LOCUS       NM_005990               5892 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens serine/threonine kinase 10 (STK10), mRNA.
ACCESSION   NM_005990 XM_001129121
VERSION     NM_005990.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5892)
  AUTHORS   Bi,L., Jia,S., Hu,W., Su,X., Chen,X. and Tang,H.
  TITLE     Systematic analysis of prognostic significance, functional
            enrichment and immune implication of STK10 in acute myeloid
            leukemia
  JOURNAL   BMC Med Genomics 15 (1), 101 (2022)
   PUBMED   35501867
  REMARK    GeneRIF: Systematic analysis of prognostic significance, functional
            enrichment and immune implication of STK10 in acute myeloid
            leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5892)
  AUTHORS   Pelaseyed,T., Viswanatha,R., Sauvanet,C., Filter,J.J.,
            Goldberg,M.L. and Bretscher,A.
  TITLE     Ezrin activation by LOK phosphorylation involves a PIP2-dependent
            wedge mechanism
  JOURNAL   Elife 6, e22759 (2017)
   PUBMED   28430576
  REMARK    GeneRIF: Binding of phosphatidylinositol 4,5-biphosphate to ezrin
            induces a conformational change permitting the insertion of the LOK
            C-terminal domain to wedge apart the membrane and F-actin-binding
            domains of ezrin. The N-terminal LOK kinase domain can then access
            a site 40 residues distal from the consensus sequence that
            collectively direct phosphorylation of the appropriate threonine
            residue.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5892)
  AUTHORS   Xu,H., Gao,J. and Wang,F.
  TITLE     Altered mitochondrial expression genes in patients receiving right
            ventricular apical pacing
  JOURNAL   Exp Mol Pathol 100 (3), 469-475 (2016)
   PUBMED   27177495
  REMARK    GeneRIF: The gene signature of OPA1, CTSA, NDUFA1, STK10 and PRDX1
            was able to identify patients post-implant with a sensitivity of
            91% and a specificity of 86% in discrimination between post-implant
            group and healthy controls.
REFERENCE   4  (bases 1 to 5892)
  AUTHORS   Fukumura,K., Yamashita,Y., Kawazu,M., Sai,E., Fujiwara,S.,
            Nakamura,N., Takeuchi,K., Ando,M., Miyazono,K., Ueno,T., Ozawa,K.
            and Mano,H.
  TITLE     STK10 missense mutations associated with anti-apoptotic function
  JOURNAL   Oncol Rep 30 (4), 1542-1548 (2013)
   PUBMED   23842845
  REMARK    GeneRIF: STK10 functions as a tumor suppressor gene, and
            dysfunction of STK10 activity either through polymorphism or
            somatic mutations may confer anti-apoptotic effects contributing to
            carcinogenesis.
REFERENCE   5  (bases 1 to 5892)
  AUTHORS   Anttila,V., Winsvold,B.S., Gormley,P., Kurth,T., Bettella,F.,
            McMahon,G., Kallela,M., Malik,R., de Vries,B., Terwindt,G.,
            Medland,S.E., Todt,U., McArdle,W.L., Quaye,L., Koiranen,M.,
            Ikram,M.A., Lehtimaki,T., Stam,A.H., Ligthart,L., Wedenoja,J.,
            Dunham,I., Neale,B.M., Palta,P., Hamalainen,E., Schurks,M.,
            Rose,L.M., Buring,J.E., Ridker,P.M., Steinberg,S., Stefansson,H.,
            Jakobsson,F., Lawlor,D.A., Evans,D.M., Ring,S.M., Farkkila,M.,
            Artto,V., Kaunisto,M.A., Freilinger,T., Schoenen,J., Frants,R.R.,
            Pelzer,N., Weller,C.M., Zielman,R., Heath,A.C., Madden,P.A.F.,
            Montgomery,G.W., Martin,N.G., Borck,G., Gobel,H., Heinze,A.,
            Heinze-Kuhn,K., Williams,F.M.K., Hartikainen,A.L., Pouta,A., van
            den Ende,J., Uitterlinden,A.G., Hofman,A., Amin,N., Hottenga,J.J.,
            Vink,J.M., Heikkila,K., Alexander,M., Muller-Myhsok,B.,
            Schreiber,S., Meitinger,T., Wichmann,H.E., Aromaa,A.,
            Eriksson,J.G., Traynor,B., Trabzuni,D., Rossin,E., Lage,K.,
            Jacobs,S.B.R., Gibbs,J.R., Birney,E., Kaprio,J., Penninx,B.W.,
            Boomsma,D.I., van Duijn,C., Raitakari,O., Jarvelin,M.R.,
            Zwart,J.A., Cherkas,L., Strachan,D.P., Kubisch,C., Ferrari,M.D.,
            van den Maagdenberg,A.M.J.M., Dichgans,M., Wessman,M., Smith,G.D.,
            Stefansson,K., Daly,M.J., Nyholt,D.R., Chasman,D. and Palotie,A.
  CONSRTM   North American Brain Expression Consortium; UK Brain Expression
            Consortium
  TITLE     Genome-wide meta-analysis identifies new susceptibility loci for
            migraine
  JOURNAL   Nat Genet 45 (8), 912-917 (2013)
   PUBMED   23793025
REFERENCE   6  (bases 1 to 5892)
  AUTHORS   Bignell,G., Smith,R., Hunter,C., Stephens,P., Davies,H.,
            Greenman,C., Teague,J., Butler,A., Edkins,S., Stevens,C.,
            O'Meara,S., Parker,A., Avis,T., Barthorpe,S., Brackenbury,L.,
            Buck,G., Clements,J., Cole,J., Dicks,E., Edwards,K., Forbes,S.,
            Gorton,M., Gray,K., Halliday,K., Harrison,R., Hills,K., Hinton,J.,
            Jones,D., Kosmidou,V., Laman,R., Lugg,R., Menzies,A., Perry,J.,
            Petty,R., Raine,K., Shepherd,R., Small,A., Solomon,H., Stephens,Y.,
            Tofts,C., Varian,J., Webb,A., West,S., Widaa,S., Yates,A.,
            Gillis,A.J., Stoop,H.J., van Gurp,R.J., Oosterhuis,J.W.,
            Looijenga,L.H., Futreal,P.A., Wooster,R. and Stratton,M.R.
  TITLE     Sequence analysis of the protein kinase gene family in human
            testicular germ-cell tumors of adolescents and adults
  JOURNAL   Genes Chromosomes Cancer 45 (1), 42-46 (2006)
   PUBMED   16175573
REFERENCE   7  (bases 1 to 5892)
  AUTHORS   Walter,S.A., Cutler,R.E. Jr., Martinez,R., Gishizky,M. and
            Hill,R.J.
  TITLE     Stk10, a new member of the polo-like kinase kinase family highly
            expressed in hematopoietic tissue
  JOURNAL   J Biol Chem 278 (20), 18221-18228 (2003)
   PUBMED   12639966
  REMARK    GeneRIF: Stk10 is a novel polo-like kinase kinase that cooperates
            with hSlk to regulate Plk1 function in human cells
REFERENCE   8  (bases 1 to 5892)
  AUTHORS   Tao,L., Wadsworth,S., Mercer,J., Mueller,C., Lynn,K., Siekierka,J.
            and August,A.
  TITLE     Opposing roles of serine/threonine kinases MEKK1 and LOK in
            regulating the CD28 responsive element in T-cells
  JOURNAL   Biochem J 363 (Pt 1), 175-182 (2002)
   PUBMED   11903060
  REMARK    GeneRIF: Opposing roles of serine/threonine kinases MEKK1 and LOK
            in regulating the CD28 responsive element in T-cells
REFERENCE   9  (bases 1 to 5892)
  AUTHORS   Endo,J., Toyama-Sorimachi,N., Taya,C., Kuramochi-Miyagawa,S.,
            Nagata,K., Kuida,K., Takashi,T., Yonekawa,H., Yoshizawa,Y.,
            Miyasaka,N. and Karasuyama,H.
  TITLE     Deficiency of a STE20/PAK family kinase LOK leads to the
            acceleration of LFA-1 clustering and cell adhesion of activated
            lymphocytes
  JOURNAL   FEBS Lett 468 (2-3), 234-238 (2000)
   PUBMED   10692593
REFERENCE   10 (bases 1 to 5892)
  AUTHORS   Kuramochi,S., Matsuda,Y., Okamoto,M., Kitamura,F., Yonekawa,H. and
            Karasuyama,H.
  TITLE     Molecular cloning of the human gene STK10 encoding
            lymphocyte-oriented kinase, and comparative chromosomal mapping of
            the human, mouse, and rat homologues
  JOURNAL   Immunogenetics 49 (5), 369-375 (1999)
   PUBMED   10199912
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA507768.1, BI459912.1,
            AB015718.1, DB068209.1, AC113342.2 and AI584023.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005990.3.
            
            Summary: This gene encodes a member of the Ste20 family of
            serine/threonine protein kinases, and is similar to several known
            polo-like kinase kinases. The protein can associate with and
            phosphorylate polo-like kinase 1, and overexpression of a
            kinase-dead version of the protein interferes with normal cell
            cycle progression. The kinase can also negatively regulate
            interleukin 2 expression in T-cells via the mitogen activated
            protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070077.1, AB015718.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000176763.10/ ENSP00000176763.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                DA507768.1         119-161
            44-132              BI459912.1         81-169
            133-937             AB015718.1         1-805
            938-1400            DB068209.1         73-535
            1401-4326           AB015718.1         1269-4194
            4327-5853           AC113342.2         61292-62818         c
            5854-5892           AI584023.1         30-68               c
FEATURES             Location/Qualifiers
     source          1..5892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..5892
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /note="serine/threonine kinase 10"
                     /db_xref="GeneID:6793"
                     /db_xref="HGNC:HGNC:11388"
                     /db_xref="MIM:603919"
     exon            1..338
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..3089
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /EC_number="2.7.11.1"
                     /note="lymphocyte-oriented kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 10"
                     /protein_id="NP_005981.3"
                     /db_xref="CCDS:CCDS34290.1"
                     /db_xref="GeneID:6793"
                     /db_xref="HGNC:HGNC:11388"
                     /db_xref="MIM:603919"
                     /translation="MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGD
                     GAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYH
                     DGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKA
                     GNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKA
                     DIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALD
                     KNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAA
                     STLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTS
                     PPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQS
                     RPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSL
                     NKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQEL
                     RELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQV
                     EKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQ
                     KMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDRE
                     AALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVR
                     QQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERL
                     QQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWR
                     DKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSADAS"
     exon            339..503
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            504..552
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            553..702
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            703..775
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            776..970
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1052
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1187
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1736
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1867
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1991
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2171
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2264
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2394
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2519
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2708
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2834
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2948
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..5892
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4329..4334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /note="hexamer: AATAAA"
     polyA_site      4354
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /note="major polyA site"
     polyA_site      4376
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
     regulatory      5875..5880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /note="hexamer: AATAAA"
     polyA_site      5892
                     /gene="STK10"
                     /gene_synonym="LOK; PRO2729"
                     /note="major polyA site"
ORIGIN      
        1 gctcccggcg cggcgctgcc cagggcacac ttgaccgagg tcgggctgcg gggaaaggcg
       61 ggtctgggga gaaccccgag agacgcggcg tcctccaact cctcctcctt ctcctcgcgg
      121 ccgccgaagc cacagcccga gcccgagccc gagcccgagc cggcgccacc gcgcccccgg
      181 ccatggcttt tgccaatttc cgccgcatcc tgcgcctgtc taccttcgag aagagaaagt
      241 cccgcgaata tgagcacgtc cgccgcgacc tggaccccaa cgaggtgtgg gagatcgtgg
      301 gcgagctggg cgacggcgcc ttcggcaagg tttacaaggc caagaataag gagacgggtg
      361 ctttggctgc ggccaaagtc attgaaacca agagtgagga ggagctggag gactacatcg
      421 tggagattga gatcctggcc acctgcgacc acccctacat tgtgaagctc ctgggagcct
      481 actatcacga cgggaagctg tggatcatga ttgagttctg tccaggggga gccgtggacg
      541 ccatcatgct ggagctggac agaggcctca cggagcccca gatacaggtg gtttgccgcc
      601 agatgctaga agccctcaac ttcctgcaca gcaagaggat catccaccga gatctgaaag
      661 ctggcaacgt gctgatgacc ctcgagggag acatcaggct ggctgacttt ggtgtgtctg
      721 ccaagaatct gaagactcta cagaaacgag attccttcat cggcacgcct tactggatgg
      781 cccccgaggt ggtcatgtgt gagaccatga aagacacgcc ctacgactac aaagccgaca
      841 tctggtccct gggcatcacg ctgattgaga tggcccagat cgagccgcca caccacgagc
      901 tcaaccccat gcgggtcctg ctaaagatcg ccaagtcgga ccctcccacg ctgctcacgc
      961 cctctaagtg gtctgtagag ttccgtgact tcctgaagat agccctggat aagaacccag
     1021 aaacccgacc cagtgccgcg cagctgctgg agcatccctt cgtcagcagc atcaccagta
     1081 acaaggctct gcgggagctg gtggctgagg ccaaggccga ggtgatggaa gagatcgaag
     1141 acggccggga tgagggggaa gaggaggacg ccgtggatgc cgcctccacc ctggagaacc
     1201 atactcagaa ctcctctgag gtgagtccgc caagcctcaa tgctgacaag cctctcgagg
     1261 agtcaccttc caccccgctg gcacccagcc agtctcagga cagtgtgaat gagccctgca
     1321 gccagccctc tggggacaga tccctccaaa ccaccagtcc cccagtcgtg gcccctggaa
     1381 atgagaacgg cctggcagtg cctgtgcccc tgcggaagtc ccgacccgtg tcaatggatg
     1441 ccagaattca ggtagcccag gagaagcaag ttgctgagca gggtggggac ctcagcccag
     1501 cagccaacag atctcaaaag gccagccaga gccggcccaa cagcagcgcc ctggagacct
     1561 tgggtgggga gaagctggcc aatggcagcc tggagccacc tgcccaggca gctccagggc
     1621 cttccaagag ggactcggac tgcagcagcc tctgcacctc tgagagcatg gactatggta
     1681 ccaatctctc cactgacctg tcgctgaaca aagagatggg ctctctgtcc atcaaggacc
     1741 cgaaactgta caaaaaaacc ctcaagcgga cacgcaaatt tgtggtggat ggtgtggagg
     1801 tgagcatcac cacctccaag atcatcagcg aagatgagaa gaaggatgag gagatgagat
     1861 ttctcaggcg ccaggaactc cgagagcttc ggctgctcca gaaagaagag catcggaacc
     1921 agacccagct gagtaacaag catgagctgc agctggagca aatgcataaa cgttttgaac
     1981 aggaaatcaa cgccaagaag aagttctttg acacggaatt agagaacctg gagcgtcagc
     2041 aaaagcagca agtggagaag atggagcaag accatgccgt gcgccgccgg gaggaggcca
     2101 ggcggatccg cctggagcag gatcgggact acaccaggtt ccaagagcag ctcaaactga
     2161 tgaagaaaga ggtgaagaac gaggtggaga agctcccccg acagcagcgg aaggaaagca
     2221 tgaagcagaa gatggaggag cacacgcaga aaaagcagct tcttgaccgg gactttgtag
     2281 ccaagcagaa ggaggacctg gagctggcca tgaagaggct caccaccgac aacaggcggg
     2341 agatctgtga caaggagcgc gagtgcctca tgaagaagca ggagctcctt cgagaccggg
     2401 aagcagccct gtgggagatg gaagagcacc agctgcagga gaggcaccag ctggtgaagc
     2461 agcagctcaa agaccagtac ttcctccagc ggcacgagct gctgcgcaag catgagaagg
     2521 agcgggagca gatgcagcgc tacaaccagc gcatgataga gcagctgaag gtgcggcagc
     2581 aacaggaaaa ggcgcggctg cccaagatcc agaggagtga gggcaagacg cgcatggcca
     2641 tgtacaagaa gagcctccac atcaacggcg ggggcagcgc agctgagcag cgtgagaaga
     2701 tcaagcagtt ctcccagcag gaggagaaga ggcagaagtc ggagcggctg cagcaacagc
     2761 agaaacacga gaaccagatg cgggacatgc tggcgcagtg tgagagcaac atgagcgagc
     2821 tgcagcagct gcagaatgaa aagtgccacc tcctggtaga gcacgaaacc cagaaactga
     2881 aggccctgga tgagagccat aaccagaacc tgaaggaatg gcgggacaag cttcggccgc
     2941 gcaagaaggc tctggaagag gatctgaacc agaagaagcg ggagcaggag atgttcttca
     3001 agctgagcga ggaggcggag tgcccaaacc cctccacccc aagcaaggcc gccaagttct
     3061 tcccctacag ttctgcggat gcttcttaac aaccgcccgg ggctgtggct ggcagcttgg
     3121 tgggccccag ggccttctcc ttcattctct gtgaacatgt aactcaggac cccttttccc
     3181 tcttgcgtct gtgccagctc aaatccagcc cctcgccctg tgccacccca actgtgcctg
     3241 atagacctgc cccagcgttc ctgacttctt gctggcctgt ggagggtgag gtgtaattat
     3301 ttgtcacctg aacctaatgt atattctcct tgagccccag atcccttcaa gctggaaggg
     3361 atggggctgt tggtggggtc agggtccaag aggaatgggt gttctgtggc ctcgagtcct
     3421 ctcctgtttg cgaaaatacc agttttgctc tctgtgggac aaagcactgc tgatgaagtc
     3481 cccgtgggct catccgggct ggaattcttg gtttttcagc cattccctgc agagtcactc
     3541 aatcatcaag tccctcacag ccatttctgt tcccagagga gccaggcctg cagctggctg
     3601 ctcaggagat ggcctcattc ctcctgttct cccagtttgc tttccactta agacaaagcc
     3661 ttgtctatgt ggggggcggg gaccggggaa agagggaggc tgaaatgttt attctgcttc
     3721 tcccgtgttt catgccatct cgcgtccccc ttcctgcaca tgggtgtgaa tgcacacaca
     3781 tacgcgtaca cacaggactt ggtctgctgg cctggcctct tctgcccagg tgggttggaa
     3841 cacgtttgct gcctgagcct gtgccactga gcatgttagg tggagcagtt ggtgtggcac
     3901 gtgcggggtg ttggcaccgg aggcatggaa aagcacaggc tgtactgcca ggctgcgatg
     3961 cgtgctggcc cccgcacagg ctcctgtgtg cagggactga ttcctcagca cacgaggctt
     4021 ccacaaccca gtctgctcca tagcactctg gcccaccctg tctgcaggtg aaacaggagg
     4081 gctgtttgcc tctgccccat ccccccgact gtgttcagga gtcccacctt gcatttcaga
     4141 cctgggctgg cagtctgttg gacttctctt caggaagaaa aagcatcagg gggaaatgga
     4201 atgcccctgc cccaggaaca tggcagaagc acaggttctg tacctcagat ggactcctgc
     4261 tgggccttcg gggtctcagt tggcttcccc cagattctga ttctacagct gcagaatgta
     4321 tataacgcaa taaaagcaaa tgtttgaacc agtatgcggg tttacttaca aggaaacctt
     4381 ttttcaccct gatttctaat tattttattg aaacaactat aaaatgtatg gtttctccag
     4441 gaagatatct gctttttaaa acaacaaaca agaacaacaa cacaaaactg gtaatgattt
     4501 ggagtaatca tgcgggcata ttgagtctgg gtagtgtttc gctggtggta gagtggttga
     4561 gacttcctgg gaggactttt tccgccttca ctcctacaga tttaagattc tttattttta
     4621 ggccgggcat ggtgactcac ctgaggtgag gagttcgaga ctagcctggc caacatggca
     4681 aaaccctgtc tctactaaaa gtacaaaaat tagccaggcg tggtggtgca tgcctataat
     4741 cccagctact cgggaggctg aggcaggaga atcgcttgaa cccaggaggc agaggttgca
     4801 gtaagccaag gtcacaccac tgcactccag cctaggtgac agggcgagac tctgtctctc
     4861 aaaaaaaaaa aaaaaaaaaa ttctttgaga cagggtctct aatatgttgc ccaagctgat
     4921 ctcaaactcg tggctcaact gattctcccg cttcaacctt gagtagctgg gacgacagat
     4981 acatgctact gcacccagct aggttaaggt tctgtatact ctgtctttct aaagcaattc
     5041 cctggaaatt ttctcaacat tggttataac tgaatgcttg ggaagggagg ggcagccctt
     5101 caacaggaaa aggggactgc ccaaatctta aatgcacagt caagattctc ttggagctag
     5161 caatggttct caggttagtg agcatttagc ttgcctgctg cagaatttga cccagatggg
     5221 ggtgtttttt aggtctctca caaatgagac aagcgaaaca attgtctcct tttattctct
     5281 ttggtgcatt ggtgctgggg aaacatgaac tagcggcagt gtaactgcag aacatagacc
     5341 cagttctacc aggccaggcc agcgttggga accaccagac agggctgctt tgggctttgc
     5401 ttacagtatt tccatgtgta gcctggcgtg tgagaaagta ttaggtgaaa tgccagtttc
     5461 atggttcagg tgaaagtctg tgatcattcc cctcgtggct cgtccttcac atcacttttg
     5521 cccttcaagg agttgccgcg tccccgctca gtgccgcctg agccctcaga gctcccctgt
     5581 gcttttctgg atggggactg gcggggtcac ctagcctcac cgtggagcca ccgtgcaatg
     5641 cccatctctg agaggcccac gcggtattcc tcgtgccctg tgttagtgct ttctgtataa
     5701 gggacagaca gaactgggtt tttttcctct gtctggtttt agagtaaatg taactaactt
     5761 ttattttccc tttatgaaag atagaaatta tttttatgta gtttccagac tttatacaaa
     5821 atttttgtaa aatgttctct ggaaagttaa ctacaagaat gtaaatatgc ttctaataaa
     5881 ataacaaggt ta
//
