LOCUS       NM_001198974            1420 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens STIMATE-MUSTN1 readthrough (STIMATE-MUSTN1), mRNA.
ACCESSION   NM_001198974
VERSION     NM_001198974.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1420)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Kennedy RB, Ovsyannikova IG, Pankratz VS, Haralambieva IH, Vierkant
            RA and Poland GA.
  TITLE     Genome-wide analysis of polymorphisms associated with cytokine
            responses in smallpox vaccine recipients
  JOURNAL   Hum Genet 131 (9), 1403-1421 (2012)
   PUBMED   22610502
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099667.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001198974.2.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring TMEM110 (transmembrane
            protein 110) and MUSTN1 (musculoskeletal, embryonic nuclear protein
            1) genes. The read-through transcript encodes a fusion protein that
            shares sequence identity with each individual gene product.
            [provided by RefSeq, Nov 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2163105
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 375346, 389125
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AC099667.2         131368-131625       c
            259-307             AC099667.2         89473-89521         c
            308-403             AC099667.2         86680-86775         c
            404-525             AC099667.2         83869-83990         c
            526-638             AC099667.2         78906-79018         c
            639-716             AC099667.2         77798-77875         c
            717-866             AC099667.2         76888-77037         c
            867-977             AC099667.2         74577-74687         c
            978-1110            AC099667.2         67694-67826         c
            1111-1420           AC099667.2         67198-67507         c
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..1420
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /note="STIMATE-MUSTN1 readthrough"
                     /db_xref="GeneID:100526772"
                     /db_xref="HGNC:HGNC:38834"
     exon            1..258
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1217
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /note="TMEM110-MUSTN1 read-through transcript;
                     TMEM110-MUSTN1 readthrough"
                     /codon_start=1
                     /product="TMEM110-MUSTN1 fusion protein"
                     /protein_id="NP_001185903.2"
                     /db_xref="GeneID:100526772"
                     /db_xref="HGNC:HGNC:38834"
                     /translation="MQGPAGNASRGLPGGPPSTVASGAGRCESGALMHSFGIFLQGLL
                     GVVAFSTLMLKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSL
                     YLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIV
                     IMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLM
                     RKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRR
                     LTPLKPVKKKKHRFGLPAGAQEAPIKKKRPPVKDEDLKGARGNLTKNQEIKSKTYQVM
                     RECEQAGSAAPSVFSRTRTGTETVFEKPKAGPTKSVFG"
     exon            259..307
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..403
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..525
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..638
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..716
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..866
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..977
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1110
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1420
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1390..1395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /note="hexamer: AATAAA"
     polyA_site      1420
                     /gene="STIMATE-MUSTN1"
                     /gene_synonym="TMEM110-MUSTN1"
                     /note="major polyA site"
ORIGIN      
        1 aggcttggga tcccggctgc gggtttggcg gcgctgcgcc ggcaggcagc gaggccgggc
       61 gggccctggg ccctcgcgcc cctcccgcga ggcctgtcat gcagggcccc gccgggaacg
      121 cgagccgggg actgccaggc gggccgccct ccacagtcgc gtccggggcg ggccgctgcg
      181 agagcggcgc gctcatgcac agcttcggca tcttcctgca ggggctgctc ggcgtcgtgg
      241 ccttcagcac gttaatgctc aaacgcttca gagaaccaaa gcatgaaaga cgtccgtgga
      301 ggatatggtt tttagacact tccaaacaag ccataggaat gctgttcatc cactttgcaa
      361 atgtatacct agcagatctc actgaagagg acccttgttc actgtacctc atcaacttcc
      421 tcctggacgc cactgtgggc atgctgctca tctacgtggg ggtgcgcgcc gtcagcgtcc
      481 tggtagagtg gcagcagtgg gagtccctgc gcttcggcga atatggagac cctctgcagt
      541 gtggagcctg ggtcgggcag tgcgctcttt acatcgtgat catgattttt gaaaagtctg
      601 tcgtcttcat cgtcctccta atacttcagt ggaaaaaggt ggccctgttg aatcccattg
      661 aaaacccaga cttgaagctg gccatcgtca tgctgatcgt ccccttcttt gtcaacgctt
      721 tgatgttttg ggtagtggac aatttcctca tgagaaaggg gaagacgaaa gctaagctag
      781 aagaaagggg agccaaccag gactcgagga atgggagcaa ggtccgctac cggagggccg
      841 catcccacga ggagtctgag tctgagatcc tgatctcagc ggatgatgag atggaggagt
      901 ccgacgtgga ggaggacctc cgcagactga cccccctcaa gcctgtgaag aaaaagaagc
      961 accgctttgg gctacccgct ggtgctcagg aagcccctat caagaagaag cgcccccctg
     1021 tgaaggacga ggacctgaag ggggcccgag gaaacctgac caagaaccag gaaatcaagt
     1081 ccaagaccta ccaggtcatg cgagagtgtg agcaagctgg ctcggccgcc ccgtcggtgt
     1141 tcagccgcac ccgcacaggt accgagactg tctttgagaa gcccaaagcc ggacccacca
     1201 agagtgtctt cggctgagaa gtgtgcgcca ctccccttgc tgcccgaatg ctcggaaaca
     1261 ggagcctttc ccaggaactc ttttttatgc cagaacgctt cctctcccct gctgtctctg
     1321 gggctgccac cctcccccac agtccaggcc cttcagccaa gggctctgca ccagcacctt
     1381 ggaagcacca ataaagagga tgcccacgtg gccccagcaa
//
