LOCUS       NM_198282               2170 bp    mRNA    linear   PRI 24-NOV-2024
DEFINITION  Homo sapiens stimulator of interferon response cGAMP interactor 1
            (STING1), transcript variant 1, mRNA.
ACCESSION   NM_198282 XM_291127
VERSION     NM_198282.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2170)
  AUTHORS   Soh,L.J., Lee,S.Y., Roebuck,M.M. and Wong,P.F.
  TITLE     Unravelling the interplay between ER stress, UPR and the cGAS-STING
            pathway: Implications for osteoarthritis pathogenesis and treatment
            strategy
  JOURNAL   Life Sci 357, 123112 (2024)
   PUBMED   39378929
  REMARK    GeneRIF: Unravelling the interplay between ER stress, UPR and the
            cGAS-STING pathway: Implications for osteoarthritis pathogenesis
            and treatment strategy.
            Review article
REFERENCE   2  (bases 1 to 2170)
  AUTHORS   Lv,B., Dion,W.A., Yang,H., Xun,J., Kim,D.H., Zhu,B. and Tan,J.X.
  TITLE     A TBK1-independent primordial function of STING in lysosomal
            biogenesis
  JOURNAL   Mol Cell 84 (20), 3979-3996 (2024)
   PUBMED   39423796
  REMARK    GeneRIF: A TBK1-independent primordial function of STING in
            lysosomal biogenesis.
REFERENCE   3  (bases 1 to 2170)
  AUTHORS   Triantafilou,K., Szomolay,B., Shepherd,M.W., Ramanjulu,J. and
            Triantafilou,M.
  TITLE     STING Orchestrates EV-D68 Replication and Immunometabolism within
            Viral-Induced Replication Organelles
  JOURNAL   Viruses 16 (10), 1541 (2024)
   PUBMED   39459875
  REMARK    GeneRIF: STING Orchestrates EV-D68 Replication and Immunometabolism
            within Viral-Induced Replication Organelles.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2170)
  AUTHORS   Pu,D., Yao,Y., Zhou,C., Liu,R., Wang,Z., Liu,Y., Wang,D., Wang,B.,
            Wang,Y., Liu,Z., Zhang,Z. and Feng,B.
  TITLE     FMT rescues mice from DSS-induced colitis in a STING-dependent
            manner
  JOURNAL   Gut Microbes 16 (1), 2397879 (2024)
   PUBMED   39324491
  REMARK    GeneRIF: FMT rescues mice from DSS-induced colitis in a
            STING-dependent manner.
REFERENCE   5  (bases 1 to 2170)
  AUTHORS   Yin,Q., Tian,Y., Kabaleeswaran,V., Jiang,X., Tu,D., Eck,M.J.,
            Chen,Z.J. and Wu,H.
  TITLE     Cyclic di-GMP sensing via the innate immune signaling protein STING
  JOURNAL   Mol Cell 46 (6), 735-745 (2012)
   PUBMED   22705373
  REMARK    GeneRIF: We elucidate the structural features of the cytosolic
            c-di-GMP binding domain (CBD) of STING and its complex with
            c-di-GMP
REFERENCE   6  (bases 1 to 2170)
  AUTHORS   Zhong,B., Zhang,L., Lei,C., Li,Y., Mao,A.P., Yang,Y., Wang,Y.Y.,
            Zhang,X.L. and Shu,H.B.
  TITLE     The ubiquitin ligase RNF5 regulates antiviral responses by
            mediating degradation of the adaptor protein MITA
  JOURNAL   Immunity 30 (3), 397-407 (2009)
   PUBMED   19285439
  REMARK    GeneRIF: E3 ubiquitin ligase RNF5 interacted with MITA in a
            viral-infection-dependent manner
REFERENCE   7  (bases 1 to 2170)
  AUTHORS   Graubert,T.A., Payton,M.A., Shao,J., Walgren,R.A., Monahan,R.S.,
            Frater,J.L., Walshauser,M.A., Martin,M.G., Kasai,Y. and Walter,M.J.
  TITLE     Integrated genomic analysis implicates haploinsufficiency of
            multiple chromosome 5q31.2 genes in de novo myelodysplastic
            syndromes pathogenesis
  JOURNAL   PLoS One 4 (2), e4583 (2009)
   PUBMED   19240791
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2170)
  AUTHORS   Zhong,B., Yang,Y., Li,S., Wang,Y.Y., Li,Y., Diao,F., Lei,C., He,X.,
            Zhang,L., Tien,P. and Shu,H.B.
  TITLE     The adaptor protein MITA links virus-sensing receptors to IRF3
            transcription factor activation
  JOURNAL   Immunity 29 (4), 538-550 (2008)
   PUBMED   18818105
  REMARK    GeneRIF: results suggest MITA is a critical mediator of
            virus-triggered IRF3 activation and IFN expression and further
            demonstrate the importance of certain mitochondrial proteins in
            innate antiviral immunity.
REFERENCE   9  (bases 1 to 2170)
  AUTHORS   Ishikawa,H. and Barber,G.N.
  TITLE     STING is an endoplasmic reticulum adaptor that facilitates innate
            immune signalling
  JOURNAL   Nature 455 (7213), 674-678 (2008)
   PUBMED   18724357
  REMARK    GeneRIF: identification, following expression cloning, of a
            molecule (STING; stimulator of interferon genes) that appears
            essential for effective innate immune signalling processes
            GeneRIF: STING (TMEM173) is an endoplasmic reticulum adaptor
            protein that facilitates innate immune signaling
            Erratum:[Nature. 2008 Nov 13;456(7219):274]
REFERENCE   10 (bases 1 to 2170)
  AUTHORS   Jin,L., Waterman,P.M., Jonscher,K.R., Short,C.M., Reisdorph,N.A.
            and Cambier,J.C.
  TITLE     MPYS, a novel membrane tetraspanner, is associated with major
            histocompatibility complex class II and mediates transduction of
            apoptotic signals
  JOURNAL   Mol Cell Biol 28 (16), 5014-5026 (2008)
   PUBMED   18559423
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI905932.1, BC047779.1 and
            BM981219.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 14, 2018 this sequence version replaced NM_198282.3.
            
            Summary: This gene encodes a five transmembrane protein that
            functions as a major regulator of the innate immune response to
            viral and bacterial infections. The encoded protein is a pattern
            recognition receptor that detects cytosolic nucleic acids and
            transmits signals that activate type I interferon responses. The
            encoded protein has also been shown to play a role in apoptotic
            signaling by associating with type II major histocompatibility
            complex. Mutations in this gene are the cause of infantile-onset
            STING-associated vasculopathy. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.90747.1,
                                           SRR1660807.12264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000330794.9/
                                                  ENSP00000331288.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BI905932.1         13-73
            62-1739             BC047779.1         11-1688
            1740-2170           BM981219.1         22-452              c
FEATURES             Location/Qualifiers
     source          1..2170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..2170
                     /gene="STING1"
                     /gene_synonym="ERIS; hMITA; hSTING; MITA; MPYS; NET23;
                     SAVI; STING; STING-beta; TMEM173"
                     /note="stimulator of interferon response cGAMP interactor
                     1"
                     /db_xref="GeneID:340061"
                     /db_xref="HGNC:HGNC:27962"
                     /db_xref="MIM:612374"
     exon            1..209
                     /gene="STING1"
                     /gene_synonym="ERIS; hMITA; hSTING; MITA; MPYS; NET23;
                     SAVI; STING; STING-beta; TMEM173"
                     /inference="alignment:Splign:2.1.0"
     exon            210..302
                     /gene="STING1"
                     /gene_synonym="ERIS; hMITA; hSTING; MITA; MPYS; NET23;
                     SAVI; STING; STING-beta; TMEM173"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1442
                     /gene="STING1"
                     /gene_synonym="ERIS; hMITA; hSTING; MITA; MPYS; NET23;
                     SAVI; STING; STING-beta; TMEM173"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N-terminal methionine-proline-tyrosine-serine plasma
                     membrane tetraspanner; endoplasmic reticulum IFN
                     stimulator; mitochondrial mediator of IRF3 activation;
                     stimulator of interferon genes protein; endoplasmic
                     reticulum interferon stimulator; stimulator of interferon
                     protein; transmembrane protein 173; sting 1; stimulator of
                     interferon response cGAMP interactor-deltaC; stimulator of
                     interferon response cGAMP interactor-deltaN"
                     /codon_start=1
                     /product="stimulator of interferon genes protein isoform
                     1"
                     /protein_id="NP_938023.1"
                     /db_xref="CCDS:CCDS4215.1"
                     /db_xref="GeneID:340061"
                     /db_xref="HGNC:HGNC:27962"
                     /db_xref="MIM:612374"
                     /translation="MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTL
                     RYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLS
                     IYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLA
                     WSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPN
                     IRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQ
                     AGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLR
                     QEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS"
     exon            303..529
                     /gene="STING1"
                     /gene_synonym="ERIS; hMITA; hSTING; MITA; MPYS; NET23;
                     SAVI; STING; STING-beta; TMEM173"
                     /inference="alignment:Splign:2.1.0"
     exon            530..713
                     /gene="STING1"
                     /gene_synonym="ERIS; hMITA; hSTING; MITA; MPYS; NET23;
                     SAVI; STING; STING-beta; TMEM173"
                     /inference="alignment:Splign:2.1.0"
     exon            714..822
                     /gene="STING1"
                     /gene_synonym="ERIS; hMITA; hSTING; MITA; MPYS; NET23;
                     SAVI; STING; STING-beta; TMEM173"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1061
                     /gene="STING1"
                     /gene_synonym="ERIS; hMITA; hSTING; MITA; MPYS; NET23;
                     SAVI; STING; STING-beta; TMEM173"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1248
                     /gene="STING1"
                     /gene_synonym="ERIS; hMITA; hSTING; MITA; MPYS; NET23;
                     SAVI; STING; STING-beta; TMEM173"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..2170
                     /gene="STING1"
                     /gene_synonym="ERIS; hMITA; hSTING; MITA; MPYS; NET23;
                     SAVI; STING; STING-beta; TMEM173"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2170
                     /gene="STING1"
                     /gene_synonym="ERIS; hMITA; hSTING; MITA; MPYS; NET23;
                     SAVI; STING; STING-beta; TMEM173"
                     /note="major polyA site"
ORIGIN      
        1 gttcattttt cactcctccc tcctaggtca cacttttcag aaaaagaatc tgcatcctgg
       61 aaaccagaag aaaaatatga gacggggaat catcgtgtga tgtgtgtgct gcctttggct
      121 gagtgtgtgg agtcctgctc aggtgttagg tacagtgtgt ttgatcgtgg tggcttgagg
      181 ggaacccgct gttcagagct gtgactgcgg ctgcactcag agaagctgcc cttggctgct
      241 cgtagcgccg ggccttctct cctcgtcatc atccagagca gccagtgtcc gggaggcaga
      301 agatgcccca ctccagcctg catccatcca tcccgtgtcc caggggtcac ggggcccaga
      361 aggcagcctt ggttctgctg agtgcctgcc tggtgaccct ttgggggcta ggagagccac
      421 cagagcacac tctccggtac ctggtgctcc acctagcctc cctgcagctg ggactgctgt
      481 taaacggggt ctgcagcctg gctgaggagc tgcgccacat ccactccagg taccggggca
      541 gctactggag gactgtgcgg gcctgcctgg gctgccccct ccgccgtggg gccctgttgc
      601 tgctgtccat ctatttctac tactccctcc caaatgcggt cggcccgccc ttcacttgga
      661 tgcttgccct cctgggcctc tcgcaggcac tgaacatcct cctgggcctc aagggcctgg
      721 ccccagctga gatctctgca gtgtgtgaaa aagggaattt caacgtggcc catgggctgg
      781 catggtcata ttacatcgga tatctgcggc tgatcctgcc agagctccag gcccggattc
      841 gaacttacaa tcagcattac aacaacctgc tacggggtgc agtgagccag cggctgtata
      901 ttctcctccc attggactgt ggggtgcctg ataacctgag tatggctgac cccaacattc
      961 gcttcctgga taaactgccc cagcagaccg gtgaccatgc tggcatcaag gatcgggttt
     1021 acagcaacag catctatgag cttctggaga acgggcagcg ggcgggcacc tgtgtcctgg
     1081 agtacgccac ccccttgcag actttgtttg ccatgtcaca atacagtcaa gctggcttta
     1141 gccgggagga taggcttgag caggccaaac tcttctgccg gacacttgag gacatcctgg
     1201 cagatgcccc tgagtctcag aacaactgcc gcctcattgc ctaccaggaa cctgcagatg
     1261 acagcagctt ctcgctgtcc caggaggttc tccggcacct gcggcaggag gaaaaggaag
     1321 aggttactgt gggcagcttg aagacctcag cggtgcccag tacctccacg atgtcccaag
     1381 agcctgagct cctcatcagt ggaatggaaa agcccctccc tctccgcacg gatttctctt
     1441 gagacccagg gtcaccaggc cagagcctcc agtggtctcc aagcctctgg actgggggct
     1501 ctcttcagtg gctgaatgtc cagcagagct atttccttcc acagggggcc ttgcagggaa
     1561 gggtccagga cttgacatct taagatgcgt cttgtcccct tgggccagtc atttcccctc
     1621 tctgagcctc ggtgtcttca acctgtgaaa tgggatcata atcactgcct tacctccctc
     1681 acggttgttg tgaggactga gtgtgtggaa gtttttcata aactttggat gctagtgtac
     1741 ttagggggtg tgccaggtgt ctttcatggg gccttccaga cccactcccc acccttctcc
     1801 ccttcctttg cccggggacg ccgaactctc tcaatggtat caacaggctc cttcgccctc
     1861 tggctcctgg tcatgttcca ttattgggga gccccagcag aagaatggag aggaggagga
     1921 ggctgagttt ggggtattga atcccccggc tcccaccctg cagcatcaag gttgctatgg
     1981 actctcctgc cgggcaactc ttgcgtaatc atgactatct ctaggattct ggcaccactt
     2041 ccttccctgg ccccttaagc ctagctgtgt atcggcaccc ccaccccact agagtactcc
     2101 ctctcacttg cggtttcctt atactccacc cctttctcaa cggtcctttt ttaaagcaca
     2161 tctcagatta
//
