LOCUS       NM_004760               3918 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens serine/threonine kinase 17a (STK17A), mRNA.
ACCESSION   NM_004760
VERSION     NM_004760.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3918)
  AUTHORS   Pang,K., Lee,J., Kim,J., Park,J., Park,Y., Hong,E., An,H.,
            Ooshima,A., Son,M., Park,K.S., Cho,J.H., Lee,C., Song,Y.S.,
            Yang,K.M. and Kim,S.J.
  TITLE     Degradation of DRAK1 by CUL3/SPOP E3 Ubiquitin ligase promotes
            tumor growth of paclitaxel-resistant cervical cancer cells
  JOURNAL   Cell Death Dis 13 (2), 169 (2022)
   PUBMED   35194034
  REMARK    GeneRIF: Degradation of DRAK1 by CUL3/SPOP E3 Ubiquitin ligase
            promotes tumor growth of paclitaxel-resistant cervical cancer
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3918)
  AUTHORS   Wang,Z., Wang,C., Jiang,B.H., Shi,L., Lin,S., Wang,L., Liu,L.Z.,
            Qiu,J.G., Qin,Y. and Jia,Y.
  TITLE     Predictive significance of STK17A in patients with gastric cancer
            and association with gastric cancer cell proliferation and
            migration
  JOURNAL   Oncol Rep 45 (6) (2021)
   PUBMED   33955523
  REMARK    GeneRIF: Predictive significance of STK17A in patients with gastric
            cancer and association with gastric cancer cell proliferation and
            migration.
REFERENCE   3  (bases 1 to 3918)
  AUTHORS   Cho,J., Park,K., Choi,S.M., Lee,J., Lee,C.H., Lee,J.K., Heo,E.Y.,
            Kim,D.K., Lee,Y.J., Park,J.S., Cho,Y.J., Yoon,H.I., Lee,J.H.,
            Lee,C.T., Kim,N., Choi,K.Y., Lee,K.H., Sung,J., Won,S. and Yim,J.J.
  TITLE     Genome-wide association study of non-tuberculous mycobacterial
            pulmonary disease
  JOURNAL   Thorax 76 (2), 169-177 (2021)
   PUBMED   33115937
  REMARK    GeneRIF: Genome-wide association study of non-tuberculous
            mycobacterial pulmonary disease.
REFERENCE   4  (bases 1 to 3918)
  AUTHORS   Park,Y., Pang,K., Park,J., Hong,E., Lee,J., Ooshima,A., Kim,H.S.,
            Cho,J.H., Han,Y., Lee,C., Song,Y.S., Park,K.S., Yang,K.M. and
            Kim,S.J.
  TITLE     Destablilization of TRAF6 by DRAK1 Suppresses Tumor Growth and
            Metastasis in Cervical Cancer Cells
  JOURNAL   Cancer Res 80 (12), 2537-2549 (2020)
   PUBMED   32265222
  REMARK    GeneRIF: Destablilization of TRAF6 by DRAK1 Suppresses Tumor Growth
            and Metastasis in Cervical Cancer Cells.
REFERENCE   5  (bases 1 to 3918)
  AUTHORS   Wei,W. and Liu,C.
  TITLE     Prognostic and predictive roles of microRNA-411 and its target
            STK17A in evaluating radiotherapy efficacy and their effects on
            cell migration and invasion via the p53 signaling pathway in
            cervical cancer
  JOURNAL   Mol Med Rep 21 (1), 267-281 (2020)
   PUBMED   31746360
  REMARK    GeneRIF: Prognostic and predictive roles of microRNA411 and its
            target STK17A in evaluating radiotherapy efficacy and their effects
            on cell migration and invasion via the p53 signaling pathway in
            cervical cancer.
REFERENCE   6  (bases 1 to 3918)
  AUTHORS   Mao,P., Hever,M.P., Niemaszyk,L.M., Haghkerdar,J.M., Yanco,E.G.,
            Desai,D., Beyrouthy,M.J., Kerley-Hamilton,J.S., Freemantle,S.J. and
            Spinella,M.J.
  TITLE     Serine/threonine kinase 17A is a novel p53 target gene and
            modulator of cisplatin toxicity and reactive oxygen species in
            testicular cancer cells
  JOURNAL   J Biol Chem 286 (22), 19381-19391 (2011)
   PUBMED   21489989
  REMARK    GeneRIF: identified STK17A as a novel direct target of p53 and a
            modulator of cisplatin toxicity and reactive oxygen species in
            testicular cancer cells.
REFERENCE   7  (bases 1 to 3918)
  AUTHORS   Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
            Honda,M. and Tokunaga,K.
  TITLE     An approach based on a genome-wide association study reveals
            candidate loci for narcolepsy
  JOURNAL   Hum Genet 128 (4), 433-441 (2010)
   PUBMED   20677014
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3918)
  AUTHORS   Landa,I., Ruiz-Llorente,S., Montero-Conde,C., Inglada-Perez,L.,
            Schiavi,F., Leskela,S., Pita,G., Milne,R., Maravall,J., Ramos,I.,
            Andia,V., Rodriguez-Poyo,P., Jara-Albarran,A., Meoro,A., del
            Peso,C., Arribas,L., Iglesias,P., Caballero,J., Serrano,J.,
            Pico,A., Pomares,F., Gimenez,G., Lopez-Mondejar,P., Castello,R.,
            Merante-Boschin,I., Pelizzo,M.R., Mauricio,D., Opocher,G.,
            Rodriguez-Antona,C., Gonzalez-Neira,A., Matias-Guiu,X.,
            Santisteban,P. and Robledo,M.
  TITLE     The variant rs1867277 in FOXE1 gene confers thyroid cancer
            susceptibility through the recruitment of USF1/USF2 transcription
            factors
  JOURNAL   PLoS Genet 5 (9), e1000637 (2009)
   PUBMED   19730683
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3918)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 3918)
  AUTHORS   Sanjo,H., Kawai,T. and Akira,S.
  TITLE     DRAKs, novel serine/threonine kinases related to death-associated
            protein kinase that trigger apoptosis
  JOURNAL   J Biol Chem 273 (44), 29066-29071 (1998)
   PUBMED   9786912
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI461892.1, AB011420.1,
            AC005189.2 and AW183478.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004760.2.
            
            Summary: This gene is a member of the DAP kinase-related
            apoptosis-inducing protein kinase family and encodes an
            autophosphorylated nuclear protein with a protein kinase domain.
            The protein has apoptosis-inducing activity. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.25120.1,
                                           SRR1803616.95452.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319357.6/ ENSP00000319192.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BI461892.1         49-67
            20-1219             AB011420.1         1-1200
            1220-3879           AC005189.2         170236-172895       c
            3880-3918           AW183478.1         17-55               c
FEATURES             Location/Qualifiers
     source          1..3918
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..3918
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /note="serine/threonine kinase 17a"
                     /db_xref="GeneID:9263"
                     /db_xref="HGNC:HGNC:11395"
                     /db_xref="MIM:604726"
     exon            1..342
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1381
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /EC_number="2.7.11.1"
                     /note="death-associated protein kinase-related 1;
                     serine/threonine kinase 17a (apoptosis-inducing); DAP
                     kinase-related apoptosis-inducing protein kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 17A"
                     /protein_id="NP_004751.2"
                     /db_xref="CCDS:CCDS5470.1"
                     /db_xref="GeneID:9263"
                     /db_xref="HGNC:HGNC:11395"
                     /db_xref="MIM:604726"
                     /translation="MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLT
                     EIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCR
                     MEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKE
                     KDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSE
                     ELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNIS
                     QMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRME
                     KALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQK
                     AISKRFKFEEPLLQEIPGEFIY"
     exon            343..555
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..700
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..827
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..876
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1056
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..3918
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1704..1709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /note="hexamer: AGTAAA"
     polyA_site      1724
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /note="major polyA site"
     regulatory      2566..2571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /note="hexamer: ATTAAA"
     polyA_site      2587
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
     regulatory      3306..3311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /note="hexamer: AATAAA"
     polyA_site      3325
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
     regulatory      3610..3615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /note="hexamer: TATAAA"
     polyA_site      3628
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
     regulatory      3713..3718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /note="hexamer: TATAAA"
     polyA_site      3748
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
     regulatory      3898..3903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
                     /note="hexamer: ATTAAA"
     polyA_site      3918
                     /gene="STK17A"
                     /gene_synonym="DRAK1"
ORIGIN      
        1 gcagtccgag cgccgcgctg gggagagcgg gtgtttgaag gctccgcgga ccggcactag
       61 gagccggggg cgggtccgtg accctccggc tgctcggagt gaacaggcgg ccaggaaaga
      121 agcgggcctg aacaccatga tccctttgga gaagccaggc agcggcggct cctccccagg
      181 cgccacctca ggctcgggcc gggcaggccg gggtctgagc gggccgtgcc ggccgccgcc
      241 gccgccccag gcccgcgggc tgctgacaga gatacgcgcc gtggtgcgca ccgagccctt
      301 ccaggacggc tacagcctgt gcccgggccg ggagctgggc agggggaaat ttgcagtggt
      361 gagaaaatgt ataaagaaag attctgggaa agaatttgct gcaaagttca tgagaaaaag
      421 aagaaaaggc caagattgtc ggatggaaat aattcatgag attgctgtac ttgaactagc
      481 acaagacaat ccttgggtca ttaatttaca tgaagtttat gagactgcat cagaaatgat
      541 cttagttctg gaatatgctg ctgggggtga aatctttgac cagtgtgttg cagacagaga
      601 agaagccttt aaagaaaaag atgttcaaag acttatgcga cagattttag aaggtgttca
      661 ctttttacac actcgtgatg tagttcatct tgatttgaag cctcagaata ttctgttgac
      721 aagtgaatct ccattgggtg acattaagat tgttgatttt ggcctttcaa gaatattgaa
      781 gaacagtgaa gagctccgag aaattatggg tacccctgaa tatgtggctc ctgaaattct
      841 tagttatgat cctataagca tggcaacaga tatgtggagc attggagtgt taacatatgt
      901 catgcttaca ggaatatcac ctttcttagg caatgataaa caagaaacat tcttaaacat
      961 ctcacagatg aatttaagtt attctgagga agaatttgat gttttgtctg agtcggctgt
     1021 tgatttcatc aggacacttt tagttaagaa acctgaagat cgagccactg ctgaagaatg
     1081 tctaaagcac ccctggttga cacagagcag tattcaagag ccttctttca ggatggaaaa
     1141 ggcactagaa gaagcaaatg ccctccaaga aggtcattct gtgcctgaaa ttaattcgga
     1201 taccgacaaa tcagaaacca aggaatccat tgtaaccgaa gagttaattg tagttacttc
     1261 atatactcta ggacaatgca gacagtctga aaaagagaaa atggagcaaa aggccatttc
     1321 caaacgattt aaatttgagg aacctttgct acaagaaatt ccaggagaat ttatctactg
     1381 agcaatattt ccctttagaa cttcaagatt tctacattga aaatgttaat attatttatg
     1441 gacctctggc caaatggtac atgtactgga agtggataac cagtatcact tacacaaaca
     1501 aaaataactt tgtcaaattt gtggagttag gtggaagcca gattttaaaa gttgccaacc
     1561 aggagattta acaggtacag ttacccgttt caatgttatt tttaagaagg gagatgttgg
     1621 cacctttgaa ttctacatcc tgtttctcca gaatgagaat ttgtgtacaa agatatttgt
     1681 attcactttc tttaaaaaat ccaagtaaaa gtgccaaaac tacacttctg taaatctctt
     1741 gcattattca tatgtgtatc tatatctgca taatgtttgt taatgtctac taaaattgct
     1801 actttttcac tttggatttg tttttggcaa aattttagtc taaacagaca tctaaatttt
     1861 cgagacttag aataacattc actaaagttt gataatgtct tttttaaata ttttcttact
     1921 gctttatagt gacttgattt ggtttctgtt gtgtttttgc ctaaatacta gtaacatatc
     1981 agtgaaaaac cctaattttt tttctcttca atgtcactag taagagaggt ggtaattttt
     2041 cacctctgaa attattctgg gtttaggtgt cagctcttga gctgcttccc tcatcacacc
     2101 acactcacat gcatctgttc tctctcacac tctatacccc tgccacttcc tggcacctcc
     2161 ccccatgctt gtcatttaat tttggccact tgtaggtatc agtgtgatct gatcaacact
     2221 ctggttacct tggtcagtga aaagatgcta ctatattgct tttgtcccaa agtgagtaaa
     2281 atcccctaga gcagagagag agagagagag agagagtgtc ttcatgccaa ccacagcctg
     2341 tttctgctga gtttcttatc agccctcaag ctatgctagg aaaagttata aaatgccaaa
     2401 atatttataa acatttactt tgtccataaa aaatttacat tggatactct gtaagtagga
     2461 ggtactttgt cccaaaaaga tgtataagaa tgtactaata gttttatttg attaggattg
     2521 aacagttcag ttgtatctat gccccacagt gaccagtaaa gtccaattaa aatatggaaa
     2581 tgtaaaagtg tatgccgaat accttaaagt aactaattat ccttacacac aaaaggctca
     2641 gtgcattaaa tatttgccta tcacctgtgt gctgtgtacc gtggccatgc ctcgctctgc
     2701 actatgaaca actcagacct gtcccttcac ggtctgatta gggtgtcaca caaagctctc
     2761 tccctaacat ggtttctcaa ctgtcaaaat catgaaaatg acagcaccta accactattt
     2821 taaagtatgt acagtaaata cccaaatgtg tgtaaatgtc atagacatat acaaagtcag
     2881 taatctcacc cagtcctgct gtgtgaacct gtcaaagcac ctgggagtgc cctttacacc
     2941 attaggtgaa attcatcagg cacttcagac aaccaggttg cactgttttc tcactaaatt
     3001 ggctttattt atacagtttc ctggaaccta gcattcctaa acaagctcca aaatgcagaa
     3061 gaagaaattg tgccacagtg atagagtttt taatgaatat ccatggccac agttttgagt
     3121 ctcaggtaag tcttggaaga agttaaacac agtattaggc aaatatttat ctctctgaaa
     3181 aaatagggag gaggtgacca ggaaaaaata accactattg aatgacacgt ttgtacttga
     3241 tggatctgtc atcaagtttt aaaatcagaa tcatttgggc tttttaaaaa ccattttata
     3301 ctcgtaataa atatatttaa tataattgct gtatttgtga gaaagatctg ttttctttta
     3361 gctggccact tcagtttgct gcgtatcttt agctgctgtt gtgcttaaat actgagtcat
     3421 agggtgcttt tttaagaggc ccttcagaat atacttgtaa aggtgtattg gcattttttg
     3481 gtttataaga taaaaacagg gcatgaagag ccttcatagt attaggccaa ataaaatcta
     3541 ttaataactg ccagctagct ctacacttat ctaaagctgt taatgttcct ttttttctat
     3601 caccaaattt ataaaggact aaacagtact attgagttta ctcggtttat aaatccagtt
     3661 ttaactataa ttcaacaata ttttggtgtg gtgaaacgtt gtttatgaaa tgtataaaat
     3721 gtataagttt taatcaactg ggaaatgata tttgattgat cttgtgtttt gttgttttca
     3781 aatgaaaact aggaggtaat taataccttt ctctagtagt ggtatagagg aaggacagat
     3841 gctcattgtt gaatctctta aatttttcca gctaacctca gtttggaaga aaaatgtatt
     3901 aaagggttat aaagatca
//
