LOCUS       NM_006819               2140 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens stress induced phosphoprotein 1 (STIP1), transcript
            variant 2, mRNA.
ACCESSION   NM_006819
VERSION     NM_006819.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2140)
  AUTHORS   Stetskaya,T.A., Krapiva,A.B., Kobzeva,K.A., Gurtovoy,D.E.,
            Komkova,G.V., Polonikov,A.V. and Bushueva,O.Y.
  TITLE     Polymorphism in Genes Encoding Adaptor Proteins ST13 and STIP1 and
            the Risk of Ischemic Stroke: a Pilot Study
  JOURNAL   Bull Exp Biol Med 176 (4), 477-480 (2024)
   PUBMED   38492099
  REMARK    GeneRIF: Polymorphism in Genes Encoding Adaptor Proteins ST13 and
            STIP1 and the Risk of Ischemic Stroke: a Pilot Study.
REFERENCE   2  (bases 1 to 2140)
  AUTHORS   Hua,H., Su,T., Han,L., Zhang,L., Huang,Y., Zhang,N. and Yang,M.
  TITLE     LINC01226 promotes gastric cancer progression through enhancing
            cytoplasm-to-nucleus translocation of STIP1 and stabilizing
            beta-catenin protein
  JOURNAL   Cancer Lett 577, 216436 (2023)
   PUBMED   37806517
  REMARK    GeneRIF: LINC01226 promotes gastric cancer progression through
            enhancing cytoplasm-to-nucleus translocation of STIP1 and
            stabilizing beta-catenin protein.
REFERENCE   3  (bases 1 to 2140)
  AUTHORS   Guo,Z. and Guo,L.
  TITLE     Tumor-promoting action of ubiquitin protease 43 in gastric cancer
            progression through deubiquitination and stabilization of
            stress-inducible phosphoprotein 1
  JOURNAL   Exp Cell Res 430 (2), 113714 (2023)
   PUBMED   37442266
  REMARK    GeneRIF: Tumor-promoting action of ubiquitin protease 43 in gastric
            cancer progression through deubiquitination and stabilization of
            stress-inducible phosphoprotein 1.
REFERENCE   4  (bases 1 to 2140)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2140)
  AUTHORS   Chao,A., Liao,M.J., Chen,S.H., Lee,Y.S., Tsai,C.N., Lin,C.Y. and
            Tsai,C.L.
  TITLE     JAK2-Mediated Phosphorylation of Stress-Induced Phosphoprotein-1
            (STIP1) in Human Cells
  JOURNAL   Int J Mol Sci 23 (5), 2420 (2022)
   PUBMED   35269562
  REMARK    GeneRIF: JAK2-Mediated Phosphorylation of Stress-Induced
            Phosphoprotein-1 (STIP1) in Human Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2140)
  AUTHORS   Zou,J., Guo,Y., Guettouche,T., Smith,D.F. and Voellmy,R.
  TITLE     Repression of heat shock transcription factor HSF1 activation by
            HSP90 (HSP90 complex) that forms a stress-sensitive complex with
            HSF1
  JOURNAL   Cell 94 (4), 471-480 (1998)
   PUBMED   9727490
REFERENCE   7  (bases 1 to 2140)
  AUTHORS   Dittmar,K.D., Demady,D.R., Stancato,L.F., Krishna,P. and Pratt,W.B.
  TITLE     Folding of the glucocorticoid receptor by the heat shock protein
            (hsp) 90-based chaperone machinery. The role of p23 is to stabilize
            receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70
  JOURNAL   J Biol Chem 272 (34), 21213-21220 (1997)
   PUBMED   9261129
REFERENCE   8  (bases 1 to 2140)
  AUTHORS   Dittmar,K.D. and Pratt,W.B.
  TITLE     Folding of the glucocorticoid receptor by the reconstituted
            Hsp90-based chaperone machinery. The initial
            hsp90.p60.hsp70-dependent step is sufficient for creating the
            steroid binding conformation
  JOURNAL   J Biol Chem 272 (20), 13047-13054 (1997)
   PUBMED   9148915
REFERENCE   9  (bases 1 to 2140)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   10 (bases 1 to 2140)
  AUTHORS   Honore,B., Leffers,H., Madsen,P., Rasmussen,H.H., Vandekerckhove,J.
            and Celis,J.E.
  TITLE     Molecular cloning and expression of a transformation-sensitive
            human protein containing the TPR motif and sharing identity to the
            stress-inducible yeast protein STI1
  JOURNAL   J Biol Chem 267 (12), 8485-8491 (1992)
   PUBMED   1569099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA781468.1 and M86752.1.
            
            On Jun 2, 2019 this sequence version replaced NM_006819.2.
            
            Summary: STIP1 is an adaptor protein that coordinates the functions
            of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM
            140571) in protein folding. It is thought to assist in the transfer
            of proteins from HSP70 to HSP90 by binding both HSP90 and
            substrate-bound HSP70. STIP1 also stimulates the ATPase activity of
            HSP70 and inhibits the ATPase activity of HSP90, suggesting that it
            regulates both the conformations and ATPase cycles of these
            chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by
            OMIM, Jul 2009].
            
            Transcript Variant: This variant (2) uses an alternate 5' terminal
            exon and thus differs in the 5' UTR and 5' coding region, and uses
            an alternate start codon, compared to variant 1. The encoded
            isoform (b) has a distinct N-terminus and is shorter than isoform
            a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002987.1, SRR1803614.190480.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305218.9/ ENSP00000305958.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DA781468.1         57-85
            30-2140             M86752.1           1-2111
FEATURES             Location/Qualifiers
     source          1..2140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2140
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /note="stress induced phosphoprotein 1"
                     /db_xref="GeneID:10963"
                     /db_xref="HGNC:HGNC:11387"
                     /db_xref="MIM:605063"
     exon            1..100
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1723
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /note="isoform b is encoded by transcript variant 2;
                     Hsp70/Hsp90-organizing protein; NY-REN-11 antigen;
                     hsc70/Hsp90-organizing protein; epididymis secretory sperm
                     binding protein Li 94n; transformation-sensitive protein
                     IEF SSP 3521; renal carcinoma antigen NY-REN-11"
                     /codon_start=1
                     /product="stress-induced-phosphoprotein 1 isoform b"
                     /protein_id="NP_006810.1"
                     /db_xref="CCDS:CCDS8058.1"
                     /db_xref="GeneID:10963"
                     /db_xref="HGNC:HGNC:11387"
                     /db_xref="MIM:605063"
                     /translation="MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNR
                     SAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHE
                     ANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLR
                     NKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDL
                     PENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYN
                     KCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPD
                     VLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPK
                     DAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDV
                     YQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLIL
                     EQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR"
     exon            101..310
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     exon            311..452
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     exon            453..594
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     exon            595..763
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     exon            764..890
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     exon            891..993
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1114
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1211
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1336
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1373
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1477
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1650
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..2140
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2111..2116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /note="hexamer: AATAAA"
     polyA_site      2140
                     /gene="STIP1"
                     /gene_synonym="HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1;
                     STI1L"
                     /note="major polyA site"
ORIGIN      
        1 agcttctagt aggttccaga aggcggcgcg tgcggttggg aacgcggagc ggacggattc
       61 gattcaacgg ggttccggac cgcgctgcgc tatggagcag gtcaatgagc tgaaggagaa
      121 aggcaacaag gccctgagcg tgggtaacat cgatgatgcc ttacagtgct actccgaagc
      181 tattaagctg gatccccaca accacgtgct gtacagcaac cgttctgctg cctatgccaa
      241 gaaaggagac taccagaagg cttatgagga tggctgcaag actgtcgacc taaagcctga
      301 ctggggcaag ggctattcac gaaaagcagc agctctagag ttcttaaacc gctttgaaga
      361 agccaagcga acctatgagg agggcttaaa acacgaggca aataaccctc aactgaaaga
      421 gggtttacag aatatggagg ccaggttggc agagagaaaa ttcatgaacc ctttcaacat
      481 gcctaatctg tatcagaagt tggagagtga tcccaggaca aggacactac tcagtgatcc
      541 tacctaccgg gagctgatag agcagctacg aaacaagcct tctgacctgg gcacgaaact
      601 acaagatccc cggatcatga ccactctcag cgtcctcctt ggggtcgatc tgggcagtat
      661 ggatgaggag gaagagattg caacacctcc accaccaccc cctcccaaaa aggagaccaa
      721 gccagagcca atggaagaag atcttccaga gaataagaag caggcactga aagaaaaaga
      781 gctggggaac gatgcctaca agaagaaaga ctttgacaca gccttgaagc attacgacaa
      841 agccaaggag ctggacccca ctaacatgac ttacattacc aatcaagcag cggtatactt
      901 tgaaaagggc gactacaata agtgccggga gctttgtgag aaggccattg aagtggggag
      961 agaaaaccga gaagactatc gacagattgc caaagcatat gctcgaattg gcaactccta
     1021 cttcaaagaa gaaaagtaca aggatgccat ccatttctat aacaagtctc tggcagagca
     1081 ccgaacccca gatgtgctca agaaatgcca gcaggcagag aaaatcctga aggagcaaga
     1141 gcggctggcc tacataaacc ccgacctggc tttggaggag aagaacaaag gcaacgagtg
     1201 ttttcagaaa ggggactatc cccaggccat gaagcattat acagaagcca tcaaaaggaa
     1261 cccgaaagat gccaaattat acagcaatcg agctgcctgc tacaccaaac tcctggagtt
     1321 ccagctggca ctcaaggact gtgaggaatg tatccagctg gagccgacct tcatcaaggg
     1381 ttatacacgg aaagccgctg cgctggaagc gatgaaggac tacaccaaag ccatggatgt
     1441 gtaccagaag gcgctagacc tggactccag ctgtaaggag gcggcagacg gctaccagcg
     1501 ctgtatgatg gcgcagtaca accggcacga cagccccgaa gatgtgaagc gacgagccat
     1561 ggccgaccct gaggtgcagc agatcatgag tgacccagcc atgcgcctta tcctggaaca
     1621 gatgcagaag gacccccagg cactcagcga acacttaaag aatcctgtaa tagcacagaa
     1681 gatccagaag ctgatggatg tgggtctgat tgcaattcgg tgatgacttg ttcatccccc
     1741 cttcccttcg ccctcatgtg gaaagaggag ctgggaccgc ggcgagcagc acggagcgga
     1801 agggagagca ggggagagaa ggcctcatct ctctatattt atacataacc ccggggaaga
     1861 cacagagact cgtacctgcg ctgtttgtgc cgccgctgcc tctgggccct cccagcacac
     1921 gcatggtctc ttcaccgctg ccctcgagtt ccatgtctct ttcccctgcc cctagttgct
     1981 gtctcggctg ctctcccata gttggttttt tttttatttg gggcagtggg catgttatgg
     2041 ggaggggagg gggttcttcc agcctcaggt cccagctgtc tcacgttgtt tattctgcgt
     2101 ccccttctcc aataaaacaa gccagttggg cgtggttata
//
