LOCUS       NM_052902               3618 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens serine/threonine kinase 11 interacting protein
            (STK11IP), mRNA.
ACCESSION   NM_052902 XM_005246262 XM_006712227 XM_011510525
VERSION     NM_052902.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3618)
  AUTHORS   Tian,M., Jiang,X., Li,X., Yang,J., Zhang,C. and Zhang,W.
  TITLE     LKB1IP promotes pathological cardiac hypertrophy by targeting
            PTEN/Akt signalling pathway
  JOURNAL   J Cell Mol Med 25 (5), 2517-2529 (2021)
   PUBMED   33486894
  REMARK    GeneRIF: LKB1IP promotes pathological cardiac hypertrophy by
            targeting PTEN/Akt signalling pathway.
            Erratum:[J Cell Mol Med. 2022 Mar;26(5):1722-1723. doi:
            10.1111/jcmm.17194.. PMID: 35253382]
REFERENCE   2  (bases 1 to 3618)
  AUTHORS   Moren,A., Raja,E., Heldin,C.H. and Moustakas,A.
  TITLE     Negative regulation of TGFbeta signaling by the kinase LKB1 and the
            scaffolding protein LIP1
  JOURNAL   J Biol Chem 286 (1), 341-353 (2011)
   PUBMED   20974850
  REMARK    GeneRIF: LKB1 and LIP1 provide negative control of TGFbeta
            signaling.
REFERENCE   3  (bases 1 to 3618)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   4  (bases 1 to 3618)
  AUTHORS   Conde,E., Suarez-Gauthier,A., Garcia-Garcia,E., Lopez-Rios,F.,
            Lopez-Encuentra,A., Garcia-Lujan,R., Morente,M., Sanchez-Verde,L.
            and Sanchez-Cespedes,M.
  TITLE     Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein
            immunostaining in human normal tissues and lung carcinomas
  JOURNAL   Hum Pathol 38 (9), 1351-1360 (2007)
   PUBMED   17521700
  REMARK    GeneRIF: observations provide complete information about the
            pattern and levels of LKB1 & p-acetyl-CoA carboxylase
            immunostaining in normal tissues and in lung tumors, and highlight
            the special relevance of abnormalities of the LKB1 pathway in lung
            adenocarcinoma
REFERENCE   5  (bases 1 to 3618)
  AUTHORS   Smith,D.P., Rayter,S.I., Niederlander,C., Spicer,J., Jones,C.M. and
            Ashworth,A.
  TITLE     LIP1, a cytoplasmic protein functionally linked to the
            Peutz-Jeghers syndrome kinase LKB1
  JOURNAL   Hum Mol Genet 10 (25), 2869-2877 (2001)
   PUBMED   11741830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY001118.1, AC009955.4, BC034051.1 and BC014114.2.
            
            On Nov 22, 2018 this sequence version replaced NM_052902.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034051.1, SRR1803613.237698.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000456909.6/ ENSP00000389383.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                HY001118.1         10-70
            62-62               AC009955.4         68807-68807
            63-1237             BC034051.1         46-1220
            1238-3616           BC014114.2         285-2663
            3617-3618           BC034051.1         3600-3601
FEATURES             Location/Qualifiers
     source          1..3618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..3618
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /note="serine/threonine kinase 11 interacting protein"
                     /db_xref="GeneID:114790"
                     /db_xref="HGNC:HGNC:19184"
                     /db_xref="MIM:607172"
     exon            1..67
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            68..154
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..3360
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /note="STK11 interacting protein; LKB1-interacting protein
                     1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 11-interacting
                     protein"
                     /protein_id="NP_443134.3"
                     /db_xref="CCDS:CCDS46521.2"
                     /db_xref="GeneID:114790"
                     /db_xref="HGNC:HGNC:19184"
                     /db_xref="MIM:607172"
                     /translation="MTTAQRDSLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHV
                     FELHLGPWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGPGPTGPI
                     KIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDFCSAL
                     PWLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISY
                     NRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLW
                     LLAELRKLYLEGNPLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSL
                     GLSPMGPPLPWPVGSTPETSGGPDLSDSLSSGGVVTQPLLHKVKSRVRVRRASISEPS
                     DTDPEPRTLNPSPAGWFVQQHPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTT
                     SAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKE
                     EGEMVEQGEEEAGEEEEEEQDQKEVEAELCRPLLVCPLEGPEGVRGRECFLRVTSAHL
                     FEVELQAARTLERLELQSLEAAEIEPEAQAQRSPRPTGSDLLPGAPILSLRFSYICPD
                     RQLRRYLVLEPDAHAAVQELLAVLTPVTNVAREQLGEARDLLLGRFQCLRCGHEFKPE
                     EPRMGLDSEEGWRPLFQKTESPAVCPNCGSDHVVLLAVSRGTPNRERKQGEQSLAPSP
                     SASPVCHPPGHGDHLDRAKNSPPQAPSTRDHGSWSLSPPPERCGLRSVDHRLRLFLDV
                     EVFSDAQEEFQCCLKVPVALAGHTGEFMCLVVVSDRRLYLLKVTGEMREPPASWLQLT
                     LAVPLQDLSGIELGLAGQSLRLEWAAGAGRCVLLPRDARHCRAFLEELLDVLQSLPPA
                     WRNCVSATEEEVTPQHRLWPLLEKDSSLEARQFFYLRAFLVEGPSTCLVSLLLTPSTL
                     FLLDEDAAGSPAEPSPPAASGEASEKVPPSGPGPAVRVREQQPLSSLSSVLLYRSAPE
                     DLRLLFYDEVSRLESFWALRVVCQEQLTALLAWIREPWEELFSIGLRTVIQEALALDR
                     "
     exon            155..360
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..435
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..531
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..639
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..711
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..838
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..942
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1038
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1080
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1227
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1312
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1696
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1902
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2019
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2197
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2428
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2532
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2630
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2809
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2891
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..2962
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3210
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3618
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3596..3601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /note="hexamer: AATAAA"
     polyA_site      3618
                     /gene="STK11IP"
                     /gene_synonym="LIP1; LKB1IP; STK11IP1"
                     /note="major polyA site"
ORIGIN      
        1 acttcctttc catcattgat aggcgccggg cagctgagct ggtaggagga ccagacgggg
       61 aggttcggct ccgcccccca gcgtcccgtg gccatgacga ccgctcagag ggactccctg
      121 ttgtggaagc tcgcggggtt gctgcgggag tccggggatg tggtcctgtc tggctgtagc
      181 accctgagcc tgctgactcc cacactgcaa cagctgaacc acgtatttga gctgcacctg
      241 gggccatggg gccctggcca gacaggcttt gtggctctgc cctcccatcc tgccgactcc
      301 cctgttattc ttcagcttca gtttctcttc gatgtgctgc agaaaacact ttcactcaag
      361 ctggtccatg ttgctggtcc tggccccaca gggcccatca agattttccc cttcaaatcc
      421 cttcggcacc tggagctccg aggtgttccc ctccactgtc tgcatggcct ccgaggcatc
      481 tactcccagc tggagaccct gatttgcagc aggagcctcc aggcattaga ggagctcctc
      541 tcagcctgcg gcggcgactt ctgctctgcc ctcccttggc tggctctgct ttctgccaac
      601 ttcagctaca atgcactgac cgccttagac agctccctgc gcctcttgtc agctctgcgt
      661 ttcttgaacc taagccacaa tcaagtccag gactgtcagg gattcctgat ggatttgtgt
      721 gagctccacc atctggacat ctcctataat cgcctgcatt tggtgccaag aatgggaccc
      781 tcaggggctg ctctgggggt cctgatactg cgaggcaatg agcttcggag cctgcatggc
      841 ctagagcagc tgaggaatct gcggcacctg gatttggcat acaacctgct ggaaggacac
      901 cgggagctgt caccactgtg gctgctggct gagctccgca agctctacct ggaggggaac
      961 cctctttggt tccaccctga gcaccgagca gccactgccc agtacttgtc accccgggcc
     1021 agggatgctg ctactggctt ccttctcgat ggcaaggtct tgtcactgac agattttcag
     1081 actcacacat ccttggggct cagccccatg ggcccacctt tgccctggcc agtggggagt
     1141 actcctgaaa cctcaggtgg ccctgacctg agtgacagcc tctcctcagg gggtgttgtg
     1201 acccagcccc tgcttcataa ggttaagagc cgagtccgtg tgaggcgggc aagcatctct
     1261 gaacccagtg atacggaccc ggagccccga actctgaacc cctctccggc tggatggttc
     1321 gtgcagcagc acccggagct ggagctcatg agcagcttcc gggaacggtt cggccgcaac
     1381 tggctgcagt acaggagtca cctggagccc tccggaaacc ctctgccggc cacccccact
     1441 acttctgcac ccagtgcacc tccagccagc tcccagggcc ccgacactgc acccagacct
     1501 tcacccccgc aggaggaagc cagaggcccc caggagtcac cacagaaaat gtcagaggag
     1561 gtcagggcgg agccacagga ggaggaagag gagaaggagg ggaaggagga gaaggaggag
     1621 ggggagatgg tggaacaggg agaagaggag gcaggagagg aggaagaaga ggagcaggac
     1681 cagaaggaag tggaagcgga actctgtcgc cccttgttgg tgtgtcccct ggaggggcct
     1741 gagggcgtac ggggcaggga atgctttctc agggtcactt ctgcccacct gtttgaggtg
     1801 gaactccaag cagctcgcac cttggagcga ctggagctcc agagtctgga ggcagctgag
     1861 atagagccgg aggcccaggc ccagaggtcg cccaggccca cgggctcaga tctgctccct
     1921 ggagccccca tcctcagtct gcgcttctcc tacatctgcc ctgaccggca gttgcgtcgc
     1981 tatttggtgc tggagcctga tgcccacgca gctgtccagg agctgcttgc cgtgttgacc
     2041 ccagtcacca atgtggctcg ggaacagctt ggggaggcca gggacctcct gctgggtaga
     2101 ttccagtgtc tacgctgtgg ccatgagttc aagccagagg agcccaggat gggattagac
     2161 agtgaggaag gctggaggcc tctgttccaa aagacagaat ctcctgctgt gtgtcctaac
     2221 tgtggtagtg accacgtggt tctcctcgct gtgtctcggg gaacccccaa cagggagcgg
     2281 aaacagggag agcagtctct ggctccttct ccgtctgcca gccctgtctg ccaccctcct
     2341 ggccatggtg accaccttga cagggccaag aacagcccac ctcaggcacc gagcacccgt
     2401 gaccatggta gttggagcct cagtcccccc cctgagcgct gtggcctccg ctctgtggac
     2461 caccgactcc ggctcttcct ggatgttgag gtgttcagcg atgcccagga ggagttccag
     2521 tgctgcctca aggtgccagt ggcattggca ggccacactg gggagttcat gtgccttgtg
     2581 gttgtgtctg accgcaggct gtacctgttg aaggtgactg gggagatgcg tgagcctcca
     2641 gctagctggc tgcagctgac cctggctgtt cccctgcagg atctgagtgg catagagctg
     2701 ggcctggcag gccagagcct gcggctagag tgggcagctg gggcgggccg ctgtgtgctg
     2761 ctgccccgag atgccaggca ttgccgggcc ttcctagagg agctccttga tgtcttgcag
     2821 tctctgcccc ctgcctggag gaactgtgtc agtgccacag aggaggaggt caccccccag
     2881 caccggctct ggccattgct ggaaaaagac tcatccttgg aggctcgcca gttcttctac
     2941 cttcgggcgt tcctggttga aggcccttcc acctgcctcg tatccctgtt gctgactccg
     3001 tccaccctgt tcctgttaga tgaggatgct gcagggtccc cggcagagcc ctctcctcca
     3061 gcagcatctg gcgaagcctc tgagaaggtg cctccctcgg ggccgggccc tgctgtgcgt
     3121 gtcagggagc agcagccact cagcagcctg agctccgtgc tgctctaccg ctcagcccct
     3181 gaggacttgc ggctgctctt ctacgatgag gtgtcccggc tggagagctt ttgggcactc
     3241 cgtgtggtgt gtcaggagca gctgacagcc ctgcttgcct ggatccggga accatgggag
     3301 gagctgtttt ccatcggact ccggacagtg atccaagagg cgctggccct tgaccgatga
     3361 gggtcccacg ctgaccttgg ccctgacctc aggagccacg ctgtagacat tccctctcct
     3421 ggtctctggg tctggcttcc aggctctggc tgtggatgtc ttcagcctct gggtgctggc
     3481 cagtgaggtc ccaaatgacc cagggcttaa gggagaggcg agagaatgat ctggcctcag
     3541 gggacaggcc acctggtcag gaggaatatt tttcctgcac tttttctcag gtatcaataa
     3601 agttgtttcc aactcata
//
