LOCUS       NM_016542               3251 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens serine/threonine kinase 26 (STK26), transcript variant
            1, mRNA.
ACCESSION   NM_016542
VERSION     NM_016542.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3251)
  AUTHORS   Eden,M., Leye,M., Hahn,J., Heilein,E., Luzarowski,M., Volschow,B.,
            Tannert,C., Sossalla,S., Lucena-Porcel,C., Frank,D. and Frey,N.
  TITLE     Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates
            cardiomyocyte growth and survival and is upregulated in human
            cardiomyopathy
  JOURNAL   J Biol Chem 300 (5), 107255 (2024)
   PUBMED   38579991
  REMARK    GeneRIF: Mst4, a novel cardiac STRIPAK complex-associated kinase,
            regulates cardiomyocyte growth and survival and is upregulated in
            human cardiomyopathy.
REFERENCE   2  (bases 1 to 3251)
  AUTHORS   Cao,J., Ji,L., Zhan,Y., Shao,X., Xu,P., Wu,B., Chen,P., Cheng,L.,
            Zhuang,X., Ou,Y., Hua,F., Sun,L., Li,F., Chen,H., Zhou,Z. and
            Cheng,Y.
  TITLE     MST4 kinase regulates immune thrombocytopenia by phosphorylating
            STAT1-mediated M1 polarization of macrophages
  JOURNAL   Cell Mol Immunol 20 (12), 1413-1427 (2023)
   PUBMED   37833401
  REMARK    GeneRIF: MST4 kinase regulates immune thrombocytopenia by
            phosphorylating STAT1-mediated M1 polarization of macrophages.
            Erratum:[Cell Mol Immunol. 2023 Dec;20(12):1533. doi:
            10.1038/s41423-023-01094-x.. PMID: 37907780]
REFERENCE   3  (bases 1 to 3251)
  AUTHORS   Caputo,M., Xia,Y., Anand,S.K., Cansby,E., Andersson,E.,
            Marschall,H.U., Konigsrainer,A., Peter,A. and Mahlapuu,M.
  TITLE     STE20-type kinases MST3 and MST4 promote the progression of
            hepatocellular carcinoma: Evidence from human cell culture and
            expression profiling of liver biopsies
  JOURNAL   FASEB J 37 (8), e23105 (2023)
   PUBMED   37490000
  REMARK    GeneRIF: STE20-type kinases MST3 and MST4 promote the progression
            of hepatocellular carcinoma: Evidence from human cell culture and
            expression profiling of liver biopsies.
REFERENCE   4  (bases 1 to 3251)
  AUTHORS   Getu,A.A., Zhou,M., Cheng,S.Y. and Tan,M.
  TITLE     The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor
            progression: Implications for therapy
  JOURNAL   Cancer Lett 563, 216183 (2023)
   PUBMED   37094736
  REMARK    GeneRIF: The mammalian Sterile 20-like kinase 4 (MST4) signaling in
            tumor progression: Implications for therapy.
            Review article
REFERENCE   5  (bases 1 to 3251)
  AUTHORS   Arora,R., Kim,J.H., Getu,A.A., Angajala,A., Chen,Y.L., Wang,B.,
            Kahn,A.G., Chen,H., Reshi,L., Lu,J., Zhang,W., Zhou,M. and Tan,M.
  TITLE     MST4: A Potential Oncogene and Therapeutic Target in Breast Cancer
  JOURNAL   Cells 11 (24), 4057 (2022)
   PUBMED   36552828
  REMARK    GeneRIF: MST4: A Potential Oncogene and Therapeutic Target in
            Breast Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3251)
  AUTHORS   Dan,I., Ong,S.E., Watanabe,N.M., Blagoev,B., Nielsen,M.M.,
            Kajikawa,E., Kristiansen,T.Z., Mann,M. and Pandey,A.
  TITLE     Cloning of MASK, a novel member of the mammalian germinal center
            kinase III subfamily, with apoptosis-inducing properties
  JOURNAL   J Biol Chem 277 (8), 5929-5939 (2002)
   PUBMED   11741893
  REMARK    GeneRIF: cloning of a germinal center iii kinase that induces
            apoptosis
REFERENCE   7  (bases 1 to 3251)
  AUTHORS   Lin,J.L., Chen,H.C., Fang,H.I., Robinson,D., Kung,H.J. and
            Shih,H.M.
  TITLE     MST4, a new Ste20-related kinase that mediates cell growth and
            transformation via modulating ERK pathway
  JOURNAL   Oncogene 20 (45), 6559-6569 (2001)
   PUBMED   11641781
REFERENCE   8  (bases 1 to 3251)
  AUTHORS   Qian,Z., Lin,C., Espinosa,R., LeBeau,M. and Rosner,M.R.
  TITLE     Cloning and characterization of MST4, a novel Ste20-like kinase
  JOURNAL   J Biol Chem 276 (25), 22439-22445 (2001)
   PUBMED   11306563
REFERENCE   9  (bases 1 to 3251)
  AUTHORS   Dan,I., Watanabe,N.M. and Kusumi,A.
  TITLE     The Ste20 group kinases as regulators of MAP kinase cascades
  JOURNAL   Trends Cell Biol 11 (5), 220-230 (2001)
   PUBMED   11316611
REFERENCE   10 (bases 1 to 3251)
  AUTHORS   Liu,K.C. and Wang,D.
  TITLE     [Synthesis of n-substituted beta-methyl DL-aspartates as potential
            hypocholesteremics (author's transl)]
  JOURNAL   Arch Pharm (Weinheim) 308 (7), 564-570 (1975)
   PUBMED   1164178
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA760264.1, AF231012.1 and
            BC070056.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016542.3.
            
            Summary: The product of this gene is a member of the GCK group III
            family of kinases, which are a subset of the Ste20-like kinases.
            The encoded protein contains an amino-terminal kinase domain, and a
            carboxy-terminal regulatory domain that mediates homodimerization.
            The protein kinase localizes to the Golgi apparatus and is
            specifically activated by binding to the Golgi matrix protein
            GM130. It is also cleaved by caspase-3 in vitro, and may function
            in the apoptotic pathway. Several alternatively spliced transcript
            variants of this gene have been described, but the full-length
            nature of some of these variants has not been determined. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070056.1, AB040057.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394334.7/ ENSP00000377867.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DA760264.1         89-115
            28-1874             AF231012.1         1-1847
            1875-2751           BC070056.1         1875-2751
            2752-3251           BC070056.1         2753-3252
FEATURES             Location/Qualifiers
     source          1..3251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     gene            1..3251
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /note="serine/threonine kinase 26"
                     /db_xref="GeneID:51765"
                     /db_xref="HGNC:HGNC:18174"
                     /db_xref="MIM:300547"
     exon            1..106
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /inference="alignment:Splign:2.1.0"
     exon            107..258
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1467
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     STE20-like kinase MST4; serine/threonine protein kinase
                     26; Mst3 and SOK1-related kinase; mammalian Ste20-like
                     protein kinase 4; mammalian sterile 20-like 4;
                     serine/threonine-protein kinase MASK; serine/threonine
                     protein kinase MST4; STE20-like kinase 4"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 26 isoform 1"
                     /protein_id="NP_057626.2"
                     /db_xref="CCDS:CCDS14631.1"
                     /db_xref="GeneID:51765"
                     /db_xref="HGNC:HGNC:18174"
                     /db_xref="MIM:300547"
                     /translation="MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDN
                     RTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYL
                     GGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKL
                     ADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPP
                     NSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK
                     NSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTVRKKPD
                     PKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAAC
                     PGITDKMVKKLIEKFQKCSADESP"
     exon            259..489
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /inference="alignment:Splign:2.1.0"
     exon            490..546
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /inference="alignment:Splign:2.1.0"
     exon            547..655
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /inference="alignment:Splign:2.1.0"
     exon            656..813
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /inference="alignment:Splign:2.1.0"
     exon            814..999
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1148
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1242
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1305
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1442
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..3251
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3228..3233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /note="hexamer: AATAAA"
     polyA_site      3251
                     /gene="STK26"
                     /gene_synonym="MASK; MST4"
                     /note="major polyA site"
ORIGIN      
        1 atcactcgag cccaggtccc agccaccacc actcacagcg ctcggcgttc aggaagagga
       61 gcagcagcgg aggcggctgc ttcagcggcg ggcgggcgcc agaaaggccc cgatcgaaaa
      121 gcctgggagg gccgccgaac tacccccgga gggaggagcc agtccgaacc caaggcgcca
      181 ccgccgcaga agcggagcga ggcagcattc gcctccatgg cccactcgcc ggtggctgtc
      241 caagtgcctg ggatgcagaa taacatagct gatccagaag aactgttcac aaaattagag
      301 cgcattggga aaggctcatt tggggaagtt ttcaaaggaa ttgataaccg tacccagcaa
      361 gtcgttgcta ttaaaatcat agaccttgag gaagccgaag atgaaataga agacattcag
      421 caagaaataa ctgtcttgag tcaatgtgac agctcatatg taacaaaata ctatgggtca
      481 tatttaaagg ggtctaaatt atggataata atggaatacc tgggcggtgg ttcagcactg
      541 gatcttcttc gagctggtcc atttgatgag ttccagattg ctaccatgct aaaggaaatt
      601 ttaaaaggtc tggactatct gcattcagaa aagaaaattc accgagacat aaaagctgcc
      661 aatgtcttgc tctcagaaca aggagatgtt aaacttgctg attttggagt tgctggtcag
      721 ctgacagata cacagattaa aagaaatacc tttgtgggaa ctccattttg gatggctcct
      781 gaagttattc aacagtcagc ttatgactca aaagctgaca tttggtcatt gggaattact
      841 gctattgaac tagccaaggg agagccacct aactccgata tgcatccaat gagagttctg
      901 tttcttattc ccaaaaacaa tcctccaact cttgttggag actttactaa gtcttttaag
      961 gagtttattg atgcttgcct gaacaaagat ccatcatttc gtcctacagc aaaagaactt
     1021 ctgaaacaca aattcattgt aaaaaattca aagaagactt cttatctgac tgaactgata
     1081 gatcgtttta agagatggaa ggcagaagga cacagtgatg atgaatctga ttccgagggc
     1141 tctgattcgg aatctaccag cagggaaaac aatactcatc ctgaatggag ctttaccacc
     1201 gtacgaaaga agcctgatcc aaagaaagta cagaatgggg cagagcaaga tcttgtgcaa
     1261 accctgagtt gtttgtctat gataatcaca cctgcatttg ctgaacttaa acagcaggac
     1321 gagaataacg ctagcaggaa tcaggcgatt gaagaactcg agaaaagtat tgctgtggct
     1381 gaagccgcct gtcccggcat cacagataaa atggtgaaga aactaattga aaaatttcaa
     1441 aagtgttcag cagacgaatc cccctaagaa acttattatt ggcttctgtt tcatatggac
     1501 ccagagagcc ccaccaaacc tacgtcaaga ttaacaatgc ttaacccatg agctccatgt
     1561 gccttttgga tctttgcaac actgaagatt tggaagaagc tattaaacta ttttgtgatg
     1621 gcgtttatca ttttatattt tgaaaggatt attttgtaag gaataacttt taatactata
     1681 gtttcacctg tattctagta aatgttgaga caccgttttg cttttaagta tccctatttc
     1741 ttaagttacg aggatgaata cctttcacat tttgatcttt agttgactct acagtcatga
     1801 aacatacagg tctttcaaag tcattctcaa tattcagctt ttgtaaatta tcaagcttca
     1861 aaaagctttt ttttttaaaa aaaaacatgc atattctaaa aatgactatt ggtggggagg
     1921 tgtaaataag tcataccttc ttaaaacaga aaatttaagt aaagtctttt aaatgaaacc
     1981 tgtaaaagta ttgactcttc taccaagttg gtatgatatt ccaggcagct caatgattat
     2041 cacatttgag accctgtgtt tgaagcattt acaggcaatg tacagcaaca gaggtacctc
     2101 ttggtgtata gtatttacat tctcttttag gtagaagagg caattttacc cttatttcac
     2161 atggttagaa atttaaagca agatcattta cccaaggata ggtgtttggt aatgttgaag
     2221 gagttagtct ggcttcatgt tttacatctt caactaaaat cccatactat ctgcttggat
     2281 ttggagagcc aaaaaataaa gctgattgtc atgtgattaa atatctgatc aacaggtatg
     2341 aatataactt aaatcagcat atttttgcca tggtaataaa ttgtcctata aactatttat
     2401 atatttttgt tcttcataat tatcactaat aagcatcagt ttgttgtttt taaaaggata
     2461 tttaagtgag cattttctag ttcatatgaa aataaccata gtacaggatg atttctgtcc
     2521 acacaaaggt taaattagat tgcacagtta attttcactt atatttatgg tactattatg
     2581 tgggtgatgc ctttttcttt taagcccagt acatatatta tgcctgccta agttctgaac
     2641 tggggctgta tttcagtagt tgtagaatta ttgatattta gttttgatag ctaatgttta
     2701 attgtttgga tctgcacagt ttggtttttg cacaaaagtc atttaaaaaa atctgagtaa
     2761 ttgtcaaata ttaaaagaaa gatattcttc ctgtaaggaa tacagttttt agtcaaagtg
     2821 gccattacat cctcttttta atttacataa tacagatact tgagaaagtt gttgtggtgt
     2881 tgtatgccaa gaaaattctt tttattggtg cctatattgt aacaattatt tttaatgcat
     2941 tgtattttga agtaacggtt cagttaaatt tttcacctgc tgtgtaactg aaacacaatt
     3001 acagtttata atcatctgta gaagtctgga gataattttg caactcatgt tatgggttaa
     3061 atgaatattt ttgtaaaagt aaaagcaaca aatttataaa ttgattattt gaaactttac
     3121 aacacaattg catcccaaat acaaattgta ttgcttattc attatagcta ttcgtcctgt
     3181 aatctgtttc taggtgaagc atactccagt gttttagggg ttttgaaaat aaatatttaa
     3241 atttcacagt c
//
