LOCUS       NM_001271977            4515 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens serine/threonine kinase 25 (STK25), transcript variant
            1, mRNA.
ACCESSION   NM_001271977
VERSION     NM_001271977.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4515)
  AUTHORS   Chen,K.Q., Lei,G.L., Ke,B.Y., Chen,L., Wang,Z.B. and Wang,S.Z.
  TITLE     STK25: a viable therapeutic target for cancer treatments?
  JOURNAL   Anticancer Drugs 34 (9), 995-1001 (2023)
   PUBMED   36728989
  REMARK    GeneRIF: STK25: a viable therapeutic target for cancer treatments?
            Review article
REFERENCE   2  (bases 1 to 4515)
  AUTHORS   Zhang,X., Wang,B.Z., Kim,M., Nash,T.R., Liu,B., Rao,J., Lock,R.,
            Tamargo,M., Soni,R.K., Belov,J., Li,E., Vunjak-Novakovic,G. and
            Fine,B.
  TITLE     STK25 inhibits PKA signaling by phosphorylating PRKAR1A
  JOURNAL   Cell Rep 40 (7), 111203 (2022)
   PUBMED   35977512
  REMARK    GeneRIF: STK25 inhibits PKA signaling by phosphorylating PRKAR1A.
REFERENCE   3  (bases 1 to 4515)
  AUTHORS   Chen,J., Gao,P., Peng,L., Liu,T., Wu,F., Xu,K., Chen,L., Tan,F.,
            Xing,P., Wang,Z., Di,J., Jiang,B. and Su,X.
  TITLE     Downregulation of STK25 promotes autophagy via the Janus kinase
            2/signal transducer and activator of transcription 3 pathway in
            colorectal cancer
  JOURNAL   Mol Carcinog 61 (6), 572-586 (2022)
   PUBMED   35349179
  REMARK    GeneRIF: Downregulation of STK25 promotes autophagy via the Janus
            kinase 2/signal transducer and activator of transcription 3 pathway
            in colorectal cancer.
REFERENCE   4  (bases 1 to 4515)
  AUTHORS   Zhou,Z., Li,H., Bai,S., Xu,Z. and Jiao,Y.
  TITLE     Loss of serine/threonine protein kinase 25 in retinal ganglion
            cells ameliorates high glucose-elicited damage through regulation
            of the AKT-GSK-3beta/Nrf2 pathway
  JOURNAL   Biochem Biophys Res Commun 600, 87-93 (2022)
   PUBMED   35217361
  REMARK    GeneRIF: Loss of serine/threonine protein kinase 25 in retinal
            ganglion cells ameliorates high glucose-elicited damage through
            regulation of the AKT-GSK-3beta/Nrf2 pathway.
REFERENCE   5  (bases 1 to 4515)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 4515)
  AUTHORS   Voss,K., Stahl,S., Schleider,E., Ullrich,S., Nickel,J.,
            Mueller,T.D. and Felbor,U.
  TITLE     CCM3 interacts with CCM2 indicating common pathogenesis for
            cerebral cavernous malformations
  JOURNAL   Neurogenetics 8 (4), 249-256 (2007)
   PUBMED   17657516
REFERENCE   7  (bases 1 to 4515)
  AUTHORS   Findlay,G.M., Yan,L., Procter,J., Mieulet,V. and Lamb,R.F.
  TITLE     A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of
            mTOR signalling
  JOURNAL   Biochem J 403 (1), 13-20 (2007)
   PUBMED   17253963
  REMARK    GeneRIF: Ste20 family member (MAP4K3) that is required for maximal
            S6K (S6 kinase)/4E-BP1 [eIF4E (eukaryotic initiation factor 4E)
            that is required for maximal S6K (S6 kinase).
REFERENCE   8  (bases 1 to 4515)
  AUTHORS   Preisinger,C., Short,B., De Corte,V., Bruyneel,E., Haas,A.,
            Kopajtich,R., Gettemans,J. and Barr,F.A.
  TITLE     YSK1 is activated by the Golgi matrix protein GM130 and plays a
            role in cell migration through its substrate 14-3-3zeta
  JOURNAL   J Cell Biol 164 (7), 1009-1020 (2004)
   PUBMED   15037601
  REMARK    GeneRIF: 14-3-3zeta is a specific substrate for YSK1 that localizes
            to the Golgi apparatus, and potentially links YSK1 signaling at the
            Golgi apparatus with protein transport.
REFERENCE   9  (bases 1 to 4515)
  AUTHORS   Osada,S., Izawa,M., Saito,R., Mizuno,K., Suzuki,A., Hirai,S. and
            Ohno,S.
  TITLE     YSK1, a novel mammalian protein kinase structurally related to
            Ste20 and SPS1, but is not involved in the known MAPK pathways
  JOURNAL   Oncogene 14 (17), 2047-2057 (1997)
   PUBMED   9160885
REFERENCE   10 (bases 1 to 4515)
  AUTHORS   Pombo,C.M., Bonventre,J.V., Molnar,A., Kyriakis,J. and Force,T.
  TITLE     Activation of a human Ste20-like kinase by oxidant stress defines a
            novel stress response pathway
  JOURNAL   EMBO J 15 (17), 4537-4546 (1996)
   PUBMED   8887545
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC091505.1, BC007852.2,
            HY315908.1 and AC110299.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001271977.1.
            
            Summary: This gene encodes a member of the germinal centre kinase
            III (GCK III) subfamily of the sterile 20 superfamily of kinases.
            The encoded enzyme plays a role in serine-threonine liver kinase B1
            (LKB1) signaling pathway to regulate neuronal polarization and
            morphology of the Golgi apparatus. The protein is translocated from
            the Golgi apparatus to the nucleus in response to chemical anoxia
            and plays a role in regulation of cell death. A pseudogene
            associated with this gene is located on chromosome 18. Multiple
            alternatively spliced transcript variants have been observed for
            this gene. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 4 and 5 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091505.1, SRR11853566.16839.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316586.9/ ENSP00000325748.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1997              BC091505.1         4-2000
            1998-2168           BC007852.2         1971-2141
            2169-2478           HY315908.1         33-342              c
            2479-4515           AC110299.3         67538-69574
FEATURES             Location/Qualifiers
     source          1..4515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..4515
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /note="serine/threonine kinase 25"
                     /db_xref="GeneID:10494"
                     /db_xref="HGNC:HGNC:11404"
                     /db_xref="MIM:602255"
     exon            1..142
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            143..272
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1523
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase 25; Ste20, yeast homolog;
                     ste20-like kinase; ste20/oxidant stress response kinase 1;
                     sterile 20/oxidant stress-response kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 25 isoform 1"
                     /protein_id="NP_001258906.1"
                     /db_xref="CCDS:CCDS2549.1"
                     /db_xref="GeneID:10494"
                     /db_xref="HGNC:HGNC:11404"
                     /db_xref="MIM:602255"
                     /translation="MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKE
                     VVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGS
                     ALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFG
                     VAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDL
                     HPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKK
                     TSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLH
                     KGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGELKEKHKQSGGSVGALEELENAFSL
                     AEESCPGISDKLMVHLVERVQRFSHNRNHLTSTR"
     exon            273..503
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..560
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..669
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..827
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1013
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1159
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1274
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1346
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1483
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..4515
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2060..2065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /note="hexamer: AAGAAA"
     polyA_site      2088
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
     regulatory      2146..2151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /note="hexamer: AATAAA"
     polyA_site      2166
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /note="major polyA site"
     regulatory      2434..2439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /note="hexamer: AATAAA"
     polyA_site      2473
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
     polyA_site      3798
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
     regulatory      4262..4267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /note="hexamer: AATAAA"
     polyA_site      4301
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
     regulatory      4462..4467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /note="hexamer: AGTAAA"
     polyA_site      4489
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
     regulatory      4491..4496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
                     /note="hexamer: AATAAA"
     polyA_site      4515
                     /gene="STK25"
                     /gene_synonym="SOK1; YSK1"
ORIGIN      
        1 gctttctccg gtcgctgccg ccaccaccgt tgcttcgcgg gctgggaggc ccggggtccc
       61 cgggcgaaca gaggctgcgg gtgggagcct tcgcgggcgc tgcagagcgg gccgggggag
      121 gccgggatgg agccccgcgg agtggactga cgccgcaggg gcgagctagc cggctccgcg
      181 cctctccgcg ggatccagac gcctcctggg gctgctggcg gagggtctga ggcggcgcgg
      241 ccatggctca cctccgggga tttgccaacc agcactctcg agtggaccct gaggagctct
      301 tcaccaagct cgaccgcatt ggcaagggct cgtttgggga ggtctacaag ggcatcgata
      361 accacacaaa ggaggtggtg gccatcaaga tcatcgacct ggaggaggcc gaggatgaga
      421 tcgaggacat ccagcaggag atcactgtcc tcagtcagtg cgacagcccc tacatcaccc
      481 gctactttgg ctcctaccta aagagcacca agctatggat catcatggag tacctgggcg
      541 gcggctcagc actggacttg cttaaaccag gtcccctgga ggagacatac attgccacga
      601 tcctgcggga gattctgaag ggcctggatt atctgcactc cgaacgcaag atccaccgag
      661 acatcaaagc tgccaacgtg ctactctcgg agcagggtga cgtgaagctg gcggactttg
      721 gggtagcagg gcagctcaca gacacgcaga ttaagaggaa cacattcgtg ggcaccccct
      781 tctggatggc acctgaggtc atcaagcagt cggcctacga cttcaaggct gacatctggt
      841 ccctggggat cacagccatc gagctggcca agggggagcc tccaaactct gacctccacc
      901 ccatgcgcgt cctgttcctg attcccaaga acagcccacc cacactggag ggccagcaca
      961 gcaagccctt caaggagttc gtggaggcct gcctcaacaa agacccccga ttccggccca
     1021 cggccaagga gctcctgaag cacaagttca tcacacgcta caccaagaag acctccttcc
     1081 tcacggagct catcgaccgc tataagcgct ggaagtcaga ggggcatggc gaggagtcca
     1141 gctctgagga ctctgacatt gatggcgagg cggaggacgg ggagcagggc cccatctgga
     1201 cgttcccccc taccatccgg ccgagtccac acagcaagct tcacaagggg acggccctgc
     1261 acagttcaca gaagcctgcg gagcccgtca agaggcagcc gaggtcccag tgcctgtcca
     1321 cgctggtccg gcccgtcttc ggagagctca aagagaagca caagcagagc ggcgggagcg
     1381 tgggtgcgct ggaggagctg gagaacgcct tcagcctggc cgaggagtcc tgccccggca
     1441 tctcagacaa gctgatggtg cacctggtgg agcgagtgca gaggttttca cacaacagaa
     1501 accacctgac atccacccgc tgaagcgcac tgctgttcag ataggggacg gaaggtcgtt
     1561 tgtttttgtt ctgagctcca taagaactgt gctgacttgg aaggtgccct gtgctatgtc
     1621 gtgcctgcag ggacacgtcg gatcccgtgg gcctcacatg ccaggtcacc aggtcaccgt
     1681 ctccttccac ccctgcagtg tgctgttgtg cacgtcaggg acgctgttct ctatgcccac
     1741 tgccctcctc cctctcctgg cccagcagta ttgctcacgg gggctccagc cgccggcgtg
     1801 gccctcatga gctacgcctg ggtcttctgc agactcatgc agccctatgg ccgctcagac
     1861 caaggcgcag agcaactatc agggcagctc tgcctcctcc tcccatgagg tggggagagg
     1921 caacagggca gcccccagag gagtgtcctg gccgctgtcc tcccggggcc catgatggcc
     1981 atagatttgc cttgtggtgt tggatcaggt actgtgtctg ctcataagta cttgtgtcat
     2041 ccagaatgtt ttgtttttta agaaaattga attacttgtt tcctgaaata ttctgaggtt
     2101 aatatgttag ttttcataga acattgagag gcccctgcca ctttcaataa agacctgact
     2161 tggagacatg caggtgtgtg tggtggggcc cgggccatgc ggggctgcag cgtccctggt
     2221 cccgagtcct catcacagca cgcagagacg gcagcccagc cccccttcga aacttccctg
     2281 tgacggattc ctgggctctg cttggcccac cggaagaaca gagcaggcag aggagaatgc
     2341 aggtggggag atgctgtttg tttattttta atcaaatgtg tgtgaacaaa gcagtcgccc
     2401 atctacttcc cgttggaagg aatgctgggc agtaataaat tagacggccc caccctccca
     2461 gggcacaggg ggactttggt ttctgcttct ctagaggtac atggggaaca agcgtggctt
     2521 ctgccagact tgtttagctg tgacctgcag ggcaggcccc tggggctgcc acttggttca
     2581 ccagatggaa ggtcagcatg gctgtgccac gcttgtctga gagggtcctg gcagtgggta
     2641 cgcagggtgt atggcagggc ctcttttcca gtgcttgctc taggccagtc ctcggcaggg
     2701 accctgctct ggggagagag gcagggtgtg cccaggcttt ggtccgatgc cgagagcact
     2761 gctcaggcct tgtctgcgtc tttgagccag gggcctggga gctgtggctt gagcggctcc
     2821 gcgctcaaga ctcgcacatt tttcccaggg ccccagatag ctgctggcat gcactaggtc
     2881 ctgggtgggg ggatgaagcc cctcccagat gttacatgag gcccacccac actgctggtg
     2941 ccagtgggga tccagtgaga ccacagccac ttcccatctg ttgagaagcc tcaggacaga
     3001 ggtcacctct gtgtcctgct gttctttgta gttgtgtcca aacctgggca ggttgagcgt
     3061 cattcctcct tccccctgac catcccctcc agccctgagg agggttgggg gccatcctgc
     3121 acgatgcttg gggccctccc ggctgagctg ctggccccct ggatcacctc catccacctg
     3181 gaggagaggg cggccatcag accagtgagc catcttgtgc tcagacactg tcccaagaac
     3241 aacccaggat atgggacaag caggacaaaa gaagggttaa aaacctgggg ccgggtgcgg
     3301 tggctcatgc ctataatccc agcactttgg gaggctgagg cagatggatc acttgaggtc
     3361 aggagttcga gaccagcctg gccaacatgg tgaaaccctg tctctactaa aaatacaaaa
     3421 attagccagg cggcgtggcg tgcatgcctg taatctcagt tactcaggag gctgaggcag
     3481 aagaatcgct tgaaccctgg aggtgcaggt tatagtgagc caagattgta tcactgcact
     3541 ccagcctgag tgacagaggg agacgccatc tccaaaaaaa aaaaaaacaa agcattgctg
     3601 ttttttggaa atgctggaag cattgctcag cccttccttt ccagggccca gaaaacttgc
     3661 ctccaccacc atgagtagaa atgggagctg agcggacatc gaaatgggca gctgaccagg
     3721 gctgcctcct gcaaaattac ctttcaaatg tgtacttgct ctcagcccgg aagaagtaga
     3781 cgtgggattt gaactggagc ttgaaaacat agtctttgtg tatgccatcg gcctccctgg
     3841 ggatgctcac gctgtagccc agcagcggga ggctggccag tgggtagtca tcctgcaaga
     3901 cagcataggg acacgggttc caggggctgg gttgccacag ggaatgccca ttcctctgct
     3961 acctgcacaa cggtggcacg tacaaatgcc cacgggccaa gggagccagt ttccctgttc
     4021 acacagcaca gggtgtgtgg gcaaagcatg ggagggcaga accaaaatac aaaagggaca
     4081 caggtgagca gggttaagtg tctgtctgct agcatcacct gcattgggct ccagtgaaac
     4141 tccagtacct gatgagtttt gtagaagaac aaacagaagt tggtaaagac gacccagagc
     4201 ttctgccagc catgactgtt tttgaacttt cttagcagat atcctgaaag ctggttctgt
     4261 caataaagga aaaatgcagg tgcattaacc agcacccagg accccttgtg ggagtgggtt
     4321 tgctccccaa gactaagcct ctgcatgctt tctccagctg aggccttggt tttacctctg
     4381 gactgctatg aacagcagct ttatcagtac ttaagtccaa cagaagcatg ttaaaaacct
     4441 agagtgacat tccaggcacc aagtaaagtg agttcccttt ccctgtgcac aataaagtca
     4501 gtgttcagta accaa
//
