LOCUS       NM_004226               5273 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens serine/threonine kinase 17b (STK17B), mRNA.
ACCESSION   NM_004226
VERSION     NM_004226.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5273)
  AUTHORS   Lu,Y., Xu,J., Li,Y., Wang,R., Dai,C., Zhang,B., Zhang,X., Xu,L.,
            Tao,Y., Han,M., Guo,R., Wu,Q., Wu,L., Meng,Z., Tan,M. and Li,J.
  TITLE     DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser56 to
            diminish pancreatic beta cell function upon overnutrition
  JOURNAL   Sci Transl Med 16 (733), eade8647 (2024)
   PUBMED   38324636
  REMARK    GeneRIF: DRAK2 suppresses autophagy by phosphorylating ULK1 at
            Ser[56] to diminish pancreatic beta cell function upon
            overnutrition.
REFERENCE   2  (bases 1 to 5273)
  AUTHORS   Li,Y., Xu,J., Lu,Y., Bian,H., Yang,L., Wu,H., Zhang,X., Zhang,B.,
            Xiong,M., Chang,Y., Tang,J., Yang,F., Zhao,L., Li,J., Gao,X.,
            Xia,M., Tan,M. and Li,J.
  TITLE     DRAK2 aggravates nonalcoholic fatty liver disease progression
            through SRSF6-associated RNA alternative splicing
  JOURNAL   Cell Metab 33 (10), 2004-2020 (2021)
   PUBMED   34614409
  REMARK    GeneRIF: DRAK2 aggravates nonalcoholic fatty liver disease
            progression through SRSF6-associated RNA alternative splicing.
REFERENCE   3  (bases 1 to 5273)
  AUTHORS   Szoltysek,K., Ciardullo,C., Zhou,P., Walaszczyk,A., Willmore,E.,
            Rand,V., Marshall,S., Hall,A., J Harrison,C., Eswaran,J. and
            Soundararajan,M.
  TITLE     DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a
            Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia
  JOURNAL   Int J Mol Sci 21 (20), 7663 (2020)
   PUBMED   33081245
  REMARK    GeneRIF: DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2
            (DRAK2) Is a Key Regulator and Molecular Marker in Chronic
            Lymphocytic Leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5273)
  AUTHORS   Lan,Y., Han,J., Wang,Y., Wang,J., Yang,G., Li,K., Song,R.,
            Zheng,T., Liang,Y., Pan,S., Liu,X., Zhu,M., Liu,Y., Meng,F.,
            Mohsin,M., Cui,Y., Zhang,B., Subash,S. and Liu,L.
  TITLE     STK17B promotes carcinogenesis and metastasis via
            AKT/GSK-3beta/Snail signaling in hepatocellular carcinoma
  JOURNAL   Cell Death Dis 9 (2), 236 (2018)
   PUBMED   29445189
  REMARK    GeneRIF: STK17B promotes carcinogenesis and metastasis via
            AKT/GSK-3beta/Snail signaling in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5273)
  AUTHORS   Landa,I., Boullosa,C., Inglada-Perez,L., Sastre-Perona,A.,
            Pastor,S., Velazquez,A., Mancikova,V., Ruiz-Llorente,S.,
            Schiavi,F., Marcos,R., Malats,N., Opocher,G., Diaz-Uriarte,R.,
            Santisteban,P., Valencia,A. and Robledo,M.
  TITLE     An epistatic interaction between the PAX8 and STK17B genes in
            papillary thyroid cancer susceptibility
  JOURNAL   PLoS One 8 (9), e74765 (2013)
   PUBMED   24086368
  REMARK    GeneRIF: A significant interaction between variants in STK17B and
            PAX8, in papillary thyroid cancer susceptibility, is reported.
            Erratum:[PLoS One. 2013;8(10).
            doi:10.1371/annotation/cd94c3eb-70f2-4dfa-85be-b3fc41e495c3]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5273)
  AUTHORS   Doherty,G.A., Byrne,S.M., Austin,S.C., Scully,G.M., Sadlier,D.M.,
            Neilan,T.G., Kay,E.W., Murray,F.E. and Fitzgerald,D.J.
  TITLE     Regulation of the apoptosis-inducing kinase DRAK2 by
            cyclooxygenase-2 in colorectal cancer
  JOURNAL   Br J Cancer 101 (3), 483-491 (2009)
   PUBMED   19638987
  REMARK    GeneRIF: Regulation of the apoptosis-inducing kinase DRAK2 by
            cyclooxygenase-2 in colorectal cancer.
REFERENCE   7  (bases 1 to 5273)
  AUTHORS   Gatzka,M., Newton,R.H. and Walsh,C.M.
  TITLE     Altered thymic selection and increased autoimmunity caused by
            ectopic expression of DRAK2 during T cell development
  JOURNAL   J Immunol 183 (1), 285-297 (2009)
   PUBMED   19542440
  REMARK    GeneRIF: Strong suppression of T cell receptor signals during
            thymic selection caused by ectopic DRAK2 expression in a DRAK2
            transgenic mouse model of autoimmune encephalomyelitis alters the
            responsiveness of peripheral T cells.
REFERENCE   8  (bases 1 to 5273)
  AUTHORS   Friedrich,M.L., Cui,M., Hernandez,J.B., Weist,B.M., Andersen,H.M.,
            Zhang,X., Huang,L. and Walsh,C.M.
  TITLE     Modulation of DRAK2 autophosphorylation by antigen receptor
            signaling in primary lymphocytes
  JOURNAL   J Biol Chem 282 (7), 4573-4584 (2007)
   PUBMED   17182616
  REMARK    GeneRIF: DRAK2 kinase activity is regulated in a calcium-dependent
            manner and that Ser(12) phosphorylation is necessary for optimal
            suppression of T cell activation by this kinase
REFERENCE   9  (bases 1 to 5273)
  AUTHORS   Matsumoto,M., Miyake,Y., Nagita,M., Inoue,H., Shitakubo,D.,
            Takemoto,K., Ohtsuka,C., Murakami,H., Nakamura,N. and Kanazawa,H.
  TITLE     A serine/threonine kinase which causes apoptosis-like cell death
            interacts with a calcineurin B-like protein capable of binding
            Na(+)/H(+) exchanger
  JOURNAL   J Biochem 130 (2), 217-225 (2001)
   PUBMED   11481038
REFERENCE   10 (bases 1 to 5273)
  AUTHORS   Sanjo,H., Kawai,T. and Akira,S.
  TITLE     DRAKs, novel serine/threonine kinases related to death-associated
            protein kinase that trigger apoptosis
  JOURNAL   J Biol Chem 273 (44), 29066-29071 (1998)
   PUBMED   9786912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114760.3 and BM994696.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004226.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.107802.1,
                                           SRR1803613.211112.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263955.9/ ENSP00000263955.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC114760.3         110969-111214       c
            247-412             AC114760.3         102898-103063       c
            413-625             AC114760.3         96075-96287         c
            626-770             AC114760.3         85547-85691         c
            771-897             AC114760.3         83196-83322         c
            898-946             AC114760.3         80885-80933         c
            947-1126            AC114760.3         79256-79435         c
            1127-5023           AC114760.3         73469-77365         c
            5024-5273           BM994696.1         18-267              c
FEATURES             Location/Qualifiers
     source          1..5273
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.3"
     gene            1..5273
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /note="serine/threonine kinase 17b"
                     /db_xref="GeneID:9262"
                     /db_xref="HGNC:HGNC:11396"
                     /db_xref="MIM:604727"
     exon            1..246
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /inference="alignment:Splign:2.1.0"
     exon            247..412
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1409
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /EC_number="2.7.11.1"
                     /note="death-associated protein kinase-related 2; DAP
                     kinase-related apoptosis-inducing protein kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 17B"
                     /protein_id="NP_004217.1"
                     /db_xref="CCDS:CCDS2315.1"
                     /db_xref="GeneID:9262"
                     /db_xref="HGNC:HGNC:11396"
                     /db_xref="MIM:604727"
                     /translation="MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKF
                     AVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYEN
                     TSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLK
                     PQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDM
                     WNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVK
                     NPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTC
                     GDREDKENIPEDSSMVSKRFRFDDSLPNPHELVSDLLC"
     exon            413..625
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..770
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /inference="alignment:Splign:2.1.0"
     exon            771..897
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /inference="alignment:Splign:2.1.0"
     exon            898..946
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1126
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..5273
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3468..3473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /note="hexamer: AATAAA"
     polyA_site      3494
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /note="major polyA site"
     regulatory      5123..5128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /note="hexamer: ATTAAA"
     polyA_site      5143
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /note="major polyA site"
     regulatory      5252..5257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
                     /note="hexamer: AATAAA"
     polyA_site      5273
                     /gene="STK17B"
                     /gene_synonym="DRAK2"
ORIGIN      
        1 aaaccgcgac tgcaagcttc ggtagtcctc tccgctgctg tcgccaggag tcacttcacg
       61 agaagccagg tcacaaccgt cggcccttgt ctggaaaagt aaaagtggat cctgccacgt
      121 tcggagctcc ctggcgcctc gcccggctgg agctagagaa ctcgtcctgt ggcggccccc
      181 ggcgtggggc gggacagcgg ccccctggag ggggcagtcc cgggagaacc tgcggcggcc
      241 ggagcggtaa aaataagtga ctaaagaagc agacctggga atcacctaac atgtcgagga
      301 ggagatttga ttgccgaagt atttcaggcc tactaactac aactcctcaa attccaataa
      361 aaatggaaaa ctttaataat ttctatatac ttacatctaa agagctaggg agaggaaaat
      421 ttgctgtggt tagacaatgt atatcaaaat ctactggcca agaatatgct gcaaaatttc
      481 taaaaaagag aagaagagga caggattgtc gagcagaaat tttacacgag attgctgtgc
      541 ttgaattggc aaagtcttgt ccccgtgtta ttaatcttca tgaggtctat gaaaatacaa
      601 gtgaaatcat tttgatattg gaatatgctg caggtggaga aattttcagc ctgtgtttac
      661 ctgagttggc tgaaatggtt tctgaaaatg atgttatcag actcattaaa caaatacttg
      721 aaggagttta ttatctacat cagaataaca ttgtacacct tgatttaaag ccacagaata
      781 tattactgag cagcatatac cctctcgggg acattaaaat agtagatttt ggaatgtctc
      841 gaaaaatagg gcatgcgtgt gaacttcggg aaatcatggg aacaccagaa tatttagctc
      901 cagaaatcct gaactatgat cccattacca cagcaacaga tatgtggaat attggtataa
      961 tagcatatat gttgttaact cacacatcac catttgtggg agaagataat caagaaacat
     1021 acctcaatat ttctcaagtt aatgtagatt attcggaaga aactttttca tcagtttcac
     1081 agctggccac agactttatt cagagccttt tagtaaaaaa tccagagaaa agaccaacag
     1141 cagagatatg cctttctcat tcttggctac agcagtggga ctttgaaaac ttgtttcacc
     1201 ctgaagaaac ttccagttcc tctcaaactc aggatcattc tgtaaggtcc tctgaagaca
     1261 agacttctaa atcctcctgt aatggaacct gtggtgatag agaagacaaa gagaatatcc
     1321 cagaggatag cagcatggtt tccaaaagat ttcgtttcga tgactcatta cccaatcccc
     1381 atgaacttgt ttcagatttg ctctgttagc acttttttct ttgactcatt tggactgaat
     1441 ttgaaatttt atatccactc cagtgagatt atgatttgta gcttcatata tgacatgttt
     1501 atattgtaaa tgcacttttc catggaataa tttagggaag tgttttaatg ttaaattact
     1561 agttgctagc atgttatgat ttcatatcct gagatagctc tgcagataag aaaatattta
     1621 aatatatgac aaaaagtaaa attgtacatg tgagtttaca tgttaatgaa ataattcaac
     1681 ttcaaatgaa cttaccagaa tgttttgcat atcaacaaaa aaagtggctt gagttttatt
     1741 atagttggtg taaactgaac acagtgaaga cattggaatt taataggttc tctctctaag
     1801 gtgactctta taccatgcct ctatcaacat aatttgttta ggaaagcagt atgaagttta
     1861 agccaaaata atttctactt tatagatgct caagagacat tttacaattg aaaatgtctt
     1921 tcaattacaa atattttgaa acttcgtaag attttcattc tctgtggtct gttatatgag
     1981 agagatcctt taactagagc aaagagggag ttagaaacct gatcagggat attctttaca
     2041 agttggagca gaggaaagag tagcatgcct tcgtatttta acgcaaatgt ctttttcctc
     2101 ctcccaacct acttgagatc tgataaggtc tggaagatgg agatatttgg tatgcaagtg
     2161 tagagttttt taatcctcca gaatttctag agtagaagat acttaggtat agttaaatat
     2221 tctgtatttt tagtcaaaca tatttattaa ttgaatatag aagaaaatgt tgacacactc
     2281 agacagctta ctgaatttta gatgtcttct gcatcttaga atacaagcca gtcattcaga
     2341 gttctaaaag tatgcataaa aaattacagc accggtaggt ctattaacac agtgcccgag
     2401 tcagcggtag caagactgat gtgatcataa aacatgacat caggctcgtc tgaagttctt
     2461 gtgtgaaatt cctagtgagt gaggaggctc agcttaaagc catctgcaga gtggcccctc
     2521 attgtggtct tttgctggga ccaatgcaag agactaggga gagcaaaatg tttgcttatg
     2581 gctagagact atatccagcc ctaatgatgg ggaaagttag tccttttcgg gtaatctttt
     2641 atgaattttc acctgatgac cgttatattg gtctgttatc atgttacgat aactgtgatc
     2701 tcatgaccat gttgctgtat cagaagaaat agtttgacaa atggtaacaa caacctgatg
     2761 ttcccccttt agacctttaa cttctcaaaa ttttggtaag tttccaaatt ctttaataat
     2821 aacttaaaac tttttgaata actatcaggt cactttattt gaccacatgg tgaattcctt
     2881 taatgtcttc agcatttgtt aaggaaaagt tttctctact tgtgtgtgta tgtgtgcaca
     2941 tgtgtgtatg tacaggtgta tgtatatatc tatagataga tacaatacat tctttagaca
     3001 cttttcaaga ttctttgctg tggtatattg tgctcaactc aggtgccaaa ggagcttttt
     3061 tttttttttt ttttttttga gatggagttt tgctctgtct ctcaggctgg agtgcagtgg
     3121 catgatctca gctcacggca acctctgcct cccgggttca agcaattctc ctgtctcagc
     3181 ctcctgagta gttgggatta caggcgcatg ccaccgtgcc cagctaattt ttgtattttt
     3241 agtagagacg gggtttcacc atgttggcca ggctggtcac aaactcctga cttcaagtga
     3301 tccacccgcc tcggcctccc aaagtgctgg gattacaggc gtgagccact gcgcccccgc
     3361 ccaggagctc ttttcttatg acatataaat tatgacattt atattcttta tatgacttta
     3421 tgttctcttc ttatgacatt taaattcttt aagtagtttg ttggtccaat aaactagacg
     3481 ttgtataatc taaattgagc ccttgtatat ctaaaactga tgagttgttt ctaaattgtt
     3541 gattgtccat ttacttgcct ttggtattaa gataatgcaa gtaaagttta gtaagtcatt
     3601 ggataatgaa atgattatgt ttctgaagac catattatat ttttaatttt tagaggaatc
     3661 atgccatccc ccaaaaaatc aagaaatatt tgaattttaa attataagtt catttgttaa
     3721 aagacatttt tacaaatgtc tgaaaatctt aaaatacttt acatctacct ttaagtagta
     3781 gaatacagag ctgtaaattt ccatgccttt tttcctgata ttaagtttta tagtaaaaaa
     3841 gcaactagtg attgcacaaa gaatataaaa atccactctt tttacaaagg tgtgaattta
     3901 aataacgtta ttgattggaa tatgaaaata gaccaatcat ttaagagctt tttagcaaat
     3961 gattcaattc ttactctttt tctcccaaga ttgaaaagca taatgtattt ctctaaagta
     4021 ggaatctaga gagcccctgt gagtggacaa atgtcagtaa cacttgaaca catgagaaga
     4081 taagtgttat gttgtgataa tttaaagtta aatttgcttt ttgggtagga tccctaaata
     4141 gatgggattt ttaaatagat gatatataga tgacaattgc aattgtcatt ttaattattt
     4201 tccctacagt aaagaaccta gctctgagca gtgaaattgt aatggcactt taaaggaagt
     4261 aagccgttaa ctgttctcta gtggagcgat ctccaactgt tttggcacta gggacgggtt
     4321 ttgtggaaga aaatttttcc acaggactgg gggtttaggg ggatggtttc aggatgattc
     4381 aagtacatta catttatcat tagattctca taaggagcat gcaacctaga tctcttgcac
     4441 gtgtggttca cagcaggatt cgagctcctt tgagaatcta atgccatggc tgatctaaca
     4501 ggaaactgag ctcaggcagt aatgcttggc accgcccccc accttctatg cagcccggtc
     4561 gtggcctggg gactggggac ccctgctcta gtcagtaata aggtacttgt gccagaatat
     4621 aaatcaacac attgcttcct ttatcaaaga agtcttgtta tttaaaaaaa gtcaactgag
     4681 ccagtatgat tagtgatgta attgattttc attctggcac aagcctcttt cattctggac
     4741 agctcacaaa tagttaatgg accatgcttt gaatagcctt cctctaagca acatttataa
     4801 atactgatat tttagaactg tttacatttc ttctgtttat ttttgaattt tcagtttgat
     4861 atcttgtcct tattcattgt tgtataaaca actgtacttt aatttcaagt agtattaaaa
     4921 gtatttcact tcagtttggg gggattatta tcaatttata attttataaa agtattttaa
     4981 agaataattg taaattttcc ataaattaca acttcctgcc atattttatt aaataataat
     5041 cttgcttaag gcatatagac agacattatt atgagtattc cagtaaaaaa aatctacatc
     5101 aacttgacca ttctggctaa aaattaaaaa gcactttttt atatctgtgg ttgtcatttg
     5161 tttcaaagca tttctaaatt tattgttctt aaaagtatgt ctgcatgttc tagcctttga
     5221 cctaggtcat ctatgaaccc tctttgtgtc taataaacat atctgtaaag gca
//
