LOCUS       NM_001032296            9605 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens serine/threonine kinase 24 (STK24), transcript variant
            2, mRNA.
ACCESSION   NM_001032296
VERSION     NM_001032296.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9605)
  AUTHORS   Wang,N., Jiang,Y., Li,M., Wang,H., Pan,J., Tang,Y., Xie,S., Xu,Y.,
            Li,X., Zhou,X., Xu,P., Lin,W. and Wang,X.
  TITLE     Protein Kinase STK24 Promotes Tumor Immune Evasion via the
            AKT-PD-L1 Axis
  JOURNAL   Adv Sci (Weinh) 11 (12), e2304342 (2024)
   PUBMED   38229183
  REMARK    GeneRIF: Protein Kinase STK24 Promotes Tumor Immune Evasion via the
            AKT-PD-L1 Axis.
REFERENCE   2  (bases 1 to 9605)
  AUTHORS   Caputo,M., Xia,Y., Anand,S.K., Cansby,E., Andersson,E.,
            Marschall,H.U., Konigsrainer,A., Peter,A. and Mahlapuu,M.
  TITLE     STE20-type kinases MST3 and MST4 promote the progression of
            hepatocellular carcinoma: Evidence from human cell culture and
            expression profiling of liver biopsies
  JOURNAL   FASEB J 37 (8), e23105 (2023)
   PUBMED   37490000
  REMARK    GeneRIF: STE20-type kinases MST3 and MST4 promote the progression
            of hepatocellular carcinoma: Evidence from human cell culture and
            expression profiling of liver biopsies.
REFERENCE   3  (bases 1 to 9605)
  AUTHORS   Lai,S., Wang,D., Sun,W. and Cao,X.
  TITLE     Serine/threonine-protein kinase STK24 induces tumorigenesis by
            regulating the STAT3/VEGFA signaling pathway
  JOURNAL   J Biol Chem 299 (3), 102961 (2023)
   PUBMED   36720310
  REMARK    GeneRIF: Serine/threonine-protein kinase STK24 induces
            tumorigenesis by regulating the STAT3/VEGFA signaling pathway.
REFERENCE   4  (bases 1 to 9605)
  AUTHORS   Sugden,P.H., McGuffin,L.J. and Clerk,A.
  TITLE     SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase
            III) kinases and their heterologous protein-protein interactions
  JOURNAL   Biochem J 454 (1), 13-30 (2013)
   PUBMED   23889253
  REMARK    GeneRIF: This review notes that in the SOK1 and MST4 germinal
            center kinase III family of proteins, exon 1 encodes a 5'
            untranslated region, but this is not the case for MST3.
            Review article
REFERENCE   5  (bases 1 to 9605)
  AUTHORS   Stegert,M.R., Hergovich,A., Tamaskovic,R., Bichsel,S.J. and
            Hemmings,B.A.
  TITLE     Regulation of NDR protein kinase by hydrophobic motif
            phosphorylation mediated by the mammalian Ste20-like kinase MST3
  JOURNAL   Mol Cell Biol 25 (24), 11019-11029 (2005)
   PUBMED   16314523
  REMARK    GeneRIF: Activation of NDR2 is a multistep process involving
            phosphorylation of the hydrophobic motif site Thr444/2 by MST3.
REFERENCE   6  (bases 1 to 9605)
  AUTHORS   Lu,T.J., Huang,C.Y., Yuan,C.J., Lee,Y.C., Leu,T.H., Chang,W.C.,
            Lu,T.L., Jeng,W.Y. and Lai,M.D.
  TITLE     Zinc ion acts as a cofactor for serine/threonine kinase MST3 and
            has a distinct role in autophosphorylation of MST3
  JOURNAL   J Inorg Biochem 99 (6), 1306-1313 (2005)
   PUBMED   15917084
REFERENCE   7  (bases 1 to 9605)
  AUTHORS   Lee,W.S., Hsu,C.Y., Wang,P.L., Huang,C.Y., Chang,C.H. and Yuan,C.J.
  TITLE     Identification and characterization of the nuclear import and
            export signals of the mammalian Ste20-like protein kinase 3
  JOURNAL   FEBS Lett 572 (1-3), 41-45 (2004)
   PUBMED   15304321
  REMARK    GeneRIF: Mst3 contains signals which may cooperate to control the
            subcellular distribution of Mst3.
REFERENCE   8  (bases 1 to 9605)
  AUTHORS   Huang,C.Y., Wu,Y.M., Hsu,C.Y., Lee,W.S., Lai,M.D., Lu,T.J.,
            Huang,C.L., Leu,T.H., Shih,H.M., Fang,H.I., Robinson,D.R.,
            Kung,H.J. and Yuan,C.J.
  TITLE     Caspase activation of mammalian sterile 20-like kinase 3 (Mst3).
            Nuclear translocation and induction of apoptosis
  JOURNAL   J Biol Chem 277 (37), 34367-34374 (2002)
   PUBMED   12107159
  REMARK    GeneRIF: Proteolytic activation of Mst3 by caspases.
REFERENCE   9  (bases 1 to 9605)
  AUTHORS   Zhou,T.H., Ling,K., Guo,J., Zhou,H., Wu,Y.L., Jing,Q., Ma,L. and
            Pei,G.
  TITLE     Identification of a human brain-specific isoform of mammalian
            STE20-like kinase 3 that is regulated by cAMP-dependent protein
            kinase
  JOURNAL   J Biol Chem 275 (4), 2513-2519 (2000)
   PUBMED   10644707
REFERENCE   10 (bases 1 to 9605)
  AUTHORS   Schinkmann,K. and Blenis,J.
  TITLE     Cloning and characterization of a human STE20-like protein kinase
            with unusual cofactor requirements
  JOURNAL   J Biol Chem 272 (45), 28695-28703 (1997)
   PUBMED   9353338
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356423.15 and AL137249.29.
            
            On May 20, 2020 this sequence version replaced NM_001032296.3.
            
            Summary: This gene encodes a serine/threonine protein kinase that
            functions upstream of mitogen-activated protein kinase (MAPK)
            signaling. The encoded protein is cleaved into two chains by
            caspases; the N-terminal fragment (MST3/N) translocates to the
            nucleus and promotes programmed cells death. There is a pseudogene
            for this gene on chromosome X. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (b) has a distinct N-terminus and is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU668350.1, BC065378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000539966.6/ ENSP00000442539.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               AL356423.15        78425-78787         c
            364-594             AL356423.15        20923-21153         c
            595-651             AL137249.29        88523-88579         c
            652-760             AL137249.29        81508-81616         c
            761-918             AL137249.29        81079-81236         c
            919-1104            AL137249.29        72634-72819         c
            1105-1250           AL137249.29        69949-70094         c
            1251-1374           AL137249.29        68032-68155         c
            1375-1443           AL137249.29        66630-66698         c
            1444-1580           AL137249.29        63426-63562         c
            1581-9605           AL137249.29        51443-59467         c
FEATURES             Location/Qualifiers
     source          1..9605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.2"
     gene            1..9605
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /note="serine/threonine kinase 24"
                     /db_xref="GeneID:8428"
                     /db_xref="HGNC:HGNC:11403"
                     /db_xref="MIM:604984"
     exon            1..363
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1617
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /EC_number="2.7.11.1"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; STE20-like kinase 3; sterile 20-like kinase 3;
                     serine/threonine kinase 24 (STE20 homolog, yeast);
                     serine/threonine-protein kinase 24; STE20-like kinase
                     MST3; mammalian STE20-like protein kinase 3; epididymis
                     secretory protein Li 95"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 24 isoform b
                     precursor"
                     /protein_id="NP_001027467.2"
                     /db_xref="CCDS:CCDS32001.1"
                     /db_xref="GeneID:8428"
                     /db_xref="HGNC:HGNC:11403"
                     /db_xref="MIM:604984"
                     /translation="MAHSPVQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDN
                     RTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYL
                     GGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKL
                     ADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPP
                     HSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILR
                     NAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDP
                     KNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEEL
                     RGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGTSSH"
     exon            364..594
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /inference="alignment:Splign:2.1.0"
     exon            595..651
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /inference="alignment:Splign:2.1.0"
     exon            652..760
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /inference="alignment:Splign:2.1.0"
     exon            761..918
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1104
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1250
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1374
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1443
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1580
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..9605
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2145..2150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /note="hexamer: AGTAAA"
     polyA_site      2167
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
     regulatory      2610..2615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /note="hexamer: AATAAA"
     polyA_site      2631
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /note="major polyA site"
     regulatory      3423..3428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /note="hexamer: AATAAA"
     polyA_site      3444
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
     regulatory      4569..4574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /note="hexamer: AATAAA"
     polyA_site      4589
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
     regulatory      9584..9589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
                     /note="hexamer: AATAAA"
     polyA_site      9605
                     /gene="STK24"
                     /gene_synonym="HEL-S-95; MST3; MST3B; STE20; STK3"
ORIGIN      
        1 actccggctc cagcggccag cgcgcgcggg cccaggccgc ccggctccag cccagcagta
       61 gcggcagcag cggcggcggc ggcagtgcgc gcgaggccct gcgcccccag cagctcctcc
      121 ctggcgccgt gcatggagac gcggcccgcc acccgccgct gagcccccgc cgcccggccg
      181 ggacccgcca gggctggggt ggcctcgggc tccggccggc cccgccgccc gagggctgcg
      241 cgcggcccgc gggcctcgcc gccccgcgcg gatcgtcgcg gcccggccgt cccgtcccag
      301 gaagtggccg tcctgagcgc catggctcac tccccggtgc agtcgggcct gcccggcatg
      361 cagaacctaa aggcagaccc agaagagctt tttacaaaac tagagaaaat tgggaagggc
      421 tcctttggag aggtgttcaa aggcattgac aatcggactc agaaagtggt tgccataaag
      481 atcattgatc tggaagaagc tgaagatgag atagaggaca ttcaacaaga aatcacagtg
      541 ctgagtcagt gtgacagtcc atatgtaacc aaatattatg gatcctatct gaaggataca
      601 aaattatgga taataatgga atatcttggt ggaggctccg cactagatct attagaacct
      661 ggcccattag atgaaaccca gatcgctact atattaagag aaatactgaa aggactcgat
      721 tatctccatt cggagaagaa aatccacaga gacattaaag cggccaacgt cctgctgtct
      781 gagcatggcg aggtgaagct ggcggacttt ggcgtggctg gccagctgac agacacccag
      841 atcaaaagga acaccttcgt gggcacccca ttctggatgg cacccgaggt catcaaacag
      901 tcggcctatg actcgaaggc agacatctgg tccctgggca taacagctat tgaacttgca
      961 agaggggaac cacctcattc cgagctgcac cccatgaaag ttttattcct cattccaaag
     1021 aacaacccac cgacgttgga aggaaactac agtaaacccc tcaaggagtt tgtggaggcc
     1081 tgtttgaata aggagccgag ctttagaccc actgctaagg agttattgaa gcacaagttt
     1141 atactacgca atgcaaagaa aacttcctac ttgaccgagc tcatcgacag gtacaagaga
     1201 tggaaggccg agcagagcca tgacgactcg agctccgagg attccgacgc ggaaacagat
     1261 ggccaagcct cggggggcag tgattctggg gactggatct tcacaatccg agaaaaagat
     1321 cccaagaatc tcgagaatgg agctcttcag ccatcggact tggacagaaa taagatgaaa
     1381 gacatcccga agaggccttt ctctcagtgt ttatctacaa ttatttctcc tctgtttgca
     1441 gagttgaagg agaagagcca ggcgtgcgga gggaacttgg ggtccattga agagctgcga
     1501 ggggccatct acctagcgga ggaggcgtgc cctggcatct ccgacaccat ggtggcccag
     1561 ctcgtgcagc ggctccagag atactctcta agtggtggag gaacttcatc ccactgaaat
     1621 tcctttggca tttggggttt tgtttttcct tttttccttc ttcatcctcc tcctttttta
     1681 aaagtcaacg agagccttcg ctgactccac cgaagaggtg cgccactggg agccacccca
     1741 gcgccaggcg cccgtccagg gacacacaca gtcttcactg tgctgcagcc agatgaagtc
     1801 tctcagatgg gtggggaggg tcagctcctt ccagcgatca ttttatttta ttttattact
     1861 tttgttttta attttaacca tagtgcacat attccaggaa agtgtcttta aaaacaaaaa
     1921 caaaccctga aatgtatatt tgggattatg ataaggcaac taaagacatg aaacctcagg
     1981 tatcctgctt taagttgata actccctctg ggagctggag aatcgctctg gtggatgggt
     2041 gtacagattt gtatataatg tcatttttac ggaaaccctt tcggcgtgca taaggaatca
     2101 ctgtgtacaa actggccaag tgcttctgta gataacgtca gtggagtaaa tattcgacag
     2161 gccataactt gagtctattg ccttgccttt attacatgta cattttgaat tctgtgacca
     2221 gtgatttggg ttttattttg tatttgcagg gtttgtcatt aataattaat gcccctctct
     2281 tacagaacac tcctatttgt acctcaacaa atgcaaattt tccccgtttg ccctacgccc
     2341 cttttggtac acctagaggt tgatttcctt tttcatcgat ggtactattt cttagtgttt
     2401 taaattggaa catatcttgc ctcatgaagc tttaaattat aattttcagt ttctccccat
     2461 gaagcgctct cgtctgacat ttgtttggaa tcgtgccact gctggtctgc gccagatgta
     2521 ccgtcctttc caatacgatt ttctgttgca ccttgtagtg gattctgcat atcatctttc
     2581 ccacctaaaa atgtctgaat gcttacacaa ataaatttta taacacgctt attttgcata
     2641 ctccttgaaa tgtgactctt cagaggacag ggcacctgct gtgtatgtgt ggccgtgcgt
     2701 gtgtactcgt ggctgtgtgt gtgtgatgag acactttgga agactccagg gagaagtccc
     2761 caggcctgga gctgccgagt gcccaggtca gcgccctgga ctgcttgcgc acttgctcac
     2821 cgagatgatg cagttggagg ttgctgatct gtgcgattgc tgtagcggtt gccggggacc
     2881 ttaagagtta ttttgcttct ctggaagggg cctatgcttg ctaggcaggc agccagtgtg
     2941 tctgtttttc ttggtttgct gtgggacctt gcttggcgag ggggaaaatc tctgggtttc
     3001 tggagtggga gggttcgtgc agcagctgtt gactggtaca tgaagcattc ttttatgttt
     3061 gttgaagctg atgattgaca tctcccgtgg gtgtgccagt tcttgtggag ttaagacagg
     3121 atttttggaa gcaaggaagt tagtgggtga gcttggggat gtagctcagc tatctgctgg
     3181 tctagtggcc tctaagctat agggagggga cagagccctg agctacagat gcttgagtgg
     3241 gttattgtgt cggtttgcta gtgcagtctg gtttttaagc tctaaaattg aggtatttta
     3301 ttagaagtgg atttgggttg aactcttaat ttgtataagg gatatatttt ggttggggaa
     3361 atagaactga gttgctaatt cttattgtac tcattactcc atacaagaat gttatgttga
     3421 ataataaaat tggagaagat ttcattttgt gtttccaggg agtattctgt gtggggaact
     3481 gtttccttac gtgaggccgg cggcataagt caaagatgag ttttgtcctt gcgaatcaca
     3541 cagattgagt ctgtgttccc cagggtgtgc cgttacctga tttttaagtg agccagggcg
     3601 gacagcagct tttctgattt acagagttct tcagatttac aaatggacaa tgacatcaca
     3661 gtttttagca ctgaagccag tctcatgcta gtaacagtgg gtgagccgct cgagggactg
     3721 ggttctaatg aatactggta tgaacgggga gtctctgcag tcgccagaca aatcatactc
     3781 agccccttcc cccgtagagc aacaagtggt tcttttagag ttgactggca gcatttcctg
     3841 tcgggggagg tggggtttga tggagttaga aagctcgcct ctgtgtacat tctctcctgg
     3901 gctgttactt tctgtagacg cacaaaatca gccccaatgt ttttaagggc atcttagcca
     3961 aggaagctgg cttttgtgtc gccacttcca ggcctgcatt aagagagagc ccaggcacca
     4021 gggctaccac tggaacctgc ctcagcgtca actgctgctg gtctgtagcc aggcccagcc
     4081 tttgagacgg gtttactgtc accagtagcc tctcagtgcc agccctgagc tgctcctggc
     4141 tcagctgccc agagcctgca gcctggggag gtactcagcc tctgggagac gagggccgtg
     4201 gactgggtgg ctggtagctc ctgcgttttt gagctgtgtc ctggctggct gctgccaatg
     4261 aggtggacac cagtgtggtt tggggtgcac tggccacttc ttgctgggtt ctgattttct
     4321 tggaagtgca tctgccttcc ttatccaata gttttatccc tgcattgctc ttgtgaagtg
     4381 gctggtttgg ttctgtatgt agcattttgt acctttcctc tggcaaaaca ctgtcagttt
     4441 ataaacattt tttatatttc cctcctttaa aaacagcttg tgtatttctg ctataaaatg
     4501 tgtcagcaaa ggcagagtga cctaataggg catgttctta agcacaggga ctgtatcatg
     4561 caggggccaa taaagctcaa gaaaacgagt atctgcatca ttgtgtgtct catgtgtagt
     4621 gtgtctcaaa ctccactcag atggactgtt acccacacta gtattttctt gagggcacac
     4681 aggaagcaga ggtgctggtc acaggtcaga accaccagtg tccagcaagt agtttggaat
     4741 caatcaatca ttcagaaata aatagctgag gagactgcct tgtccccaag tctccaggaa
     4801 tgagtgagtg gtgacttctg gagggagcct gatgctgctg tgtggcccgg agctgtttgt
     4861 ttgctctgcc cctgcctgga ggtgggggga gcatagggaa cagtgggggg caggccctcc
     4921 ctgtgtcact ctgaacactg gggctttaga aacccttgct ggagtgtccc cttcccccct
     4981 ccccccccac acagaaaatg aagactacag acaaagttgg ttgttttgcc ttaaaacatc
     5041 aatatgctgg attgtggcgt gaggtatttt tattcccttt gttagtactg gaaaccgtct
     5101 ggtacatctt gtaaggcaaa tgattaacac acggcaggct cttcgtccgt ttgcaagttg
     5161 ctgtttgttt ccagctacac cagtcagagc tccacagaga gggtgcgttc ctggttctca
     5221 ggtgggcagg tgctatggtg cggggcgctg gaaagaatgg ggttgaattg gccctcgcct
     5281 ccgcttgttt gagactctcg ttagaaaggg cttaggaaaa ccaagggaat ggcagccacc
     5341 ccatcaccat cgagaacagg cagacgtttc ccgagtaggg gccaaagcca ctggaaaccg
     5401 tgttccctgt gcagtccgac tgacactacc ccatgcctgg ggggaatgag tataaaaagg
     5461 gaaatgtttt tgaagacagg cacgatatat actactagag aatgcgcagt ttcaaaccac
     5521 agttgcagga ggatatagga ataacgacag gtgccgggga ctacgtacca tgatttcata
     5581 gtgctctgca gccagcaggc tcactaaacg ctcatcacgg aacataccac aaatggtgct
     5641 gatcaatgac acacgggttt tcatgcttgt gacacagaca gacagcaaaa caccacggct
     5701 tattatcttc ccattgtgta caccactcac aggacggtga cagtccaggt attgcactgg
     5761 atctcggctt tgcttaacag aaaacaaccc tgctacggtt ggaaagagtt accacttaaa
     5821 acgatttggt caacttgcac caagaagtag gttgggaaca ggtgttttca ggtgagcgtg
     5881 aaaccccgca gtggaacgct gtgtgctgca aattgcttat taatcagaga agtgagtcct
     5941 actaacttcc tattattaca aaagtagaaa gactgaaaaa aaaaatgaaa tctgaaaatg
     6001 atctcatttg cttaaggctg cactgagtgt attgcaaaca aacaaacaaa caccgggaag
     6061 tccacttcgt aaaatgcagc agccaatagg tgaaaataat aaaagaaaga acttttttta
     6121 ggaagaaaaa cacttgccct gtcttgtgtt gaacggatgt gtgtgtactg tttttcaggg
     6181 gcagggtgga gggaagatgt catttggcac tctcgtaatg acaatgtttt aatactggca
     6241 ctagctaaag aacagcgccc ccagcggatg ccaggactgg aggtgggagc gctgttcatt
     6301 cagacgctga gaggtcgggg ttaaaaaacg cggctgtgga gacaggagag ctgctgggaa
     6361 gccatgtttt tgattttcag acaggtgtta attttaccag gcttcattaa tacagaagaa
     6421 aggaaacgtc ttccaggaaa gcagccactg cggaaacgag tgtgtccggc catcaataca
     6481 caagagactc tttgtgactc aacacgtggg gtcgcgaggc agagctggtg gcactgcgga
     6541 tcacttccat ccacctgcaa cacgggaacg ccagttagtc aaccttttgt ttggacggac
     6601 tcctgacact ttggtgggca tcgcttacag aaacacaagg tgaagtcagg ccgcctggtt
     6661 ggtaatctgc cacttcagca gaagagcaag ggaacagcca gcacccaggc gttcctgagg
     6721 tacagtggag acccactggc ctgggcactc actcagtgtg gagctggaag taccttgctg
     6781 cagtgacact gcccgctcca ttggagcagt taggagcgag gtggcctctg gttgctgggg
     6841 agaacgctac ctcctatttt catggacatg gcagagaatg gcgggacgtg tcccatcctg
     6901 cttagtggaa gctctccctt ccttttttct ttttcttttt tttttgagac agggtctggc
     6961 tctgtcactc atactggagt tcagtggtgc agttatcgcc cactgtagct acctcctggg
     7021 ctcaatcgat cctccagcct tggcctccca ggagatggga ctacaggctt gcaccaccac
     7081 gcccaaatct ccctttttat atatttgtgt atttgctctc taccggtgct tctcaaatgg
     7141 gtgcaatgct gtcccatttg gtaaagtctg gagacatttt tagatgtccc aactgagggg
     7201 ttgctgcggg catctagtgg gtggccaggg atgccgctga acatcctgca caatgcagga
     7261 cggactcccc aaattacctg gccttgtccc aggcctttca ggatctggac tgcaaggctg
     7321 gaccctttgt cacaataata gcaaaatccc aactttgatc aacccagctc tcaacccagc
     7381 tctcgagctc agtccaggat cagatttgag aatggctctc ctctaggttc ctttttcagg
     7441 tgatgttgtt taggaggtgc tcagcatatt gctgaggacc cctccccttc tgcctcccgg
     7501 ggcgaggagg gctcagcagg gcaaactgca caagtagtcg gcttggggat gcaatttgca
     7561 gaggcccagg atctctattc aaaatatgaa ttgcaggaac agtcttaggc ctgactgttg
     7621 catttctttc ttggctaaat gaagtctgca gtccctgcca ttacaccatg taggcagtct
     7681 cactggggct tagcttcatc atcccggaca cgttatgtca gagatctcca agcaagatgt
     7741 ctagggcctc agccaacacc gtgcagggta agggcgcagg gaagttggga ccccactttc
     7801 tgccatgaga acagaatcgc ctgctggtgt cgggcagtgg gaccccaggt ctaaacgctt
     7861 agttggcagg gaagggtggg gccatctcac tcgctgactt gggagaaatc ctgatgtttg
     7921 gaagaggggg tcctcttctg cagggccctg tgcgtgggaa gggggtgtct acctttcgaa
     7981 cgtgtactcg ctttccgccc tgaagtagta gacgtgggac ttgaagtgca gcttgaacac
     8041 gtagtctttc tggatgttct cggactcaga ggggatggtg agcgagtagc cgagcagagg
     8101 caggctggca aggggatgat tgtcctggaa aggggaaaca aagcaaagtg gcttttcggg
     8161 gtcagcttct gctgctgggc ctggctgctg ccccgcatca gacagggact tgggagccca
     8221 ggcagctccc tcctcgggcg tgggcctgga agggaccatg gcagccagtg tttgcctgta
     8281 cgtgatggcc cgggtggcaa gtcccgccag gactgagctg tagataaagc caacccccgt
     8341 cccttgtcca ggcagaagac aggtggccct tcctagggca gaagttgtcc ttcagtggat
     8401 gataatgtca gtcttcccta gagttgaggg cctcgggtgg acagggcccc ccgccagcat
     8461 ccctgtcatc cccgtgacac ctggagccca agaggcctga gtcattccag aggagggcgg
     8521 ccccctcacc tcatgctgcc acccccaagg tcccagggcc acctgccctg tgcgagacac
     8581 ttacctggtg tgatttgtag aagaacaggc agaagtttgt gaacaccacc cacagcttct
     8641 gccacccgtt gctgtttttg aatttcctca gcaggtttcc agacaactga ttctgaaagg
     8701 caaggaggcc tgtgagaagc acagcgggca cctgccccag gagggcacag agagcagctc
     8761 tccctgcacc agggccctgg gctggggcat gtccgtgact gaaggatgtg ggccccaccc
     8821 ccgctccccc gtgtgtgggg agacttggca ggtcctggga ccctgatctc atcacttccc
     8881 cttgtcactt gctgtggggc atcttggggt ccctgtgtcc ccccaaaaga cacgttgagg
     8941 tcctgactac cagtacctta gaacacaggc ttatttggaa ataggctcgt tgcagggtaa
     9001 ctagtgaaga cgagatcaca ctggggtagg gtgggcccta aatccaacgg gagtggtgtc
     9061 ctgaggagaa gagccacctt gaggggagag gggtgtgccc tgtgacaccg aggcagaaat
     9121 gggggcgcag gaccccatgc attgccagca ggcggaagct gaaggaggga aagatccatc
     9181 ccaacaagct cagagcagca ctcgttttga ggggccaggc accctaccca ggaagtgggg
     9241 cctggggtgc atgtgagtgg ctcccacatg ccctctagtg gcccaggagg cagttgcagc
     9301 cctgcccacc tccaggctca gggccggccc agcccctgga gcattgttag gatgcgctgc
     9361 agcccagcta gggggcaggg acaggcacct gtgtccatgc tacctccaaa caactctgag
     9421 caggcctgac gcactggtgg ctcatttcgt ccctttgcca aagtgacatc accagcagag
     9481 actcaaagca gttgcaccac cttgtaaagg cacttaatgc cactgaattg ttcccgtaaa
     9541 aatcgttaag ttggccaata ttgtggtata gctattttac cacaataaaa aatacagacc
     9601 tccga
//
