccgtggctgc
     1621 agcagctgag cccacacttg ttgctgctca acaggactgc actcgtctct gccctgccca
     1681 cccagagccc ctctttgtgc cctgatggtc cctgtctcac ccctgaaaac atcagatgca
     1741 gaaaaagccc tggacttgga gctgggaagc ctgggttctg gtcccatctc catgactgat
     1801 tcacgtgtga cctcagacaa gtcacgccct ctctgtgcct ccgttttctg catctgccaa
     1861 aggggttaaa cacttctgcc ccacttcaaa ttacaagatt atggggagaa cccaattagg
     1921 taggaaacat gaaaaacctt tgatatttat aaaatcattt ttacgtgcaa aatataacct
     1981 taatatttga agtgaccccc attccccaaa gcaatcaaac cgtcatgact ttgcaatttg
     2041 gcacatccta gcttgttaga gggcacttcc gaaaaacaca gccctgacag caaaataaag
     2101 gtctgatatg ttggcccctt ctatggaaac aacgctgcca aatcctggag caaaacctga
     2161 agtgtcttca tgtgcattct ctggcaggcc acagtcctga gcttgtaaga tggtgcagca
     2221 tgcagaccag acttgtcccc aaggtctcag cgctgcggtc tcactcctcc cctcatttaa
     2281 gaagactatc cttacctttt agtttcagca gtcctcacca ccaccatatc cccagtgctg
     2341 ggatggcaca caggtgtcca ttcagatgag agttgggtcg ctgagcattg gttactcctg
     2401 cagagtgtaa tcagcacccc atccaactgg cccgaaagcc cagacctgca gcagaactct
     2461 ccaactctct atcagctttc agggttttct ctcctgggaa gggtgtaaaa tcagcttgtc
     2521 agattcttct tacagagagt atccaatcgg tattggtgga gcggctccct atttatacaa
     2581 taggaagcat gggtgcttag aaagtttatt tcaggaggaa aatgggttca cacaaaaagc
     2641 aaactacatt ctggtctgct cagggagaag cttgcctttg aactggaaga tgttgggatg
     2701 agcagggaaa gcttagactt tggagtcagg tttgtgttca gaatccagcc ctgctggcta
     2761 ctaactaact gggagacctt aggcaaagca tgcaatcgct ctgaatggca gtttcctcat
     2821 ttttaaacag ggataataaa actaatattg caggggagtt acagggttaa ataagatcct
     2881 gtgtgtaacc ccaagcattg gatgactcat agaatggcct tttttgtcag cataatcgtc
     2941 atcattattt agatactttc ttccttcact cacccagcag gtcagttttc tgtgcaaaca
     3001 aacctgttta ggattcttcc aaatgttctt cctggggtct ttgatatttg tttgttacat
     3061 cctgctgaag ttcgactgtg tttttatttt ttcatccaac ttccattttt cactttttac
     3121 atgattactc aatccttggg gctgtccatg tcatctctta gatttcttaa aagacatttt
     3181 aatgtatggt taggttttat atttttattt tttaaaaaag aaatagtcag tgttttcctc
     3241 ctttcaaccg agactatttc tggattgtgt gctcctcgtc agttgacttg ttttgcacac
     3301 ttttctttac ttcatgtccc catcaacaac cgtcctgctc cccacctccc ccaggaaata
     3361 aggggcctgc tcctctccct actgtgaccc tggaggctct taagatgatg atggtttttt
     3421 ttattgggct gagttcacga attaggggca ggagctggaa gtcgccctag gaacaccaga
     3481 tttcctggtt ctgttcaagt tggcatttct tgtttggaat aaactatttc ttgga
//
