LOCUS       NM_001330213            3118 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens serine/threonine kinase 16 (STK16), transcript variant
            2, mRNA.
ACCESSION   NM_001330213 NR_026909
VERSION     NM_001330213.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3118)
  AUTHORS   Zhu,Z., Xiang,Q., Li,S., Chen,C. and Shi,J.
  TITLE     Serine/Threonine kinase 16 phosphorylates STAT3 and confers a
            JAK2-Inhibition resistance phenotype in triple-negative breast
            cancer
  JOURNAL   Biochem Pharmacol 225, 116268 (2024)
   PUBMED   38723720
  REMARK    GeneRIF: Serine/Threonine kinase 16 phosphorylates STAT3 and
            confers a JAK2-Inhibition resistance phenotype in triple-negative
            breast cancer.
REFERENCE   2  (bases 1 to 3118)
  AUTHORS   Peng,L., Guangshi,L., Wusman,L.B. and Tao,L.
  TITLE     STK16 promoted colorectal cancer progress in a c-MYC
            signaling-dependent manner
  JOURNAL   Mol Med 30 (1), 50 (2024)
   PUBMED   38622518
  REMARK    GeneRIF: STK16 promoted colorectal cancer progress in a c-MYC
            signaling-dependent manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3118)
  AUTHORS   Wang,X., Huang,R., Lu,Z., Wang,Z., Chen,X. and Huang,D.
  TITLE     Exosomes from M1-polarized macrophages promote apoptosis in lung
            adenocarcinoma via the miR-181a-5p/ETS1/STK16 axis
  JOURNAL   Cancer Sci 113 (3), 986-1001 (2022)
   PUBMED   35092121
  REMARK    GeneRIF: Exosomes from M1-polarized macrophages promote apoptosis
            in lung adenocarcinoma via the miR-181a-5p/ETS1/STK16 axis.
REFERENCE   4  (bases 1 to 3118)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3118)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3118)
  AUTHORS   Guinea,B., Ligos,J.M., Lain de Lera,T., Martin-Caballero,J.,
            Flores,J., Gonzalez de la Pena,M., Garcia-Castro,J. and Bernad,A.
  TITLE     Nucleocytoplasmic shuttling of STK16 (PKL12), a Golgi-resident
            serine/threonine kinase involved in VEGF expression regulation
  JOURNAL   Exp Cell Res 312 (2), 135-144 (2006)
   PUBMED   16310770
  REMARK    GeneRIF: The Endogenous STK16 subcellular localization was
            evaluated by indirect immunofluorescence in NRK cells,
            demonstrating a Golgi-associated pattern that appears to be
            independent of signals provided by integrin pathways.
REFERENCE   7  (bases 1 to 3118)
  AUTHORS   Ligos,J.M., de Lera,T.L., Hinderlich,S., Guinea,B., Sanchez,L.,
            Roca,R., Valencia,A. and Bernad,A.
  TITLE     Functional interaction between the Ser/Thr kinase PKL12 and
            N-acetylglucosamine kinase, a prominent enzyme implicated in the
            salvage pathway for GlcNAc recycling
  JOURNAL   J Biol Chem 277 (8), 6333-6343 (2002)
   PUBMED   11741987
REFERENCE   8  (bases 1 to 3118)
  AUTHORS   Ohta,S., Takeuchi,M., Deguchi,M., Tsuji,T., Gahara,Y. and Nagata,K.
  TITLE     A novel transcriptional factor with Ser/Thr kinase activity
            involved in the transforming growth factor (TGF)-beta signalling
            pathway
  JOURNAL   Biochem J 350 Pt 2 (Pt 2), 395-404 (2000)
   PUBMED   10947953
REFERENCE   9  (bases 1 to 3118)
  AUTHORS   Berson,A.E., Young,C., Morrison,S.L., Fujii,G.H., Sheung,J., Wu,B.,
            Bolen,J.B. and Burkhardt,A.L.
  TITLE     Identification and characterization of a myristylated and
            palmitylated serine/threonine protein kinase
  JOURNAL   Biochem Biophys Res Commun 259 (3), 533-538 (1999)
   PUBMED   10364453
REFERENCE   10 (bases 1 to 3118)
  AUTHORS   Ligos,J.M., Gerwin,N., Fernandez,P., Gutierrez-Ramos,J.C. and
            Bernad,A.
  TITLE     Cloning, expression analysis, and functional characterization of
            PKL12, a member of a new subfamily of ser/thr kinases
  JOURNAL   Biochem Biophys Res Commun 249 (2), 380-384 (1998)
   PUBMED   9712705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068946.4.
            
            On Nov 22, 2018 this sequence version replaced NM_001330213.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.878412.1,
                                           SRR1163657.189383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396738.7/ ENSP00000379964.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AC068946.4         139837-140154
            319-508             AC068946.4         140254-140443
            509-728             AC068946.4         141015-141234
            729-862             AC068946.4         141471-141604
            863-983             AC068946.4         141773-141893
            984-1079            AC068946.4         142020-142115
            1080-1201           AC068946.4         142551-142672
            1202-3118           AC068946.4         142779-144695
FEATURES             Location/Qualifiers
     source          1..3118
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..3118
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /note="serine/threonine kinase 16"
                     /db_xref="GeneID:8576"
                     /db_xref="HGNC:HGNC:11394"
                     /db_xref="MIM:604719"
     exon            1..318
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..508
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..1340
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 2;
                     protein kinase expressed in day 12 fetal liver;
                     serine/threonine-protein kinase 16; protein kinase PKL12;
                     TGF-beta-stimulated factor 1; myristoylated and
                     palmitoylated serine/threonine-protein kinase;
                     tyrosine-protein kinase STK16"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 16 isoform 1"
                     /protein_id="NP_001317142.1"
                     /db_xref="CCDS:CCDS42822.1"
                     /db_xref="GeneID:8576"
                     /db_xref="HGNC:HGNC:11394"
                     /db_xref="MIM:604719"
                     /translation="MGHALCVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGH
                     FYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFK
                     RGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEG
                     QPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDV
                     WSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVD
                     PHQRPHIPLLLSQLEALQPPAPGQHTTQI"
     exon            509..728
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..862
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..983
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1079
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1201
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..3118
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1662..1667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /note="hexamer: AATAAA"
     polyA_site      1686
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /note="major polyA site"
     regulatory      3099..3104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
                     /note="hexamer: AATAAA"
     polyA_site      3118
                     /gene="STK16"
                     /gene_synonym="hPSK; KRCT; MPSK; PKL12; PSK; TSF1"
ORIGIN      
        1 agcactgctt ccggtcggtg gcgcttctct ctggcccgag ccaggtcagt ccggcagtgc
       61 agatggccca tcccgggctc tgggctccta gaccggggtg ggccctgcca ggagtgggcc
      121 tgagcctcgc acgtcctctg aaactacgct atgctctgct tttgcggcgc gatgggcgtg
      181 ggagcggggg ctgcccaaag atgggctggg gttggaggaa gtggcccggt agccgctgtg
      241 tgtcctgagg ccgtaaggcg cctgacccca cccctgaagc tggcgacgga gcagggcctg
      301 ttttctctac actatagtca tgatccgctg ggcccccagc gcatctcctg gaagagccca
      361 ctcaccctgg acgagctctt cggtagcctc agaccgtcct tgaagaggat gactgagaca
      421 ttatgggcca cgcgctgtgt gtctgctctc ggggaactgt catcattgac aataagcgct
      481 acctcttcat ccagaaactg ggggagggtg ggttcagcta tgtggaccta gtggaagggt
      541 tacatgatgg acacttctac gccctgaagc gaatcctgtg tcacgagcag caggaccggg
      601 aggaggccca gcgagaagcc gacatgcatc gcctcttcaa tcaccccaac atccttcgcc
      661 tcgtggctta ctgtctgagg gaacggggtg ctaagcatga ggcctggctg ctgctaccat
      721 tcttcaagag aggtacgctg tggaatgaga tagaaaggct gaaggacaaa ggcaacttcc
      781 tgaccgagga tcaaatcctt tggctgctgc tggggatctg cagaggcctt gaggccattc
      841 atgccaaggg ttatgcccac agagacttga agcccaccaa tatattgctt ggagatgagg
      901 ggcagccagt tttaatggac ttgggttcca tgaatcaagc atgcatccat gtggagggct
      961 cccgccaggc tctgaccctg caggactggg cagcccagcg gtgcaccatc tcctaccgag
     1021 ccccagagct cttctctgtg cagagtcact gtgtcatcga tgagcggact gatgtctggt
     1081 ccctaggctg cgtgctatat gccatgatgt ttggggaagg cccttatgac atggtgttcc
     1141 aaaagggtga cagtgtggcc cttgctgtgc agaaccaact cagcatccca caaagcccca
     1201 ggcattcttc agcattgcgg cagctcctga actcgatgat gaccgtggac ccgcatcagc
     1261 gtcctcacat tcctctcctc ctcagtcagc tggaggcgct tcagccccca gctcctggcc
     1321 aacatactac ccaaatctga aaaagcagca tgttgagaag atggcccctt gtgccttgga
     1381 aagaggttcc catccctcat tggaatcacc acccattcca tccaggactt ctcttacact
     1441 tgggggtagc ggggtcagga caatcatctc agtcctgcat cttttcttct gctttcttcc
     1501 ctccaagagc aaaacctggg caaggggact tactgagtgg gggtgggtgg gggttgggaa
     1561 aagggaaact ggtgggatat ggaacatggc tctgagcagg actgttgagc tcacatagtg
     1621 ttctgactcc aaatctggga gcaggagaat gtgtaaacaa gaataaagtg gaagcaggtt
     1681 ggtgtagatc ttagtctcag tgttcctgga gtgagagaag aggtgcaagg ggcccaaagt
     1741 caggttgcca tttcaggcga actgcctggg aaggaggaat ggtgcagagt cggcaatggt
     1801 gtgacttcat tctacaggag gttggttagc agtggacagt tctagcttgt cttagatcaa
     1861 aacttaaagc tgcttgggct caagctggca tctgcctgtg tcaagaacta gggcccccta
     1921 aaaacactca actagttctt tccttccttc actcctgggg tgagtagctt agtcaaagct
     1981 gcctagccgg tttgctaggc aagggcctct gggtggagac acctgaggaa gctttgagac
     2041 aggtagatta caggtctccc atcctcagcc taggggcgag gggagtggag gtggcagcgg
     2101 cagctgtttt ggcctgtgtc tccctgatcg ttcaagctca tacatggtta atgattaatg
     2161 aggcagtgtg gtgtggcagt atccagctgc cacttcctgc ctactctgct gagtaaacag
     2221 gggccctgtc ttagctgggc ttcaaacctg ttccctaggg aagggctctg ttccctgaat
     2281 caccagggag gaaaggcaag ggcagggttg gcatctcctg ctcttttgtg atccaagcct
     2341 cctcccccga accatgtcta ccccacagta tgacatcagc atggggcctg gggctcctgt
     2401 tagcaaagtt gaagctttcc ccagggccct agcaggagtc tcccactagc tagcacagag
     2461 gctgaggcca gaaagaaatc acaaacagag gggagatgac ctgactttta atggcacagc
     2521 cccagctcca gcaaagcagc aagacaggaa gctatgcaaa gctgctcaga ggtgcagtgg
     2581 cacaaacaac tctaggagat cgcctgtgtt ccctcccatc ccccaagctt atgacgtggc
     2641 tccatgccca ggaactctgg gccagcccag ccccactccc aaaccctcat aatgcacaga
     2701 ggagcctggg ccaagccttg cttccagagt tggtaaatgt agaggcagca ggaagaacag
     2761 ggtagcagtc taactttcaa agacagaaac cactggatta tactcctact tggaaaggag
     2821 ctgaagactc atccttcaac agtttgtgcc tggattttgg tcctcatttc ctccctatac
     2881 tgagtaaccc taggacttca atttaaagtc cctggggtta tgcttcctgg gcctggcaag
     2941 aacccctttg caggtctcac cttcagcgat ggaagggata agggtcatga acagcaaaca
     3001 gagcagcagc agcatgaagg ggaaggcagc agaagctcaa gcactcagag ggaacaagaa
     3061 accgtgcaag gaaactgttt atttcgaaag gattttgcaa taaacatagt gaataggc
//
