LOCUS       NM_000455               3293 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens serine/threonine kinase 11 (STK11), transcript variant
            1, mRNA.
ACCESSION   NM_000455
VERSION     NM_000455.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3293)
  AUTHORS   Han,J., Huang,J., Hu,J., Shi,W., Wang,H., Zhang,W., Wang,J.,
            Shao,H., Shen,H., Bo,H., Tao,C. and Wu,F.
  TITLE     miR-744-5p promotes T-cell differentiation via inhibiting STK11
  JOURNAL   Gene 926, 148635 (2024)
   PUBMED   38830518
  REMARK    GeneRIF: miR-744-5p promotes T-cell differentiation via inhibiting
            STK11.
REFERENCE   2  (bases 1 to 3293)
  AUTHORS   Hou,J., Mei,K., Wang,D., Ke,S., Chen,X., Shang,J., Li,G., Gao,Y.,
            Xiong,H., Zhang,H., Chen,L., Zhang,W., Deng,Y., Hong,X., Liu,D.A.,
            Hu,T., Guo,W. and Zhan,Y.Y.
  TITLE     TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis
            upon LKB1 inactivation
  JOURNAL   Cell Rep 43 (8), 114604 (2024)
   PUBMED   39146185
  REMARK    GeneRIF: TGM1/3-mediated transamidation of Exo70 promotes tumor
            metastasis upon LKB1 inactivation.
REFERENCE   3  (bases 1 to 3293)
  AUTHORS   Principe,D.R., Pasquinelli,M.M., Nguyen,R.H., Munshi,H.G.,
            Hulbert,A., Aissa,A.F. and Weinberg,F.
  TITLE     Loss of STK11 Suppresses Lipid Metabolism and Attenuates
            KRAS-Induced Immunogenicity in Patients with Non-Small Cell Lung
            Cancer
  JOURNAL   Cancer Res Commun 4 (8), 2282-2294 (2024)
   PUBMED   39113608
  REMARK    GeneRIF: Loss of STK11 Suppresses Lipid Metabolism and Attenuates
            KRAS-Induced Immunogenicity in Patients with Non-Small Cell Lung
            Cancer.
REFERENCE   4  (bases 1 to 3293)
  AUTHORS   Wang,X., Li,Y., Zhang,J., Liu,C., Deng,A. and Li,J.
  TITLE     Genetic variation at a splicing branch point in intron 7 of STK11:
            a rare variant decreasing its expression in a Chinese family with
            Peutz-Jeghers syndrome
  JOURNAL   World J Surg Oncol 22 (1), 202 (2024)
   PUBMED   39080663
  REMARK    GeneRIF: Genetic variation at a splicing branch point in intron 7
            of STK11: a rare variant decreasing its expression in a Chinese
            family with Peutz-Jeghers syndrome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3293)
  AUTHORS   Liu,M., Gu,L., Zhang,Y., Li,Y., Zhang,L., Xin,Y., Wang,Y. and
            Xu,Z.X.
  TITLE     LKB1 inhibits telomerase activity resulting in cellular senescence
            through histone lactylation in lung adenocarcinoma
  JOURNAL   Cancer Lett 595, 217025 (2024)
   PUBMED   38844063
  REMARK    GeneRIF: LKB1 inhibits telomerase activity resulting in cellular
            senescence through histone lactylation in lung adenocarcinoma.
REFERENCE   6  (bases 1 to 3293)
  AUTHORS   Bignell,G.R., Barfoot,R., Seal,S., Collins,N., Warren,W. and
            Stratton,M.R.
  TITLE     Low frequency of somatic mutations in the LKB1/Peutz-Jeghers
            syndrome gene in sporadic breast cancer
  JOURNAL   Cancer Res 58 (7), 1384-1386 (1998)
   PUBMED   9537235
REFERENCE   7  (bases 1 to 3293)
  AUTHORS   Hemminki,A., Markie,D., Tomlinson,I., Avizienyte,E., Roth,S.,
            Loukola,A., Bignell,G., Warren,W., Aminoff,M., Hoglund,P.,
            Jarvinen,H., Kristo,P., Pelin,K., Ridanpaa,M., Salovaara,R.,
            Toro,T., Bodmer,W., Olschwang,S., Olsen,A.S., Stratton,M.R., de la
            Chapelle,A. and Aaltonen,L.A.
  TITLE     A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
  JOURNAL   Nature 391 (6663), 184-187 (1998)
   PUBMED   9428765
REFERENCE   8  (bases 1 to 3293)
  AUTHORS   Jenne,D.E., Reimann,H., Nezu,J., Friedel,W., Loff,S., Jeschke,R.,
            Muller,O., Back,W. and Zimmer,M.
  TITLE     Peutz-Jeghers syndrome is caused by mutations in a novel serine
            threonine kinase
  JOURNAL   Nat Genet 18 (1), 38-43 (1998)
   PUBMED   9425897
REFERENCE   9  (bases 1 to 3293)
  AUTHORS   Hemminki,A., Tomlinson,I., Markie,D., Jarvinen,H., Sistonen,P.,
            Bjorkqvist,A.M., Knuutila,S., Salovaara,R., Bodmer,W., Shibata,D.,
            de la Chapelle,A. and Aaltonen,L.A.
  TITLE     Localization of a susceptibility locus for Peutz-Jeghers syndrome
            to 19p using comparative genomic hybridization and targeted linkage
            analysis
  JOURNAL   Nat Genet 15 (1), 87-90 (1997)
   PUBMED   8988175
REFERENCE   10 (bases 1 to 3293)
  AUTHORS   McGarrity,T.J., Amos,C.I. and Baker,M.J.
  TITLE     Peutz-Jeghers Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301443
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011544.6, BU174122.1,
            BQ222023.1, BC007981.2, BC019334.1, BU739451.1 and BM993274.1.
            
            On Aug 31, 2019 this sequence version replaced NM_000455.4.
            
            Summary: The protein encoded by this gene is a serine/threonine
            kinase that regulates cell polarity and energy metabolism and
            functions as a tumor suppressor. Mutations in this gene have been
            associated with the autosomal dominant Peutz-Jeghers syndrome, as
            well as with skin, pancreatic, and testicular cancers. [provided by
            RefSeq, May 2022].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019334.1, AF035625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326873.12/ ENSP00000324856.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC011544.6         26171-26191
            22-360              BU174122.1         1-339
            361-686             BQ222023.1         1-326
            687-2957            BC007981.2         1-2271
            2958-3053           BC019334.1         2093-2188
            3054-3265           BU739451.1         46-257              c
            3266-3293           BM993274.1         23-50               c
FEATURES             Location/Qualifiers
     source          1..3293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3293
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /note="serine/threonine kinase 11"
                     /db_xref="GeneID:6794"
                     /db_xref="HGNC:HGNC:11389"
                     /db_xref="MIM:602216"
     exon            1..1426
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /inference="alignment:Splign:2.1.0"
     CDS             1137..2438
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase 11; polarization-related
                     protein LKB1; renal carcinoma antigen NY-REN-19;
                     serine/threonine-protein kinase LKB1; liver kinase B1;
                     serine/threonine-protein kinase STK11"
                     /codon_start=1
                     /product="serine/threonine-protein kinase STK11 isoform 1"
                     /protein_id="NP_000446.1"
                     /db_xref="CCDS:CCDS45896.1"
                     /db_xref="GeneID:6794"
                     /db_xref="HGNC:HGNC:11389"
                     /db_xref="MIM:602216"
                     /translation="MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAK
                     LIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLL
                     RRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQL
                     IDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPA
                     FQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPG
                     DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRS
                     MTVVPYLEDLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCM
                     NGTEAAQLSTKSRAEGRAPNPARKACSASSKIRRLSACKQQ"
     exon            1427..1510
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1600
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1733
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1870
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1998
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2056
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2244
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2454
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..3293
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2940..2945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /note="hexamer: AATAAA"
     polyA_site      2957
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
     regulatory      3272..3277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /note="hexamer: AATAAA"
     polyA_site      3293
                     /gene="STK11"
                     /gene_synonym="hLKB1; LKB1; PJS"
                     /note="major polyA site"
ORIGIN      
        1 gaggtaaaca agatggcggc ggcgtgtcgg gcgcggaagg gggaggcggc ccggggcgcc
       61 cgcgagtgag gcgcggggcg gcgaagggag cgcgggtggc ggcacttgct gccgcggcct
      121 tggatgggct gggcccccct cgccgctccg cctcctccac acgcgcggcg gccgcggcga
      181 gggggacgcg ccgcccgggg cccggcacct tcgggaaccc cccggcccgg agcctgcggc
      241 ctgcgccgcc tcggccgccg ggagccccgt ggagcccccg ccgccgcgcc gccccgcgga
      301 ccggacgctg agggcactcg gggcggggcg cgcgctcggg cagacgtttg cggggagggg
      361 ggcgcctgcc gggccccggc gaccaccttg ggggtcgcgg gccggctcgg ggggcgccca
      421 gtgcgggccc tcgcgggcgc cgggcagcga ccagccctga gcggagctgt tggccgcggc
      481 gggaggcctc ccggacgccc ccagcccccc gaacgctcgc ccgggccggc gggagtcggc
      541 gccccccggg aggtccgctc ggtcgtccgc ggcggagcgt ttgctcctgg gacaggcggt
      601 gggaccgggg cgtcgccgga gacgccccca gcgaagttgg gctctccagg tgtgggggtc
      661 ccggggggta gcgacgtcgc ggacccggcc tgtgggatgg gcggcccgga gaagactgcg
      721 ctcggccgtg ttcatacttg tccgtgggcc tgaggtcccc ggaggatgac ctagcactga
      781 aaagccccgg ccggcctccc cagggtcccc gaggacgaag ttgaccctga ccgggccgtc
      841 tcccagttct gaggcccggg tcccactgga actcgcgtct gagccgccgt cccggacccc
      901 cggtgcccgc cggtccgcag accctgcacc gggcttggac tcgcagccgg gactgacgtg
      961 tagaacaatc gtttctgttg gaagaagggt ttttcccttc cttttggggt ttttgttgcc
     1021 tttttttttt cttttttctt tgtaaaattt tggagaaggg aagtcggaac acaaggaagg
     1081 accgctcacc cgcggactca gggctggcgg cgggactcca ggaccctggg tccagcatgg
     1141 aggtggtgga cccgcagcag ctgggcatgt tcacggaggg cgagctgatg tcggtgggta
     1201 tggacacgtt catccaccgc atcgactcca ccgaggtcat ctaccagccg cgccgcaagc
     1261 gggccaagct catcggcaag tacctgatgg gggacctgct gggggaaggc tcttacggca
     1321 aggtgaagga ggtgctggac tcggagacgc tgtgcaggag ggccgtcaag atcctcaaga
     1381 agaagaagtt gcgaaggatc cccaacgggg aggccaacgt gaagaaggaa attcaactac
     1441 tgaggaggtt acggcacaaa aatgtcatcc agctggtgga tgtgttatac aacgaagaga
     1501 agcagaaaat gtatatggtg atggagtact gcgtgtgtgg catgcaggaa atgctggaca
     1561 gcgtgccgga gaagcgtttc ccagtgtgcc aggcccacgg gtacttctgt cagctgattg
     1621 acggcctgga gtacctgcat agccagggca ttgtgcacaa ggacatcaag ccggggaacc
     1681 tgctgctcac caccggtggc accctcaaaa tctccgacct gggcgtggcc gaggcactgc
     1741 acccgttcgc ggcggacgac acctgccgga ccagccaggg ctccccggct ttccagccgc
     1801 ccgagattgc caacggcctg gacaccttct ccggcttcaa ggtggacatc tggtcggctg
     1861 gggtcaccct ctacaacatc accacgggtc tgtacccctt cgaaggggac aacatctaca
     1921 agttgtttga gaacatcggg aaggggagct acgccatccc gggcgactgt ggccccccgc
     1981 tctctgacct gctgaaaggg atgcttgagt acgaaccggc caagaggttc tccatccggc
     2041 agatccggca gcacagctgg ttccggaaga aacatcctcc ggctgaagca ccagtgccca
     2101 tcccaccgag cccagacacc aaggaccggt ggcgcagcat gactgtggtg ccgtacttgg
     2161 aggacctgca cggcgcggac gaggacgagg acctcttcga catcgaggat gacatcatct
     2221 acactcagga cttcacggtg cccggacagg tcccagaaga ggaggccagt cacaatggac
     2281 agcgccgggg cctccccaag gccgtgtgta tgaacggcac agaggcggcg cagctgagca
     2341 ccaaatccag ggcggagggc cgggccccca accctgcccg caaggcctgc tccgccagca
     2401 gcaagatccg ccggctgtcg gcctgcaagc agcagtgagg ctggccgcct gcagcccgtg
     2461 tccaggagcc ccgccaggtg cccgcgccag gccctcagtc ttcctgccgg ttccgcccgc
     2521 cctcccggag aggtggccgc catgcttctg tgccgaccac gccccaggac ctccggagcg
     2581 ccctgcaggg ccgggcaggg ggacagcagg gaccgggcgc agccctcccc cctcggccgc
     2641 ccggcagtgc acgcggcttg ttgacttcgc agccccgggc ggagccttcc cgggcgggcg
     2701 tgggaggagg gaggcggcct ccatgcactt tatgtggaga ctactggccc cgcccgtggc
     2761 ctcgtgctcc gcagggcgcc cagcgccgtc cggcggcccc gccgcagacc agctggcggg
     2821 tgtggagacc aggctcctga ccccgccatg catgcagcgc cacctggaag ccgcgcggcc
     2881 gctttggttt tttgtttggt tggttccatt ttcttttttt cttttttttt ttaagaaaaa
     2941 ataaaaggtg gatttgagct gtggctgtga ggggtgtttg ggagctgctg ggtggcaggg
     3001 gggctgtggg gtcgggctca cgtcgcggcc gcctttgcgc tctcgggtca ccctgctttg
     3061 gcggcccggc cggagggcag gaccctcacc tctcccccaa ggccactgcg ctcttgggac
     3121 cccagagaaa acccggagca agcaggagtg tgcggtcaat atttatatca tccagaaaag
     3181 aaaaacacga gaaacgccat cgcgggatgg tgcagacgcg gcggggactc ggagggtgcc
     3241 gtgcgggcga ggccgcccaa atttggcaat aaataaagct tgggaagctt gga
//
