LOCUS       NM_031414               3274 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens serine/threonine kinase 31 (STK31), transcript variant
            1, mRNA.
ACCESSION   NM_031414
VERSION     NM_031414.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3274)
  AUTHORS   Hassan,N.A., Idriss,N.K., Gaber,N., Ibrahim,A., Tawfeek,M.A.,
            Mossad,E., Mosa,A.A., Ahmed,E.H., Sayed,S.A., Ahmed,H.A. and
            Mohamed,A.A.M.
  TITLE     Spastic Paraplegia 20 and Serine/Threonine Protein Kinase 31
            Expression for the Detection of Colorectal Cancer
  JOURNAL   Cell Physiol Biochem 56 (2), 138-149 (2022)
   PUBMED   35389570
  REMARK    GeneRIF: Spastic Paraplegia 20 and Serine/Threonine Protein Kinase
            31 Expression for the Detection of Colorectal Cancer.
REFERENCE   2  (bases 1 to 3274)
  AUTHORS   Bae,D.H., Kim,H.J., Yoon,B.H., Park,J.L., Kim,M., Kim,S.K.,
            Kim,S.Y., Lee,S.I., Song,K.S. and Kim,Y.S.
  TITLE     STK31 upregulation is associated with chromatin remodeling in
            gastric cancer and induction of tumorigenicity in a xenograft mouse
            model
  JOURNAL   Oncol Rep 45 (4) (2021)
   PUBMED   33649810
  REMARK    GeneRIF: STK31 upregulation is associated with chromatin remodeling
            in gastric cancer and induction of tumorigenicity in a xenograft
            mouse model.
REFERENCE   3  (bases 1 to 3274)
  AUTHORS   Yuan,W., Gao,H., Wang,G., Miao,Y., Jiang,K., Zhang,K. and Wu,J.
  TITLE     Higher miR-543 levels correlate with lower STK31 expression and
            longer pancreatic cancer survival
  JOURNAL   Cancer Med 9 (24), 9632-9640 (2020)
   PUBMED   33128354
  REMARK    GeneRIF: Higher miR-543 levels correlate with lower STK31
            expression and longer pancreatic cancer survival.
REFERENCE   4  (bases 1 to 3274)
  AUTHORS   Xiong,J., Xing,S., Dong,Z., Niu,L., Xu,Q., Liu,P. and Yang,P.
  TITLE     STK31 regulates the proliferation and cell cycle of lung cancer
            cells via the Wnt/beta-catenin pathway and feedback regulation by
            c-myc
  JOURNAL   Oncol Rep 43 (2), 395-404 (2020)
   PUBMED   31894338
  REMARK    GeneRIF: STK31 regulates the proliferation and cell cycle of lung
            cancer cells via the Wnt/betacatenin pathway and feedback
            regulation by cmyc.
REFERENCE   5  (bases 1 to 3274)
  AUTHORS   Watany,M.M., Elmashad,N.M., Badawi,R. and Hawash,N.
  TITLE     Serum FBLN1 and STK31 as biomarkers of colorectal cancer and their
            ability to noninvasively differentiate colorectal cancer from
            benign polyps
  JOURNAL   Clin Chim Acta 483, 151-155 (2018)
   PUBMED   29715435
  REMARK    GeneRIF: FBLN1 and STK31 can be possible screening and
            differentiating biomarkers of colorectal cancer
REFERENCE   6  (bases 1 to 3274)
  AUTHORS   Carvill,G.L., Weckhuysen,S., McMahon,J.M., Hartmann,C.,
            Moller,R.S., Hjalgrim,H., Cook,J., Geraghty,E., O'Roak,B.J.,
            Petrou,S., Clarke,A., Gill,D., Sadleir,L.G., Muhle,H., von
            Spiczak,S., Nikanorova,M., Hodgson,B.L., Gazina,E.V., Suls,A.,
            Shendure,J., Dibbens,L.M., De Jonghe,P., Helbig,I., Berkovic,S.F.,
            Scheffer,I.E. and Mefford,H.C.
  TITLE     GABRA1 and STXBP1: novel genetic causes of Dravet syndrome
  JOURNAL   Neurology 82 (14), 1245-1253 (2014)
   PUBMED   24623842
REFERENCE   7  (bases 1 to 3274)
  AUTHORS   Kuo,P.L., Huang,Y.L., Hsieh,C.C., Lee,J.C., Lin,B.W. and Hung,L.Y.
  TITLE     STK31 is a cell-cycle regulated protein that contributes to the
            tumorigenicity of epithelial cancer cells
  JOURNAL   PLoS One 9 (3), e93303 (2014)
   PUBMED   24667656
  REMARK    GeneRIF: the aberrant expression of STK31 contributes to
            tumorigenicity in somatic cancer cells
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3274)
  AUTHORS   Fok,K.L., Chung,C.M., Yi,S.Q., Jiang,X., Sun,X., Chen,H.,
            Chen,Y.C., Kung,H.F., Tao,Q., Diao,R., Chan,H., Zhang,X.H.,
            Chung,Y.W., Cai,Z. and Chang Chan,H.
  TITLE     STK31 maintains the undifferentiated state of colon cancer cells
  JOURNAL   Carcinogenesis 33 (11), 2044-2053 (2012)
   PUBMED   22828137
  REMARK    GeneRIF: High STK31 expression is associated with colon cancer.
REFERENCE   9  (bases 1 to 3274)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
REFERENCE   10 (bases 1 to 3274)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB065148.1, BC059374.1 and
            AC003087.2.
            
            On Nov 23, 2018 this sequence version replaced NM_031414.4.
            
            Summary: This gene is similar to a mouse gene that encodes a
            putative protein kinase with a tudor domain, and shows
            testis-specific expression. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059374.1, AF285599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355870.8/ ENSP00000348132.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-530               DB065148.1         1-530
            531-3269            BC059374.1         490-3228
            3270-3274           AC003087.2         34121-34125
FEATURES             Location/Qualifiers
     source          1..3274
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..3274
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /note="serine/threonine kinase 31"
                     /db_xref="GeneID:56164"
                     /db_xref="HGNC:HGNC:11407"
                     /db_xref="MIM:605790"
     exon            1..117
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..3127
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1; tudor
                     domain containing 8; serine/threonine-protein kinase 31;
                     sugen kinase 396; serine/threonine-protein kinase NYD-SPK;
                     testis tissue sperm-binding protein Li 78m"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 31 isoform a"
                     /protein_id="NP_113602.2"
                     /db_xref="CCDS:CCDS5386.1"
                     /db_xref="GeneID:56164"
                     /db_xref="HGNC:HGNC:11407"
                     /db_xref="MIM:605790"
                     /translation="MWVQGHSSRASATESVSFSGIVQMDEDTHYDKVEDVVGSHIEDA
                     VTFWAQSINRNKDIMKIGCSLSEVCPQASSVLGNLDPNKIYGGLFSEDQCWYRCKVLK
                     IISVEKCLVRYIDYGNTEILNRSDIVEIPLELQFSSVAKKYKLWGLHIPSDQEVTQFD
                     QGTTFLGSLIFEKEIKMRIKATSEDGTVIAQAEYGSVDIGEEVLKKGFAEKCRLASRT
                     DICEEKKLDPGQLVLRNLKSPIPLWGHRSNQSTFSRPKGHLSEKMTLDLKDENDAGNL
                     ITFPKESLAVGDFNLGSNVSLEKIKQDQKLIEENEKLKTEKDALLESYKALELKVEQI
                     AQELQQEKAAAVDLTNHLEYTLKTYIDTRMKNLAAKMEILKEMRHVDISVRFGKDLSD
                     AIQVLDEGCFTTPASLNGLEIIWAEYSLAQENIKTCEYVSEGNILIAQRNEMQQKLYM
                     SVEDFILEVDESSLNKRLKTLQDLSVSLEAVYGQAKEGANSDEILKKFYDWKCDKREE
                     FTSVRSETDASLHRLVAWFQRTLKVFDLSVEGSLISEDAMDNIDEILEKTESSVCKEL
                     EIALVDQGDADKEIISNTYSQVLQKIHSEERLIATVQAKYKDSIEFKKQLIEYLNKSP
                     SVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPDGSQIEKIKEEITQLRNNVFQEI
                     YHEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGGLLTMSLERDLLDAEPMKELS
                     SKRPLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLPLIFLFL
                     CKSDPMAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQGLHTLHKADIIHGSLH
                     QNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAY
                     GCLLLWLSVQNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECF
                     LMPKEQSVPNPEKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC"
     exon            118..164
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            165..217
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            218..316
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            317..391
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            392..550
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            551..909
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1084
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1200
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1360
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1483
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1663
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1780
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1900
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2032
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2134
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2215
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2341
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2467
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2554
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2704
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2827
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2896
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3274
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3248..3253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /note="hexamer: AATAAA"
     polyA_site      3274
                     /gene="STK31"
                     /gene_synonym="SGK396; TDRD8"
                     /note="major polyA site"
ORIGIN      
        1 gcggtcgaag ctcacgcggt aagccgctgc acgtgtgcta cggcgggcgg agggccgaaa
       61 gtccagtatg tgggtccagg gtcactcttc tagagcttcc gcaacggaaa gtgtgagttt
      121 ttcaggaatt gttcaaatgg atgaagatac acattacgat aaagtggaag atgtggttgg
      181 aagtcacata gaagatgcag taacattttg ggcccagagt atcaatagaa ataaggatat
      241 catgaagatt ggttgctcac tgtctgaagt ttgcccccag gccagttcag ttttggggaa
      301 tcttgaccca aacaagattt atggtggatt attttctgaa gatcagtgtt ggtacagatg
      361 caaagtactg aaaatcatca gcgttgaaaa gtgtctggtg aggtacattg actatggaaa
      421 tactgaaatt ctaaatcgat ctgatatagt tgaaattcct ttggagctgc agttttctag
      481 tgttgccaaa aagtataaac tttggggact acacattcct tctgatcaag aagttaccca
      541 gtttgatcag ggcacaacct ttttggggag cttgattttt gaaaaggaaa taaaaatgag
      601 aattaaagca acctctgaag atggaacagt tattgctcag gctgagtatg gcagtgtgga
      661 tataggggaa gaggtgctta agaaaggatt tgcagagaaa tgcagacttg cttccagaac
      721 tgacatctgt gaggaaaaaa aattggatcc tggtcaactt gttctcagga acctcaaaag
      781 ccccattcct ttgtgggggc atagatcaaa ccagtcaacc ttcagcaggc ccaaggggca
      841 cttaagtgag aaaatgactc ttgacttgaa ggatgaaaat gatgcaggca atcttataac
      901 atttccaaag gaaagtttgg ctgttggtga ctttaattta gggtctaacg tcagcctgga
      961 aaaaattaag caggaccaga aactgattga agaaaatgaa aaacttaaaa cagagaagga
     1021 cgctcttctt gaaagttata aggcgttaga attgaaagta gagcagattg cccaggagct
     1081 gcagcaagag aaggcagctg ctgtggattt gactaaccac ttagaataca ctctgaagac
     1141 ctatatagat accagaatga aaaatctggc agctaagatg gaaatactga aagaaatgag
     1201 gcatgtcgac atcagtgtcc gtttcggaaa agacctttca gatgctatac aagtgttgga
     1261 tgaagggtgc tttactactc cagcttcttt gaatggatta gagataatat gggcagaata
     1321 cagtctggct caggagaata ttaaaacttg tgaatatgtg agtgaaggga atattttgat
     1381 tgcccaaaga aatgaaatgc agcagaagct gtacatgtca gtagaagatt ttattctgga
     1441 agttgatgag tcatctctta ataaacgctt aaaaacattg caggatttgt cagtctcttt
     1501 agaagcagtg tatggacaag ccaaagaagg agcaaattct gatgaaatac ttaaaaaatt
     1561 ttatgactgg aagtgtgata aaagagagga gttcaccagt gttagaagtg aaacagacgc
     1621 ttctctgcac cgtcttgtag catggttcca aagaacctta aaggtttttg acctatctgt
     1681 ggaaggatca ctgatttcag aagacgcaat ggataatatt gatgaaatcc tagagaagac
     1741 tgagtcaagt gtctgcaaag agctggagat agctctggtt gatcaaggtg atgcagacaa
     1801 ggagataatt tcaaatacat atagtcaagt actgcaaaag attcattcag aggaaaggct
     1861 cattgccaca gtacaagcta agtacaagga cagtattgag tttaaaaagc agcttattga
     1921 atatttaaat aagagtccca gtgtggatca cttgctatcc attaagaaga cattgaaaag
     1981 cttaaaagct ctactcagat ggaaattggt tgaaaagagt aatttggaag agtcagatga
     2041 tcctgatggc tctcaaattg agaaaataaa agaagaaata actcagctgc gcaataatgt
     2101 ctttcaggaa atttatcatg agagagagga atatgagatg ctaactagtt tggcacagaa
     2161 atggttccct gagctgcctc tgcttcatcc tgaaatagga ttactcaaat acatgaactc
     2221 tggtggtctc cttacaatga gcttggaacg agatcttctt gatgctgagc ccatgaagga
     2281 acttagcagc aagcgtcctt tggtacgttc tgaggttaat gggcagataa ttctgttaaa
     2341 gggctattct gtggatgttg acacagaagc caaggtgatt gagagagcag ccacctacca
     2401 tagagcttgg agagaagctg aaggagactc agggttactg ccattgatat tcctgttttt
     2461 atgtaagtct gatcctatgg cttatctgat ggtcccatac taccctaggg caaacctgaa
     2521 tgctgttcaa gccaacatgc ctttaaattc agaagaaact ttaaaggtca tgaaaggtgt
     2581 tgcccagggt ctgcatacat tgcataaggc tgacataatt catggatcac ttcatcagaa
     2641 caatgtattt gctttaaacc gtgaacaagg aattgttgga gattttgact tcaccaaatc
     2701 tgtgagtcag cgagcctcgg tgaacatgat ggttggtgac ttgagtttga tgtcacctga
     2761 gttgaaaatg ggaaaacctg cttctccagg ttcagactta tatgcttatg gctgcctctt
     2821 attatggctt tctgttcaaa atcaggagtt tgagataaat aaagatggaa tccccaaagt
     2881 ggatcagttt catctggatg ataaagtcaa atccctcctc tgtagcttga tatgttatag
     2941 aagttcaatg actgctgaac aagttttaaa tgctgaatgt ttcttgatgc caaaggagca
     3001 atcagttcca aacccagaaa aagatactga atacacccta tataaaaagg aagaagaaat
     3061 aaagacggag aacttggata aatgtatgga gaagacaaga aatggtgaag ccaactttga
     3121 ttgttaaatt attattgttg ttgttgcaga ggttcttttt aaaaactttg gtttggttaa
     3181 tacacagaaa tatctagaaa tgttctggga ctagttgagt tgtatcttta gtattcaggt
     3241 tgtgaaaaat aaagatgttt ggctatgcac aaaa
//
