LOCUS       NM_001112724            5333 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens serine/threonine kinase 32A (STK32A), transcript
            variant 1, mRNA.
ACCESSION   NM_001112724
VERSION     NM_001112724.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5333)
  AUTHORS   Ma,F., Xie,Y., Lei,Y., Kuang,Z. and Liu,X.
  TITLE     The microRNA-130a-5p/RUNX2/STK32A network modulates tumor invasive
            and metastatic potential in non-small cell lung cancer
  JOURNAL   BMC Cancer 20 (1), 580 (2020)
   PUBMED   32571328
  REMARK    GeneRIF: The microRNA-130a-5p/RUNX2/STK32A network modulates tumor
            invasive and metastatic potential in non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5333)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5333)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   4  (bases 1 to 5333)
  AUTHORS   Koskinen,L.L., Einarsdottir,E., Korponay-Szabo,I.R., Kurppa,K.,
            Kaukinen,K., Sistonen,P., Pocsai,Z., Szeles,G., Adany,R., Maki,M.,
            Kere,J. and Saavalainen,P.
  TITLE     Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the
            Finnish and Hungarian populations
  JOURNAL   Tissue Antigens 74 (5), 408-416 (2009)
   PUBMED   19845895
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 5333)
  AUTHORS   Schmutz,J., Martin,J., Terry,A., Couronne,O., Grimwood,J.,
            Lowry,S., Gordon,L.A., Scott,D., Xie,G., Huang,W., Hellsten,U.,
            Tran-Gyamfi,M., She,X., Prabhakar,S., Aerts,A., Altherr,M.,
            Bajorek,E., Black,S., Branscomb,E., Caoile,C., Challacombe,J.F.,
            Chan,Y.M., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Grigoriev,I., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Israni,S.,
            Jett,J., Kadner,K., Kimball,H., Kobayashi,A., Lopez,F., Lou,Y.,
            Martinez,D., Medina,C., Morgan,J., Nandkeshwar,R., Noonan,J.P.,
            Pitluck,S., Pollard,M., Predki,P., Priest,J., Ramirez,L.,
            Retterer,J., Rodriguez,A., Rogers,S., Salamov,A., Salazar,A.,
            Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N., Wheeler,J.,
            Wu,K., Yang,J., Dickson,M., Cheng,J.F., Eichler,E.E., Olsen,A.,
            Pennacchio,L.A., Rokhsar,D.S., Richardson,P., Lucas,S.M.,
            Myers,R.M. and Rubin,E.M.
  TITLE     The DNA sequence and comparative analysis of human chromosome 5
  JOURNAL   Nature 431 (7006), 268-274 (2004)
   PUBMED   15372022
REFERENCE   6  (bases 1 to 5333)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA110948.1, DR006392.1, BC021666.1, EB386256.1, DA231845.1 and
            AC009189.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001112724.1.
            
            Transcript Variant: This variant (1) differs in the 3' UTR and
            coding sequence compared to variant 3. The resulting isoform (1)
            has a shorter and distinct C-terminus compared to isoform 3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.50348.1,
                                           SRR1660809.97822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397936.8/ ENSP00000381030.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                DA110948.1         11-108
            99-244              DR006392.1         1-146
            245-278             BC021666.1         168-201
            279-854             DR006392.1         181-756
            855-1252            EB386256.1         409-806
            1253-1683           DA231845.1         153-583
            1684-5333           AC009189.6         102534-106183
FEATURES             Location/Qualifiers
     source          1..5333
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..5333
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /note="serine/threonine kinase 32A"
                     /db_xref="GeneID:202374"
                     /db_xref="HGNC:HGNC:28317"
     exon            1..174
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            175..322
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1461
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     A930015B13Rik; serine/threonine-protein kinase 32A; yet
                     another novel kinase 1; CTB-108O6.2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 32A isoform 1"
                     /protein_id="NP_001106195.1"
                     /db_xref="CCDS:CCDS47299.1"
                     /db_xref="GeneID:202374"
                     /db_xref="HGNC:HGNC:28317"
                     /translation="MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKND
                     TKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDL
                     LLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHV
                     HITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLR
                     GRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQ
                     NFPYMNDINWDAVFQKRLIPGFIPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKKE
                     KDMRKCDSSQTCLLQEHLDSVQKEFIIFNREKVNRDFNKRQPNLALEQTKDPQGEDGQ
                     NNNL"
     exon            323..378
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..530
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..704
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..742
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..832
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..930
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1047
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1173
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1302
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1367
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..5333
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5308..5313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /note="hexamer: ATTAAA"
     polyA_site      5333
                     /gene="STK32A"
                     /gene_synonym="YANK1"
                     /note="major polyA site"
ORIGIN      
        1 agtccagcgc agcccagccc agcccagccc ggcgctcgca gcctccgccg cttccgggca
       61 gataggtgcc ttttcttgct ccttgctctt ggagttcttc tcttagtccc tgttccctgg
      121 atgaaagcat cgctccgagc ctcatgggag gaatgaagga agaatcgaga ctagatatcc
      181 aactaaggct tcgggacatg ttttgagcga agatgggtgt ttctgcccgg atagtataaa
      241 tcgaggatcc aggtctgggc agattcaacc atgggagcga acacttcaag aaaaccacca
      301 gtgtttgatg aaaatgaaga tgtcaacttt gaccactttg aaattttgcg agccattggg
      361 aaaggcagtt ttgggaaggt ctgcattgta cagaagaatg ataccaagaa gatgtacgca
      421 atgaagtaca tgaataaaca aaagtgcgtg gagcgcaatg aagtgagaaa tgtcttcaag
      481 gaactccaga tcatgcaggg tctggagcac cctttcctgg ttaatttgtg gtattccttc
      541 caagatgagg aagacatgtt catggtggtg gacctcctgc tgggtggaga cctgcgttat
      601 cacctgcaac agaacgtcca cttcaaggaa gaaacagtga agctcttcat ctgtgagctg
      661 gtcatggccc tggactacct gcagaaccag cgcatcattc acagggatat gaagcctgac
      721 aatattttac ttgacgaaca tgggcacgtg cacatcacag atttcaacat tgctgcgatg
      781 ctgcccaggg agacacagat taccaccatg gctggcacca agccttacat ggcacctgag
      841 atgttcagct ccagaaaagg agcaggctat tcctttgctg ttgactggtg gtccctggga
      901 gtgacggcat atgaactgct gagaggccgg agaccgtatc atattcgctc cagtacttcc
      961 agcaaggaaa ttgtacacac gtttgagacg actgttgtaa cttacccttc tgcctggtca
     1021 caggaaatgg tgtcacttct taaaaagcta ctcgaaccta atccagacca acgattttct
     1081 cagttatctg atgtccagaa cttcccgtat atgaatgata taaactggga tgcagttttt
     1141 cagaagaggc tcattccagg tttcattcct aataaaggca ggctgaattg tgatcctacc
     1201 tttgaacttg aggaaatgat tttggagtcc aaacctctac ataagaaaaa aaagcgtctg
     1261 gcaaagaagg agaaggatat gaggaaatgc gattcttctc agacatgtct tcttcaagag
     1321 caccttgact ctgtccagaa ggagttcata attttcaaca gagaaaaagt aaacagggac
     1381 tttaacaaaa gacaaccaaa tctagccttg gaacaaacca aagacccaca aggtgaggat
     1441 ggtcagaata acaacttgta aaggcctcat gtcttcttct tgggacaatc tcatgccaga
     1501 aacttctaat tacatatgtc aagaaaagct gacagtagtt cttgccactc cacacaccat
     1561 gacttagaaa atgtgaatga atatatttca aaaaaggcag cacaacacag tgaagggtcc
     1621 tgggcctgag ctcctgggat gtcatttcac atcaatcaac tgtgtgatct agagcaagtc
     1681 acttagccac tttctgtgct ttactttatt tatctaaaat gagagggtta tactagacga
     1741 gccataccct gcctttttag tgctatagtt gttattctaa accgccttta tttttatttt
     1801 aaaattaata tatgaatata gatttatttt tccactcctt ctaattatgc agtgacaaat
     1861 ggacaaatgg acacaggact cagtgagact tttcagacct cgaaagtttc ataaagtggt
     1921 cagaatgccc caggctactt ggataaagat aaggaattct atcagggagg catgaatgga
     1981 atcagattaa aagtaacaga gatggatgag ggccttccag tgatatgcgt gaatcagcat
     2041 tagatccgct tatctcagct ggcaggagcc tgctgtgcac accacttccc agctccctct
     2101 tcaacaatgt gaaagtggta acttgaaatt ggtaataatg ggagcattta caccacggaa
     2161 actggtaaat gctcgttttt tccctcctaa caagtgaatt gctaaatatt agcccaccac
     2221 tccttccaag aagcatgttc cttgagggct aattgtcctc tgaagattag cagagacctg
     2281 tatctggaga ggatcagaaa agaatgtcat cacactgaaa gtatgtccac cttgcagttc
     2341 agaaaagttg catcttatat ggggtttatt gtctaagtta gaaatgaatt tagaagatag
     2401 taaaatttac cgttgaaaaa ccccttaaat tacccataaa gtatatggga agtatctttt
     2461 ctcagtaaag cccaatacag tgtcaccttt cactaatgaa acaagccatt gcttttgttt
     2521 tgttttgact tagttatttt tatttttggt ctcattttgg ctaataccag atgagctaaa
     2581 atgttgaaca aattatactt gtttttatag actagaatta ctcttttttt tcttttcagg
     2641 cagagtctca ctctgtcacc caggctggag tgcagtggca tgatctctgc tcactacatc
     2701 tgcctcccgg gttcaagtga ttcttgtgtc tcagcctcct aagtagctgg gatcgcatgt
     2761 gtgtgccacc atgtgtagct aattttttgt atttttagta gagataggat tttgctaagc
     2821 tggccaggtt ggtttcaaac tcctggtctc aagtgatccg cccaccttgg cctcccaaag
     2881 tgctgggatt acaggcgtga gccaccaaac ctggccttag aattactctt agaacagtgg
     2941 aatgcccaca catccaagac aggcaagttc atggagacta agggaacagt ggtatcatgt
     3001 ctcccttctc ccttgtgctt actacaagaa tggcaggcag aattccctac ttatttaaaa
     3061 tatcactgat gtctcactct ttttctttat attttattta ttgatttgcc acaaagttta
     3121 attcacctaa gtgagacgtg catatgatgt aactccactg tacagataca cagatcttta
     3181 cagaagaact atttttggca acccctatgc ccctgggtag ggtccagaag tgaacaggct
     3241 tggtggggga ttgttttcac ctcttggcta ctcagagtac ctaaacctgt ccttacttat
     3301 ggagagcatg tgtcacacca agatggcagt aagctggcaa ctgcgaagac ctgactgatg
     3361 cccatttggg aagccaggca agtgaaaatg gaccgaagaa acagagatgg ctgtctttta
     3421 tgcagggctt ttccataaag aggttacact ggggcaacca agtatgtgta gaaagccaga
     3481 gctaaacttc agcttggcat tcacagtttt ctcttcactg agctaatagg cccagagttt
     3541 cgggcagagc tgtgaaatag tgcttctcta atagcaacca tattattgtt acataattaa
     3601 aagccagctc ttttgttgtt tgtttgattc cttttcccta cagttcccac atcatttgtc
     3661 tgtgctattc tgtttttctc caaacactat aaacttgaag caattgccct gactcgattt
     3721 cagagaaggg gatgtgttgg aaagagcaag aataagaaag tgaccagatt ctgctgcagt
     3781 ctggtaaccc cacgagtgtc agggactact tgcatgttta cttctatcct tcatttgttt
     3841 tgattcaagc ctttatgtgc tgtggactca cctccctaag taaccaggtt cctcctctcg
     3901 ctgcaacctt gtttgcatcc ttcccaagaa gaggctttgg gaaatttttc tgtaattaca
     3961 cttaccaaag agccatggaa ccattaggat ctccactgtg atgagagtta agccatagtg
     4021 ccatttcaca cgtatacatt tatgatggga tgggaacccg atacaatctc tgtaggctga
     4081 atccctagtt ttatttccag tgagctgctt ctgtgactga agcacctctg tgggcttttg
     4141 ggaaccatgg atgcacagat gagagagcac aggctcagag agtaagatgg atttctagtg
     4201 ctagccaggt gaatgacaca cagtgtattt caagtttgaa aagcaaaacc atggtatctg
     4261 acagtgctga ttgtaatcac ctcccaccac tgtgcatttt aaacatgaga acaaaaaact
     4321 tttccaaaat ttaaactttt cctaaatctt tgtggtcatt gctagttgtt gacatcagat
     4381 cctttggttt tattctataa cttgggctaa acgttaatat cccactaggt ggaacatgtc
     4441 tcttccggag ttgtgacaac cgaggctcag agctgtgatt tttagaaaac aagatgacta
     4501 ttaaatcctt tggcctggta ttcttgaatg tttttctccc agtgcttccc ttgcctgtat
     4561 ggagcatctg caaagtctga gcaggttttg aagtccaaga gcatcccagc tataaggctc
     4621 ttgcactgtg acagagctgc ccacctccag tacaccctca gtgacctcga gtagatgcgt
     4681 agggcagtca aacccggcaa cttatgccac aaccctaatt ccaggaagtc gtctgctaat
     4741 ggctaaccca ctgccatggt ggcactggtt ttgcctgagg tcattgctag ggcaggaatg
     4801 aacagcaacc agcacagagc attgctaaat taattacagt aatctaatta attagtagct
     4861 aggcttcttc tgataggaaa gtttcaacca gaaaccacta gatgttctat tatcatagct
     4921 tttgtagatt ggatggaaga ataagtagga agaaagagta ttaatgtagc tagtagggac
     4981 cagtgttgct gcttgtggct gaggcagtaa tgctaaggct ttagctcttc aaaagcagaa
     5041 tgaaaaggca caaaaagcac ttcaagcttg tttctgtacc cagttgtccc tgtattgtct
     5101 acataaaatc ctgtttcctg ctatctgtct gtgattcctg tttattacaa attcagtgtg
     5161 tctgactgat attaaacact gatattaaaa tttcaaactt cacttatctg tgctgttgtg
     5221 aacaggcagc tgatctggca gccctcgaat gggaaacaag tgcttctgtt gagctgtagc
     5281 atatataata taaatgtgcc tatgtgtatt aaaatgtctt ctgtaaacaa tga
//
