LOCUS       NM_198563               4744 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens STIM activating enhancer (STIMATE), mRNA.
ACCESSION   NM_198563 XM_351554
VERSION     NM_198563.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4744)
  AUTHORS   Quintana,A., Rajanikanth,V., Farber-Katz,S., Gudlur,A., Zhang,C.,
            Jing,J., Zhou,Y., Rao,A. and Hogan,P.G.
  TITLE     TMEM110 regulates the maintenance and remodeling of mammalian
            ER-plasma membrane junctions competent for STIM-ORAI signaling
  JOURNAL   Proc Natl Acad Sci U S A 112 (51), E7083-E7092 (2015)
   PUBMED   26644574
  REMARK    GeneRIF: Research on calcium signaling has centered on STIM1,
            ORAI1, and proteins that modulate their function. TMEM110 regulates
            the maintenance of ER-plasma membrane junctions and the short-term
            remodeling of junctions during store-dependent calcium signaling.
REFERENCE   2  (bases 1 to 4744)
  AUTHORS   Jing,J., He,L., Sun,A., Quintana,A., Ding,Y., Ma,G., Tan,P.,
            Liang,X., Zheng,X., Chen,L., Shi,X., Zhang,S.L., Zhong,L.,
            Huang,Y., Dong,M.Q., Walker,C.L., Hogan,P.G., Wang,Y. and Zhou,Y.
  TITLE     Proteomic mapping of ER-PM junctions identifies STIMATE as a
            regulator of Ca(2) influx
  JOURNAL   Nat Cell Biol 17 (10), 1339-1347 (2015)
   PUBMED   26322679
  REMARK    GeneRIF: Data show that transmembrane protein 110 STIMATE is an
            endoplasmic reticulum (ER)-resident protein that co-localizes with
            membrane protein STIM1.
REFERENCE   3  (bases 1 to 4744)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (bases 1 to 4744)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   5  (bases 1 to 4744)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
            Vierkant,R.A. and Poland,G.A.
  TITLE     Genome-wide analysis of polymorphisms associated with cytokine
            responses in smallpox vaccine recipients
  JOURNAL   Hum Genet 131 (9), 1403-1421 (2012)
   PUBMED   22610502
REFERENCE   6  (bases 1 to 4744)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099667.2.
            
            On Feb 27, 2020 this sequence version replaced NM_198563.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4185348.1,
                                           SRR14038191.4086466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355083.11/ ENSP00000347195.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AC099667.2         131368-131625       c
            259-307             AC099667.2         89473-89521         c
            308-403             AC099667.2         86680-86775         c
            404-525             AC099667.2         83869-83990         c
            526-638             AC099667.2         78906-79018         c
            639-716             AC099667.2         77798-77875         c
            717-866             AC099667.2         76888-77037         c
            867-4744            AC099667.2         70810-74687         c
FEATURES             Location/Qualifiers
     source          1..4744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..4744
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /note="STIM activating enhancer"
                     /db_xref="GeneID:375346"
                     /db_xref="HGNC:HGNC:30526"
                     /db_xref="MIM:617189"
     exon            1..258
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..983
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /note="STIM-activating enhancer encoded by TMEM110;
                     transmembrane protein 110"
                     /codon_start=1
                     /product="store-operated calcium entry regulator STIMATE"
                     /protein_id="NP_940965.1"
                     /db_xref="CCDS:CCDS2866.1"
                     /db_xref="GeneID:375346"
                     /db_xref="HGNC:HGNC:30526"
                     /db_xref="MIM:617189"
                     /translation="MQGPAGNASRGLPGGPPSTVASGAGRCESGALMHSFGIFLQGLL
                     GVVAFSTLMLKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSL
                     YLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIV
                     IMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLM
                     RKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRR
                     LTPLKPVKKKKHRFGLPV"
     exon            259..307
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /inference="alignment:Splign:2.1.0"
     exon            308..403
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /inference="alignment:Splign:2.1.0"
     exon            404..525
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /inference="alignment:Splign:2.1.0"
     exon            526..638
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /inference="alignment:Splign:2.1.0"
     exon            639..716
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /inference="alignment:Splign:2.1.0"
     exon            717..866
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /inference="alignment:Splign:2.1.0"
     exon            867..4744
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1240
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /note="major polyA site"
     polyA_site      1595
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /note="major polyA site"
     regulatory      4703..4708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /note="hexamer: AATAAA"
     regulatory      4721..4726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /note="hexamer: ATTACA"
     polyA_site      4721
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
                     /note="major polyA site"
     polyA_site      4744
                     /gene="STIMATE"
                     /gene_synonym="TMEM110"
ORIGIN      
        1 aggcttggga tcccggctgc gggtttggcg gcgctgcgcc ggcaggcagc gaggccgggc
       61 gggccctggg ccctcgcgcc cctcccgcga ggcctgtcat gcagggcccc gccgggaacg
      121 cgagccgggg actgccaggc gggccgccct ccacagtcgc gtccggggcg ggccgctgcg
      181 agagcggcgc gctcatgcac agcttcggca tcttcctgca ggggctgctc ggcgtcgtgg
      241 ccttcagcac gttaatgctc aaacgcttca gagaaccaaa gcatgaaaga cgtccgtgga
      301 ggatatggtt tttagacact tccaaacaag ccataggaat gctgttcatc cactttgcaa
      361 atgtatacct agcagatctc actgaagagg acccttgttc actgtacctc atcaacttcc
      421 tcctggacgc cactgtgggc atgctgctca tctacgtggg ggtgcgcgcc gtcagcgtcc
      481 tggtagagtg gcagcagtgg gagtccctgc gcttcggcga atatggagac cctctgcagt
      541 gtggagcctg ggtcgggcag tgcgctcttt acatcgtgat catgattttt gaaaagtctg
      601 tcgtcttcat cgtcctccta atacttcagt ggaaaaaggt ggccctgttg aatcccattg
      661 aaaacccaga cttgaagctg gccatcgtca tgctgatcgt ccccttcttt gtcaacgctt
      721 tgatgttttg ggtagtggac aatttcctca tgagaaaggg gaagacgaaa gctaagctag
      781 aagaaagggg agccaaccag gactcgagga atgggagcaa ggtccgctac cggagggccg
      841 catcccacga ggagtctgag tctgagatcc tgatctcagc ggatgatgag atggaggagt
      901 ccgacgtgga ggaggacctc cgcagactga cccccctcaa gcctgtgaag aaaaagaagc
      961 accgctttgg gctacccgta tgacacattc ccatgctggg ggtgacggga gggccccgcc
     1021 agccgctggt gtgcagaggt catcccgcag catcgttcct taccctctct ctgcccttcc
     1081 tttctacctc tgctcctctt gctgtctctg cccgctctcg cctgccccca gactactgtg
     1141 acttaaaaag agggaagagg agccagcgcc cgagggggcc actggcggct ggaggtcccc
     1201 attcagttgc actacaaaca ctgaccaaat atgcaaggaa ggagctgtgt ttgtttgttg
     1261 tcgtcccaga cagtgttgtg agggacctga ggccctgccc cgtgtccgac caccgagtgg
     1321 caaggtggaa ggaagcacag gcacacagac cgtgggtggg tctcctcacc gtggctgtgg
     1381 gcagtgcgaa cacataacac cctcgggcta aaagtgactc gttgaccaag ttggaaccgg
     1441 aatgctttct tactcaaaat ggcttttgta actattgatt tctgaagctg gttttatgag
     1501 ttgtgacagt gttaccaggt tgggggtatg tgtttatttc ctacaaagta cttacgggac
     1561 taatgggcaa aacagagatt tttaagtctt ccgtatgctg tttgactttt atatttttaa
     1621 gttatatttt catactattg tatttaaaaa ctctttttag tccccaaaga aatgggttta
     1681 tttgcctttc atggggtgtg ggctggcagg aggaaaaatc gggagttttt tatttggaat
     1741 attattagat gatgccctat gataagatga gacaaatgat ggggagggaa ggaggatggc
     1801 ccttctctag aatcagcaaa cccaatggtt ctgtgaaggt cagacccaag cttggagcag
     1861 ctggtctgga tgcagatcca ggagctgcag agtgtggaac aggaaaggct ctgcccaggg
     1921 cccatgagct ctagcattcc tgctggcaga ttagagatct tagttaaatt tgaccaagaa
     1981 aggagcttag ctaagaggtc tttgtttcca gaggacccaa gactaccaga ctcctgtgca
     2041 gtctgcctgt ctgcagagcc tccaatcacg gtttaaagtg gtcttggcct cccagccccc
     2101 actgctgcag ccttcagagc cagcctctgg actcagcgcc aggagcctcc tctcctgctg
     2161 ccctggtacc tgtcatccta gtgtcaccta tttgttttgc acagcattct ggagaacatg
     2221 tgcctcacaa agtgatcctg tttttctcac cctccaaagc tgaggtggct aagggaggca
     2281 ggggtgagag agctcactct ctaaaccaca ggcagggcaa ggtgcttcta ggccgtgtcc
     2341 cctccctggg gaatggtcac tactcctcag catggccaca ggcccctgtg gttttgggag
     2401 tttgctgagt gactgtggaa tgggctgacc ccagccgttt ccctgctgtg gaaacagcaa
     2461 ggtaggggca ctgcttggtg gtttgtcaag ctcagaggca gccacggatg gttaggaaca
     2521 ggaagccaca ctgctaaggt gtgatgagct agaagggaga catcctggac ttcaagtgag
     2581 acaagtgcag aggaggccac tccacttagg accttccttt tagacctgca tgagcacgtg
     2641 tttcacttaa gcacattggg tccgaattgg gcgcatgaac ccagctgtta aaccaggtac
     2701 cctgggactg ccctctgcct ctcagagccc tacctgtcct ggacttgaag gcgagcatca
     2761 ggcaggcctt ctcagcccat cttccaccag gagtgcagag ccagggtgct gagaggagca
     2821 gggactgtaa ctacagtagg aggcaacttt gctggtgtca ttcctgctcg gattgacttt
     2881 gtgctccctc ccatccacag ctatggtagc cagtatttcc ccagcagctc tctagtgggg
     2941 aagagtggct agaaccaggc cattctcagt cgaatttagg aagaccaaga ctcatgttcc
     3001 tgacaggacg gtcattccct catggcatca ctgactcagt tctaattcct cccctcctgt
     3061 ttcattttgg tttgaacaac ctgtgcctgc agctgtttct tccaccttcc tggagctcac
     3121 aattggagct tcatgttcag tcttgagctc ctaatgtttc cagacagggc aggggatagg
     3181 agagccataa tctatgaaag ctgtgaaaca aaccctgggt tatatagatc tcagatggtc
     3241 tcatctgaag gctttgccca cttcccagtg agcagagggt ttggggaaca aagaggtagc
     3301 tgaagagtgg tggtttttcc ctgtatcctg attttcagaa agggctttag tctctgagct
     3361 gtggctagta gctggctggc tgaccagggg acgggggtct aatagggtgt ctgaccatag
     3421 gacacctctc gtgtttggcc ttccctttct tgtgtgtttg tgtgtgtgtg tgcacgtgca
     3481 cgtgcacaca catgtacaca cacaaatctg tatccccagg agtgcctcct gcagtcactg
     3541 ggggctcttc cgtggtgcac catcccatga gagcagatca gagggctgtg gtcaggactt
     3601 cctcccgagc tgccctccct ccctgggatg agtttcctct ccacctgctc caaggtgcct
     3661 tacgaggtgc agctcttcac ctggccacat ggcatccatc accgtgttga gaaatggtgg
     3721 gacgttggct ggatattgtg tgctatgaat ctgatttgtc caaatctgga cctcagccaa
     3781 gccacctgtg gtggaacctt gcaagtcaag gtcatgaaca aatttcttgt aactattgga
     3841 aataaactaa tgaggtagaa ctgtcatatc caaatggaag aggtggttgg tactgttact
     3901 tccttttgct gtcagagggt tgttgacaat ggcaaggggg gatgttagtg agatccaggt
     3961 ggtggtggct tcttggtcca ctcagcttgc acacatgcaa gaggagggtc tgtggcccct
     4021 cagccgtgct ggtggcctcc ttcctcaagc tttaacttgt gccctccctg gcaacaggga
     4081 gtcatgggtt aatgtcacct gtcatgcctc tttcttcagg gaaaatatta aaaggctcaa
     4141 atccaagctg tgacttccct tagacagtgt aagcctgtag ggtgcagccc caagtttatg
     4201 tccaaaggct gcctcagaac cctggaggga gcagcgccca gctggcagct cactctgccc
     4261 ttgcagttca ctggcctttt cgcagccagg ctaagatagg cagtgcaagg agcttcccac
     4321 tggccagagc agctgccttg tagaatgtgg ggctggcttt tagaagtttc acacgcttgc
     4381 agctaagagt gcagagctct ctgttttact tcgtgaaaca ttagcagctc tgaggggctt
     4441 ggcttttggt aagggactta tggtctgact tgccacaagc accttgagct cctgggttgg
     4501 ttggtggttg gttggttggg ttgttttaaa tttgattttt cttttcctga agtttgttag
     4561 aagtcagacc tatgcaagga aaaccatggc ccacttcagc agccatccag tgggggtgct
     4621 taatcggtgg tggtaggatt catggaaacg tttttttgaa atgaaagaga agatgatgta
     4681 cttacattgt aaaatggttt acaataaagt ttggcatctt attacagttt tttttaaaaa
     4741 gaaa
//
